352 research outputs found
Homotopic contralesional excitation suppresses spontaneous circuit repair and global network reconnections following ischemic stroke
Understanding circuit-level manipulations that affect the brain\u27s capacity for plasticity will inform the design of targeted interventions that enhance recovery after stroke. Following stroke, increased contralesional activity (e.g. use of the unaffected limb) can negatively influence recovery, but it is unknown which specific neural connections exert this influence, and to what extent increased contralesional activity affects systems- and molecular-level biomarkers of recovery. Here, we combine optogenetic photostimulation with optical intrinsic signal imaging to examine how contralesional excitatory activity affects cortical remodeling after stroke in mice. Following photothrombosis of left primary somatosensory forepaw (S1FP) cortex, mice either recovered spontaneously or received chronic optogenetic excitation of right S1FP over the course of 4 weeks. Contralesional excitation suppressed perilesional S1FP remapping and was associated with abnormal patterns of stimulus-evoked activity in the unaffected limb. This maneuver also prevented the restoration of resting-state functional connectivity (RSFC) within the S1FP network, RSFC in several networks functionally distinct from somatomotor regions, and resulted in persistent limb-use asymmetry. In stimulated mice, perilesional tissue exhibited transcriptional changes in several genes relevant for recovery. Our results suggest that contralesional excitation impedes local and global circuit reconnection through suppression of cortical activity and several neuroplasticity-related genes after stroke, and highlight the importance of site selection for targeted therapeutic interventions after focal ischemia
KRATTA, a triple telescope array for charged reaction products
KRATTA, a new, low threshold, broad energy range triple telescope array has been built to measure the energy, emission angles and isotopic composition of light charged reaction products. It has been equipped with fully digital chains of electronics. The array performed very well during the ASY-EOS experiment, conducted in May 2011 at GSI. The structure and performance of the array are presented using the first experimental results
The ASY-EOS experiment at GSI: investigating the symmetry energy at supra-saturation densities
The elliptic-flow ratio of neutrons with respect to protons in reactions of
neutron rich heavy-ions systems at intermediate energies has been proposed as
an observable sensitive to the strength of the symmetry term in the nuclear
Equation Of State (EOS) at supra-saturation densities. The recent results
obtained from the existing FOPI/LAND data for Au+Au collisions
at 400 MeV/nucleon in comparison with the UrQMD model allowed a first estimate
of the symmetry term of the EOS but suffer from a considerable statistical
uncertainty. In order to obtain an improved data set for Au+Au collisions and
to extend the study to other systems, a new experiment was carried out at the
GSI laboratory by the ASY-EOS collaboration in May 2011.Comment: Talk given by P. Russotto at the 11th International Conference on
Nucleus-Nucleus Collisions (NN2012), San Antonio, Texas, USA, May 27-June 1,
2012. To appear in the NN2012 Proceedings in Journal of Physics: Conference
Series (JPCS
Gross Properties and Isotopic Phenomena in Spectator Fragmentation
A systematic study of isotopic effects in the break-up of projectile
spectators at relativistic energies has been performed with the ALADiN
spectrometer at the GSI laboratory. Searching for signals of criticality in the
fragment production we have applied the model independent universal
fluctuations theory already proposed to track criticality signals in
multifragmentation to our data. The fluctuation of the largest fragment charge
and of the asymmetry of the two and three largest fragments and their bimodal
distribution have also been analysed.Comment: 6 pages, 4 figures, IX International Conference on Nucleus-Nucleus
Collisions, Rio de Janeiro, Brazil, August 28 - September 1, 200
Discriminant Analysis and Secondary-Beam Charge Recognition
The discriminant-analysis method has been applied to optimize the exotic-beam
charge recognition in a projectile fragmentation experiment. The experiment was
carried out at the GSI using the fragment separator (FRS) to produce and select
the relativistic secondary beams, and the ALADIN setup to measure their
fragmentation products following collisions with Sn target nuclei. The beams of
neutron poor isotopes around 124La and 107Sn were selected to study the isospin
dependence of the limiting temperature of heavy nuclei by comparing with
results for stable 124Sn projectiles. A dedicated detector to measure the
projectile charge upstream of the reaction target was not used, and alternative
methods had to be developed. The presented method, based on the multivariate
discriminant analysis, allowed to increase the efficacy of charge recognition
up to about 90%, which was about 20% more than achieved with the simple scalar
methods.Comment: 6 pages, 7 eps figures, elsart, submitted to Nucl. Instr. and Meth.
Isotopic Dependence of the Nuclear Caloric Curve
The A/Z dependence of projectile fragmentation at relativistic energies has
been studied with the ALADIN forward spectrometer at SIS. A stable beam of
124Sn and radioactive beams of 124La and 107Sn at 600 MeV per nucleon have been
used in order to explore a wide range of isotopic compositions. Chemical
freeze-out temperatures are found to be nearly invariant with respect to the
A/Z of the produced spectator sources, consistent with predictions for expanded
systems. Small Coulomb effects (\Delta T \approx 0.6 MeV) appear for residue
production near the onset of multifragmentation.Comment: 11 pages, 3 figures, accepted for publ. in Phys. Rev. Let
Tracing a phase transition with fluctuations of the largest fragment size: Statistical multifragmentation models and the ALADIN S254 data
A phase transition signature associated with cumulants of the largest
fragment size distribution has been identified in statistical
multifragmentation models and examined in analysis of the ALADIN S254 data on
fragmentation of neutron-poor and neutron-rich projectiles. Characteristics of
the transition point indicated by this signature are weakly dependent on the
A/Z ratio of the fragmenting spectator source. In particular, chemical
freeze-out temperatures are estimated within the range 5.9 to 6.5 MeV. The
experimental results are well reproduced by the SMM model.Comment: 7 pages, 3 figures, Proceedings of the International Workshop on
Multifragmentation and Related Topics (IWM2009), Catania, Italy, November
2009
Charged particle densities from Au+Au collisions at sqrt{s_{NN}}=130 GeV
We present charged particle densities as a function of pseudorapidity and
collision centrality for the 197Au+197Au reaction at sqrt{s_{NN}}=130 GeV. An
integral charged particle multiplicity of 3860+/-300 is found for the 5% most
central events within the pseudorapidity range -4.7 <= eta <= 4.7. At
mid-rapidity an enhancement in the particle yields per participant nucleon pair
is observed for central events. Near to the beam rapidity, a scaling of the
particle yields consistent with the ``limiting fragmentation'' picture is
observed. Our results are compared to other recent experimental and theoretical
discussions of charged particle densities in ultra-relativistic heavy-ion
collisions.Comment: 14 pages, 4 figures; to be published in Phys. Lett.
Neutron recognition in the LAND detector for large neutron multiplicity
The performance of the LAND neutron detector is studied. Using an
event-mixing technique based on one-neutron data obtained in the S107
experiment at the GSI laboratory, we test the efficiency of various analytic
tools used to determine the multiplicity and kinematic properties of detected
neutrons. A new algorithm developed recently for recognizing neutron showers
from spectator decays in the ALADIN experiment S254 is described in detail. Its
performance is assessed in comparison with other methods. The properties of the
observed neutron events are used to estimate the detection efficiency of LAND
in this experiment.Comment: 16 pages, 8 figure
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