Searching for physics beyond the Standard Model in the decay B+ -> K+K+pi-

The observation potential of the decay B+ -> K+K+pi- with the ATLAS detector at LHC is described in this paper. In the Standard Model this decay mode is highly suppressed, while in models beyond the Standard Model it could be significantly enhanced. To improve the selection of the K+K+pi- final state, a charged hadron identification using Time-over-Threshold measurements in the ATLAS Transition Radiation Tracker was developed and used.Comment: 12 pages, 4 figures, 1 tabl

Dependable Distributed Computing for the International Telecommunication Union Regional Radio Conference RRC06

The International Telecommunication Union (ITU) Regional Radio Conference (RRC06) established in 2006 a new frequency plan for the introduction of digital broadcasting in European, African, Arab, CIS countries and Iran. The preparation of the plan involved complex calculations under short deadline and required dependable and efficient computing capability. The ITU designed and deployed in-situ a dedicated PC farm, in parallel to the European Organization for Nuclear Research (CERN) which provided and supported a system based on the EGEE Grid. The planning cycle at the RRC06 required a periodic execution in the order of 200,000 short jobs, using several hundreds of CPU hours, in a period of less than 12 hours. The nature of the problem required dynamic workload-balancing and low-latency access to the computing resources. We present the strategy and key technical choices that delivered a reliable service to the RRC06

Opioid-Induced Constipation in Advanced Illness: Safety and Efficacy of Methylnaltrexone Bromide

Constipation, one of the major side effects of opiates used in palliative care, can impair patients’ quality of life to a point where it prevents sufficient pain control. Methylnaltrexone is a novel μ-receptor antagonist, which does not pass the blood brain barrier. It is licensed to treat opiate induced constipation for patients with advanced diseases. This review article presents an overview of pharmacology and safety of its application, evidence of its efficacy and economic aspects of its use in clinical practice. Available data are limited but strongly suggest that methylnaltrexone causes laxation in less than 24 hours for at least half of those patients over the first two weeks of usage without impairing pain control or causing serious adverse effects. To avoid danger of gastrointestinal perforation it is contraindicated for patients at risk for that complication. More research is needed to evaluate its long-term efficacy and economic impact

Time-resolved photometry of the young dipper RX~J1604.3-2130A:Unveiling the structure and mass transport through the innermost disk

Context. RX J1604.3-2130A is a young, dipper-type, variable star in the Upper Scorpius association, suspected to have an inclined inner disk, with respect to its face-on outer disk. Aims. We aim to study the eclipses to constrain the inner disk properties. Methods. We used time-resolved photometry from the Rapid Eye Mount telescope and Kepler 2 data to study the multi-wavelength variability, and archival optical and infrared data to track accretion, rotation, and changes in disk structure. Results. The observations reveal details of the structure and matter transport through the inner disk. The eclipses show 5 d quasi-periodicity, with the phase drifting in time and some periods showing increased/decreased eclipse depth and frequency. Dips are consistent with extinction by slightly processed dust grains in an inclined, irregularly-shaped inner disk locked to the star through two relatively stable accretion structures. The grains are located near the dust sublimation radius (similar to 0.06 au) at the corotation radius, and can explain the shadows observed in the outer disk. The total mass (gas and dust) required to produce the eclipses and shadows is a few % of a Ceres mass. Such an amount of mass is accreted/replenished by accretion in days to weeks, which explains the variability from period to period. Spitzer and WISE infrared variability reveal variations in the dust content in the innermost disk on a timescale of a few years, which is consistent with small imbalances (compared to the stellar accretion rate) in the matter transport from the outer to the inner disk. A decrease in the accretion rate is observed at the times of less eclipsing variability and low mid-IR fluxes, confirming this picture. The v sin i = 16 km s(-1) confirms that the star cannot be aligned with the outer disk, but is likely close to equator-on and to be aligned with the inner disk. This anomalous orientation is a challenge for standard theories of protoplanetary disk formation.Science & Technology Facilities Council (STFC): ST/S000399/1. ESO fellowship. European Union (EU): 823 823. German Research Foundation (DFG): FOR 2634/1 TE 1024/1-1. French National Research Agency (ANR): ANR-16-CE31-0013. Alexander von Humboldt Foundation. European Research Council (ERC): 678 194. European Research Council (ERC): 742 095. National Aeronautics & Space Administration (NASA). National Science Foundation (NSF). National Aeronautics & Space Administration (NASA): NNG05GF22G. National Science Foundation (NSF): AST-0909182, AST-1 313 422

