Optimal measurement setup for damage detection in piezoelectric plates

[EN] An optimization of the excitation-measurement configuration is proposed for the characterization of damage in PZT-4 piezoelectric plates, from a numerical point of view. To perform such an optimization, a numerical method to determine the location and extent of defects in piezoelectric plates is developed by combining the solution of an identification inverse problem, using genetic algorithms and gradient-based methods to minimize a cost functional, and using an optimized finite element code and meshing algorithm. In addition, a semianalytical estimate of the probability of detection is developed and validated, which provides a flexible criterion to optimize the experimental design. The experimental setup is optimized upon several criteria: maximizing the probability of detection against noise effects, ensuring robust search algorithm convergence and increasing the sensitivity to the presence of the defect. The measurement of voltage phi is concluded to provide the highest identifiability, combined with an excitation of the specimen by a mechanical traction transverse to the polarization direction. Sufficient accuracy is predicted for the damage location and sizing under realistic noise levels. (c) 2008 Elsevier Ltd. All rights reserved.This research was supported by the Ministry of Education of Spain through Grant No. FPU AP-2006-02372.Rus, G.; Palma Guerrero, R.; Pérez-Aparicio, JL. (2009). Optimal measurement setup for damage detection in piezoelectric plates. International Journal of Engineering Science. 47(4):554-572. https://doi.org/10.1016/j.ijengsci.2008.09.006S55457247

Usefulness of optic nerve ultrasound to predict clinical progression in multiple sclerosis

Introducción La pérdida neuronal/axonal progresiva se considera la causa más importante de discapacidad neurológica en la esclerosis múltiple (EM). El sistema visual está frecuentemente afectado en esta enfermedad y su accesibilidad a test funcionales y estructurales ha permitido que se convierta en un modelo para estudiar in vivo la patogenia de la EM. La ecografía orbitaria permite evaluar, de forma no invasiva y en tiempo real, las diversas estructuras de la órbita, incluido el nervio óptico. Material y métodos Se ha llevado a cabo un estudio observacional ambispectivo en pacientes con EM recogiéndose datos evolutivos de la enfermedad. La ecografía orbitaria se realizó en todos los pacientes según el principio de mínima potencia necesaria (ALARA). También se recogieron los datos de tomografía de coherencia óptica (OCT) en aquellos que tenían realizadas ambas pruebas. El estudio estadístico se efectuó con el programa SPSS 22.0. Resultados Se encontraron correlaciones estadísticamente significativas entre las medidas ecográficas y la progresión de la enfermedad (p = 0,041 para el ojo derecho y p = 0,037 para el ojo izquierdo), y la Expanded Disability Status Scale (EDSS) final en el seguimiento (p = 0,07 para el ojo derecho y p = 0,043 para el ojo izquierdo). No fue así para los datos referentes a brotes y a otras variables clínicas. Discusión La medición del diámetro del nervio óptico por ecografía podría utilizarse como medida predictiva en la evolución de la EM, ya que la disminución del mismo se asocia con progresión clínica y mayor discapacidad, medidas con la EDSS.Introduction Progressive neuronal and axonal loss are considered the main causes of disability in patients with multiple sclerosis (MS). The disease frequently involves the visual system; the accessibility of the system for several functional and structural tests has made it a model for the in vivo study of MS pathogenesis. Orbital ultrasound is a non-invasive technique that enables various structures of the orbit, including the optic nerve, to be evaluated in real time. Material and methods We conducted an observational, ambispective study of MS patients. Disease progression data were collected. Orbital ultrasound was performed on all patients, with power set according to the ‘as low as reasonably achievable’ (ALARA) principle. Optical coherence tomography (OCT) data were also collected for those