23 research outputs found

    Design of the ALPS II Optical System

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    International audienceThe Any Light Particle Search II (ALPS II) is an experiment currently being built at DESY in Hamburg, Germany, that will use a light-shining-through-a-wall (LSW) approach to search for axionlike particles. ALPS II represents a significant step forward for these types of experiments as it will use 24 superconducting dipole magnets, along with dual, high-finesse, 122 m long optical cavities. This paper gives the first comprehensive recipe for the realization of the idea, proposed over 30 years ago, to use optical cavities before and after the wall to increase the power of the regenerated photon signal. The experiment is designed to achieve a sensitivity to the coupling between axion-like particles and photons down to g αγγ = 2 × 10-11 GeV-1 for masses below 0.1 meV, more than three orders of magnitude beyond the sensitivity of previous laboratory experiments. The layout and main components that define ALPS II are discussed along with plans for reaching design sensitivity. An accompanying paper (Hallal, et al [1]) offers a more in-depth description of the heterodyne detection scheme, the first of two independent detection systems that will be implemented in ALPS II

    Self-discharge during treatment for acute recreational drug toxicity: an observational study from emergency departments in seven European countries

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    Abstract Background Self-discharge is a risk factor for readmission and excess mortality. We assess the rate of self-discharge from the emergency department (ED) among presentations for acute recreational drug toxicity and identify factors associated with self-discharge. Methods From the Euro-DEN Plus database of presentations to the ED with acute recreational drug toxicity, we extracted data from 11 centres in seven European countries from 2014 to 2017. Self-discharge was defined as taking one’s own discharge or escaping from the ED before being medically cleared. We used multiple logistic regression analyses to look for factors associated with self-discharge. Results Among 15,135 included presentations, 1807 (11.9%) self-discharged. Self-discharge rates varied from 1.7 to 17.1% between centres. Synthetic cannabinoids were associated with self-discharge, adjusted odds ratio 1.44 (95% confidence interval 1.10–1.89), as were heroin, 1.44 (1.26–1.64), agitation, 1.27 (1.10–1.46), and naloxone treatment, 1.27 (1.07–1.51), while sedation protected from self-discharge, 0.38 (0.30–0.48). Conclusion One in eight presentations self-discharged. There was a large variation in self-discharge rates across the participating centres, possibly partly reflecting different discharge procedures and practices. Measures to improve the management of agitation and cautious administration of naloxone to avoid opioid withdrawal symptoms may be approaches worth exploring to reduce self-discharge

    Design of the ALPS II Optical System

    No full text
    The Any Light Particle Search II (ALPS II) is an experiment currently being built at DESY in Hamburg, Germany, that will use a light-shining-through-a-wall (LSW) approach to search for axion-like particles. ALPS II represents a significant step forward for these types of experiments as it will use 24 superconducting dipole magnets, along with dual high-finesse, 122 m long optical cavities. This paper gives the first comprehensive recipe for the realization of the idea, proposed over 30 years ago, to use optical cavities before and after the wall to increase the power of the regenerated photon signal. This concept will allow the experiment to achieve a sensitivity to the coupling between axion-like particles and photons down to g = 2e-11 1/GeV for masses below 0.1 meV, more than three orders of magnitude beyond the sensitivity of previous laboratory experiments. The layout and main components that define ALPS II are discussed along with plans for reaching design sensitivity. A set of top level requirements for the subsystems is also provided for the first time and includes the requirements on the coherence and spatial mode matching of the cavity eigenmodes. An accompanying paper (Hallal, et al [1]) offers a more in-depth description of the heterodyne detection scheme, the first of two independent detection systems that will be implemented in ALPS II

    Emergencies related to recreational drug abuse in Spain compared to emergencies attended in 3 European areas.

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    OBJECTIVES To analyze epidemiologic, clinical, and care characteristics in cases in which patients came to 2 Spanish emergency departments (EDs) with symptoms caused by recreational drug abuse. To compare the characteristics with those reported for other areas of Europe. MATERIAL AND METHODS Secondary analysis of the registry of the European Drug Emergencies Network (Euro-DEN Plus), which collects cases in 14 European countries and 20 EDs. The registry included all patients attending EDs with symptoms of recreational drug abuse (excepting cases involving alcohol alone) over a period of 39 consecutive months (October 2013 to December 2016). We compared the cases from the 2 Spanish EDs (in Barcelona and Palma de Mallorca) to those from the 5 EDs in Ireland and the UK, 6 in northern Europe, and 7 in central Europe. RESULTS A total of 17 104 patients' cases were included: Spain, 1186; UK and Ireland, 6653; northern Europe, 6097; and central Europe, 3168. Spain saw more emergencies related to cocaine (48.4%) and fewer related to opioids (12.4%) than the other areas. The Spanish patients were younger (32.2 years) on average than those in northern Europe and older than those in the UK and Ireland and central Europe. Fewer patients were women in Spain (21.9%) than in northern or central Europe. Fewer arrived in ambulances in Spain (70.0%) than in the UK and Ireland or northern Europe. The Spanish EDs recorded the temperature and respiratory frequency of fewer patients (29.8% and 30.3%, respectively). Clinical signs differed between geographical areas attributable to differences in drug-use patterns. In Spain, naloxone was used by fewer patients (9.6%) than in the UK and Ireland and northern Europe, and flumazenil was used by more patients (5.6%) than in other areas. Spain saw lower percentages of admissions (4.6%) and patients who left without an ED discharge (6.2%) in comparison with other areas. Mortality rates in the Spanish EDs (0.4%) and after discharge from them (0.7%) were higher than in northern Europe. CONCLUSION The characteristics of emergencies related to recreational drug abuse registered by the Spanish EDs were differed from those registered in other parts of Europe due to different patterns of drug use. We also detected differences between the Spanish and other European EDs with respect to examinations or tests performed, treatment given, and discharge disposition
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