Evidence of Deep Water Penetration in Silica during Stress Corrosion Fracture

We measure the thickness of the heavy water layer trapped under the stress corrosion fracture surface of silica using neutron reflectivity experiments. We show that the penetration depth is 65–85 Å, suggesting the presence of a damaged zone of ~100 Å extending ahead of the crack tip during its propagation. This estimate of the size of the damaged zone is compatible with other recent results

Inelastic interaction mean free path of negative pions in tungsten

The inelastic interaction mean free paths lambda of 5, 10, and 15 GeV/c pions were measured by determining the distribution of first interaction locations in a modular tungsten-scintillator ionization spectrometer. In addition to commonly used interaction signatures of a few (2-5) particles in two or three consecutive modules, a chi2 distribution is used to calculate the probability that the first interaction occurred at a specific depth in the spectrometer. This latter technique seems to be more reliable than use of the simpler criteria. No significant dependence of lambda on energy was observed. In tungsten, lambda for pions is 206 plus or minus 6 g/sq cm

A Multi-Compartment, Single and Multiple Dose Pharmacokinetic Study of the Vaginal Candidate Microbicide 1% Tenofovir Gel

Background: Tenofovir (TFV) gel is being evaluated as a microbicide with pericoital and daily regimens. To inhibit viral replication locally, an adequate concentration in the genital tract is critical. Methods and Findings: Forty-nine participants entered a two-phase study: single-dose (SD) and multi-dose (MD), were randomized to collection of genital tract samples (endocervical cells [ECC], cervicovaginal aspirate and vaginal biopsies) at one of seven time points [0.5, 1, 2, 4, 6, 8, or 24 hr(s)] post-dose following SD exposure of 4 mL 1% TFV gel and received a single dose. Forty-seven were randomized to once (QD) or twice daily (BID) dosing for 2 weeks and to collection of genital tract samples at 4, 8 or 24 hrs after the final dose, but two discontinued prior to gel application. Blood was collected during both phases at the seven times post-dose. TFV exposure was low in blood plasma for SD and MD; median C max was 4.0 and 3.4 ng/mL, respectively (C≤29 ng/mL). TFV concentrations were high in aspirates and tissue after SD and MD, ranging from 1.2×10 4 to 9.9×10 6 ng/mL and 2.1×10 2 to 1.4×10 6 ng/mL, respectively, and did not noticeably differ between proximal and distal tissue. TFV diphosphate (TFV-DP), the intracellular active metabolite, was high in ECC, ranging from 7.1×10 3 to 8.8×10 6 ng/mL. TFV-DP was detectable in approximately 40% of the tissue samples, ranging from 1.8×10 2 to 3.5×10 4 ng/mL. AUC for tissue TFV-DP was two logs higher after MD compared to SD, with no noticeable differences when comparing QD and BID. Conclusions: Single-dose and multiple-dose TFV gel exposure resulted in high genital tract concentrations for at least 24 hours post-dose with minimal systemic absorption. These results support further study of TFV gel for HIV prevention. Trial registration: ClinicalTrials.gov NCT00561496. © 2011 Schwartz et al

Young Stars and Protostellar Cores near NGC 2023

We investigate the young (proto)stellar population in NGC 2023 and the L 1630 molecular cloud bordering the HII region IC 434, using Spitzer IRAC and MIPS archive data, JCMT SCUBA imaging and spectroscopy as well as targeted BIMA observations of one of the Class 0 protostars, NGC 2023 MM1. We have performed photometry of all IRAC and MIPS images, and used color-color diagrams to identify and classify all young stars seen within a 22'x26' field along the boundary between IC 434 and L 1630. For some stars, which have sufficient optical, IR, and/or sub-millimeter data we have also used the online SED fitting tool for a large 2D archive of axisymmetric radiative transfer models to perform more detailed modeling of the observed SEDs. We identify 5 sub-millimeter cores in our 850 and 450 micron SCUBA images, two of which have embedded class 0 or I protostars. Observations with BIMA are used to refine the position and characteristics of the Class 0 source NGC 2023 MM 1. These observations show that it is embedded in a very cold cloud core, which is strongly enhanced in NH2D. We find that HD 37903 is the most massive member of a cluster with 20 -- 30 PMS stars. We also find smaller groups of PMS stars formed from the Horsehead nebula and another elephant trunk structure to the north of the Horsehead. We refine the spectral classification of HD 37903 to B2 Ve. Our study shows that the expansion of the IC 434 HII region has triggered star formation in some of the dense elephant trunk structures and compressed gas inside the L 1630 molecular cloud. This pre-shock region is seen as a sub-millimeter ridge in which stars have already formed. The cluster associated with NGC 2023 is very young, and has a large fraction of Class I sources.Comment: 21 pages, 11 figures. Accepted for publication in A&A Replaced with higher resolution figure