Valorization of strawberry extrudate waste: Recovery of phenolic compounds by direct-hydrothermal treatment and subsequent methane production by mesophilic semi-continuous anaerobic digestion

This research was funded by the Spanish Ministry of Economy, Industry, and Competitiveness through Project CTM2017-83870-R. The authors are grateful to the Regional Government of Andalusia, Junta de Andalucia, Consejeria de Economia y Conocimiento (Project UHU-1257728) , for providing additional financial support.Strawberry extrudate (SE) is an underused by-product from strawberry industry. Recovery of the phenolic compounds present in SE would represent a very interesting valorisation option. Two main challenges need to be solved, firstly, the solubilisation and recovery of the phenolic compounds contained in SE, and, after that, the stabilisation of the resulted de-phenolized SE. The present research evaluates the potential of a biorefinery process combining a hydrothermal pre-treatment, followed by a phenolic extraction process and, finally, the anaerobic digestion of the remaining SE for producing energy that will contribute to compensate the energy requirements of the whole system. Following the hydrothermal pre-treatment at 170 degrees C for 60 min, an extraction of 0.6 +/- 0.1 g of gallic acid per kilogram of SE was achieved using an adsorbent resin, representing a recovery rate of 64 %. Long-term semi-continuous anaerobic digestion of de-phenolized SE was evaluated at different organic loading rates to evaluate the stability of the process. The anaerobic digestion of pre-treated SE achieved a stable methane production value of 243 +/- 34 mL CH4.g volatile solids.L-1.d(-1) at an organic loading rate (ORL) of 1.25 g volatile solids.L-1.d(-1). During the operation at this ORL, the control parameters including pH, alkalinity, soluble chemical organic demand (sCOD), and volatile fatty acid (VFA) remained stable and consistently constant. Specifically, the VFA in the reactor during this stable period achieved a value of 102 +/- 128 mg O2/L. Also, an economic balance showed that the minimal price of the generated phenolic extract for having benefited from the proposed biorefinery system was 0.812 epsilon.(g of gallic acid equivalents)(-1), a price within the range of phenolic compounds used in the food industry.Spanish Government CTM2017-83870-RRegional Government of Andalusia UHU-125772

Concept learning consistency under three‑way decision paradigm

Concept Mining is one of the main challenges both in Cognitive Computing and in Machine Learning. The ongoing improvement of solutions to address this issue raises the need to analyze whether the consistency of the learning process is preserved. This paper addresses a particular problem, namely, how the concept mining capability changes under the reconsideration of the hypothesis class. The issue will be raised from the point of view of the so-called Three-Way Decision (3WD) paradigm. The paradigm provides a sound framework to reconsider decision-making processes, including those assisted by Machine Learning. Thus, the paper aims to analyze the influence of 3WD techniques in the Concept Learning Process itself. For this purpose, we introduce new versions of the Vapnik-Chervonenkis dimension. Likewise, to illustrate how the formal approach can be instantiated in a particular model, the case of concept learning in (Fuzzy) Formal Concept Analysis is considered.This work is supported by State Investigation Agency (Agencia Estatal de Investigación), project PID2019-109152GB-100/AEI/10.13039/501100011033. We acknowledge the reviewers for their suggestions and guidance on additional references that have enriched our paper. Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature

Los vínculos existentes entre los recursos hídricos y la sostenibilidad de los sistemas naturales y humanos en la Marina Baixa

Comunicación presentada en el IV Congreso Ibérico sobre Gestión y Planificación del Agua, Tortosa, 8-12 diciembre 2004.En el marco del proyecto AQUADAPT sobre la gestión del agua se estudian las relaciones entre los sistemas natural y humano en la comarca de la Marina Baixa. Se discute la sostenibilidad de dichos sistemas y la importancia de las dinámicas coevolutivas entre ellos

Quantification and characterization of the microstructural damage of recycled aggregate self-compacting concrete under cyclic temperature changes

Recycled Aggregate (RA) usually increases porosity and weakens Interfacial Transition Zones (ITZs) of concrete, which favors the appearance of internal thermal damage. Four Self-Compacting Concrete (SCC) mixes with coarse and fine RA were subjected to positive and negative cyclic temperature variations to characterize their thermal damage and quantify its effects. Two damage mechanisms were found. On the one hand, micro-cracks appeared in the ITZs. On the other hand, micro-cracks arose from the micro-pores and propagated through the cementitious matrix. Both damage mechanisms were promoted by the use of coarse and fine RA, respectively. The damage was most notable at sub-zero temperatures and when adding coarse RA. Furthermore, it primarily affected compressive strength, although ultrasonic pulse velocity and hardened density also decreased, which served as non-destructive indicators to indirectly quantify the level of thermal internal damage of SCC.This work was funded by MICINN, AEI, EU, ERDF and NextGenerationEU/PRTR [PID2020-113837RB-I00; 10.13039/501100011033; TED2021-129715B-I00; FPU17/03374]; JCyL and ERDF [UIC-231]; and the University of Burgos [SUCONS, Y135.GI]