Neurological determination of death in isolated brainstem lesions: A case report to highlight the issues involved

The neurological determination of death in patients with isolated brainstem lesions or by disruption of the posterior cerebral circulation is uncommon and many intensivists may never see such a case in their career. It is also the only major difference between the “whole brain” and “brain stem” formulations for the neurological determination of death. We present a case of a patient with infarction of the structures supplied by the posterior cerebral circulation in whom death was diagnosed using neurological criteria, to illustrate the issues involved. We also suggest that international consensus may be achieved if ancillary tests, such as CT angiography, are made mandatory in this situation o demonstrate loss of blood flow in the anterior cerebral circulation as well the posterior circulation

Mapping young stellar populations towards Orion with Gaia DR1

We use the first data release of the Gaia mission to explore the three dimensional arrangement and the age ordering of the many stellar groups towards the Orion OB association, aiming at a new classification and characterization of the stellar population. We make use of the parallaxes and proper motions provided in the Tycho Gaia Astrometric Solution (TGAS) sub-set of the Gaia catalogue, and of the combination of Gaia and 2MASS photometry. In TGAS we find evidence for the presence of a young population, at a parallax $\varpi \sim 2.65 \, \mathrm{mas}$, loosely distributed around some known clusters: 25 Ori, $\epsilon$ Ori and $\sigma$ Ori, and NGC 1980 ($\iota$ Ori). The low mass counterpart of this population is visible in the color-magnitude diagrams constructed by combining Gaia and 2MASS photometry. We study the density distribution of the young sources in the sky. We find the same groups as in TGAS, and also some other density enhancements that might be related to the recently discovered Orion X group, the Orion dust ring, and to the $\lambda$ Ori complex. We estimate the ages of this population and we infer the presence of an age gradient going from 25 Ori (13-15 Myr) to the ONC (1-2 Myr). We confirm this age ordering by repeating the Bayesian fit using the Pan-STARRS1 data. The estimated ages towards the NGC 1980 cluster span a broad range of values. This can either be due to the presence of two populations coming from two different episodes of star formation or to a large spread along the line of sight of the same population. Our results form the first step towards using the Gaia data to unravel the complex star formation history of the Orion region in terms of the different star formation episodes, their duration, and their effects on the surrounding interstellar medium.Comment: 17 pages, 17 figure

An ALMA Survey of Protoplanetary Disks in the σ\sigma Orionis Cluster

The $\sigma$ Orionis cluster is important for studying protoplanetary disk evolution, as its intermediate age ($\sim$3-5 Myr) is comparable to the median disk lifetime. We use ALMA to conduct a high-sensitivity survey of dust and gas in 92 protoplanetary disks around $\sigma$ Orionis members with $M_{\ast}\gtrsim0.1 M_{\odot}$. Our observations cover the 1.33 mm continuum and several CO $J=2-1$ lines: out of 92 sources, we detect 37 in the mm continuum and six in $^{12}$CO, three in $^{13}$CO, and none in C$^{18}$O. Using the continuum emission to estimate dust mass, we find only 11 disks with $M_{\rm dust}\gtrsim10 M_{\oplus}$, indicating that after only a few Myr of evolution most disks lack sufficient dust to form giant planet cores. Stacking the individually undetected continuum sources limits their average dust mass to 5$\times$ lower than that of the faintest detected disk, supporting theoretical models that indicate rapid dissipation once disk clearing begins. Comparing the protoplanetary disk population in $\sigma$ Orionis to those of other star-forming regions supports the steady decline in average dust mass and the steepening of the $M_{\rm dust}$-$M_{\ast}$ relation with age; studying these evolutionary trends can inform the relative importance of different disk processes during key eras of planet formation. External photoevaporation from the central O9 star is influencing disk evolution throughout the region: dust masses clearly decline with decreasing separation from the photoionizing source, and the handful of CO detections exist at projected separations $>1.5$ pc. Collectively, our findings indicate that giant planet formation is inherently rare and/or well underway by a few Myr of age.Comment: 16 pages, 9 figures; published in AJ; The full machine readable tables can be obtained by downloading and extracting the gzipped tar source file listed under "Other formats.