patients who underwent the procedure. Statistical analysis was conducted using SPSS version 22.0. Results Disease progression was significantly correlated with ultrasound findings (P = .041 for the right eye and P = .037 for the left eye) and with Expanded Disability Status Scale (EDSS) score at the end of the follow-up period (P = .07 for the right eye and P = .043 for the left eye). No statistically significant differences were found with relation to relapses or other clinical variables. Discussion Ultrasound measurement of optic nerve diameter constitutes a useful, predictive factor for the evaluation of patients with MS. Smaller diameters are associated with poor clinical progression and greater disability (measured by EDSS)

Multiphysics and Thermodynamic Formulations for Equilibrium and Non-equilibrium Interactions: Non-linear Finite Elements Applied to Multi-coupled Active Materials

[EN] Combining several theories this paper presents a general multiphysics framework applied to the study of coupled and active materials, considering mechanical, electric, magnetic and thermal fields. The framework is based on thermodynamic equilibrium and non-equilibrium interactions, both linked by a two-temperature model. The multi-coupled governing equations are obtained from energy, momentum and entropy balances; the total energy is the sum of thermal, mechanical and electromagnetic parts. The momentum balance considers mechanical plus electromagnetic balances; for the latter the Abraham rep- resentation using the Maxwell stress tensor is formulated. This tensor is manipulated to automatically fulfill the angular momentum balance. The entropy balance is for- mulated using the classical Gibbs equation for equilibrium interactions and non-equilibrium thermodynamics. For the non-linear finite element formulations, this equation requires the transformation of thermoelectric coupling and conductivities into tensorial form. The two-way thermoe- lastic Biot term introduces damping: thermomechanical, pyromagnetic and pyroelectric converse electromagnetic dynamic interactions. Ponderomotrix and electromagnetic forces are also considered. The governing equations are converted into a variational formulation with the resulting four-field, multi-coupled formalism implemented and val- idated with two custom-made finite elements in the research code FEAP. Standard first-order isoparametric eight-node elements with seven degrees of freedom (dof) per node (three displacements, voltage and magnetic scalar potentials plus two temperatures) are used. Non-linearities and dynamics are solved with Newton-Raphson and New- mark-b algorithms, respectively. Results of thermoelectric, thermoelastic, thermomagnetic, piezoelectric, piezomag- netic, pyroelectric, pyromagnetic and galvanomagnetic interactions are presented, including non-linear depen- dency on temperature and some second-order interactions.This research was partially supported by grants CSD2008-00037 Canfranc Underground Physics, Polytechnic University of Valencia under programs PAID 02-11-1828 and 05-10-2674. The first author used the grant Generalitat Valenciana BEST/2014/232 for the completion of this work.Pérez-Aparicio, JL.; Palma, R.; Taylor, R. (2016). Multiphysics and Thermodynamic Formulations for Equilibrium and Non-equilibrium Interactions: Non-linear Finite Elements Applied to Multi-coupled Active Materials. Archives of Computational Methods in Engineering. 23:535-583. https://doi.org/10.1007/s11831-015-9149-9S53558323Abraham M (1910) Sull’elettrodinamica di Minkowski. Rend Circ Mat 30:33–46Allik H, Hughes TJR (1970) Finite elment method for piezoelectric vibration. Int J Numer Methods Eng 2:151–157Antonova EE, Looman DC (2005) Finite elements for thermoelectric device analysis in ANSYS. In: International conference on thermoelectricsAtulasimha J, Flatau AB (2011) A review of magnetostrictive iron–gallium alloys. Smart Mater Struct 20:1–15Ballato A (1995) Piezoelectricity: old effect, new thrusts. IEEE Trans Ultrason Ferroelectr Freq Control 42(5):916–926Baoyuan S, Jiantong W, Jun Z, Min Q (2003) A new model describing physical effects in crystals: the diagrammatic and