Zero leakage design for ducts and tube connections for deep space travel. Volume 5 - Tube connector design principles and evaluation Final report, 5 Jul. 1963 - 30 Jun. 1967

Principles of connector testing, design evaluation of commercial connectors, and assessment of design rules for threaded connector

Private languages and private theorists

Simon Blackburn objects that Wittgenstein's private language argument overlooks the possibility that a private linguist can equip himself with a criterion of correctness by confirming generalizations about the patterns in which his private sensations occur. Crispin Wright responds that appropriate generalizations would be too few to be interesting. But I show that Wright's calculations are upset by his failure to appreciate both the richness of the data and the range of theories that would be available to the private linguist

Macrophage Migration Is Impaired within Candida albicans Biofilms

Acknowledgments: We thank the Microscopy and Histology Core Facility at the University of Aberdeen. This work was funded by NHS Grampian Endowments (grant RG10191); the Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (grant 097377); the Wellcome Trust Investigator award (grants 101873, 086827, 075470, & 200208) and the Medical Research Council Centre for Medical Mycology (grant MR/N006364/1).Peer reviewedPublisher PD

Hyphal growth of phagocytosed fusarium oxysporum causes cell lysis and death of murine macrophages

Peer reviewedPublisher PD

A review of peer-assisted learning to deliver interprofessional supplementary image interpretation skills.

Background Peer-assisted learning provides a means through which individuals can learn from one another through a reciprocal process. Radiographic image interpretation skills are fundamental to both diagnostic radiography students and medical students due to their shared role in preliminary evaluation of conventional radiographic images. Medical students on graduation, may not be well prepared to carry out image interpretation, since evidence suggests that they perform less well than radiographers in e.g. Accident and Emergency situations. Method A review of literature was conducted exploring the application of peer-assisted learning within diagnostic radiography and health education more widely as well as the practice of initial image interpretation. An extensive and systematic search strategy was developed which provided a range of material related to the areas. Findings An overview was obtained of the effectiveness of peer-assisted learning and the issues associated with development of image interpretation skills and a degree of discrepancy was identified between the two cohorts regarding their interpretative competence and confidence. This inconsistency may create an opportunity to apply peer-assisted learning, better preparing both disciplines for the practical application of image interpretation skills. Conclusion The review identified the lack of a substantial evidence base relating to peer-assisted learning in radiography. Peer-assisted learning is not widely embraced in an interprofessional context. Multiple positive factors of such an intervention are identified which outweigh perceived negative issues. Student teacher and learner may benefit as should the clinical service from enhanced practitioner performance. The findings justify further research to develop the evidence base

Candida albicans Hypha Formation and Mannan Masking of β-Glucan Inhibit Macrophage Phagosome Maturation

Received 28 August 2014 Accepted 28 October 2014 Published 2 December 2014 This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license. ACKNOWLEDGMENTS We thank Janet Willment, Aberdeen Fungal Group, University of Aberdeen, for kindly providing the soluble Dectin-1-Fc reporter. All microscopy was performed with the assistance of the University of Aberdeen Core Microscopy & Histology Facility, and we thank the IFCC for their assistance with flow cytometry. We thank the Wellcome Trust for funding (080088, 086827, 075470, 099215, 097377, and 101873). E.R.B. and A.J.P.B. are funded by the European Research Council (ERC-2009-AdG-249793), and J.L. is funded by a Medical Research Council Clinical Training Fellowship.Peer reviewedPublisher PD

A Note on D-brane - Anti-D-brane Interactions in Plane Wave Backgrounds

We study aspects of the interaction between a D-brane and an anti-D-brane in the maximally supersymmetric plane wave background of type IIB superstring theory, which is equipped with a mass parameter mu. An early such study in flat spacetime (mu=0) served to sharpen intuition about D-brane interactions, showing in particular the key role of the ``stringy halo'' that surrounds a D-brane. The halo marks the edge of the region within which tachyon condensation occurs, opening a gateway to new non-trivial vacua of the theory. It seems pertinent to study the fate of the halo for non--zero mu. We focus on the simplest cases of a Lorentzian brane with p=1 and an Euclidean brane with p=-1, the D--instanton. For the Lorentzian brane, we observe that the halo is unaffected by the presence of non--zero mu. This most likely extends to other (Lorentzian) p. For the Euclidean brane, we find that the halo is affected by non-zero mu. As this is related to subtleties in defining the exchange amplitude between Euclidean branes in the open string sector, we expect this to extend to all Euclidean branes in this background.Comment: 14 pages, LaTeX, 2 eps figures. v2: a reference and some clarifying remarks added; v3: Considerably revised version; halo unaffected by plane wave background for Lorentzian branes, but Euclidean branes' halo is modifie

A population Monte Carlo scheme with transformed weights and its application to stochastic kinetic models

This paper addresses the problem of Monte Carlo approximation of posterior probability distributions. In particular, we have considered a recently proposed technique known as population Monte Carlo (PMC), which is based on an iterative importance sampling approach. An important drawback of this methodology is the degeneracy of the importance weights when the dimension of either the observations or the variables of interest is high. To alleviate this difficulty, we propose a novel method that performs a nonlinear transformation on the importance weights. This operation reduces the weight variation, hence it avoids their degeneracy and increases the efficiency of the importance sampling scheme, specially when drawing from a proposal functions which are poorly adapted to the true posterior. For the sake of illustration, we have applied the proposed algorithm to the estimation of the parameters of a Gaussian mixture model. This is a very simple problem that enables us to clearly show and discuss the main features of the proposed technique. As a practical application, we have also considered the popular (and challenging) problem of estimating the rate parameters of stochastic kinetic models (SKM). SKMs are highly multivariate systems that model molecular interactions in biological and chemical problems. We introduce a particularization of the proposed algorithm to SKMs and present numerical results.Comment: 35 pages, 8 figure

Strained tetragonal states and Bain paths in metals

Paths of tetragonal states between two phases of a material, such as bcc and fcc, are called Bain paths. Two simple Bain paths can be defined in terms of special imposed stresses, one of which applies directly to strained epitaxial films. Each path goes far into the range of nonlinear elasticity and reaches a range of structural parameters in which the structure is inherently unstable. In this paper we identify and analyze the general properties of these paths by density functional theory. Special examples include vanadium, cobalt and copper, and the epitaxial path is used to identify an epitaxial film as related uniquely to a bulk phase.Comment: RevTeX, 4 pages, 4 figures, submitted to Phys. Rev. Let