Santos Herceg, José. Cartografía crítica. El quehacer profesional de la filosofía en Chile. Santiago de Chile, La Cañada, 2015, 299 p.

Fil: Pérez Javaloyes, Andrés C. G.. CONICET. CRICYT. INCIHUSA (Instituto de Ciencias Sociales, Humanas y Ambientales

Compression of the Left Innominated Vein between the Brachiocephalic Trunk and Left Carotid Artery

AbstractWe present a case of a 25-year-old male who looked for medical attention for symptoms like dysesthesias in his left arm. Physical examination revealed severe dilations of the superficial veins in his left forearm and arm.An ultrasound showed no signs of thrombosis. Dynamic phlebography ruled out the presence of extrinsic compression of the left innominated vein. The angioMRI confirmed that the innominated vein was compressed between the braquiocephalic trunk and left carotid.Therefore, we describe a previously unreported congenital anomaly of the left brachiocephalic vein where the fundamental symptom is the compression of the left innominated trunk

Intravenous antibiotic therapy after laparoscopic appendectomy in complicated acute appendicitis: the patient's clinical response is key

INTRODUCCIÓN: Las guías sobre apendicitis aguda complicada (ACA) recomiendan 3-5 días de antibióticos intravenosos postoperatorios (VAT). Sin embargo, el tiempo seleccionado por el cirujano puede variar según la respuesta clínica del paciente, el tipo de ACA y la experiencia profesional. Una vez obtenida una respuesta clínica adecuada, el cambio de IVA a antibiótico oral (AO) podría realizarse sin el tiempo de espera establecido con resultados satisfactorios. OBJETIVO: Determinar si un ciclo corto de IVA y/o cambio a vía oral es seguro en función de la respuesta clínica del paciente. MATERIAL Y MÉTODOS: Estudio de cohortes prospectivo observacional a partir de la base de datos de un centro de referencia de cirugía general desde julio de 2019. RESULTADOS Y CONCLUSIÓN: Se incluyeron 48 pacientes con hallazgos intraoperatorios de ACA. Respecto al manejo antibiótico postoperatorio, solo IVA preoperatorio: 7 (14,58%), IVA 1-3 días: 1 (20,83%), IVA 1-3 días y cambio a OA: 21 (43,75%), IVA > 3 días: 6 (12,5%), y sólo OA: 3 (27,08%). El análisis bivariante no mostró diferencias estadísticamente significativas en reconsulta (p = 0,81), rehospitalización (p = 0,44) e infección del sitio quirúrgico (p = 0,56) entre el esquema antibiótico basado en la respuesta clínica postoperatoria y el tradicional en cuanto a la tasa de colecciones intraabdominales, las estancias hospitalarias y los costes de hospitalización. Copyright: © 2023 Permanyer. INTRODUCCIÓN: Las guías sobre apendicitis aguda complicada (AAC) recomiendan 3-5 días de antibióticos intravenosos (VIA) postoperatorios. Sin embargo, el tiempo seleccionado por el cirujano puede variar según la respuesta clínica del paciente, el tipo de ACA y la experiencia profesional. Una vez obtenida una respuesta clínica adecuada, el cambio de VIA a antibiótico oral (AO) podría realizarse sin esperar el tiempo establecido con resultados satisfactorios. OBJETIVO: Determinar si un ciclo corto de VIA y/o cambio a OA según la respuesta clínica del paciente es seguro. MATERIAL Y MÉTODOS: Estudio de cohortes observacional prospectivo a partir de la base de datos de un centro de referencia de cirugía general desde julio de 2019. RESULTADOS Y CONCLUSIÓN: Se incluyeron 48 pacientes con hallazgos intraoperatorios de ACA. En cuanto al manejo antibiótico postoperatorio, VAT solo preoperatorio: 7 (14,58%), VAT 1-3 días: 1 (20,83%), VAT 1-3 días y cambio de OA: 21 (43,75%), VAT > 3 días: 6 (12,5%) y sólo OA: 3 (27,08%). El análisis bivariante no mostró diferencias estadísticamente significativas en la reconsulta (p = 0,81), la rehospitalización (p = 0,44) y la infección del sitio operatorio (p = 0,56) entre la pauta antibiótica basada en la respuesta clínica postoperatoria y la tradicional con respecto a la tasa de recogida intraabdominal, la estancia hospitalaria y los costes de hospitalización.INTRODUCTION: The guidelines about acute complicated appendicitis (ACA) recommend 3-5 days of postoperative intravenous antibiotics (VAT). Nevertheless, the time selected by the surgeon