A Comparative Study of Characteristics and Outcomes of Patients with Proved and Suggested Sarcoid Uveitis Occurring after Ophthalmic Procedure

Purpose. To describe patients with new onset sarcoid uveitis occurring after an ophthalmic procedure and compare them with patients with sarcoid uveitis without ocular procedure. Methods. Retrospective analysis of case records from patients with postophthalmic procedure sarcoid uveitis seen at our institution between April 2004 and October 2016. Patients with a previous history of uveitis were not included. Each patient was randomly matched with four controls from our incident cohort of new onset sarcoid uveitis without ophthalmic procedure. Results. We identified 11 patients (8.5%) from our incident cohort of sarcoid uveitis (n=130), who were all women, with a postophthalmic procedure uveitis (mostly after cataract surgery (36%)). These patients were older (69.7 vs 52.7 years) and presented more synechiae than controls. After a mean follow-up of 30 (3–60) months, there was no significant difference between the postprocedure and the control group with regard to demography, clinical presentation, disease course, treatment, and outcome. Conclusions. Sarcoid uveitis has similar characteristics in patients with new onset sarcoid uveitis after or without ophthalmic procedure. As a consequence, ophthalmic intervention should be seen as a potential trigger of latent sarcoidosis

Synthetic styrene-based bioinspired model of the [FeFe]-hydrogenase active site for electrocatalytic hydrogen evolution

Integration of molecular catalysts inside polymeric scaffolds has gained substantial attention over the past decade, as it provides a path towards generating systems with enhanced stability as well as enzyme-like morphologies and properties. In the context of solar fuels research and chemical energy conversion, this approach has been found to improve both rates and energy efficiencies of a range of catalytic reactions. However, system performance still needs to be improved to reach technologically relevant currents and stability, parameters that are heavily influenced by the nature of the incorporated molecular catalyst. Here, we have focused on the integration of a biomimetic {Fe2(& mu;-adt)(CO)6} (-CH2NHCH2S-, azadithiolate or adt2-) based active site ("[2Fe2S]adt"), inspired by the catalytic cofactor of [FeFe] hydrogenases, within a synthetic polymeric scaffold using free radical polymerization. The resulting metallopolymers [2Fe2S]adtk[DMAEMA]l[PyBMA]m (DMAEMA = dimethylaminoethyl methacrylate as water soluble monomer; PyBMA = 4-(pyren-1-yl)-butyl methacrylate as hydrophobic anchor for heterogenization) were found to be active for electrochemical H2 production in neutral aqueous media. The pyrene content was varied to optimize durability and activity. Following immobilization on multiwalled carbon nanotubes (MWNT) the most active metallopolymer, containing & SIM;2.3 mol% of PyBMA, could reach a turnover number for hydrogen production (TONH2) of & SIM;0.4 x105 over 20 hours of electrolysis at an overpotential of 0.49 V, two orders of magnitude higher than the isolated catalyst counterpart. The study provides a synthetic methodology for incorporating catalytic units featuring second coordination sphere functional groups, and highlights the benefit of the confinement within the polymer matrix for catalytic performance.A multifunctional polymer matrix allows significant improvement over an isolated FeFeADT hydrogenase mimic for electrocatalytic hydrogen evolution

Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies

International audienc

Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies

International audienc