ESTUDIO DE LA CONECTIVIDAD DE REDES WIFI EN LOS COLEGIOS PÚBLICOS DE LA COMUNA 8 DE LA CIUDAD DE CÚCUTA

En los últimos años las redes de las telecomunicaciones y las tecnologías inalámbricas han tendido a crecer yavanzar cada día más, su desarrollo ha permitido que se optimicen procesos en los diferentes sectores económicosy para nuestro caso de estudio lo relacionado al sector educación, el cual ha facilitado los procesos deaprendizaje del estudiantado en general y ayuda a los docentes a desarrollar estrategias pedagógicas innovadorasy creativas que son prácticas a la hora de desarrollar las clases.El propósito de esta investigación es el estudio de las redes WIFI en los colegios públicos de la comuna 8 de laciudad de Cúcuta. En este proyecto participaron los colegios: Instituto técnico padre Manuel Briceño Jáuregui (fey alegría), Institución educativa el rodeo, Colegio pablo Neruda, Colegio presbítero Daniel Jordán, colegio Jaimegarzón, Instituto técnico Carlos Ramírez parís, Colegio Rafael Uribe, Colegio Claudia maría Prada Ayala, Colegiobicentenario (operado por u. Pamplona). En cuanto a los instrumentos de evaluación que se utilizaron para medirel nivel de satisfacción de las redes WIFI de los colegios de la comuna 8 se aplicaron encuestas a estudiantes,docentes y personal administrativo, a su vez se realizó entrevistas con el personal encargado de la red WIFI decada institución, todo esto con el fin de conocer la problemáticas del servicio WIFI que existe en estos colegios.Entre los resultados obtenidos se puede observar que por parte de los colegios de la comuna 8 de la ciudad deCúcuta todos presentan la misma problemática mostrando altos niveles de insatisfacción del servicio WIFI, ya queeste servicio no cumple con las necesidades mínimas de quienes lo usan.PALABRAS CLAVE: Colegios, Conectividad Redes, Tecnologías Inalámbricas, WIFI.Abstract: During the last years, telecommunications networks and wireless technologies have achieved huge advances; itsdevelopments have allowed the optimization of many processes in several economic sectors including the education.Nowadays, students have the tools to learn easier and faster and also teachers are able to develop creativepedagogical strategies for their classes.The proposal of this investment is TO study WIFI networks operation in the public education of the comuna 8in Cúcuta city. The schools selected for the study were: Instituto técnico padre Manuel Briceño Jáuregui (fe yalegría), Institución educativa el rodeo, Colegio pablo Neruda, Colegio presbítero Daniel Jordán, colegio Jaimegarzón, Instituto técnico Carlos Ramírez parís, Colegio Rafael Uribe, Colegio Claudia maría Prada Ayala, Colegiobicentenario (operated by Pamplona university).Regarding to the evaluation tools used for assessing the satisfactionlevel of the WIFI networks in the schools of comuna 8, it was applied polls to students, teachers and administrativearea workers. Additionally, some interviews were done to the WIFI support team in each institution inorder to understand the possible problems related to the WIFI service.As a conclusion, the study showed very lowsatisfaction levels in all the schools, the service was considered below expectations by the users.KEYWORDS: Connectivity, Networks, Schools, WIFI, Wireless Technologies

Toxic epidermal necrolysis in a patient infected by human immunodeficiency virus

La necrólisis epidérmica tóxica es un trastorno multifactorial, en el cual interactúan infecciones virales, medicamentosas y cierta susceptibilidad genética que se traduce en reacciones cutáneas adversas. Con este artículo se expone un caso de esta poco común entidad, la cual tiene un alto índice de morbimortalidad y secuelas. Se trata de un varón de 32 años, con antecedentes de síndrome convulsivo tratado con fenobarbital y fenitoína y con coinfección por virus de inmunodeficiencia humana de diagnóstico reciente pero sin seguimiento ni tratamiento, quien luego de consumir durante 12 días ciprofloxacino por fiebre elevada, presenta lesiones vesiculosas de fondo eritematoso.Toxic epidermal necrolysis is a multifactorial disorder, in which viral infections, medications and a certain genetic susceptibility interact, resulting in adverse skin reactions. This article presents a case of this rare entity, which has a high rate of morbidity and mortality and sequelae. This is a 32-year-old man with a history of seizure syndrome treated with phenobarbital and phenytoin and coinfection with HIV. human immunodeficiency of recent diagnosis but without follow-up or treatment, who after consuming ciprofloxacin for 12 days due to high fever, presents vesicular lesions with an erythematous background