can vary according to patient clinical response, ACA type, and professional experience. Once an adequate clinical response is obtained, the change from IVA to oral antibiotic (OA) could be realized without the waiting time established with satisfactory results. OBJECTIVE: Determine if a short course of IVA and/or switch to oral route is safe based on the patient clinical response. MATERIALS AND METHODS: Observational prospective cohort study from a general surgery reference center database since July 2019. RESULTS AND CONCLUSION: 48 patients with ACA intraoperative findings were included. Regarding postoperative antibiotic management, only preoperative IVA: 7 (14.58%), IVA 1-3 days: 1 (20.83%), IVA 1-3 days and change to OA: 21 (43.75%), IVA > 3 days: 6 (12.5%), and only OA: 3 (27.08%). The bivariate analysis did not show statistically significant differences in reconsultation (p = 0.81), rehospitalization (p = 0.44), and surgical site infection (p = 0.56) between the antibiotic scheme based on the postoperative clinical response and the traditional one regarding intra-abdominal collection rate, the hospital stays, and hospitalization costs. Copyright: © 2023 Permanyer. INTRODUCTION: Guidelines on complicated acute appendicitis (CAA) recommend 3-5 days of postoperative intravenous antibiotics (VIA). However, the time selected by the surgeon may vary according to the patient's clinical response, type of ACA and professional experience. Once an adequate clinical response is obtained, the change from VIA to oral antibiotic (OA) could be performed without waiting the established time with satisfactory results. OBJECTIVE: To determine whether a short course of VIA and/or switching to OA according to the patient's clinical response is safe. MATERIALS AND METHODS: Prospective observational cohort study from a general surgery referral center database from July 2019. RESULTS AND CONCLUSION: Forty-eight patients with intraoperative findings of ACA were included. Regarding postoperative antibiotic management, preoperative VAT only: 7 (14.58%), VAT 1-3 days: 1 (20.83%), VAT 1-3 days and OA change: 21 (43.75%), VAT > 3 days: 6 (12.5%) and OA only: 3 (27.08%). Bivariate analysis showed no statistically significant differences in reconsultation (p = 0.81), rehospitalization (p = 0.44) and operative site infection (p = 0.56) between the antibiotic schedule based on postoperative clinical response and the traditional one with respect to intra-abdominal collection rate, hospital stay and hospitalization costs

Avian emotions: Comparative perspectives on fear and frustration

Emotions are complex reactions that allow individuals to cope with significant positive and negative events. Research on emotion was pioneered by Darwin's work on emotional expressions in humans and animals. But Darwin was concerned mainly with facial and bodily expressions of significance for humans, citing mainly examples from mammals (e.g., apes, dogs, and cats). In birds, emotional expressions are less evident for a human observer, so a different approach is needed. Understanding avian emotions will provide key evolutionary information on the evolution of related behaviors and brain circuitry. Birds and mammals are thought to have evolved from different groups of Mesozoic reptiles, theropod dinosaurs and therapsids, respectively, and therefore, their common ancestor is likely to be a basal reptile living about 300 million years ago, during the Carboniferous or Permian period. Yet, birds and mammals exhibit extensive convergence in terms of relative brain size, high levels of activity, sleep/wakefulness cycles, endothermy, and social behavior, among others. This article focuses on two basic emotions with negative valence: fear and frustration. Fear is related to the anticipation of dangerous or threatening stimuli (e.g., predators or aggressive conspecifics). Frustration is related to unexpected reward omissions or devaluations (e.g., loss of food or sexual resources). These results have implications for an understanding of the conditions that promote fear and frustration and for the evolution of supporting brain circuitry. © 2019 Papini, Penagos-Corzo and Pérez-Acosta

