Cavendish Square and Spencer House: Neo-classicism, opportunity and nostalgia

The Society of Dilettanti planned a temple-fronted academy of arts on the north side of Cavendish Square in the early 1750s. It can now be shown that stone bought and cut for this building was used in the Green Park elevation of Spencer House (1756–9), shedding new light on design there. The Cavendish Square site stayed empty until speculative pairs of houses were built in 1768–70. Their temple-fronted stone façades, hitherto explained as incorporating stone from the 1750s, must now be understood not as the result of salvage, but as a conscious echo of the abandoned academy project

Vernacular Revival and Ideology - What's Left?

This essay derives from a lecture first given at a Vernacular Architecture Group conference on vernacular revivals in 2015, reprised to generally younger audiences at the Bartlett School of Architecture and the University of Westminster. Its retrospection about vernacular architecture, anonymity, revival and left-wing ideologies was prompted primarily by a bemused awareness of recent advances in self-building. It seemed timely to try to get at how and why certain ideas retain traction. Then, coincidentally, young and old were recombining behind Jeremy Corbyn to reinvigorate Labour, and the self-styled design ‘collective’ Assemble won the Turner Prize. John Ruskin, William Morris, the Arts and Crafts Movement and Romanticism arise (how could they not?), but only in passing, for a revisionist view of what has come since. It is taken as read that a strong commitment to architectural design as being rooted in labour and everyday or subaltern agency tallied with the emergence of socialism and was an important part of architectural thinking and history in late-19th-century England. This is an attempt to relate that history to the present in a new overview for a new framework. It adopts an unconventional or purist definition of what vernacular means that will clash with many preconceptions

The Survey of London's approaches to the history of East London

The Survey of London began in East London in the 1890s. Its founder Charles Robert Ashbee had a strong socialist commitment to the advancement of equality through understandings of a common built environment. The Survey’s first monograph, subtitled an ‘Object Lesson in National History’, was devoted to Trinity Hospital, almshouses on the Mile End Road. It interwove architectural and social history in a preservation campaign that emphasised the social value of historic buildings. In 1910 the Survey was taken under the wing of the London County Council (LCC) where its purposes knitted well with the dominant Progressive party’s determination to raise historical consciousness as a counter to the interests of private property. After the Second World War the LCC took the Survey back to its roots to re-engage with development and destruction. An early fruit of this was a volume devoted to Spitalfields (volume 27, 1957). Not only did this bring attention to the district’s previously uncelebrated eighteenthcentury houses, but it also broadened to account for humble and recent buildings, even those of the inter-war period. In 2016 the Survey once again returned to East London, to work towards publication on Whitechapel, a place currently witnessing huge change. An innovation for the Survey is an interactive map-based website (‘Survey of London – histories of Whitechapel’ http://surveyoflondon.org). This allows the public to contribute knowledge, memories and images to research on the area, a melding of ‘official’ and ‘unofficial’ history that takes the Survey onto new methodological ground. It is also a reaffirmation of Ashbee’s original mission

Speculative development and the origins and history of East India Company settlement in Cavendish Square and Harley Street

As London grew north and west in the eighteenth century, wealth settled on the new-built streets of the Cavendish-Harley (later Portland, now Howard de Walden) estate. This paper describes how, why and where individuals enriched through the East India Company came to ground in this part of London. The cases of Francis Shepheard, scion of an important company family, Governor Robert Adams, in flight from Tellicherry, his nephew Robert Orme, the historian of India, General Richard Smith, a notorious ‘Nabob’, and a few others elucidate the market-based origins and accidental then deliberate consolidation of this settlement and stand for many more East India Company names about whom at this point less is known

Control of somatosensory cortical processing by thalamic posterior medial nucleus: A new role of thalamus in cortical function

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Current knowledge of thalamocortical interaction comes mainly from studying lemniscal thalamic systems. Less is known about paralemniscal thalamic nuclei function. In the vibrissae system, the posterior medial nucleus (POm) is the corresponding paralemniscal nucleus. POm neurons project to L1 and L5A of the primary somatosensory cortex (S1) in the rat brain. It is known that L1 modifies sensory-evoked responses through control of intracortical excitability suggesting that L1 exerts an influence on whisker responses. Therefore, thalamocortical pathways targeting L1 could modulate cortical firing. Here, using a combination of electrophysiology and pharmacology in vivo, we have sought to determine how POm influences cortical processing. In our experiments, single unit recordings performed in urethane- anesthetized rats showed that POm imposes precise control on the magnitude and duration of supra- and infragranular barrel cortex whisker responses. Our findings demonstrated that L1 inputs from POm imposed a time and intensity dependent regulation on cortical sensory processing. Moreover, we found that blocking L1 GABAergic inhibition or blocking P/Q-type Ca2+ channels in L1 prevents POm adjustment of whisker responses in the barrel cortex. Additionally, we found that POm was also controlling the sensory processing in S2 and this regulation was modulated by corticofugal activity from L5 in S1. Taken together, our data demonstrate the determinant role exerted by the POm in the adjustment of somatosensory cortical processing and in the regulation of cortical processing between S1 and S2. We propose that this adjustment could be a thalamocortical gain regulation mechanism also present in the processing of information between cortical areas.This work was supported by a grant from Ministerio de Economia y Competitividad (BFU2012- 36107

