El insight emocional. Análisis de las campañas navideñas de Campofrío

El presente Trabajo de Fin de Grado aborda el concepto insight desde el punto de vista de la emoción y su uso como herramienta de diferenciación con centro en los consumidores. Todo ello ilustrado con el análisis descriptivo de las Campañas de Navidad de la marca Campofrío.Departamento de Historia Moderna, Contemporánea y de América, Periodismo y Comunicación Audiovisual y PublicidadGrado en Publicidad y Relaciones Pública

Polymorphisms indicating risk of inflammatory bowel disease or antigenicity to anti-TNF drugs as biomarkers of response in children

Crohn’s disease; Polymorphism; PediatricEnfermedad de Crohn; Polimorfismo; PediátricoMalaltia de Crohn; Polimorfisme; PediatriaFew genetic polymorphisms predict early response to anti-TNF drugs in inflammatory bowel disease (IBD), and even fewer have been identified in the pediatric population. However, it would be of considerable clinical interest to identify and validate genetic biomarkers of long-term response. Therefore, the aim of the study was to analyze the usefulness of biomarkers of response to anti-TNFs in pediatric IBD (pIBD) as long-term biomarkers and to find differences by type of IBD and type of anti-TNF drug. The study population comprised 340 children diagnosed with IBD who were treated with infliximab or adalimumab. Genotyping of 9 selected SNPs for their association with early response and/or immunogenicity to anti-TNFs was performed using real-time PCR. Variants C rs10508884 (CXCL12), A rs2241880 (ATG16L1), and T rs6100556 (PHACTR3) (p value 0.049; p value 0.03; p value 0.031) were associated with worse long-term response to anti-TNFs in pIBD. DNA variants specific to disease type and anti-TNF type were identified in the pediatric population. Genotyping of these genetic variants before initiation of anti-TNFs would enable, if validated in a prospective cohort, the identification of pediatric patients who are long-term responders to this therapy.This research was funded by Instituto de Salud Carlos III, grant number PI19/00792 and PI22/00584 (L.L-F.), both cofunded by the European Union, by Instituto de Investigación Sanitaria Gregorio Marañón, grant number 2021-II-postdoc-01 (S.S-M.), and by Consejería de Educación, Universidades, Ciencia y Portavocía Comunidad de Madrid, grant number PEJ-2021-AI/BMD-21866 (P.Z-C.)

Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort

Adalimumab; Infliximab; PharmacogeneticsAdalimumab; Infliximab; FarmacogenèticaAdalimumab; Infliximab; FarmacogenéticaThe genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed an observational, multicenter, ambispective study in which we selected 340 IBD patients under 18 years of age diagnosed with IBD and treated with anti-TNF drugs from a network of Spanish hospitals. Genotypes and failure of anti-TNF drugs were analyzed using Kaplan-Meier curves and Cox logistic regression. The homozygous G allele of rs2395185 and the C allele of rs2097432 were associated with impaired long-term response to anti-TNF drugs in children with IBD after 3 and 9 years of follow-up. Being a carrier of both polymorphisms increased the risk of anti-TNF failure. The SNP rs2395185 but not rs2097432 was associated with response to infliximab in adults with CD treated with infliximab but not in children after 3 or 9 years of follow-up. Conclusions: SNPs rs2395185 and rs2097432 were associated with a long-term response to anti-TNFs in IBD in Spanish children. Differences between adults and children were observed in patients diagnosed with CD and treated with infliximab.This research was funded by Instituto de Salud Carlos III, grant number PI19/00792 (L.A.L.-F.) and Juan Rodes program JR19/00005 (E.L.-M.), by Instituto de Investigación Sanitaria Gregorio Marañón, grant number 2021-II-postdoc-01 (S.S.-M.), and by Consejería de Educación, Universidades, Ciencia y Portavocía Comunidad de Madrid, grant number PEJ-2021-AI/BMD-21866 (P.Z.-C.). The study was co-funded by the European Union

Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study

Producción CientíficaIn comparison with hip fractures, increased expression of genes in the Wnt pathway and increased Wnt activity were found in bone samples and osteoblast cultures from patients with osteoarthritis, suggesting the involvement of this pathway in subchondral bone changes. No consistent differences were found in the genetic association study

Propuesta Estratégica de Mejora en la Implementación de los Estándares Mínimos del Sistema de la Seguridad y Salud en el Trabajo (SG-SST) en la Empresa Rapylac para el año 2020