analytic methods for macro-phenomenological theory. J Mater Process Technol 139:444–447Bargmann S, Steinmann P (2005) Finite element approaches to non-classical heat conduction in solids. Comput Model Eng Sci 9(2):133–150Bargmann S, Steinmann P (2006) Theoretical and computational aspects of non-classical thermoelasticity. Comput Methods Appl Mech Eng 196:516–527Bargmann S, Steinmann P (2008) Modeling and simulation of first and second sound in solids. Int J Solids Struct 45:6067–6073Barnett SM (2010) Resolution of the Abraham–Minkowski dilemma. Phys Rev Lett 104:070401Benbouzid MH, Meunier G, Meunier G (1995) Dynamic modelling of giant magnetostriction in Terfenol-D rods by the finite element method. IEEE Trans Magn 31(3):1821–1824Benbouzid MH, Reyne G, Meunier G (1993) Nonlinear finite element modelling of giant magnetostriction. IEEE Trans Magn 29(6):2467–2469Benbouzid MH, Reyne G, Meunier G (1995) Finite elment modelling of magnetostrictive devices: investigations for the design of the magnetic circuit. IEEE Trans Magn 31(3):1813–1816Besbes M, Ren Z, Razek A (1996) Finite element analysis of magneto-mechanical coupled phenomena in magnetostrictive materials. IEEE Trans Magn 32(3):1058–1061Biot MA (1956) Thermoelasticity and irreversible thermodynamics. J Appl Phys 27(3):240–253Bisio G, Cartesegna M, Rubatto G (2001) Thermodynamic analysis of elastic systems. Energy Convers Manag 42:799–812Blun SL (1974) Materials for radiation detection. National Academy of Sciences, WashingtonBonet J, Wood RD (1997) Nonlinear continuum mechanics for finite element analysis. Cambridge University Press, CambridgeBorovik-Romanov AS (1960) Piezomagnetism in the antiferromagnetic fluorides of cobalt and manganese. Sov Phys 11:786Bowyer P (2005) The momentum of light in media: the Abraham–Minkowski controversy. http://bit.ly/1M7wyATBrauer JR, Ruehl JJ, MacNeal BE, Hirtenfelder F (1995) Finite element analysis of Hall effect and magnetoresistance. IEEE Trans Electron Devices 42(2):328–333Bustamante R, Dorfmann A, Ogden RW (2009) On electric body forces and Maxwell stresses in nonlinearly electroelastic solids. Int J Eng Sci 47:1131–1141Callen HB (1948) The application of Onsager’s reciprocal relations to thermoelectric, thermomagnetic, and galvanomagnetic effects. Phys Rev 73(11):1349–1358Callen HB (1985) Thermodynamics and an introduction to thermostatistics. Wiley, New YorkCarter JP, Booker JR (1989) Finite element analysis of coupled thermoelasticity. Comput Struct 31(1):73–80Cattaneo C (1938) Sulla conduzione del calore. Atti Semin Mat Fis Univ Modena 3:83–1013Chaplik AV (2000) Some exact solutions for the classical Hall effect in an inhomogeneous magnetic field. JETP Lett 72:503Chen PJ, Gurtin ME (1968) On a theory of heat conduction involving two temperatures. J Z Angew Math Phys ZAMP 19(4):614–627Chu LJ, Haus HA, Penfield P (1966) The force density in polarizable and magnetizable fluids. In: Proceedings of the IEEEClin Th, Turenne S, Vasilevskiy D, Masut RA (2009) Numerical simulation of the thermomechanical behavior of extruded bismuth telluride alloy module. J Electron Mater 38(7):994–1001Coleman BD (1964) Thermodynamics of materials with memory. Arch Ration Mech Anal 17:1–46de Groot SR (1961) Non-equilibrium themodynamics of systems in an electromagnetic field. J Nucl Energy C Plasma Phys 2:188–194de Groot SR, Mazur P (1984) Non-equilibrium thermodynamics. Dover, MineolaDebye P (1913) On the theory of anomalous dispersion in the region of long-wave electromagnetic radiation. Verh dtsch phys Ges 15:777–793del Castillo LF, García-Colín LS (1986) Thermodynamic basis for dielectric relaxation in complex materials. Phys Rev B 33(7):4944–4951Delves RT (1964) Figure of merit for Ettingshausen cooling. Br J Appl Phys 15:105–106Dorf RC (1997) The electrical engineering handbook. CRC Press, UKEarle R, Richards JFC (1956) Theophrastus: on stones. Ohio State University, ColumbusEbling D, Jaegle M, Bartel M, Jacquot A, Bottner H (2009) Multiphysics simulation of thermoelectric systems for comparison with experimental device performance. J Electron Mater 38(7):1456–1461El-Karamany AS, Ezzat MA (2011) On the two-temperature