Franco\u27s Spain, Queer Nation?

This Article discusses how, through its juridical apparatus, the Spanish dictatorship of Francisco Franco sought to define and to contain homosexuality, followed by examples of how underground queer activism contested homophobic laws. The Article concludes by analyzing a literary work to illustrate the social impact of Francoism\u27s homophobic law against homosexuality

Cristina Peri Rossi. Erotismo, transgresión y exilio: Las voces de Cristina Peri Rossi, Jesús Gómez-de-Tejada (coord.). Sevilla, Editorial Universidad de Sevilla, 2017

Obra ressenyada: Jesús GÓMEZ-DE-TEJADA (coord.), Cristina Peri Rossi. Erotismo, transgresión y exilio: Las voces de Cristina Peri Rossi. Sevilla: Editorial Universidad de Sevilla, 2017

Echoes of Fairy Tales: Fantasy and Everyday Horrors in Guillermo del Toro’s Filmography

Guillermo del Toro’s filmography uses recurrently old formulas such as archetypal folk and fairy- tale motifs and characters, adapting them to contemporary culture and society. The fantastic acts as a parallel universe to our logical world. His films describe a supernatural reality that intertwines with the ordinary world, using the archetypes of these narrations in the real world. Del Toro claims the figure of the monster as one of his outstanding characters, showing that the classical monsters are usually represented as vulnerable creatures subjected to the brutality of the human being. His films have a utopian spirit, mixed with fairy tales exclusively for adults, morality, goodness or the capacity of sacrifice of his protagonists, the overcoming of obstacles and the deepening of a state of knowledge and virtue. Fantasy serves the director as a vehicle to introduce political and social issues through a series of metaphors, which are appreciable in films such as Pan’s Labyrinth, Crimson Peak or The Shape of Water.2019-2

Verification of precipitation forecast in HARMONIE-AROME

Póster presentado en: 40th EWGLAM & 25nd SRNWP Meetings celebrado del 1 al 4 de octubre de 2018 en Salzburgo, Austria

Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma

The lysyl oxidase-like protein 2 (LOXL2) contributes to tumour progression and metastasis in different tumour entities, but its role in pancreatic ductal adenocarcinoma (PDAC) has not been evaluated in immunocompetent in vivo PDAC models.Towards this end, we used PDAC patient data sets, patient-derived xenograft in vivo and in vitro models, and four conditional genetically-engineered mouse models (GEMMS) to dissect the role of LOXL2 in PDAC. For GEMM-based studies, K-Ras +/LSL-G12D;Trp53 LSL-R172H;Pdx1-Cre mice (KPC) and the K-Ras +/LSL-G12D;Pdx1-Cre mice (KC) were crossed with Loxl2 allele floxed mice (Loxl2 Exon2 fl/fl) or conditional Loxl2 overexpressing mice (R26Loxl2 KI/KI) to generate KPCL2 KO or KCL2 KO and KPCL2 KI or KCL2 KI mice, which were used to study overall survival; tumour incidence, burden and differentiation; metastases; epithelial to mesenchymal transition (EMT); stemness and extracellular collagen matrix (ECM) organisation. Using these PDAC mouse models, we show that while Loxl2 ablation had little effect on primary tumour development and growth, its loss significantly decreased metastasis and increased overall survival. We attribute this effect to non-cell autonomous factors, primarily ECM remodelling. Loxl2 overexpression, on the other hand, promoted primary and metastatic tumour growth and decreased overall survival, which could be linked to increased EMT and stemness. We also identified tumour-associated macrophage-secreted oncostatin M (OSM) as an inducer of LOXL2 expression, and show that targeting macrophages in vivo affects Osm and Loxl2 expression and collagen fibre alignment.Taken together, our findings establish novel pathophysiological roles and functions for LOXL2 in PDAC, which could be potentially exploited to treat metastatic diseaseg JCL-G received support from a ’la Caixa’ Foundation (ID 100010434) fellowship (LCF/BQ/DR21/11880011). This study was supported by ISCIII FIS grants PI18/00757 and PI21/01110 (BSJ) and PI18/00267 (LG-B), and grants from the Spanish Ministry of Economy and Innovation SAF2016-76504-R (ACan and FP), PID2019-111052RB-I00 (FP), PID2019-104644RB-I00 (GM-B), a Ramón y Cajal Merit Award RYC-2012–12104 (BSJ) and ISCIII, CIBERONC, CB16/12/00446 (ACar) and CB16/12/00295 (ACan and GM-B), all of them co-financed through Fondo Europeo de Desarrollo Regional (FEDER) ’Una manera de hacer Europa’; a Fero Foundation Grant (BSJ); a Coordinated grant (GC16173694BARB) from the Fundación Científica Asociación Española Contra el Cáncer (FC-AECC) (BSJ); a Miguel Servet award (CP16/00121) (PS); a DFG, German Research Foundation Grant—Project no: 492 436 553 (KG); and a Max Eder Fellowship of the German Cancer Aid (111746) (PCH

The NWP Activities at AEMET (Spain): 29th ALADIN Workshop & HIRLAM ASM [Póster]

Póster presentado en: Joint 29th ALADIN Workshop & HIRLAM All Staff Meeting, celebrado del 1 al 5 de abril de 2019 en la Sede central de AEMET en Madrid

HARMONIE/AROME: predicción operativa a escalas convectivas

Ponencia presentada en: XXXIII Jornadas Científicas de la AME y el XIV Encuentro Hispano Luso de Meteorología celebrado en Oviedo, del 7 al 9 de abril de 2014

Plataforma digital interactiva como modelo de gestión en el campo de la arquitectura e ingeniería: ecosistema parque natural de 'El Hondo'

Plataforma digital interactiva como modelo de gestión en el campo de la arquitectura e ingeniería: ecosistema parque natural de 'El Hondo