X-Shooter study of accretion in Chamaeleon I

DF acknowledges support from the Italian Ministry of Science and Education (MIUR), project SIR (RBSI14ZRHR) and from the ESTEC Faculty Visiting Scientist Programme.We present the analysis of 34 new VLT/X-Shooter spectra of young stellar objects in the Chamaeleon I star-forming region, together with four more spectra of stars in Taurus and two in Chamaeleon II. The broad wavelength coverage and accurate flux calibration of our spectra allow us to estimate stellar and accretion parameters for our targets by fitting the photospheric and accretion continuum emission from the Balmer continuum down to ~700 nm. The dependence of accretion on stellar properties for this sample is consistent with previous results from the literature. The accretion rates for transitional disks are consistent with those of full disks in the same region. The spread of mass accretion rates at any given stellar mass is found to be smaller than inmany studies, but is larger than that derived in the Lupus clouds using similar data and techniques. Differences in the stellar mass range and in the environmental conditions between our sample and that of Lupus may account for the discrepancy in scatter between Chamaeleon I and Lupus.Complete samples in Chamaeleon I and Lupus are needed to determine whether the difference in scatter of accretion rates and the lack of evolutionary trends are not influenced by sample selection.PostprintPeer reviewe

Exploring the dimming event of RW Aur A through multi-epoch VLT/X-Shooter spectroscopy

RW Aur A is a CTTS that has suddenly undergone three major dimming events since 2010. We aim to understand the dimming properties, examine accretion variability, and derive the physical properties of the inner disc traced by the CO ro-vibrational emission at NIR wavelengths (2.3 mic). We compared two epochs of X-Shooter observations, during and after the dimming. We modelled the rarely detected CO bandhead emission in both epochs to examine whether the inner disc properties had changed. The SED was used to derive the extinction properties of the dimmed spectrum and compare the infrared excess between the two epochs. Lines tracing accretion were used to derive the mass accretion rate in both states. The CO originates from a region with physical properties of T=3000 K, N$_{CO}$=1x10$^{21}$ cm$^{-2}$ and vsini=113 km/s. The extinction properties of the dimming layer were derived with the effective optical depth ranging from teff 2.5-1.5 from the UV to the NIR. The inferred mass accretion rate Macc is $1.5x 10^{-8}$ Msun/yr and $\sim 2x 10^{-8}$ Msun/yr after and during the dimming respectively. By fitting the SED, additional emission is observed in the IR during the dimming event from dust grains with temperatures of 500-700K. The physical conditions traced by the CO are similar for both epochs, indicating that the inner gaseous disc properties do not change during the dimming events. The extinction curve is flatter than that of the ISM, and large grains of a few hundred microns are thus required. When we correct for the observed extinction, Macc is constant in the two epochs, suggesting that the accretion is stable and therefore does not cause the dimming. The additional hot emission in the NIR is located at about 0.5 au from the star. The dimming events could be due to a dust-laden wind, a severe puffing-up of the inner rim, or a perturbation caused by the recent star-disc encounter.Comment: Accepted by Astronomy & Astrophysic

Probing UV-sensitive Pathways for CN and HCN Formation in Protoplanetary Disks with the Hubble Space Telescope

The UV radiation field is a critical regulator of gas-phase chemistry in surface layers of disks around young stars. In an effort to understand the relationship between photocatalyzing UV radiation fields and gas emission observed at infrared and submillimeter wavelengths, we present an analysis of new and archival Hubble Space Telescope (HST), Spitzer, ALMA, IRAM, and SMA data for five targets in the Lupus cloud complex and 14 systems in Taurus-Auriga. The HST spectra were used to measure Lyα and far-UV (FUV) continuum fluxes reaching the disk surface, which are responsible for dissociating relevant molecular species (e.g., HCN, N₂). Semi-forbidden C II] λ2325 and UV-fluorescent H₂ emission were also measured to constrain inner disk populations of C⁺ and vibrationally excited H2. We find a significant positive correlation between 14 μm HCN emission and fluxes from the FUV continuum and C II] λ2325, consistent with model predictions requiring N₂ photodissociation and carbon ionization to trigger the main CN/HCN formation pathways. We also report significant negative correlations between submillimeter CN emission and both C II] and FUV continuum fluxes, implying that CN is also more readily dissociated in disks with stronger FUV irradiation. No clear relationships are detected between either CN or HCN and Lyα or UV-H₂ emission. This is attributed to the spatial stratification of the various molecular species, which span several vertical layers and radii across the inner and outer disk. We expect that future observations with the James Webb Space Telescope will build on this work by enabling more sensitive IR surveys than were possible with Spitzer