Green–Naghdi thermoelasticity theories. J Therm Stress 34:1207–1226Eringen AC (1980) Mechanics of continua. Robert E Krieger, MalabarEringen AC, Maugin GA (1990) Electrodynamics of continua I. Springer, New YorkErsoy Y (1984) A new nonlinear constitutive theory for conducting magnetothermoelastic solids. Int J Eng Sci 22(6):683–705Ersoy Y (1986) A new nonlinear constitutive theory of electric and heat conductions for magnetoelastothermo-electrical anisotropic solids. Int J Eng Sci 24(6):867–882Ferrari A, Mittica A (2013) Thermodynamic formulation of the constitutive equations for solids and fluids. Energy Convers Manag 66:77–86Galushko D, Ermakov N, Karpovski M, Palevski A, Ishay JS, Bergman DJ (2005) Electrical, thermoelectric and thermophysical properties of hornet cuticle. Semicond Sci Technol 20:286–289Gao JL, Du QG, Zhang XD, Jiang XQ (2011) Thermal stress analysis and structure parameter selection for a Bi2Te3-based thermoelectric module. J Electron Mater 40(5):884–888Gaudenzi P, Bathe KJ (1995) An iterative finite element procedure for the analysis of piezoelectric continua. J Intell Mater Syst Struct 6:266–273Gavela D, Pérez-Aparicio JL (1998) Peltier pellet analysis with a coupled, non-linear 3D finite element model. In: 4th European workshop on thermoelectricsGoudreau GL, Taylor RL (1972) Evaluation of numerical integration methods in elastodynamics. Comput Methods Appl Mech Eng 2:69–97Griffiths DJ (1999) Introduction to electrodynamics. Prentice-Hall Inc, Upper Saddle RiverGros L, Reyne G, Body C, Meunier G (1998) Strong coupling magneto mechanical methods applied to model heavy magnetostrictive actuators. IEEE Trans Magn 34(5):3150–3153Gurtin ME, Williams WO (1966) On the Clausius–Duhem inequality. J Z Angew Math Phys ZAMP 17(5):626–633Hamader VM, Patil TA, Chovan SH (1987) Free vibration response of two-dimensional magneto-electro-elastic laminated plates. Build Mater Sci 9:249–253Hausler C, Milde G, Balke H, Bahr HA, Gerlach G (2001) 3-D modeling of pyroelectric sensor arrays part I: multiphysics finite-element simulation. IEEE Sens J 8(12):2080–2087He Y (2004) Heat capacity, thermal conductivity and thermal expansion of barium titanate-based ceramics. Thermochimica 419:135–141Hernández-Lemus E, Orgaz E (2002) Hysteresis in nonequilibrium steady states: the role of dissipative couplings. Rev Mex Fís 48:38–45Hinds EA (2009) Momentum exchange between light and a single atom: Abraham or Minkowski? Phys Rev Lett 102:050403Hirsinger L, Billardon R (1995) Magneto-elastic finite element analysis including magnetic forces and magnetostriction effects. IEEE Trans Magn 31(3):1877–1880Huang MJ, Chou PK, Lin MC (2008) An investigation of the thermal stresses induced in a thin-film thermoelectric cooler. J Therm Stress 31:438–454IEEE Standards Board (1988) IEEE standard on piezoelectricity. ANSI/IEEE Std 176-1987. doi: 10.1109/IEEESTD.1988.79638IEEE Standards Board (1991) IEEE standard on magnetostrictive materials: piezomagnetic nomenclature. IEEE Std 319-1990. doi: 10.1109/IEEESTD.1991.101048Ioffe Institute (2013) INSb—indium antimonide. Ioffe Institute. www.ioffe.rssi.ru/SVA/NSM/Semicond/InSb/index.htmlJackson JD (1962) Classical electrodynamics. Wiley, New YorkJaegle M (2008) Multiphysics simulation of thermoelectric systems—modeling of Peltier—cooling and thermoelectric generation. In: Proceedings of the COMSOLJaegle M, Bartel M, Ebling D, Jacquot A, Bottner H (2008) Multiphysics simulation of thermoelectric systems. In: European conference on thermoelectrics ECT2008Jiménez JL, Campos I (1996) Advanced electromagnetism: foundations, theory and applications, chapter The balance equations of energy and momentum in classical electrodynamics. World Scientific Publishing, SingaporeJohnstone S (2008) Is there potential for use of the Hall effect in analytical science? Analyst 133:293–296Jou D, Lebon G (1996) Extended irreversible thermodynamics. Springer, BerlinKaltenbacher M, Kaltenbacher B, Hegewald T, Lerch R (2010) Finite element formulation for ferroelectric hysteresis of piezoelectric materials. J Intell Mater Syst Struct 21:773–785Kaltenbacher M, Meiler M, Ertl M (2009) Physical modeling and numerical