Se busca por medio de este informe, describir la transición que tuvo la empresa RAPYLAC respecto a las dos normas (resolución 1016 de 1989 y decreto 1111 del 2017). Por medio de un diagnóstico de los requisitos actualmente actualizados a través de la matriz de evaluación de los criterios mínimos, se evalúa el estado de la empresa en cuanto al SG SST y se plantean recomendaciones para cumplir con a cabalidad las actividades del SG SST con El fin de diseñar planos y programas de mejoramiento que requieren contar con un ambiente laboral sano y seguro, enfocado en mejoras de productividad y bienestar humano en la empresa.The purpose of this report is to describe the transition that the RAPYLAC company had with respect to the two standards (resolution 1016 of 1989 and decree 1111 of 2017). By means of a diagnosis of the requirements currently updated through the evaluation matrix of the minimum criteria, the state of the company in relation to the OSH is evaluated and recommendations are made to fully comply with the activities of the OSH with the In order to design plans and improvement programs that require having a healthy and safe work environment, focused on improvements in productivity and human well-being in the company

Dynamic Intracellular Metabolic Cell Signaling Profiles During Ag-Dependent B-Cell Differentiation

© 2021 Díez, Pérez-Andrés, Bøgsted, Azkargorta, García-Valiente, Dégano, Blanco, Mateos-Gomez, Bárcena, Santa Cruz, Góngora, Elortza, Landeira-Viñuela, Juanes-Velasco, Segura, Manzano-Román, Almeida, Dybkaer, Orfao and Fuentes.Human B-cell differentiation has been extensively investigated on genomic and transcriptomic grounds; however, no studies have accomplished so far detailed analysis of antigen-dependent maturation-associated human B-cell populations from a proteomic perspective. Here, we investigate for the first time the quantitative proteomic profiles of B-cells undergoing antigen-dependent maturation using a label-free LC-MS/MS approach applied on 5 purified B-cell subpopulations (naive, centroblasts, centrocytes, memory and plasma B-cells) from human tonsils (data are available via ProteomeXchange with identifier PXD006191). Our results revealed that the actual differences among these B-cell subpopulations are a combination of expression of a few maturation stage-specific proteins within each B-cell subset and maturation-associated changes in relative protein expression levels, which are related with metabolic regulation. The considerable overlap of the proteome of the 5 studied B-cell subsets strengthens the key role of the regulation of the stoichiometry of molecules associated with metabolic regulation and programming, among other signaling cascades (such as antigen recognition and presentation and cell survival) crucial for the transition between each B-cell maturation stage.We gratefully acknowledge financial support from the Spanish Health Institute Carlos III (ISCIII) for the grants: FIS PI14/01538, FIS PI17/01930 and CB16/12/00400. We also acknowledge Fondos FEDER (EU) and Junta Castilla-León (COVID19 grant COV20EDU/00187). Fundación Solórzano FS/38-2017.The Proteomics Unit belongs to ProteoRed, PRB3-ISCIII, supported by grant PT17/0019/0023, of the PE I + D + I 2017-2020, funded by ISCIII and FEDER. AL-V is supported by VIII Centenario-USAL PhD Program. PJ-V is supported by JCYL PhD Program and scholarship JCYL-EDU/601/2020. PD and EB are supported by a JCYL-EDU/346/2013 Ph.D. scholarship

Taller Integrado I "Orgía Mecánica". Innovación Educativa

Un espacio pedagógico de convergencia para el aprendizaje y la práctica dialógica de la Aequitectura. Memoria de la experiencia realizada en la Escuela Técnica Superior de Arquitectura de Madrid en Noviembre de 200

Investigación Formativa en Diseño de Moda a través del Proyecto Integrador de Semestre (PISE) 2018-3

Se toma como tema de investigación general “capital animal”; proyectos artísticos y culturales para la defensa de los derechos de los animales, en el cual el programa de Diseño de Modas desarrolló un proceso investigativo desde cada asignatura de diseño, que involucró las asignaturas técnicas; como son las Arquitecturas del Vestido (patronaje y confección); y las de Dibujo e Ilustración. Los semestres II y III orientaron su trabajo hacia la Línea de Investigación de Facultad y de Programa “Patrimonio y Cultura”, los semestres IV, V y VI lo hicieron hacia la Línea “Diseño e Innovación”, y el semestre VII, hacia la Línea “Comunicación Interactiva”. Los sub-temas para cada semestre se apoyaron en los núcleos problémicos de estas líneas, que van desde: saberes e identidad cultural, significados culturales, producción de artefactos hasta el lenguaje y comunicación visual; con el fin de generar un proceso creativo que diera como resultado una colección de moda, materializada en productos visuales e interactivos como un indumento, portafolio y página web

Fomento de una universidad inclusiva. Mejora de la accesibilidad en los servicios de atención odontológica de la Facultad de Odontología. Aplicación en los sistemas de mentorías. Proyectos Aprendizaje-Servicio aplicados en el alumnado

Depto. de Especialidades Clínicas OdontológicasFac. de OdontologíaFALSEsubmitte