Antitumor effect of lysine-isopeptides

Isopeptides (ε-peptides) of lysine, with a given Mw and low polydispersity (10–400 units), were synthesized to study the relationship between their chemical structure and biological effect. The designed compounds were of high purity, low polydispersity and high stereochemical purity. The effect of the compounds was tested on a human erythroleukemia cell line (K-562) and on four transplantable mouse tumors (L1210 lymphoid leukemia, P38 macrophage derived tumor, Ehrlich ascites carcinoma, Lewis lung tumor /LLT/). In case of the L1210 and P388 tumors and the Ehrlich carcinoma, survival of the animals was used as an indicator of the effect. In case of the Lewis lung tumor, the number and size of metastases in the lung and/or liver of treated and untreated mice were used as indicators. The polymers of polymerisation degree 80–120 (Mw 10.2–15.4 KD) showed the strongest antiproliferative effect both on K562 cells and the tumors growing in vivo. This effect was manifest with a significantly higher survival rate as compared to the control (L1210, P38, Ehrlich ascites), furthermore, by a decrease in the number and size of liver and lung metastases (LLT)

The randomly driven Ising ferromagnet, Part II: One and two dimensions

We consider the behavior of an Ising ferromagnet obeying the Glauber dynamics under the influence of a fast switching, random external field. In Part I, we introduced a general formalism for describing such systems and presented the mean field theory. In this article we derive results for the one dimensional case, which can be only partially solved. Monte Carlo simulations performed on a square lattice indicate that the main features of the mean field theory survive the presence of strong fluctuations.Comment: 10 pages in REVTeX/LaTeX format, 17 eps/ps figures. Submitted to Journal of Physics

Refined stellar, orbital and planetary parameters of the eccentric HAT-P-2 planetary system

We present refined parameters for the extrasolar planetary system HAT-P-2 (also known as HD 147506), based on new radial velocity and photometric data. HAT-P-2b is a transiting extrasolar planet that exhibits an eccentric orbit. We present a detailed analysis of the planetary and stellar parameters, yielding consistent results for the mass and radius of the star, better constraints on the orbital eccentricity, and refined planetary parameters. The improved parameters for the host star are M_star = 1.36 +/- 0.04 M_sun and R_star = 1.64 +/- 0.08 R_sun, while the planet has a mass of M_p = 9.09 +/- 0.24 M_Jup and radius of R_p = 1.16 +/- 0.08 R_Jup. The refined transit epoch and period for the planet are E = 2,454,387.49375 +/- 0.00074 (BJD) and P = 5.6334729 +/- 0.0000061 (days), and the orbital eccentricity and argument of periastron are e = 0.5171 +/- 0.0033 and omega = 185.22 +/- 0.95 degrees. These orbital elements allow us to predict the timings of secondary eclipses with a reasonable accuracy of ~15 minutes. We also discuss the effects of this significant eccentricity including the characterization of the asymmetry in the transit light curve. Simple formulae are presented for the above, and these, in turn, can be used to constrain the orbital eccentricity using purely photometric data. These will be particularly useful for very high precision, space-borne observations of transiting planets.Comment: Revised version, accepted for publication in MNRAS, 11 pages, 6 figure

First observations of W Virginis stars with K2: detection of period doubling

We present the first analysis of W Vir stars observed by the Kepler space telescope in the K2 mission. Clear cycle-to-cycle variation were detected in the light curves of KT Sco and the globular cluster member M80-V1. While the variations in the former star seems to be irregular on the short time scale of the K2 data, the latter appears to experience period doubling in its pulsation. Ground-based colour data confirmed that both stars are W Vir-type pulsators, while a comparison with historical photometric time-series data revealed drastic period changes in both stars. For comparison we reexamine ground-based observations of W Vir, the prototype of the class, and conclude that it shows period doubling instead of mode beating. These results support the notion that nonlinear dynamics plays an important role in the pulsation of W Virginis-type stars.Comment: 8 pages, 7 figures, accepted for publication in MNRA

Pushing the limits, episode 2: K2 observations of extragalactic RR Lyrae stars in the dwarf galaxy Leo IV

