2,990 research outputs found

    Financial services used by small businesses: evidence from the 1998 survey of small business finances

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    Using newly available data from the 1998 Survey of Small Business Finances, this article offers preliminary findings regarding the characteristics of small businesses in the United States and their use of credit and other financial services. The main goals of the survey are to provide information on credit accessibility for small businesses, their use of financial services, and the sources of those services. The survey also provides a general-purpose database that can be used to study small business financing. Preliminary findings suggest that although the financial landscape has changed markedly since the previous survey in 1993, financing patterns and the use of particular suppliers have not.Small business ; Financial services industry

    The role of quantum fluctuations in the optomechanical properties of a Bose-Einstein condensate in a ring cavity

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    We analyze a detailed model of a Bose-Einstein condensate trapped in a ring optical resonator and contrast its classical and quantum properties to those of a Fabry-P{\'e}rot geometry. The inclusion of two counter-propagating light fields and three matter field modes leads to important differences between the two situations. Specifically, we identify an experimentally realizable region where the system's behavior differs strongly from that of a BEC in a Fabry-P\'{e}rot cavity, and also where quantum corrections become significant. The classical dynamics are rich, and near bifurcation points in the mean-field classical system, the quantum fluctuations have a major impact on the system's dynamics.Comment: 11 pages, 11 figures, submitted to PR

    Inferring Species Trees Directly from Biallelic Genetic Markers: Bypassing Gene Trees in a Full Coalescent Analysis

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    The multi-species coalescent provides an elegant theoretical framework for estimating species trees and species demographics from genetic markers. Practical applications of the multi-species coalescent model are, however, limited by the need to integrate or sample over all gene trees possible for each genetic marker. Here we describe a polynomial-time algorithm that computes the likelihood of a species tree directly from the markers under a finite-sites model of mutation, effectively integrating over all possible gene trees. The method applies to independent (unlinked) biallelic markers such as well-spaced single nucleotide polymorphisms (SNPs), and we have implemented it in SNAPP, a Markov chain Monte-Carlo sampler for inferring species trees, divergence dates, and population sizes. We report results from simulation experiments and from an analysis of 1997 amplified fragment length polymorphism (AFLP) loci in 69 individuals sampled from six species of {\em Ourisia} (New Zealand native foxglove)

    Evidence for a dynamic phase transition in [Co/Pt]_3 magnetic multilayers

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    A dynamic phase transition (DPT) with respect to the period P of an applied alternating magnetic field has been observed previously in numerical simulations of magnetic systems. However, experimental evidence for this DPT has thus far been limited to qualitative observations of hysteresis loop collapse in studies of hysteresis loop area scaling. Here, we present significantly stronger evidence for the experimental observation of this DPT, in a [Co(4 A)/Pt(7 A)]_3-multilayer system with strong perpendicular anisotropy. We applied an out-of-plane, time-varying (sawtooth) field to the [Co/Pt]_3 multilayer, in the presence of a small additional constant field, H_b. We then measured the resulting out-of-plane magnetization time series to produce nonequilibrium phase diagrams (NEPDs) of the cycle-averaged magnetization, Q, and its variance, Var(Q), as functions of P and H_b. The experimental NEPDs are found to strongly resemble those calculated from simulations of a kinetic Ising model under analagous conditions. The similarity of the experimental and simulated NEPDs, in particular the presence of a localized peak in the variance Var(Q) in the experimental results, constitutes strong evidence for the presence of this DPT in our magnetic multilayer samples. Technical challenges related to the hysteretic nature and response time of the electromagnet used to generate the time-varying applied field precluded us from extracting meaningful critical scaling exponents from the current data. However, based on our results, we propose refinements to the experimental procedure which could potentially enable the determination of critical exponents in the future.Comment: substantial revision; 26 pages, 9 figures; to appear in Phys. Rev.

    Conjugate field and fluctuation-dissipation relation for the dynamic phase transition in the two-dimensional kinetic Ising model

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    The two-dimensional kinetic Ising model, when exposed to an oscillating applied magnetic field, has been shown to exhibit a nonequilibrium, second-order dynamic phase transition (DPT), whose order parameter Q is the period-averaged magnetization. It has been established that this DPT falls in the same universality class as the equilibrium phase transition in the two-dimensional Ising model in zero applied field. Here we study for the first time the scaling of the dynamic order parameter with respect to a nonzero, period-averaged, magnetic `bias' field, H_b, for a DPT produced by a square-wave applied field. We find evidence that the scaling exponent, \delta_d, of H_b at the critical period of the DPT is equal to the exponent for the critical isotherm, \delta_e, in the equilibrium Ising model. This implies that H_b is a significant component of the field conjugate to Q. A finite-size scaling analysis of the dynamic order parameter above the critical period provides further support for this result. We also demonstrate numerically that, for a range of periods and values of H_b in the critical region, a fluctuation-dissipation relation (FDR), with an effective temperature T_{eff}(T, P, H_0) depending on the period, and possibly the temperature and field amplitude, holds for the variables Q and H_b. This FDR justifies the use of the scaled variance of Q as a proxy for the nonequilibrium susceptibility, \partial / \partial H_b, in the critical region.Comment: revised version; 31 pages, 12 figures; accepted by Phys. Rev.

    Investigating magnetic activity in very stable stellar magnetic fields: long-term photometric and spectroscopic study of the fully convective M4 dwarf V374 Peg

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    The ultrafast-rotating (Prot≈0.44dP_\mathrm{rot}\approx0.44 d) fully convective single M4 dwarf V374 Peg is a well-known laboratory for studying intense stellar activity in a stable magnetic topology. As an observable proxy for the stellar magnetic field, we study the stability of the light curve, and thus the spot configuration. We also measure the occurrence rate of flares and coronal mass ejections (CMEs). We analyse spectroscopic observations, BV(RI)CBV(RI)_C photometry covering 5 years, and additional RCR_C photometry that expands the temporal base over 16 years. The light curve suggests an almost rigid-body rotation, and a spot configuration that is stable over about 16 years, confirming the previous indications of a very stable magnetic field. We observed small changes on a nightly timescale, and frequent flaring, including a possible sympathetic flare. The strongest flares seem to be more concentrated around the phase where the light curve indicates a smaller active region. Spectral data suggest a complex CME with falling-back and re-ejected material, with a maximal projected velocity of ≈\approx675km/s. We observed a CME rate much lower than expected from extrapolations of the solar flare-CME relation to active stars.Comment: 15 figures, 4 tables, accepted for publication in A&

    Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat

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    Superoxide is the proximal reactive oxygen species (ROS) produced by the mitochondrial respiratory chain and plays a major role in pathological oxidative stress and redox signaling. While there are tools to detect or decrease mitochondrial superoxide, none can rapidly and specifically increase superoxide production within the mitochondrial matrix. This lack impedes progress, making it challenging to assess accurately the roles of mitochondrial superoxide in cells and in vivo. To address this unmet need, we synthesized and characterized a mitochondria-targeted redox cycler, MitoParaquat (MitoPQ) that comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat. MitoPQ accumulates selectively in the mitochondrial matrix driven by the membrane potential. Within the matrix, MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ increased mitochondrial superoxide in isolated mitochondria and cells in culture ~a thousand-fold more effectively than untargeted paraquat. MitoPQ was also more toxic than paraquat in the isolated perfused heart and in Drosophila in vivo. MitoPQ enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo

    Is the tolerability of long-term thiazolidinedione therapy overstated?

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