Necrólisis epidérmica tóxica en paciente infectado por virus de inmunodeficiencia humana

La necrólisis epidérmica tóxica es un trastorno multifactorial,\ud en el cual interactúan infeccionesvirales,medicamentosas y\ud cierta susceptibilidad genética que se traduce en reacciones\ud cutáneas adversas. Con este artículo se expone un caso de\ud esta poco común entidad, la cual tiene un alto índice de\ud morbimortalidad y secuelas. Se trata de un varón de 32\ud años, con antecedentes de síndrome convulsivo tratado con\ud fenobarbital y fenitoína y con coinfección por virus de\ud inmunodeficiencia humana de diagnóstico reciente pero sin\ud seguimiento ni tratamiento, quien luego de consumirdurante\ud 12 días ciprofloxacino por fiebre elevada, presenta lesiones\ud vesiculosas de fondo eritematoso, confluentes hasta formar\ud flictenas en pared anterior tórax, de contenido seroso y con\ud desprendimiento de la epidermis al ejercer suave presión\ud sobre la piel afectada dejando áreas húmedas y rojas, con\ud signo de Nikolsky positivo. La extensión de las lesiones\ud compromete el 91% de su superficie corporal total, acompa-\ud ñada de prurito de moderada intensidad. Durante la estancia\ud hospitalaria se realiza manejo terapéutico con ciclosporinaA\ud e inmunoglobulina G específica humana, cubrimiento\ud antibiótico y antimicótico, con evolución satisfactoria del\ud estado hemodinámico del paciente y las lesiones en piel

Predicting dynamic response to neoadjuvant chemotherapy in breast cancer: a novel metabolomics approach

We are especially grateful to all the patients and their families who contributed the data that made this study possible. In addition, we thank the staff of the Clinical Research Unit of the Medical Oncology Service of the University Hospital of Jaen for their time and assistance, and the Fundacion MEDINA for their technical support. Lastly, we thank the Fundacion Bancaria Unicaja for the financial support. Jose Camacho is partly supported by the Agencia Andaluza del Conocimiento, Regional Government of Andalucia, in Spain, and ERDF (European Regional Development Fund) funds through project B-TIC-136-UGR20.Neoadjuvant chemotherapy (NACT) outcomes vary according to breast cancer (BC) subtype. Since pathologic complete response is one of the most important target endpoints of NACT, further investigation of NACT outcomes in BC is crucial. Thus, identifying sensitive and specific predictors of treatment response for each phenotype would enable early detection of chemoresistance and residual disease, decreasing exposures to ineffective therapies and enhancing overall survival rates. We used liquid chromatography high-resolution mass spectrometry (LC-HRMS)-based untargeted metabolomics to detect molecular changes in plasma of three different BC subtypes following the same NACT regimen, with the aim of searching for potential predictors of response. The metabolomics data set was analyzed by combining univariate and multivariate statistical strategies. By using ANOVA–simultaneous component analysis (ASCA), we were able to determine the prognostic value of potential biomarker candidates of response to NACT in the triple-negative (TN) subtype. Higher concentrations of docosahexaenoic acid and secondary bile acids were found at basal and presurgery samples, respectively, in the responders group. In addition, the glycohyocholic and glycodeoxycholic acids were able to classify TN patients according to response to treatment and overall survival with an area under the curve model > 0.77. In relation to luminal B (LB) and HER2+ subjects, it should be noted that significant differences were related to time and individual factors. Specifically, tryptophan was identified to be decreased over time in HER2+ patients, whereas LysoPE (22:6) appeared to be increased, but could not be associated with response to NACT. Therefore, the combination of untargeted-based metabolomics along with longitudinal statistical approaches may represent a very useful tool for the improvement of treatment and in administering a more personalized BC follow-up in the clinical practice.Fundacion MEDINAFundacion Bancaria UnicajaAgencia Andaluza del Conocimiento, Regional Government of AndaluciaEuropean Commission B-TIC-136-UGR2

Does the meteorological origin of heat waves influence their impact on health? A 6-year morbidity and mortality study in Madrid (Spain)

In Spain, two synoptic-scale conditions influence heat wave formation. The first involves advection of warm and dry air masses carrying dust of Saharan origin. Objective: to determine whether the impact of heat waves on health outcomes in Madrid (Spain) during 2013–2018 varied by synoptic-scale condition.The authors wish to thank the funding provided by the ENPY 304/20, and ENPY 436/21 projects of the National Health Institute Carlos III (ISCIII)