Sol-gel synthesis of spherical monodispersed bioactive glass nanoparticles co-doped with boron and copper

In this work, an optimized sol-gel process for the synthesis of spherical and monodispersed bioactive glass nanoparticles doped with boron and copper was developed, by investigating different synthesis parameters. The obtained glasses were characterized in terms of morphology, composition, dispersibility, structure and in vitro reactivity. The performed characterizations demonstrated that shape, dimension and dispersion can be tailored by acting on the timing of the addition of the catalyst and on the synthesis process, in particular the centrifugation step. The optimized glass particles showed a spherical shape, good ions incorporation and good dispersion. In vitro bioactivity test demonstrated that the boron and copper addition did not interfere with the glass ability to induce the precipitation of hydroxyapatite. The shape, dispersion, bioactive behavior and content of boron and copper of these novel bioactive glass particles make them very promising for both hard and soft tissue engineering applications

Herpetofauna, municipality of Porto Murtinho, Chaco region, state of Mato Grosso do Sul, Brazil

Among the physiographic regions included in the central South American diagonal of open formations,the Chaco, with some endemic species, represents the southernmost dry area. In Brazil, the Chaco is foundin southwestern corner of Mato Grosso do Sul state, mostly in the municipality of Porto Murtinho along theParaguay and Apa rivers. From February 2008 to December 2009, we carried out an inventory of amphibiansand reptiles in Porto Murtinho, using pitfall traps, time-limited searches, and occasional encounters. A total of34 amphibian and 39 reptile species were registered. Although some typical Chacoan species were found, mostof the species are open area dwellers that also occur in other open biomes, such as the Cerrado and Caatinga

Fluorimetric methods for the measurement of intermediate metabolites (lactate, pyruvate, alanine, β-hydroxybutyrate, glycerol) using a COBAS FARA centrifugal analyser

Intermediate products of the metabolism of glucose, fat and amino-acid are important in the evaluation of such metabolic disorders as diabetes mellitus, liver disease and metabolic acidosis. In the present study, methods for the measurement of intermediate metabolites (lactate, pyruvate, alanine, β-hydroxybutyrate and glycerol) have been adapted to a fast centrifugal analyzer: the COBAS FARA. Correlation coeffcients rangedfrom 0.90 to 0.99, compared to established manual spectrophotometric methods. Within-run coeffcients of variation (CVs) ranged between 2.9 and 8.8% at low levels, between 1.5 and 5.7% at medium levels and between 1.2 and 5.6% at high levels. Between-run CVs were between 4.0 and 15.0% at low levels, between 1.7 and 7.0% at medium levels and between 1.3 and 2.7% at high levels. These fluorimetric assays for the determination of intermediate metabolites on COBAS FARA (Roche) have a good sensitivity and precision, are less costly than manual methods and can be used on a routine basis

Chemical evolution of the Small Magellanic Cloud based on planetary nebulae

We investigate the chemical evolution of the Small Magellanic Cloud (SMC) based on abundance data of planetary nebulae (PNe). The main goal is to investigate the time evolution of the oxygen abundance in this galaxy by deriving an age-metallicity relation. Such a relation is of fundamental importance as an observational constraint of chemical evolution models of the SMC. We have used high quality PNe data in order to derive the properties of the progenitor stars, so that the stellar ages could be estimated. We collected a large number of measured spectral fluxes for each nebula, and derived accurate physical parameters and nebular abundances. New spectral data for a sample of SMC PNe obtained between 1999 and 2002 are also presented. These data are used together with data available in the literature to improve the accuracy of the fluxes for each spectral line. We obtained accurate chemical abundances for PNe in the Small Magellanic Cloud, which can be useful as tools in the study of the chemical evolution of this galaxy and of Local Group galaxies. We present the resulting oxygen versus age diagram and a similar relation involving the [Fe/H] metallicity based on a correlation with stellar data. We discuss the implications of the derived age-metallicity relation for the SMC formation, in particular by suggesting a star formation burst in the last 2-3 Gyr.Comment: 11 pages, 6 figures, accepted for publication in Astronomy and Astrophysic

Event-based surveillance during EXPO Milan 2015. Rationale, tools, procedures, and initial results

More than 21 million participants attended EXPO Milan from May to October 2015, making it one of the largest protracted mass gathering events in Europe. Given the expected national and international population movement and health security issues associated with this event, Italy fully implemented, for the first time, an event-based surveillance (EBS) system focusing on naturally occurring infectious diseases and the monitoring of biological agents with potential for intentional release. The system started its pilot phase in March 2015 and was fully operational between April and November 2015. In order to set the specific objectives of the EBS system, and its complementary role to indicator-based surveillance, we defined a list of priority diseases and conditions. This list was designed on the basis of the probability and possible public health impact of infectious disease transmission, existing statutory surveillance systems in place, and any surveillance enhancements during the mass gathering event. This article reports the methodology used to design the EBS system for EXPO Milan and the results of 8 months of surveillance

