2,788 research outputs found
Evaluation of Donor and Recipient Characteristics Involved in Descemet Stripping Automated Endothelial Keratoplasty Outcomes
Aims: To evaluate both donor and recipient features involved in visual acuity restoring and complication insurgence in eyes that have undergone Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: In this retrospective study, charts of 111 eyes of 96 patients (mean age 70.25 ± 8.58 years) that underwent DSAEK were evaluated. Only Fuch's Distrophy (FD) or Bullous Keratopathy (BK) due to cataract surgery eyes were included. A complete ophthalmic check with endothelial cell density (ECD) and central corneal thickness (CCT) measurement was performed before surgery and at 1, 3, 6, and 12 months follow-up. Each DSAEK was performed by the same well-trained surgeon; only pre-cut lenticules, provided by same Eye Bank, were implanted. Results: A total of 48 (43%) complications have been observed (most of them were 22 partial graft detachments and 17 IOP spikes). At the last follow-up (mean: 8.58 ± 4.09 months), a significant increase (p < 0.05) of best corrected visual acuity (BCVA) was detected. Overall mean BCVA of the eyes evaluated was 0.40 ± 0.43 LogMAR with BK eyes showing a significantly higher improvement (p < 0.05) compared to FD eyes. The only factor showing a significant correlation (p < 0.05) with visual acuity enhancement was the implant of a lenticule thinner than 100 μm. Recipient features significantly (p < 0.05) associated with complications observed after surgery were glaucoma and diabetes mellitus. Conclusion: The use of a graft thinner than 100 μm can provide better visual acuity recovery while recipients affected by glaucoma or diabetes mellitus are more prone to develop complications after surgery
Correlation between choriocapillaris density and retinal sensitivity in age-related macular degeneration
Purpose: The purpose of this study was to investigate the relationship between perfusion of the choriocapillaris (CC) and retinal sensitivity in eyes with intermediate agerelated macular degeneration (iAMD). Methods: This prospective study included patients with iAMD and healthy controls. All enrolled subjects underwent optical coherence tomography angiography (OCT-A) in order to compute the percent perfused choriocapillaris area (PPCA). In patients with iAMD, microperimetry (MP) testing was performed in order to quantify: mean retinal sensitivity (MRS), over an area of 10 degrees; mean macular sensitivity (MMS), over the macular area scanned with OCT-A; and retinal sensitivity (RS) in each macular point. Results: Eighteen eyes of 13 patients were included in the analysis. In addition, 18 eyes of 12 healthy subjects were enrolled as controls. No statistically significant difference (P value > 0.2) was observed in age between patients (73.9 ± 2.0 years) and controls (70.1 ± 2.8 years). We observed significantly lower values of PPCA between patients with iAMD and healthy controls (42.0% ± 3.8% vs. 66.4% ± 3.0%; -Β = 23.8%; P value < 0.001). Among iAMD eyes, higher values of PPCA were significantly associated with higher values of MRS (P value=0.002) and MMS (P value=0.013). Finally, higher values of RS in eachmacular point analyzedwithMPwere significantly (P value<0.001) associated with higher values of PPCA computed in circular regions of interest (ROIs) centered in each analyzed MP point with radii of 0.5 degrees and 1.0 degree. Conclusions: Using OCT-A, we demonstrated a significant association between CC impairment and macular dysfunction, quantified by MP, in iAMD eyes. Translational Relevance: OCT-A could be a useful tool for detecting CC alterations and to monitor disease progression
Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain.
A distinct branch of the Mycobacterium tuberculosis W phylogenetic lineage (W14 group) has been identified and characterized by various genotyping techniques. The W14 group comprises three strain variants: W14, W23, and W26, which accounted for 26 clinical isolates from the New York City metropolitan area. The W14 group shares a unique IS6110 hybridizing banding motif as well as distinct polymorphic GC-rich repetitive sequence and variable number tandem repeat patterns. All W14 group members have high levels of streptomycin resistance. When the streptomycin resistance rpsL target gene was sequenced, all members of this strain family had an identical mutation in codon 43. Patients infected with the W14 group were primarily of non- Hispanic black origin (77%); all were US-born. Including HIV positivity, 84% of the patients had at least one known risk factor for tuberculosis
Near-Infrared Accretion Signatures from the Circumbinary Planetary-Mass Companion Delorme 1 (ab)b
Accretion signatures from bound brown dwarf and protoplanetary companions provide evidence for ongoing planet formation, and accreting substellar objects have enabled new avenues to study the astrophysical mechanisms controlling the formation and accretion processes. Delorme 1 (AB)b, a ?1/430-45 Myr circumbinary planetary-mass companion, was recently discovered to exhibit strong Hα emission. This suggests ongoing accretion from a circumplanetary disk, somewhat surprising given canonical gas disk dispersal timescales of 5-10 Myr. Here, we present the first NIR detection of accretion from the companion in Paβ, Pa?3, and Br?3 emission lines from SOAR/TripleSpec 4.1, confirming and further informing its accreting nature. The companion shows strong line emission, with L line ≈ 1-6 × 10-8 L ? across lines and epochs, while the binary host system shows no NIR hydrogen line emission (L line \u3c 0.32-11 × 10-7 L ?). Observed NIR hydrogen line ratios are more consistent with a planetary accretion shock than with local line excitation models commonly used to interpret stellar magnetospheric accretion. Using planetary accretion shock models, we derive mass accretion rate estimates of Ṁpla?1/43 -4 × 10-8 M J yr-1, somewhat higher than expected under the standard star formation paradigm. Delorme 1 (AB)b\u27s high accretion rate is perhaps more consistent with formation via disk fragmentation. Delorme 1 (AB)b is the first protoplanet candidate with clear (signal-to-noise ratio ?1/45) NIR hydrogen line emission
Measurement of the branching ratio of the decay
From the 2002 data taking with a neutral kaon beam extracted from the
CERN-SPS, the NA48/1 experiment observed 97 candidates with a background contamination of events.