América Latina, la construcción del orden

Reseña de libroAnsaldi, Waldo y Verónica Giordano (2012) América Latina, la construcción del orden: de las sociedades de masas a las sociedades en proceso de reestructuración. Capítulo 6: El orden en sociedades de violencia. Págs. 245-500. Buenos Aires: Ariel. (749 páginas). ISBN 978-987-1496-29-

Santos Herceg, José. Cartografía crítica. El quehacer profesional de la filosofía en Chile.

Reseña de la obra de José Santos Herceg Cartografía crítica. El quehacer profesional de la filosofía en Chile. Santiago de Chile, La Cañada, 2015, 299 p

Molecular analysis of menadione-induced resistance against biotic stress in Arabidopsis

19 páginas, 6 figuras, 2 tablas.Menadione sodium bisulphite (MSB) is a water-soluble derivative of vitamin K3, or menadione, and has been previously demonstrated to function as a plant defence activator against several pathogens in several plant species. However, there are no reports of the role of this vitamin in the induction of resistance in the plant model Arabidopsis thaliana. In the current study, we demonstrate that MSB induces resistance by priming in Arabidopsis against the virulent strain Pseudomonas syringae pv. tomato DC3000 (Pto) without inducing necrosis or visible damage. Changes in gene expression in response to 0.2 mm MSB were analysed in Arabidopsis at 3, 6 and 24 h post-treatment using microarray technology. In general, the treatment with MSB does not correlate with other publicly available data, thus MSB produces a unique molecular footprint. We observed 158 differentially regulated genes among all the possible trends. More up-regulated genes are included in categories such as 'response to stress' than the background, and the behaviour of these genes in different treatments confirms their role in response to biotic and abiotic stress. In addition, there is an over-representation of the G-box in their promoters. Some interesting functions are represented among the individual up-regulated genes, such as glutathione S-transferases, transcription factors (including putative regulators of the G-box) and cytochrome P450s. This work provides a wide insight into the molecular cues underlying the effect of MSB as a plant resistance inducer.This work was partially funded by an INVESCAN, S.L. grant (No.OTT2001438) to the CSIC and by a BIO2006-02168 grant of MICINN to PT. The microarrays were funded in part by the “Genome España” Foundation. MER was supported by a research contract (ID-TF-06/002) from the Consejería de Industria, Comercio y Nuevas Tecnologías (Gobierno de Canarias). The authors thank CajaCanarias for their research support. We also thank Lorena Perales for her help in performing the bacterial growth curves, Dr. Héctor Cabrera for his useful advice on writing the manuscript, the English translation service of the Universidad Politécnica de Valencia and Mrs. Pauline Agnew whose endeavoured to edit the English translation of this paper.Peer reviewe

Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders

This is an open access paper.-- et al.The European Myeloma Network (EMN) organized two flow cytometry workshops. The first aimed to identify specific indications for flow cytometry in patients with monoclonal gammopathies, and consensus technical approaches through a questionnaire-based review of current practice in participating laboratories. The second aimed to resolve outstanding technical issues and develop a consensus approach to analysis of plasma cells. The primary clinical applications identified were: differential diagnosis of neoplastic plasma cell disorders from reactive plasmacytosis; identifying risk of progression in patients with MGUS and detecting minimal residual disease. A range of technical recommendations were identified, including: 1) CD38, CD138 and CD45 should all be included in at least one tube for plasma cell identification and enumeration. The primary gate should be based on CD38 vs. CD138 expression; 2) after treatment, clonality assessment is only likely to be informative when combined with immunophenotype to detect abnormal cells. Flow cytometry is suitable for demonstrating a stringent complete remission; 3) for detection of abnormal plasma cells, a minimal panel should include CD19 and CD56. A preferred panel would also include CD20, CD117, CD28 and CD27; 4) discrepancies between the percentage of plasma cells detected by flow cytometry and morphology are primarily related to sample quality and it is, therefore, important to determine that marrow elements are present in follow-up samples, particularly normal plasma cells in MRD negative cases.The meetings were sponsored by the European Myeloma.Peer Reviewe