Clump stars in the Solar Neighbourhood

Hipparcos data has allowed the identification of a large number of clump stars in the Solar Neighbourhood. We discuss our present knowledge about their distributions of masses, ages, colours, magnitudes, and metallicities. We point out that the age distribution of clump stars is ``biased'' towards intermediate-ages. Therefore, the metallicity information they contain is different from that provided by the local G dwarfs. Since accurate abundance determinations are about to become available, these may provide useful constraints to chemical evolution models of the local disc.Comment: 6 pages, proc. of the Sept. 20-24, 1999 Vulcano Workshop "The chemical evolution of the Milky Way: stars vs. clusters", eds. F. Matteucci, F. Giovanell

A New Giant Branch Clump Structure In the Large Magellanic Cloud

We present Washington C, T1 CCD photometry of 21 fields located in the northern part of the Large Magellanic Cloud (LMC), and spread over a region of more than 2.52 degrees approximately 6 degrees from the bar. The surveyed areas were chosen on the basis of their proximity to SL 388 and SL 509, whose fields showed the presence of a secondary giant clump, observationally detected by Bica et al. (1998, AJ, 116, 723). From the collected data we found that most of the observed field CMDs do not show a separate secondary clump, but rather a continuous vertical structure (VS), which is clearly seen for the first time. Its position and size are nearly the same throughout the surveyed regions: it lies below the Red Giant Clump (RGC) and extends from the bottom of the RGC to approximately 0.45 mag fainter, spanning the bluest color range of the RGC. The more numerous the VS stars in a field, the larger the number of LMC giants in the same zone. Our analysis demonstrate that VS stars belong to the LMC and are most likely the consequence of some kind of evolutionary process in the LMC, particularly in those LMC regions with a noticeable large giant population. Our results suggest that in order to trigger the formation of VS stars, there should be other conditions besides the appropriate age, metallicity, and the necessary red giant star density. Indeed, stars satisfying the requisites mentioned above are commonly found throughout the LMC, but the VS phenomenon is only clearly seen in some isolated regions. Finally, the fact that clump stars have an intrinsic luminosity dispersion further constrains the use of the clump magnitude as a reliable distance indicator.Comment: 25 pages, 9 figures, 3 tables; to be published in AJ, Dec. issu

Respiratory morbidity in preschool and school-age children born very preterm and its association with parents' health-related quality of life and family functioning

The purpose [CMC1] of this study is to describe [CMC2] the prevalence and severity of respiratory symptoms in children born very preterm and to assess their association with parents’ health-related quality of life (HRQoL) and family functioning. We conducted a cross-sectional study and recruited children born less than 32 weeks’ gestation between January 2006 and December 2019, in the greater Zurich area, Switzerland. Between May and December 2021, parents were invited to complete an online survey for their preterm child and for a control term born (≥ 37 weeks’ gestation) sibling aged 1 to 18 years. We used a validated questionnaire to assess respiratory symptoms and the Pediatrics Quality of Life Family Impact Module (PedsQL FIM) to assess parents’ HRQoL and family functioning. The survey was completed for 616 very preterm children (99 with bronchopulmonary dysplasia (BPD)) and 180 controls. Girls made up 45% (46% in controls) of the sample, and 63% (60% in controls) of participants were aged 6 to 18 years (school-age). Very preterm children reported a higher risk of respiratory symptoms than controls, especially preschoolers and those with moderate-to-severe BPD. Parents of children with “mild” and “moderate-severe” respiratory symptoms had on average −3.9 (95%CI: −6.6 to −1.1) and −8.2 (−11.2 to −5.2) lower PedsQL FIM total score, respectively, than parents of children with no symptoms. The same pattern was observed after stratifying by age categories. [CMC1]LE: Please check if the edit to the sentence “The purpose of this study is to...” retained its intended meaning. Otherwise, please amend. [CMC2]LE: As per journal style, abstract should be unstructured and should end with a conclusion as a new paragraph. Thus, the other headings were removed. Please check if appropriate.   Conclusions: Our study suggests that respiratory morbidity in very preterm children has a negative impact on parents’ HRQoL and family functioning, even beyond the first years of life. What is Known:• The burden of respiratory morbidity associated with very premature birth is high and last far beyond the neonatal period.• Respiratory morbidity contributes to lower health-related quality of life (HRQoL) in parents of very preterm children in early infancy. What is New:• Respiratory morbidity in very preterm children has a negative impact on parents’ HRQoL and family functioning beyond the first years of life.• Parents of very preterm children with moderate and severe respiratory symptoms are the ones who report lower scores, both for preschool and school-age children