People and Things on the Move: Domestic Material Culture, Poverty and Mobility in Victorian London

© 2016, The Author(s). The development of what Mayne and Lawrence (Urban History 26: 325–48, 1999) termed “ethnographic” approaches to studying nineteenth-century households and urban communities has gathered momentum in recent years. As such research agendas have taken hold and been applied to new contexts, so critiques, methodological developments, and new intellectual and theoretical currents, have provided opportunities to enhance and develop approaches. This article contributes to this on-going process. Drawing upon household archaeological research on Limehouse, a poor neighborhood in Victorian London, and inspired by the theoretical insights provided by the “new mobilities paradigm,” it aims to place “mobility” as a central and enabling intellectual framework for understanding the relationships between people, place, and poverty. Poor communities in nineteenth-century cities were undeniably mobile and transient. Historians and archaeologists have often regarded this mobility as an obstacle to studying everyday life in such contexts. However, examining temporal routines and geographical movements across a variety of time frames and geographical scales, this article argues that mobility is actually key to understanding urban life and an important mechanism for interpreting the fragmented material and documentary traces left by poor households in the nineteenth-century metropolis.We are grateful to the UK’s Arts and Humanities Research Council who funded the research upon which this paper is based (Grant Reference AH/E002285/1): ‘Living in Victorian London: Towards a Material History of Everyday Domestic Life in the Nineteenth-Century Metropolis

Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience

We demonstrated previously that antenatal glucocorticoid treatment (AGT, gestational days 16-19) altered the size and organization of the adult rat midbrain dopaminergic (DA) populations. Here we investigated the consequences of these AGT-induced cytoarchitectural disturbances on indices of DA function in adult rats. We show that in adulthood, enrichment of striatal DA fiber density paralleled AGT-induced increases in the numbers of midbrain DA neurons, which retained normal basal electrophysiological properties. This was co-incident with changes in (i) striatal D2-type receptor levels (increased, both sexes); (ii) D1-type receptor levels (males decreased; females increased); (iii) DA transporter levels (males increased; females decreased) in striatal regions; and (iv) amphetamine-induced mesolimbic DA release (males increased; females decreased). However, despite these profound, sexually dimorphic changes in markers of DA neurotransmission, in-utero glucocorticoid overexposure had a modest or no effect on a range of conditioned and unconditioned appetitive behaviors known to depend on mesolimbic DA activity. These findings provide empirical evidence for enduring AGT-induced adaptive mechanisms within the midbrain DA circuitry, which preserve some, but not all, functions, thereby casting further light on the vulnerability of these systems to environmental perturbations. Furthermore, they demonstrate these effects are achieved by different, often opponent, adaptive mechanisms in males and females, with translational implications for sex biases commonly found in midbrain DA-associated disorders

Exploring the Event-Related Potentials' Time Course of Associative Recognition in Autism

Behavioral data on episodic recollection in autism spectrum disorders (ASD) point limited relational memory functioning. However, the involvement of successive memory processes in the profile of episodic memory in ASD needs more study. Here, we used event-related potentials (ERP) to investigate the time course of episodic recollection with an associative recognition paradigm with picture pairs. Twenty-two participants with ASD and 32 with typical development (TD), all right-handed, were included. Behavioral results confirmed difficulties in correctly recognizing identical pairs in the ASD relative to TD group. We found an unexpected amplitude decrement on the P2 (220-270 msec) and FN400 (350-470 msec) potentials, suggesting diminished priming and familiarity effects in the ASD relative to TD group. However, ERP data revealed that the recognition of associative information relies on the same electrophysiological process (old/new effect in the 600-700-msec late positive component) in ASD participants as in TD ones, with a parietal extension in the ASD group. These results suggest that the electrophysiological processes of associative recognition are qualitatively similar in individuals with and without ASD but may differ quantitatively. This difference may be driven by the reduced early processing of picture pairs that may in turn lead to their diminished integration into the semantic memory system, being partially compensated by a greater involvement of associative memory during the recollection process. Other studies would be useful to go further in identifying these cognitive processes involved in atypical recognition in ASD and their neural substrates. LAY SUMMARY: We identified diminished performance on the associative recognition of picture pairs in adolescents and young adults with autism when compared to typical development. Electrophysiological data revealed qualitative similarities but quantitative differences between-group, with diminished priming and familiarity processes partially compensated by an enhanced parietal recollection process