From this sample, the BR() is measured to be
Peering into the Young Planetary System AB Pic. Atmosphere, Orbit, Obliquity & Second Planetary Candidate
We aim to revisit the system AB Pic which has a known companion at the
exoplanet/ brown-dwarf boundary. We based this study on a rich set of
observations to investigate the companion's orbit and atmosphere. We composed a
spectrum of AB Pic b merging archival VLT/SINFONI K-band data, with published
spectra at J and H-band (SINFONI) and Lp-band (Magellan-AO), and photometric
measurements (HST and Spitzer). We modeled the spectrum with ForMoSA, based on
two atmospheric models: ExoREM and BT-SETTL13. We determined the orbital
properties of b fitting the astrometric measurements from NaCo (2003 and 2004)
and SPHERE (2015). The orbital solutions favor a semi-major axis of 190au
viewed edge-on. With Exo-REM, we derive a T of 170050K and surface
gravity of 4.50.3dex, consistent with previous works, and we report for
the first time a C/O ratio of 0.580.08 (solar). The posteriors are
sensitive to the wavelength interval and the family of models used. Given the
2.1hr rotation period and our vsin(i) of 73km/s, we estimate for the
first time the true obliquity to be 45 or 135deg, indicating a
significant misalignment between the planet's spin and orbit orientations.
Finally, the existence of a proper motion anomaly between the Hipparcos and
Gaia eDR3 compared to our SPHERE detection limits and adapted radial velocity
limits indicate the existence of a 6M inner planet orbiting from
2 to 10au (40-200mas). The possible existence of an inner companion, together
with the likely miss-alignment of the spin axis orientation, strongly favor a
formation path by gravitational instability or core accretion within a disk
closer inside followed by dynamical interactions. Confirmation and
characterization of planet c and access to a broader wavelength coverage for
planet b will be essential to probe the uncertainties associated with the
parameters.Comment: 17 pages, 13 Figures, 6 Tables. Accepted for publication in A&A (31
of October
ChPT tests at the NA48 and NA62 experiments at CERN
The NA48/2 Collaboration at CERN has accumulated unprecedented statistics of
rare kaon decays in the Ke4 modes: Ke4(+-) ()
and Ke4(00) () with nearly one percent
background contamination. The detailed study of form factors and branching
rates, based on these data, has been completed recently. The results brings new
inputs to low energy strong interactions description and tests of Chiral
Perturbation Theory (ChPT) and lattice QCD calculations. In particular, new
data support the ChPT prediction for a cusp in the invariant mass
spectrum at the two charged pions threshold for Ke4(00) decay. New final
results from an analysis of about 400 rare
decay candidates collected by the NA48/2 and NA62 experiments at CERN during
low intensity runs with minimum bias trigger configurations are presented. The
results include a model-independent decay rate measurement and fits to ChPT
description.Comment: XIIth International Conference on Heavy Quarks and Leptons 2014,
Mainz, German
Recent NA48/2 and NA62 results
The NA48/2 Collaboration at CERN has accumulated and analysed unprecedented
statistics of rare kaon decays in the modes: () and ()
with nearly one percent background contamination. It leads to the improved
measurement of branching fractions and detailed form factor studies. New final
results from the analysis of 381 rare decay
candidates collected by the NA48/2 and NA62 experiments at CERN are presented.
The results include a decay rate measurement and fits to Chiral Perturbation
Theory (ChPT) description.Comment: Prepared for the Proceedings of "Moriond QCD and High Energy
Interactions. March 22-29 2014." conferenc
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Search for lepton-flavour-violating decays of Higgs-like bosons.
A search is presented for a Higgs-like boson with mass in the range 45 to 195 GeV/c2 decaying into a muon and a tau lepton. The dataset consists of proton-proton interactions at a centre-of-mass energy of 8 TeV , collected by the LHCb experiment, corresponding to an integrated luminosity of 2 fb-1 . The tau leptons are reconstructed in both leptonic and hadronic decay channels. An upper limit on the production cross-section multiplied by the branching fraction at 95% confidence level is set and ranges from 22 pb for a boson mass of 45 GeV/c2 to 4 pb for a mass of 195 GeV/c2
First Observation and Measurement of the Decay K+- -> pi+- e+ e- gamma
Using the full data set of the NA48/2 experiment, the decay K+- -> pi+- e+ e-
gamma is observed for the first time, selecting 120 candidates with 7.3 +- 1.7
estimated background events. With K+- -> pi+- pi0D as normalisation channel,
the branching ratio is determined in a model-independent way to be Br(K+- ->
pi+- e+ e- gamma, m_eegamma > 260 MeV/c^2) = (1.19 +- 0.12_stat +- 0.04_syst) x
10^-8. This measured value and the spectrum of the e+ e- gamma invariant mass
allow a comparison with predictions of Chiral Perturbation Theory.Comment: 13 pages, 3 figures. Accepted for publication in Phys.Lett.
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