computation of magnetostriction. Int J Comput Math Electr Electron Eng 28(4):819–832Kamlah M, Bohle U (2001) Finite element analysis of piezoceramic components taking into account ferroelectric hysteresis behavior. Int J Solids Struct 38:605–633Kannan KS, Dasgupta A (1997) A nonlinear Galerkin finite-element theory for modeling magnetostrictive smart structures. Smart Mater Struct 6:341–350Kiang J, Tong L (2010) Nonlinear magneto-mechanical finite element analysis of Ni–Mn–Ga single crystals. Smart Mater Struct 19:1–17Kinsler P, Favaro A, McCall MW (2009) Four Poynting theorems. Eur J Phys 30:983–993Klinckel S, Linnemann K (2008) A phenomenological constitutive model for magnetostrictive materials and ferroelectric ceramics. Proc Appl Math Mech 8:10507–10508Kosmeier D (2013) Hornets: Gentle Giants! Wikipedia: the free encyclopedia. www.hornissenschutz.de/hornets.htmLahmer T (2008) Forward and inverse problems in piezoelectricity. PhD thesis, Universität Erlangen-NürnbergLandau LD, Lifshitz EM (1982) Mechanics. Butterworth-Heinemann, OxfordLandau LD, Lifshitz EM (1984) Electrodynamics of continuous media. Pergamon Press, OxfordLandis CM (2002) A new finite-element formulation for electromechanical boundary value problems. Int J Numer Methods Eng 55:613–628Díaz Lantada A (2011) Handbook of active materials for medical devices: advances and applications. CRC Press, Boca RatonLebon G, Jou D, Casas-Vázquez J (2008) Understanding non-equilibrium thermodynamics. Springer, BerlinLinnemann K, Klinkel S (2006) A constitutive model for magnetostrictive materials—theory and finite element implementation. Proc Appl Math Mech 6:393–394Linnemann K, Klinkel S, Wagner W (2009) A constitutive model for magnetostrictive and piezoelectric materials. Int J Solids Struct 46:1149–1166Llebot JE, Jou D, Casas-Vázquez J (1983) A thermodynamic approach to heat and electric conduction in solids. Physica 121(A):552–562Lu X, Hanagud V (2004) Extended irreversible thermodynamics modeling for self-heating and dissipation in piezoelectric ceramics. IEEE Trans Ultrason Ferroelectr Freq Control 51(12):1582–1592Lubarda VA (2004) On thermodynamic potentials in linear thermoelasticity. Int J Solids Struct 41:7377–7398Mansuripur M (2012) Trouble with the lorentz law of force: incompatibility with special relativity and momentum conservation. Phys Rev Lett 108:193901Maruszewski B, Lebon G (1986) An extended irreversible thermodynamic description of electrothermoelastic semiconductors. Int J Eng Sci 24(4):583–593McMeeking RM, Landis CM (2005) Electrostatic forces and stored energy for deformable dielectric materials. J Appl Mech 72:581–590McMeeking RM, Landis CM, Jimenez MA (2007) A principle of virtual work for combined electrostatic and mechanical loading of materials. Int J Non Linear Mech 42:831–838MELCOR (2000) Thermoelectric handbook. Melcor, a unit of Laird Technologies. http://www.lairdtech.comMinkowski H (1908) Nachr. ges. wiss. Gottingen 53Naranjo B, Gimzewski JK, Putterman S (2005) Observation of nuclear fusion driven by a pyroelectric crystal. Nature 28(434):1115–1117Nédélec JC (1980) Mixed finite elements in $${R}^3$$ R 3 . Numer Math 35:314–345Nettleton RE, Sobolev SL (1995) Applications of extended thermodynamics to chemical, rheological, and transport processes: a special survey part I. approaches and scalar rate processes. J Non-Equilib Thermodyn 20:205–229Nettleton RE, Sobolev SL (1995) Applications of extended thermodynamics to chemical, rheological, and transport processes: a special survey part II. vector transport processes, shear relaxation and rheology. J Non-Equilib Thermodyn 20:297–331Nettleton RE, Sobolev SL (1996) Applications of extended thermodynamics to chemical, rheological, and transport processes: a special survey part III. wave phenomena. J Non-Equilib Thermodyn 21:1–16Newmark N (1959) A method of computation for structural dynamics. ASCE J Eng Mech 85:67–94Newnham RE (2005) Properties of materials: anisotropy, symmetry, structure. Oxford University Press, OxfordNour AE, Abd-Alla N, Maugin GA (1990) Nonlinear equations for thermoelastic magnetizable conductors. Int J Eng Sci 27(7):589–603Nowacki A (1962) International