Nonlinear analysis of a simple model of temperature evolution in a satellite

We analyse a simple model of the heat transfer to and from a small satellite orbiting round a solar system planet. Our approach considers the satellite isothermal, with external heat input from the environment and from internal energy dissipation, and output to the environment as black-body radiation. The resulting nonlinear ordinary differential equation for the satellite's temperature is analysed by qualitative, perturbation and numerical methods, which show that the temperature approaches a periodic pattern (attracting limit cycle). This approach can occur in two ways, according to the values of the parameters: (i) a slow decay towards the limit cycle over a time longer than the period, or (ii) a fast decay towards the limit cycle over a time shorter than the period. In the first case, an exactly soluble average equation is valid. We discuss the consequences of our model for the thermal stability of satellites.Comment: 13 pages, 4 figures (5 EPS files

Metodología para la medición de la huella hídrica en la producción de tilapia, cachama y trucha: estudios de caso para el Valle del Cauca (Colombia)

(Eng) The pisciculture sector in Colombia, has grown 13% annually between 1988 and 2013, and it is the sixth major water user. Considering the influence that pisciculture has over the water resources, the water footprint of pisciculture was studied as a sustainability indicator, a method was developed to estimate the water footprint of the sector, which include not only the direct and indirect components, but also the green, blue and grey water footprint. The method was applied to the three most produced species in the country: tilapia (Oreochromis mossambicus), cachama (Piaractus brachypomus) and trout (Oncorhynchus mykiss), to corresponding case studies in Valle del Cauca, Colombia. It was found that the water footprint of tilapia culture is 5,486 m3/Ton, cachama culture is 6,193 m3/Ton, and trout culture is 19,854 m3/Ton. The highest total water footprint for tilapia was that of the concentrated feed, followed by the blue water footprint, associated with the amount of water that remains stored in the ponds, whereas for the cachama and trout, the highest water footprint was grey, due to the high concentrations of solids and nutrients present in fish excretions and unconsumed feed.(Spa) El sector piscícola en Colombia creció en promedio 13% anual de 1988 a 2013 y es el sexto mayor usuario de agua en el país. Considerando la presión que ejerce la producción piscícola sobre las fuentes de agua, se estudió la huella hídrica (HH) de la piscicultura como un indicador de sostenibilidad. Para ello se desarrolló una metodología que mide la HH en el sector, que incluye sus componentes directos e indirectos, así como las huellas hídricas verde, azul y gris. La metodología se aplicó a las tres especies piscícolas más producidas en el país: tilapia (Oreochromis mossambicus), cachama (Piaractus brachypomus) y trucha (Oncorhynchus mykiss), para sendos casos de estudio en el Valle del Cauca, Colombia. Se encontró que la HH total del cultivo de tilapia es de 5,486 m3/Ton, la del cultivo de cachama de 6,193 m3/Ton y la del cultivo de trucha de 19,854 m3/Ton. La huella hídrica total más alta para la tilapia fue la del alimento concentrado, seguida por la huella hídrica azul, asociada a la cantidad de agua que permanece almacenada en los estanques; en la cachama y trucha la mayor huella hídrica total fue la gris, relacionada con las altas concentraciones de sólidos y nutrientes, presentes en las excretas de los peces y en el alimento concentrado no consumido