We present the first observations of extragalactic pulsating stars in the K2 ecliptic survey of the Kepler space telescope. Variability of all three RR Lyrae stars in the dwarf spheroidal galaxy Leo IV were successfully detected, at a brightness of Kp~21.5 mag, from data collected during Campaign 1. We identified one modulated star and another likely Blazhko candidate with periods of 29.8+-0.9 d and more than 80 d, respectively. EPIC 210282473 represents the first star beyond the Magellanic Clouds for which the Blazhko period and cycle-to-cycle variations in the modulation were unambiguously measured.The photometric [Fe/H] indices of the stars agree with earlier results that Leo IV is a very metal-poor galaxy. Two out of three stars blend with brighter background galaxies in the K2 frames. We demonstrate that image subtraction can be reliably used to extract photometry from faint confused sources that will be crucial not only for the K2 mission but for future space photometric missions as well.Comment: 8 pages, 6 figures, accepted for publication in the Astrophysical Journal. Light curves can be downloaded from http://konkoly.hu/KIK/data.htm

Pushing the limits: K2 observations of the trans-Neptunian objects 2002 GV31 and (278361) 2007 JJ43

We present the first photometric observations of trans-Neptunian objects (TNOs) taken with the Kepler space telescope, obtained in the course of the K2 ecliptic survey. Two faint objects have been monitored in specifically designed pixel masks that were centered on the stationary points of the objects, when their daily motion was the slowest. In the design of the experiment, only the apparent path of these objects were retrieved from the detectors, i.e. the costs in terms of Kepler pixels were minimized. Because of the faintness of the targets we employ specific reduction techniques and co-added images. We measure rotational periods and amplitudes in the unfiltered Kepler band as follows: for (278361) 2007 JJ43 and 2002 GV31 we get P_rot=12.097 h and P_rot=29.2 h while 0.10 and 0.35 mag for the total amplitudes, respectively. Future space missions, like TESS and PLATO are not well suited to this kind of observations. Therefore, we encourage to include the brightest TNOs around their stationary points in each observing campaign to exploit this unique capability of the K2 Mission -- and therefore to provide unbiased rotational, shape and albedo characteristics of many objects.Comment: Accepted for publication in ApJ Letters, 5.2 pages in emulateapj style, misspelled 2007 JJ43 designation correcte

Maximal violation of the I3322 inequality using infinite dimensional quantum systems

The I3322 inequality is the simplest bipartite two-outcome Bell inequality beyond the Clauser-Horne-Shimony-Holt (CHSH) inequality, consisting of three two-outcome measurements per party. In case of the CHSH inequality the maximal quantum violation can already be attained with local two-dimensional quantum systems, however, there is no such evidence for the I3322 inequality. In this paper a family of measurement operators and states is given which enables us to attain the largest possible quantum value in an infinite dimensional Hilbert space. Further, it is conjectured that our construction is optimal in the sense that measuring finite dimensional quantum systems is not enough to achieve the true quantum maximum. We also describe an efficient iterative algorithm for computing quantum maximum of an arbitrary two-outcome Bell inequality in any given Hilbert space dimension. This algorithm played a key role to obtain our results for the I3322 inequality, and we also applied it to improve on our previous results concerning the maximum quantum violation of several bipartite two-outcome Bell inequalities with up to five settings per party.Comment: 9 pages, 3 figures, 1 tabl

Evidence for fresh frost layer on the bare nucleus of comet Hale--Bopp at 32 AU distance

Here we report that the activity of comet Hale--Bopp ceased between late 2007 and March, 2009, at about 28 AU distance from the Sun. At that time the comet resided at a distance from the Sun that exceeded the freeze-out distance of regular comets by an order of magnitude. A Herschel Space Observatory PACS scan was taken in mid-2010, in the already inactive state of the nucleus. The albedo has been found to be surprisingly large (8.1$\pm$0.9%{}), which exceeds the value known for any other comets. With re-reduction of archive HST images from 1995 and 1996, we confirm that the pre-perihelion albedo resembled that of an ordinary comet, and was smaller by a factor of two than the post-activity albedo. Our further observations with the Very Large Telescope (VLT) also confirmed that the albedo increased significantly by the end of the activity. We explain these observations by proposing gravitational redeposition of icy grains towards the end of the activity. This is plausible for such a massive body in a cold environment, where gas velocity is lowered to the range of the escape velocity. These observations also show that giant comets are not just the upscaled versions of the comets we know but can be affected by processes that are yet to be fully identified.Comment: 7 pages, 6 figures, accepted for publication in Ap