315 research outputs found

    Les effets pathologiques des explosions sous l'eau

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    Valade Paul. Les effets pathologiques des explosions sous l’eau. In: Bulletin de l'Académie Vétérinaire de France tome 104 n°4, 1951. pp. 251-260

    Histo-pathologie d’effets radiants de caractère aigu et d’action totale

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    Valade Paul. Histo-pathologie d’effets radiants de caractère aigu et d’action totale. In: Bulletin de l'Académie Vétérinaire de France tome 117 n°9, 1964. pp. 427-442

    A propos de la thèse de M. P. Bonart : « De l’influence du christianisme sur l’évolution de la médecine vétérinaire ». Confrontation avec le Père Teilhard de Chardin

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    Valade Paul. A propos de la thèse de M. P. Bonart : «De l’influence du christianisme sur l’évolution de la Médecine Vétérinaire». Confrontation avec le Père Teilhard de Chardin. In: Bulletin de l'Académie Vétérinaire de France tome 118 n°6, 1965. pp. 227-236

    The condition-dependent transcriptional landscape of Burkholderia pseudomallei

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    This is the final version of the article. Available from the publisher via the DOI in this record.Burkholderia pseudomallei (Bp), the causative agent of the often-deadly infectious disease melioidosis, contains one of the largest prokaryotic genomes sequenced to date, at 7.2 Mb with two large circular chromosomes (1 and 2). To comprehensively delineate the Bp transcriptome, we integrated whole-genome tiling array expression data of Bp exposed to >80 diverse physical, chemical, and biological conditions. Our results provide direct experimental support for the strand-specific expression of 5,467 Sanger protein-coding genes, 1,041 operons, and 766 non-coding RNAs. A large proportion of these transcripts displayed condition-dependent expression, consistent with them playing functional roles. The two Bp chromosomes exhibited dramatically different transcriptional landscapes--Chr 1 genes were highly and constitutively expressed, while Chr 2 genes exhibited mosaic expression where distinct subsets were expressed in a strongly condition-dependent manner. We identified dozens of cis-regulatory motifs associated with specific condition-dependent expression programs, and used the condition compendium to elucidate key biological processes associated with two complex pathogen phenotypes--quorum sensing and in vivo infection. Our results demonstrate the utility of a Bp condition-compendium as a community resource for biological discovery. Moreover, the observation that significant portions of the Bp virulence machinery can be activated by specific in vitro cues provides insights into Bp's capacity as an "accidental pathogen", where genetic pathways used by the bacterium to survive in environmental niches may have also facilitated its ability to colonize human hosts.This work was funded by a core grant provided by the Agency for Science, Technology and Research to the Genome Institute of Singapore, and funding from the Defence Medical and Environmental Research Institute, Singapore. This work was supported in part through NIAID contract HHSN266200400035C to BWS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

    Les modifications histologiques des nerfs traités par l’Alcoolisation

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    Valade M.-P. Les modifications histologiques des nerfs traités par l’alcoolisation. In: Bulletin de l'Académie Vétérinaire de France tome 107 n°5, 1954. pp. 191-200

    Étude pharmacologique et anatomo-pathologique d’un insecticide : le thiophosphate de di-éthyle et de paranitrophényle

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    Valade Paul, Salle J. Étude pharmacologique et anatomo-pathologique d’un insecticide : le tiopliosphate de di-éthyle et de paranitrophényle. In: Bulletin de l'Académie Vétérinaire de France tome 103 n°5, 1950. pp. 255-262

    A vertically discretised canopy description for ORCHIDEE (SVN r2290) and the modifications to the energy, water and carbon fluxes

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    Since 70% of global forests are managed and forests impact the global carbon cycle and the energy exchange with the overlying atmosphere, forest management has the potential to mitigate climate change. Yet, none of the land surface models used in Earth system models, and therefore none of today’s predictions of future climate, account for the interactions between climate and forest management. We addressed this gap in modelling capability by developing and parametrizing a version of the land surface model ORCHIDEE to simulate the biogeochemical and biophysical effects of forest management. The most significant changes between the new branch called ORCHIDEE-CAN (SVN r2290) and the trunk version of ORCHIDEE (SVN r2243) are the allometric-based allocation of carbon to leaf, root, wood, fruit and reserve pools; the transmittance, absorbance and reflectance of radiation within the canopy; and the vertical discretisation of the energy budget calculations. In addition, conceptual changes were introduced towards a better process representation for the interaction of radiation with snow, the hydraulic architecture of plants, the representation of forest management and a numerical solution for the photosynthesis formalism of Farquhar, von Caemmerer and Berry. For consistency reasons, these changes were extensively linked throughout the code. Parametrization was revisited after introducing twelve new parameter sets that represent specific tree species or genera rather than a group of often distantly related or even unrelated species, as is the case in widely used plant functional types. Performance of the new model was compared against the trunk and validated against independent spatially explicit data for basal area, tree height, canopy strucure, GPP, albedo and evapotranspiration over Europe. For all tested variables ORCHIDEE-CAN outperformed the trunk regarding its ability to reproduce large-scale spatial patterns as well as their inter-annual variability over Europe. Depending on the data stream, ORCHIDEE-CAN had a 67% to 92% chance to reproduce the spatial and temporal variability of the validation data.JRC.H.5-Land Resources Managemen

    Éléments de pathologie « sonique » : Le syndrome traumato-vibratoire expérimental

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    Valade Paul, Bugard P., Coste F., Salle J. Éléments de pathologie «sonique» : Le syndrome traumato-vibratoire expérimental. In: Bulletin de l'Académie Vétérinaire de France tome 106 n°2, 1953. pp. 113-122
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