S-PRAC: Fast Partial Packet Recovery with Network Coding in Very Noisy Wireless Channels

Well-known error detection and correction solutions in wireless communications are slow or incur high transmission overhead. Recently, notable solutions like PRAC and DAPRAC, implementing partial packet recovery with network coding, could address these problems. However, they perform slowly when there are many errors. We propose S-PRAC, a fast scheme for partial packet recovery, particularly designed for very noisy wireless channels. S-PRAC improves on DAPRAC. It divides each packet into segments consisting of a fixed number of small RLNC encoded symbols and then attaches a CRC code to each segment and one to each coded packet. Extensive simulations show that S-PRAC can detect and correct errors quickly. It also outperforms DAPRAC significantly when the number of errors is high

Lessons from LIMK1 enzymology and their impact on inhibitor design

LIM domain kinase 1 (LIMK1) is a key regulator of actin dynamics. It is thereby a potential therapeutic target for the prevention of fragile X syndrome and amyotrophic lateral sclerosis. Herein, we use X-ray crystallography and activity assays to describe how LIMK1 accomplishes substrate specificity, to suggest a unique ‘rock-and-poke’ mechanism of catalysis and to explore the regulation of the kinase by activation loop phosphorylation. Based on these findings, a differential scanning fluorimetry assay and a RapidFire mass spectrometry activity assay were established, leading to the discovery and confirmation of a set of small-molecule LIMK1 inhibitors. Interestingly, several of the inhibitors were inactive towards the closely related isoform LIMK2. Finally, crystal structures of the LIMK1 kinase domain in complex with inhibitors (PF-477736 and staurosporine, respectively) are presented, providing insights into LIMK1 plasticity upon inhibitor binding

An approach to permutation symmetry for the electroweak theory

The form of the leptonic mixing matrix emerging from experiment has, in the last few years, generated a lot of interest in the so-called tribimaximal type. This form may be naturally associated with the possibility of a discrete permutation symmetry ($S_3$) among the three generations. However, trying to implement this attractive symmetry has resulted in some problems and it seems to have fallen out of favor. We suggest an approach in which the $S_3$ holds to first approximation, somewhat in the manner of the old SU(3) flavor symmetry of the three flavor quark model. It is shown that in the case of the neutrino sector, a presently large experimentally allowed region can be fairly well described in this first approximation. We briefly discuss the nature of the perturbations which are the analogs of the Gell-Mann Okubo perturbations but confine our attention for the most part to the $S_3$ invariant model. We postulate that the $S_3$ invariant mass spectrum consists of non zero masses for the $(\tau,b,t)$ and zero masses for the other charged fermions but approximately degenerate masses for the three neutrinos. The mixing matrices are assumed to be trivial for the charged fermions but of tribimaximal type for the neutrinos in the first approximation. It is shown that this can be implemented by allowing complex entries for the mass matrix and spontaneous breakdown of the $S_3$ invariance of the Lagrangian.Comment: 24 pages, 1 figure, minor corrections and acknowledgment added. To appear in IJM

Draft Whole-Genome Sequence of the Alkaliphilic Alishewanella aestuarii Strain HH-ZS, Isolated from Historical Lime Kiln WasteContaminated Soil

Here, we present the whole-genome sequence of an environmental Gram-negative Alishewanella aestuarii strain (HH-ZS), isolated from the hyperalkaline contaminated soil of a historical lime kiln in Buxton, United Kingdom

Global energy transition: From the main determinants to economic challenges

Dynamic global energy transition has been accelerating for the last decade. Interestingly, the energy transition is multidimensional and concerns both the dimensions of technique/ technology and the economic, social, institu-tional, and legal spheres

Observations of neutral circulation at mid-latitudes during the Equinox Transition Study

Measurements of ion drift velocity made by the Millstone Hill incoherent scatter radar have been used to calculate the meridional neutral wind velocity during the Sept. 17 to 24, 1984 period. Strong daytime southward neutral surges were observed during the magnetically disturbed days of September 19 and 23, in contrast to the small daytime winds obtained as expected during the magnetically quiet days. The surge on September 19 was also seen at Arecibo. In addition, two approaches have been used to calculate the meridional wind component from the radar-derived height of the F-layer electron density peak. Results confirm the wind surge, particularly when the strong electric fields measured during the disturbed days are included in the calculations. The two approaches for the F-layer peak wind calculations are applied to the radar-derived electron density peak height as a function of latitude to study the variation of the southward daytime surges with latitude

Intraday Markets for Power: Discretizing the Continuous Trading

A fundamental question regarding the design of electricity markets is whether adding auctions to the continuous intraday trading is improving the performance of the market. To approach this question, we assess the experience with the implementation of the 3 pm local auction for quarters in Germany at the European Power Exchange (EPEX SPOT) in December 2014 to assess the impact on trading volumes/liquidity, prices, as well as market depth. We discuss further opportunities and challenges that are linked with a potential implementation of an intraday auction