series of monographs in aeronautics and astronautics. Pergamon Press, OxfordOkumura H, Hasegawa Y, Nakamura H, Yamaguchi S (1999) A computational model of thermoelectric and thermomagnetic semiconductors. In: 18th international conference on thermoelectricsOkumura H, Yamaguchi S, Nakamura H, Ikeda K, Sawada K (1998) Numerical computation of thermoelectric and thermomagnetic effects. In: 17th international conference on thermoelectricsOliver X, Agelet C (2000) Continuum mechanics for engineers. Edicions UPC, Barcelona. http://hdl.handle.net/2099.3/36197Shankar K, Kondaiah P, Ganesan N (2013) Pyroelectric and pyromagnetic effects on multiphase magneto-electro-elastic cylindrical shells for axisymmetric temperature. Smart Mater Struct 22(2):025007Palma R, Pérez-Aparicio JL, Bravo R (2013) Study of hysteretic thermoelectric behavior in photovoltaic materials using the finite element method, extended thermodynamics and inverse problems. Energy Convers Manag 65:557–563Palma R, Pérez-Aparicio JL, Taylor RL (2012) Non-linear finite element formulation applied to thermoelectric materials under hyperbolic heat conduction model. Comput Method Appl Mech Eng 213–216:93–103Palma R, Rus G, Gallego R (2009) Probabilistic inverse problem and system uncertainties for damage detection in piezoelectrics. Mech Mater 41:1000–1016Pérez-Aparicio JL, Gavela D (1998) 3D, non-linear coupled, finite element model of thermoelectricity. In: 4th European workshop on thermoelectricsPérez-Aparicio JL, Palma R, Taylor RL (2012) Finite element analysis and material sensitivity of Peltier thermoelectric cells coolers. Int J Heat Mass Transf 55:1363–1374Pérez-Aparicio JL, Sosa H (2004) A continuum three-dimensional, fully coupled, dynamic, non-linear finite element formulation for magnetostrictive materials. Smart Mater Struct 13:493–502Perez-Aparicio JL, Sosa H, Palma R (2007) Numerical investigations of field-defect interactions in piezoelectric ceramics. Int J Solids Struct 44:4892–4908Pérez-Aparicio JL, Taylor RL, Gavela D (2007) Finite element analysis of nonlinear fully coupled thermoelectric materials. Comput Mech 40:35–45Qi H, Fang D, Yao Z (1997) FEM analysis of electro-mechanical coupling effect of piezoelectric materials. Comput Mater Sci 8:283–290Pérez-Aparicio JL, Palma R, Abouali-Sánchez S (2014) Complete finite element method analysis of galvanomagnetic and thermomagnetic effects. Appl Therm Eng (submitted)Perez-Aparicio JL, Palma R, Moreno-Navarro P (2014) Elasto-thermoelectric non-linear, fully coupled, and dynamic finite element analysis of pulsed thermoelectrics. Appl Therm Eng (submitted)Ramírez F, Heyliger PR, Pan E (2006) Free vibration response of two-dimensional magneto-electro-elastic laminated plates. J Sound Vib 292:626–644Reitz JR, Milford FJ (1960) Foundations of electromagnetic theory. Addison-Wesley, BostonReng Z, Ionescu B, Besbes M, Razek A (1995) Calculation of mechanical deformation of magnetic materials in electromagnetic devices. IEEE Trans Magn 31(3):1873–1876Restuccia L (2010) On a thermodynamic theory for magnetic relaxation phenomena due to n microscopic phenomena described by n internal variables. J Non-Equilib Thermodyn 35:379–413Restuccia L, Kluitenberg GA (1988) On generalizations of the Debye equation for dielectric relaxation. Phys A 154:157–182Restuccia L, Kluitenberg GA (1992) On the heat dissipation function for dielectric relaxation phenomena in anisotropic media. Int J Eng Sci 30(3):305–315Riffat SB, Ma X (2003) Thermoelectrics: a review of present and potential applications. Appl Therm Eng 23:913–935Rinaldi C, Brenner H (2002) Body versus surface forces in continuum mechanics: is the Maxwell stress tensor a physically objective Cauchy stress? Phys Rev E 65:036615Rowe DM (ed) (1995) CRC handbook of thermoelectrics. CRC Press, UKRus G, Palma R, Pérez-Aparicio JL (2009) Optimal measurement setup for damage detection in piezoelectric plates. Int J Eng Sci 47:554–572Rus G, Palma R, Pérez-Aparicio JL (2012) Experimental design of dynamic model-based damage identification in piezoelectric ceramics. Mech Syst Signal Process 26:268–293Sadiku MNO (2001) Numerical techniques in electromagnetics. CRC