Cross-country migration linked to people who inject drugs challenges the long-term impact of national HCV elimination programmes

To the Editor: As of 2018, the majority of Western European countries – including Spain – have lifted restrictions to therapy based on disease severity in the context of HCV infections.1 Long overdue, most national elimination programmes now also include access to care for people who inject drugs (PWID), 2 who are at the core of ongoing HCV transmission.3 Macías et al.4 have recently shown in this Journal that high viral cure rates can be achieved in this group, hereby providing evidence that targeting PWID in treatment programmes is worthwhile. However, the extent to which such national efforts can reduce the HCV burden not only depends on the uptake into care and treatment success rates, it is also determined by the relative importance of within-country transmission and virus importation from elsewhere. As the chronic nature of most HCV infections hampers reliably reconstructing contact networks from patient interviews, virus genetic data can be a valuable alternative source of information for elucidating the geographic history of virus lineages (e.g. [5], [6]). Using such data, we have recently shown that for the most prevalent subtype among PWID in Spain (40%, 7), HCV1a, infections often link to infections abroad – in recent years >50% link to Western European countries, mostly European Union (EU) member states – as opposed to other infections ..

Resultados del estudio geológico a escala 1/25.000 del término municipal de Madrid.

Se exponen de forma abreviada los rasgos en cuanto a metodología y conclusiones del estudio geológico a escala 1/25000 realizado en el Municipio de Madrid en los años 1982/83. Las diferentes unidades expresadas en la cartografiase describen en función de las pautas mayores observables en los materiales que forman cada una de ellas, analizándose sus relaciones estratigráficas. El Proyecto «Estudio Geológico a escala 1/25000 del Término Municipal de Madrid ha sido llevado a cabo a lo largo de los años 1982-83 como resultado de la colaboración científica entre diversos organismos de la Administración (Facultad de CC. Geológicas-Universidad Complutense, Instituto Geológico y Minero. Ayuntamiento de Madrid, Instituto de Geología de Madrid-CSIC, y otros). Constituye una de las áreas de actuación definidas dentro del Convenio de Colaboración Técnica y Cultural para el conocimiento de las Características del Suelo y Subsuelo de Madrid», propiciado y patrocinado por el Excmo. Ayuntamiento. La financiación del proyecto especifico de Geología ha sido realizada íntegramente por el IGME, organismo encargado además de su supervisión. El desarrollo del Proyecto tiene un marcado carácter interdisciplinar, fruto del trasvase de información entre los distintos grupos que abarca el Convenio general (aparte de los ya referidos, el SGOP, COPLACO, Laboratorio «José Luis Escario» siendo precisamente uno de los objetivos del trabajo el servir de apoyo a las restantes áreas de investigación. Los estudios geológicos realizados se plasman en un total de siete mapas a escala 1/25000 elaborados según la normativa Magna de cartografía geológica mapas que toman como referencia, aunque en algunos casos no las completan y en otros adosan porciones de hojas adyacentes, las hojas 1/25000 de Madrid, Alcorcón, El Pardo, San Femando de Henares, Pozuelo de Alarcón, Alcobendas y Castillo de Viñuelas

Role of age and comorbidities in mortality of patients with infective endocarditis

Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Methods: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015. Patients were stratified into three age groups:<65 years, 65 to 80 years, and = 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. Results: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 = 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients =80 years who underwent surgery were significantly lower compared with other age groups (14.3%, 65 years; 20.5%, 65-79 years; 31.3%, =80 years). In-hospital mortality was lower in the <65-year group (20.3%, <65 years;30.1%, 65-79 years;34.7%, =80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%, =80 years; p = 0.003).Independent predictors of mortality were age = 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI = 3 (HR:1.62; 95% CI:1.39–1.88), and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared, the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. Conclusion: There were no differences in the clinical presentation of IE between the groups. Age = 80 years, high comorbidity (measured by CCI), and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Diferencias psicológicas en pacientes con cáncer de mama según el tipo de cirugía mamaria Psychological differences of breast cancer patients according to the type of breast surgery

Las pacientes con cáncer de mama pueden experimentar importantes secuelas psicológicas producidas por la mastectomía, considerándose la reconstrucción mamaria como un procedimiento reversivo de las mismas. Para conocer si la sintomatología ansiosa y depresiva, las estrategias de afrontamiento empleadas o la calidad de vida manifestada por las pacientes, difiere de unas a otras según el tipo de cirugía realizada (mastectomía unilateral o reconstrucción mamaria) se estudiaron 2 grupos. Un primer grupo formado por 36 pacientes sometidas a mastectomía unilateral (simple o radical modificada) y un segundo grupo constituido por 36 mujeres con reconstrucción mamaria postmastectomía (inmediata o diferida). Para la evaluación psicológica se empleó una Encuesta Psicosocial, junto a la Escala de Ansiedad y Depresión en Hospital (HAD), la Escala de Afrontamiento del Cáncer (MAC) y el Cuestionario de Calidad de Vida para Cáncer de la EORTC (QLQ-C30). En general, las pacientes mastectomizadas presentaron una mayor presencia de sintomatología ansiosa y depresiva que las pacientes con reconstrucción mamaria postmastectomía. Igualmente, las pacientes con reconstrucción mamaria emplearon estrategias de afrontamiento más eficaces y gozaron de una mayor calidad de vida que las mujeres mastectomizadas.Breast cancer patients could experiment an important reduction in psychological adjustment due to mastectomy. So, breast reconstruction is considered a procedure to reverse the sequels of breast mastectomy. Two groups were evaluated in order to determine if anxiety and depression symptoms, coping style and quality of life in breast cancer patients are different for each kind of patient, according to the type of surgery (mastectomy or breast reconstruction). A first group was made up of 36 patients with breast cancer who had undergone unilateral mastectomy (simple or modified radical) and the second group was formed by 36 patients with breast reconstruction postmastectomy (immediate or delayed). This study used a psychosocial survey, the Hospital Anxiety and Depression Scale (HAD), Mental Adjustment to Cancer Scale (MAC), and The EORTC QLQ-C30 for the evaluation. In general, mastectomy patients showed higher symptoms of anxiety and depression than the breast reconstruction patients. In the same way, breast reconstruction patients develops more effective coping strategies and reports better quality of life than breast mastectomy patients

Validez del exceso de bases como factor pronóstico de mortalidad en pacientes traumatizados

5 páginasBackground: Base excess is used to determine the mag-nitude of metabolic abnormality secondary to hemorrhage or direct organ damage of patients with polytrauma Objective: To determine what are the values of change that BE can have over time and that allow predicting early mortality in patients with polytrauma. Methods: Retrospective cohort study in subjects older than 18 years, who were admitted to the intensive care unit for any type of trauma. The response to the change of the base excess at 6, 12 and 24 hours after the trauma was evaluated. Results: 261 subjects were included, 22.6% (59/261) died. Polytrauma occurred in 73.2% (191/261) and traf-fic accident was the most common mechanism of trauma in the study population with 75.9%. The change in BE between admission and the first 6 hours was 1.7 mEq/L (SD: 4.02) in the living population and 1.9 mEq/L (SD: 8.1) in the deceased (p<0.001). The change in mEq/L between admission and first 6 hours showed a low receiver operat-ing characteristics curve area of 0.661 (95% CI: 0.523-0.8; p=0.025). Conclusión: The change in base excess between the first 6 to 12 hours after patient admission can be used to esti-mate mortality in patients diagnosed with trauma. © 2023, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology. All rights reserved