536 research outputs found
The EDELWEISS Experiment : Status and Outlook
The EDELWEISS Dark Matter search uses low-temperature Ge detectors with heat
and ionisation read- out to identify nuclear recoils induced by elastic
collisions with WIMPs from the galactic halo. Results from the operation of 70
g and 320 g Ge detectors in the low-background environment of the Modane
Underground Laboratory (LSM) are presented.Comment: International Conference on Dark Matter in Astro and Particle Physics
(Dark 2000), Heidelberg, Germany, 10-16 Jul 2000, v3 minor revision
Event categories in the EDELWEISS WIMP search experiment
Four categories of events have been identified in the EDELWEISS-I dark matter
experiment using germanium cryogenic detectors measuring simultaneously charge
and heat signals. These categories of events are interpreted as electron and
nuclear interactions occurring in the volume of the detector, and electron and
nuclear interactions occurring close to the surface of the detectors(10-20 mu-m
of the surface). We discuss the hypothesis that low energy surface nuclear
recoils,which seem to have been unnoticed by previous WIMP searches, may
provide an interpretation of the anomalous events recorded by the UKDMC and
Saclay NaI experiments. The present analysis points to the necessity of taking
into account surface nuclear and electron recoil interactions for a reliable
estimate of background rejection factors.Comment: 11 pages, submitted to Phys. Lett.
Dark Matter Search in the Edelweiss Experiment
Preliminary results obtained with 320g bolometers with simultaneous
ionization and heat measurements are described. After a few weeks of data
taking, data accumulated with one of these detectors are beginning to exclude
the upper part of the DAMA region. Prospects for the present run and the second
stage of the experiment, EDELWEISS-II, using an innovative reversed cryostat
allowing data taking with 100 detectors, are briefly described.Comment: IDM 2000, 3rd International Workshop on the Identification of Dark
Matter, York (GB), 18-22/09/2000, v2.0 minor modification
IgG 3 + B cells are associated with the development of multiple sclerosis
Objectives
Diseaseâmodifying therapies (DMTs) targeting B cells are amongst the most effective for preventing multiple sclerosis (MS) progression. IgG3 antibodies and their uncharacterised Bâcell clones are predicted to play a pathogenic role in MS. Identifying subsets of IgG3+ B cells involved in MS progression could improve diagnosis, could inform timely disease intervention and may lead to new DMTs that target B cells more specifically.
Methods
We designed a 31âparameter Bâcellâfocused mass cytometry panel to interrogate the role of peripheral blood IgG3+ B cells in MS progression of two different patient cohorts: one to investigate the Bâcell subsets involved in conversion from clinically isolated syndrome (CIS) to MS; and another to compare MS patients with inactive or active stages of disease. Each independent cohort included a group of nonâMS controls.
Results
Nine distinct CD20+IgDâIgG3+ Bâcell subsets were identified. Significant changes in the proportion of CD21+CD24+CD27âCD38â and CD27+CD38hiCD71hi memory Bâcell subsets correlated with changes in serum IgG3 levels and time to conversion from CIS to MS. The same CD38â doubleânegative Bâcell subset was significantly elevated in MS patients with active forms of the disease. A third CD21+CD24+CD27+CD38â subset was elevated in patients with active MS, whilst narrowband UVB significantly reduced the proportion of this switchedâmemory Bâcell subset.
Conclusion
We have identified previously uncharacterised subsets of IgG3+ B cells and shown them to correlate with autoimmune attacks on the central nervous system (CNS). These results highlight the potential for therapies that specifically target IgG3+ B cells to impact MS progression
First Results of the EDELWEISS WIMP Search using a 320 g Heat-and-Ionization Ge Detector
The EDELWEISS collaboration has performed a direct search for WIMP dark
matter using a 320 g heat-and-ionization cryogenic Ge detector operated in a
low-background environment in the Laboratoire Souterrain de Modane. No nuclear
recoils are observed in the fiducial volume in the 30-200 keV energy range
during an effective exposure of 4.53 kg.days. Limits for the cross-section for
the spin-independent interaction of WIMPs and nucleons are set in the framework
of the Minimal Supersymmetric Standard Model (MSSM). The central value of the
signal reported by the experiment DAMA is excluded at 90% CL.Comment: 14 pages, Latex, 4 figures. Submitted to Phys. Lett.
SICANE: a Detector Array for the Measurement of Nuclear Recoil Quenching Factors using Monoenergetic Neutron Beam
SICANE is a neutron scattering multidetector facility for the determination
of the quenching factor (ratio of the response to nuclear recoils and to
electrons) of cryogenic detectors used in direct WIMP searches. Well collimated
monoenergetic neutron beams are obtained with inverse (p,n) reactions. The
facility is described, and results obtained for the quenching factors of
scintillation in NaI(Tl) and of heat and ionization in Ge are presented.Comment: 30 pages, Latex, 11 figures. Submitted to NIM
Experimental Study of electron acceleration by plasma beat-waves with Nd lasers
International audienceWe have observed the acceleration of electrons by a beat-wave generated in a deuterium plasma by two Nd-YAG and Nd-YLF laser wavelengths. Electrons injected at an energy of 3.3 MeV are observed to be accelerated up to 4.7 MeV after the plasma. The energy gain is compatible with a peak electric field of the order of 1.2 GV/m. The experiment has been performed with different injection energies, from 2.5 to 3.3 MeV, with different plasma dimensions, and with different laser intensitie
Final results of the EDELWEISS-II WIMP search using a 4-kg array of cryogenic germanium detectors with interleaved electrodes
The EDELWEISS-II collaboration has completed a direct search for WIMP dark
matter with an array of ten 400-g cryogenic germanium detectors in operation at
the Laboratoire Souterrain de Modane. The combined use of thermal phonon
sensors and charge collection electrodes with an interleaved geometry enables
the efficient rejection of gamma-induced radioactivity as well as near-surface
interactions. A total effective exposure of 384 kg.d has been achieved, mostly
coming from fourteen months of continuous operation. Five nuclear recoil
candidates are observed above 20 keV, while the estimated background is 3.0
events. The result is interpreted in terms of limits on the cross-section of
spin-independent interactions of WIMPs and nucleons. A cross-section of
4.4x10^-8 pb is excluded at 90%CL for a WIMP mass of 85 GeV. New constraints
are also set on models where the WIMP-nucleon scattering is inelastic.Comment: 23 pages, 5 figures; matches published versio
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