Rapid Formation of Massive Planetary Cores in a Pressure Bump

Models of planetary core growth by either planetesimal or pebble accretion are traditionally disconnected from the models of dust evolution and formation of the first gravitationally-bound planetesimals. The state-of-the-art models typically start with massive planetary cores already present. We aim to study the formation and growth of planetary cores in a pressure bump, motivated by the annular structures observed in protoplanetary disks, starting with sub-micron-sized dust grains. We connect the models of dust coagulation and drift, planetesimal formation in the streaming instability, gravitational interactions between planetesimals, pebble accretion, and planet migration, into one uniform framework. We find that planetesimals forming early at the massive end of the size distribution grow quickly dominantly by pebble accretion. These few massive bodies grow on the timescales of ~100 000 years and stir the planetesimals formed later preventing the emergence of further planetary cores. Additionally, a migration trap occurs allowing for retention of the growing cores. Pressure bumps are favourable locations for the emergence and rapid growth of planetary cores by pebble accretion as the dust density and grain size are increased and the pebble accretion onset mass is reduced compared to a smooth-disk model.Comment: 15 pages, 11 figures, accepted by A&

The impact of dynamic pressure bumps on the observational properties of protoplanetary disks

Over the last years, large (sub-)millimetre surveys of protoplanetary disks have well constrained the demographics of disks, such as their millimetre luminosities, spectral indices, and disk radii. Additionally, several high-resolution observations have revealed an abundance of substructures in the disks dust continuum. The most prominent are ring like structures, likely due to pressure bumps trapping dust particles. The origins and characteristics of these bumps, nevertheless, need to be further investigated. The purpose of this work is to study how dynamic pressure bumps affect observational properties of protoplanetary disks. We further aim to differentiate between the planetary- versus zonal flow-origin of pressure bumps. We perform one-dimensional gas and dust evolution simulations, setting up models with varying pressure bump features. We subsequently run radiative transfer calculations to obtain synthetic images and the different quantities of observations. We find that the outermost pressure bump determines the disks dust size across different millimetre wavelengths. Our modelled dust traps need to form early (< 0.1 Myr), fast (on viscous timescales), and must be long lived (> Myr) to obtain the observed high millimetre luminosities and low spectral indices of disks. While the planetary bump models can reproduce these observables irrespectively of the opacity prescription, the highest opacities are needed for the zonal flow bump model to be in line with observations. Our findings favour the planetary- over the zonal flow-origin of pressure bumps and support the idea that planet formation already occurs in early class 0-1 stages of circumstellar disks. The determination of the disks effective size through its outermost pressure bump also delivers a possible answer to why disks in recent low-resolution surveys appear to have the same sizes across different millimetre wavelengths.Comment: 22 pages, 15 figures. To be published in Astronomy & Astrophysic

ELISA - Experimental Large Italian Seismic Array

The Italian Seismic Network (ISN) operated by the INGV consists of more than 200 seismic stations and has recently been upgraded by some dozen broadband seismic stations (Nanometrics Trident 24 bit digitizers, Trillium seismometers). Real time data acquisition at Central Data Analysis Centre at the INGV-Rome is realized by satellite data transmission (Libra VSAT)

Favipiravir vs. Deferiprone: Tautomeric, photophysical, in vitro biological studies, and binding interactions with SARS-Cov-2-MPro/ACE2

Coronavirus disease 2019 (COVID-19) still remains the most disastrous infection continuously affecting millions of people worldwide. Herein, we performed a comparative study between the anti-influenza drug favipiravir (FAV) and the anti-thalassemia drug deferiprone (DFP) in order to examine their potential as basic scaffolds for the generation of most effective and structurally novel antivirals. To conduct the initial molecular modelling and virtual screening steps, our recently proposed single crystal X-ray diffraction (SCXRD)/HYdrogen DEssolvation (HYDE) technology platform has been used. This platform allows molecular design, interactive prioritization and virtual evaluation of newly designed molecules, simultaneously affecting two COVID-related targets, including angiotensin-converting enzyme 2 (ACE2) as a host-cellular receptor (host-based approach) and the main protease (Mpro) enzyme of the spike glycoprotein of SARS-Cov-2 (virus-based approach). Based on the molecular docking results, DFP has shown higher binding affinity (Ki HYDE values) over FAV towards both biological targets. The tautomeric, physicochemical, and biological properties of FAV and DFP have been studied both experimentally and theoretically using molecular spectroscopy (UV–VIS absorption), parallel artificial membrane permeability assay, and cell biology (PAMPA and MTT assay), as well as DFT quantum chemical calculations. According to the obtained results, the enol tautomers of both compounds are considerably more stable in different organic solvents. However, the keto tautomer of FAV was estimated to be most preferable under physiological conditions, which is in good agreement with the molecular docking studies. The isolated crystal structure of DFP is in an excellent agreement with the computation in respect of the most stable tautomer. Combined single X-ray/molecular modeling studies including HYDE analyses provided not only insights into the protein–ligand interactions within the binding site of SARS-Cov-2-ACE2 and SARS-Cov-2-Mpro, but also a valuable information regarding the most stable enol tautomeric form of DFP that contributes to its estimated higher potency against these targets