Press LLC, Boca RatonSemenov AS, Kessler H, Liskowsky A, Balke H (2006) On a vector potential formulation for 3D electromechanical finite element analysis. Commun Numer Methods Eng 22:357–375Serra E, Bonaldi M (2008) A finite element formulation for thermoelastic damping analysis. Int J Numer Methods Eng 78(6):671–691Several. Wikipedia. Wikipedia: The Free Encyclopedia, SeveralSoh AK, Liu JX (2005) On the constitutive equations of magnetoelectroelastic solids. J Intell Mater Syst Struct 16:597–602Stefanescu DM (2011) Handbook of force transducers: principles and components. Springer, BerlinTamma KK, Namburu RR (1992) An effective finite element modeling/analysis approach for dynamic thermoelasticity due to second sound effects. Comput Mech 9:73–84Tang T, Yu W (2009) Micromechanical modeling of the multiphysical behavior of smart materials using the variational asymptotic method. Smart Mater Struct 18:1–14Taylor RL (2010) FEAP a finite element analysis program: user manual. University of California, Berkeley. http://www.ce.berkeley.edu/feapThurston RN (1994) Warren p. Mason (1900–1986) physicist, engineer, inventor, author, teacher. IEEE Trans Ultrason Ferroelectr Freq Control 41(4):425–434Tian X, Shen Y, Chen C, He T (2006) A direct finite element method study of generalized thermoelastic problems. Int J Solids Struct 43:2050–2063Tinder RF (2008) Tensor properties of solids: phenomenological development of the tensor properties of crystals. Morgan and Claypool, San RafaelTruesdell C (1968) Thermodynamics for beginners, in irreversible aspects of continuum mechanics. Springer, BerlinTzou HS, Ye R (1996) Pyroelectric and thermal strain effects of piezoelectric (PVDF and PZT) devices. Mech Syst Signal Process 10(4):459–469Walser R (1972) Application of pyromagnetic phenomena to radiation detection

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

Consenso de expertos sobre el uso de alemtuzumab en la práctica clínica diaria en España

Introducción: Alemtuzumab es un fármaco de alta eficacia aprobado por la Agencia Europea de Medicamentos como tratamiento modificador de la enfermedad en pacientes con esclerosis múltiple remitente recurrente. Objetivo: Elaborar un documento de consenso sobre el manejo de alemtuzumab en la práctica clínica habitual, que sea de aplicación en el ámbito español. Desarrollo: Un grupo de expertos en esclerosis múltiple revisó las publicaciones disponibles hasta diciembre de 2017, de tratamiento con alemtuzumab y esclerosis múltiple. Se incluyeron trabajos sobre eficacia, efectividad y seguridad, despistaje de infecciones y vacunación, administración y monitorización. La propuesta inicial de recomendaciones fue desarrollada por un grupo coordinador con base en la evidencia disponible y en su experiencia clínica. El proceso de consenso se llevó a cabo en 2 etapas; se estableció como porcentaje inicial de acuerdo grupal el 80%. El documento final con todas las recomendaciones acordadas por el grupo de trabajo se sometió a revisión externa y los comentarios recibidos fueron considerados por el grupo coordinador. Conclusiones: El documento aportado pretende ser una herramienta útil para facilitar el manejo del fármaco en condiciones de práctica clínica habitual.Introduction: Alemtuzumab is a highly effective drug approved by the European Medicines Agency as a disease-modifying drug for the treatment of relapsing-remitting multiple sclerosis. Objective: A consensus document was drafted on the management of alemtuzumab in routine clinical practice in Spain. Development: A group of multiple sclerosis specialists reviewed articles addressing treatment with alemtuzumab in patients with multiple sclerosis and published before December 2017. The included studies assessed the drug's efficacy, effectiveness, and safety; screening for infections and vaccination; and administration and monitoring aspects. The initial proposed recommendations were developed by a coordinating group and based on the available evidence and their clinical experience. The consensus process was carried out in 2 stages, with the initial threshold percentage for group agreement established at 80%. The final document with all the recommendations agreed by the working group was submitted for external review and the comments received were considered by the coordinating group. Conclusion: The present document is intended to be used as a tool for optimising the management of alemtuzumab in routine clinical practice

