Attitudes towards artificial intelligence within dermatology: an international online survey.

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Character-level interaction in multimodal computer-assisted transcription of text images

“The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-21257-4_85To date, automatic handwriting text recognition systems are far from being perfect and heavy human intervention is often required to check and correct the results of such systems. As an alternative, an interactive framework that integrates the human knowledge into the transcription process has been presented in previous works. In this work, multimodal interaction at character-level is studied. Until now, multimodal interaction had been studied only at whole-word level. However, character-level pen-stroke interactions may lead to more ergonomic and friendly interfaces. Empirical tests show that this approach can save significant amounts of user effort with respect to both fully manual transcription and non-interactive post-editing correction.Work supported by the Spanish Government (MICINN and “Plan E”) under the MITTRAL (TIN2009-14633-C03-01) research project and under the research programme Consolider Ingenio 2010: MIPRCV (CSD2007-00018), and by the Generalitat Valenciana under grant Prometeo/2009/014.Martín-Albo Simón, D.; Romero Gómez, V.; Toselli ., AH.; Vidal, E. (2011). Character-level interaction in multimodal computer-assisted transcription of text images. En Pattern Recognition and Image Analysis. Springer Verlag (Germany). 684-691. https://doi.org/10.1007/978-3-642-21257-4S68469

3D morphable model fitting for low-resolution facial images

This paper proposes a new algorithm for fitting a 3D morphable face model on low-resolution (LR) facial images. We analyse the criterion commonly used by the main fitting algorithms and by comparing with an image formation model, show that this criterion is only valid if the resolution of the input image is high. We then derive an imaging model to describe the process of LR image formation given the 3D model. Finally, we use this imaging model to improve the fitting criterion. Experimental results show that our algorithm significantly improves fitting results on LR images and yields similar parameters to those that would have been obtained if the input image had a higher resolution. We also show that our algorithm can be used for face recognition in low-resolutions where the conventional fitting algorithms fail

Revealing the molecular signatures of host-pathogen interactions.

Advances in sequencing technology and genome-wide association studies are now revealing the complex interactions between hosts and pathogen through genomic variation signatures, which arise from evolutionary co-existence

Indications for Digital Monitoring of Patients With Multiple Nevi: Recommendations from the International Dermoscopy Society

Introduction: In patients with multiple nevi, sequential imaging using total body skin photography (TBSP) coupled with digital dermoscopy (DD) documentation reduces unnecessary excisions and improves the early detection of melanoma. Correct patient selection is essential for optimizing the efficacy of this diagnostic approach. Objectives: The purpose of the study was to identify, via expert consensus, the best indications for TBSP and DD follow-up. Methods: This study was performed on behalf of the International Dermoscopy Society (IDS). We attained consensus by using an e-Delphi methodology. The panel of participants included international experts in dermoscopy. In each Delphi round, experts were asked to select from a list of indications for TBSP and DD. Results: Expert consensus was attained after 3 rounds of Delphi. Participants considered a total nevus count of 60 or more nevi or the presence of a CDKN2A mutation sufficient to refer the patient for digital monitoring.  Patients with more than 40 nevi were only considered an indication in case of personal history of melanoma or red hair and/or a MC1R mutation or history of organ transplantation. Conclusions: Our recommendations support clinicians in choosing appropriate follow-up regimens for patients with multiple nevi and in applying the time-consuming procedure of sequential imaging more efficiently. Further studies and real-life data are needed to confirm the usefulness of this list of indications in clinical practice

Skin Lesion Analyser: An Efficient Seven-Way Multi-Class Skin Cancer Classification Using MobileNet

Skin cancer, a major form of cancer, is a critical public health problem with 123,000 newly diagnosed melanoma cases and between 2 and 3 million non-melanoma cases worldwide each year. The leading cause of skin cancer is high exposure of skin cells to UV radiation, which can damage the DNA inside skin cells leading to uncontrolled growth of skin cells. Skin cancer is primarily diagnosed visually employing clinical screening, a biopsy, dermoscopic analysis, and histopathological examination. It has been demonstrated that the dermoscopic analysis in the hands of inexperienced dermatologists may cause a reduction in diagnostic accuracy. Early detection and screening of skin cancer have the potential to reduce mortality and morbidity. Previous studies have shown Deep Learning ability to perform better than human experts in several visual recognition tasks. In this paper, we propose an efficient seven-way automated multi-class skin cancer classification system having performance comparable with expert dermatologists. We used a pretrained MobileNet model to train over HAM10000 dataset using transfer learning. The model classifies skin lesion image with a categorical accuracy of 83.1 percent, top2 accuracy of 91.36 percent and top3 accuracy of 95.34 percent. The weighted average of precision, recall, and f1-score were found to be 0.89, 0.83, and 0.83 respectively. The model has been deployed as a web application for public use at (https://saketchaturvedi.github.io). This fast, expansible method holds the potential for substantial clinical impact, including broadening the scope of primary care practice and augmenting clinical decision-making for dermatology specialists.Comment: This is a pre-copyedited version of a contribution published in Advances in Intelligent Systems and Computing, Hassanien A., Bhatnagar R., Darwish A. (eds) published by Chaturvedi S.S., Gupta K., Prasad P.S. The definitive authentication version is available online via https://doi.org/10.1007/978-981-15-3383-9_1

Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability

The efficacy of GABAergic synaptic inhibition is a principal factor in controlling neuronal activity. We demonstrate here that brain-derived neurotrophic factor modulates the activity of GABA(A) receptors, the main sites of fast synaptic inhibition in the brain, within minutes of application. Temporally, this comprised an early enhancement in the miniature IPSC amplitude, followed by a prolonged depression. This modulation was concurrent with enhanced PKC-mediated phosphorylation, followed by protein phosphatase 2A (PP2A)-mediated dephosphorylation of the GABA(A) receptor. Mechanistically, these events were facilitated by differential recruitment of PKC, receptor for activated C-kinase, and PP2A to GABA(A) receptors, depending on the phosphorylation state of the receptor beta(3)-subunit. Thus, transient formation of GABA(A) receptor signaling complexes has the potential to provide a basis for acute changes in receptor function underlying GABAergic synaptic plasticity