Proposal for a unified nomenclature for target site mutations associated with resistance to fungicides

Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein. The convention for describing amino-acid substitutions is to cite the wild type amino acid, the codon number and the new amino acid, using the one letter amino acid code. It has frequently been observed that orthologous amino acid mutations have been selected in different species by fungicides from the same mode of action class, but the amino acids have different numbers. These differences in numbering arise from the different lengths of the proteins in each species. The purpose of the current paper is to propose a system for unifying the labelling of amino acids in fungicide target proteins. To do this we have produced alignments between fungicide target proteins of relevant species fitted to a well-studied “archetype” species. Orthologous amino acids in all species are then assigned numerical “labels” based on the position of the amino acid in the archetype protein

The diagnostic value of ultrasonography-derived edema of the temporal artery wall in giant cell arteritis: a second meta-analysis

<p>Abstract</p> <p>Background</p> <p>Ultrasonography of temporal arteries is not commonly used in the approach of patients with suspected giant cell arteritis (GCA) in clinical practice. A meta-analysis of primary studies available through April 2004 concluded that ultrasonography could indeed be helpful in diagnosing GCA. We specifically re-examined the diagnostic value of the ultrasonography-derived halo sign, a dark hypoechoic circumferential thickening around the artery lumen, indicating vasculitic wall edema, in GCA.</p> <p>Methods</p> <p>Original, prospective studies in patients with suspected GCA that examined ultrasonography findings of temporal arteries using the ACR 1990 classification criteria for GCA as reference standard, published through 2009, were identified. Only eight studies involving 575 patients, 204 of whom received the final diagnosis of GCA, fulfilled technical quality criteria for ultrasound. Weighted sensitivity and specificity estimates of the halo sign were assessed, their possible heterogeneity was investigated and pooled diagnostic odds ratio was determined.</p> <p>Results</p> <p>Unilateral halo sign achieved an overall sensitivity of 68% (95% CI, 0.61-0.74) and specificity of 91% (95% CI, 0.88-0.94) for GCA. The values of inconsistency coefficient (I²) of both sensitivity and specificity of the halo sign, showed significant heterogeneity concerning the results between studies. Pooled diagnostic odds ratio, expressing how much greater the odds of having GCA are for patients with halo sign than for those without, was 34 (95% CI, 8.21-138.23). Diagnostic odds ratio was further increased to 65 (95% CI, 17.86-236.82) when bilateral halo signs were present (sensitivity/specificity of 43% and 100%, respectively). In both cases, it was found that DOR was constant across studies.</p> <p>Conclusion</p> <p>Temporal artery edema demonstrated as halo sign should be always looked for in ultrasonography when GCA is suspected. Providing that currently accepted technical quality criteria are fulfilled, halo sign's sensitivity and specificity are comparable to those of autoantibodies used as diagnostic tests in rheumatology. Validation of revised GCA classification criteria which will include the halo sign may be warranted.</p

The anthropology of extraction: critical perspectives on the resource curse

Attempts to address the resource curse remain focussed on revenue management, seeking technical solutions to political problems over examinations of relations of power. In this paper, we provide a review of the contribution anthropological research has made over the past decade to understanding the dynamic interplay of social relations, economic interests and struggles over power at stake in the political economy of extraction. In doing so, we show how the constellation of subaltern and elite agency at work within processes of resource extraction is vital in order to confront the complexities, incompatibilities, and inequities in the exploitation of mineral resources

Temporal and structural genetic variation in reindeer (Rangifer tarandus) associated with the pastoral transition in Northwestern Siberia

Funding Information NordForsk. Grant Number: 76915 ERC Advanced Grant. Grant Numbers: 295458, ESRC ES/, M011054/1 JPI HUMANOR ERC Starting GrantPeer reviewedPublisher PD