Consensus statement on the use of alemtuzumab in daily clinical practice in Spain

Introducción: Alemtuzumab es un fármaco de alta eficacia aprobado por la Agencia Europeade Medicamentos como tratamiento modificador de la enfermedad en pacientes con esclerosismúltiple remitente recurrente.Objetivo: Elaborar un documento de consenso sobre el manejo de alemtuzumab en la práctica clínica habitual, que sea de aplicación en el ámbito español.Desarrollo: Un grupo de expertos en esclerosis múltiple revisó las publicaciones disponibles hasta diciembre de 2017, de tratamiento con alemtuzumab y esclerosis múltiple. Se incluyeron trabajos sobre eficacia, efectividad y seguridad, despistaje de infecciones y vacunación, admi-nistración y monitorización. La propuesta inicial de recomendaciones fue desarrollada por un grupo coordinador con base en la evidencia disponible y en su experiencia clínica. El proceso de consenso se llevó a cabo en 2 etapas; se estableció como porcentaje inicial de acuerdo grupal el 80%. El documento final con todas las recomendaciones acordadas por el grupo de trabajo se sometió a revisión externa y los comentarios recibidos fueron considerados por el grupo coordinador. Conclusiones: El documento aportado pretende ser una herramienta útil para facilitar el manejo del fármaco en condiciones de práctica clínica habitualtIntroduction: Alemtuzumab is a highly effective drug approved by the European Medicines Agency as a disease-modifying drug for the treatment of relapsing-remitting multiple sclerosis. Objective: A consensus document was drafted on the management of alemtuzumab in routineclinical practice in Spain. Development: A group of multiple sclerosis specialists reviewed articles addressing treatment with alemtuzumab in patients with multiple sclerosis and published before December 2017. The included studies assessed the drug’s efficacy, effectiveness, and safety; screening for infections and vaccination; and administration and monitoring aspects. The initial proposed recommendations were developed by a coordinating group and based on the available evidence and their clinical experience. The consensus process was carried out in 2 stages, with the initial threshold percentage for group agreement established at 80%. The final document with all the recom-mendations agreed by the working group was submitted for external review and the comments received were considered by the coordinating group. Conclusion: The present document is intended to be used as a tool for optimising the management of alemtuzumab in routine clinical practiceLa elaboración de este manuscrito ha sido financiada por Sanofi-Genzym

An enigma in the genetic responses of plants to salt stresses

Soil salinity is one of the main factors restricting crop production throughout the world. Various salt tolerance traits and the genes controlling these traits are responsible for coping with salinity stress in plants. These coping mechanisms include osmotic tolerance, ion exclusion, and tissue tolerance. Plants exposed to salinity stress sense the stress conditions, convey specific stimuli signals, and initiate responses against stress through the activation of tolerance mechanisms that include multiple genes and pathways. Advances in our understanding of the genetic responses of plants to salinity and their connections with yield improvement are essential for attaining sustainable agriculture. Although a wide range of studies have been conducted that demonstrate genetic variations in response to salinity stress, numerous questions need to be answered to fully understand plant tolerance to salt stress. This chapter provides an overview of previous studies on the genetic control of salinity stress in plants, including signaling, tolerance mechanisms, and the genes, pathways, and epigenetic regulators necessary for plant salinity tolerance