A versatile Montgomery multiplier architecture with characteristic three support

We present a novel unified core design which is extended to realize Montgomery multiplication in the fields GF(2n), GF(3m), and GF(p). Our unified design supports RSA and elliptic curve schemes, as well as the identity-based encryption which requires a pairing computation on an elliptic curve. The architecture is pipelined and is highly scalable. The unified core utilizes the redundant signed digit representation to reduce the critical path delay. While the carry-save representation used in classical unified architectures is only good for addition and multiplication operations, the redundant signed digit representation also facilitates efficient computation of comparison and subtraction operations besides addition and multiplication. Thus, there is no need for a transformation between the redundant and the non-redundant representations of field elements, which would be required in the classical unified architectures to realize the subtraction and comparison operations. We also quantify the benefits of the unified architectures in terms of area and critical path delay. We provide detailed implementation results. The metric shows that the new unified architecture provides an improvement over a hypothetical non-unified architecture of at least 24.88%, while the improvement over a classical unified architecture is at least 32.07%

The Relationship Between Dietary Intakes and Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease Dietary Intake and Polycystic Kidney Volume

Aim: There is a need to understand autosomal dominant polycystic kidney disease (ADPKD) patients’ dietary habits since dietary interventions may have potential effects on ADPKD. In this study, we aimed to analyze the relationship between dietary nutrient intake and total kidney volume (TKV). Methods: This cross-sectional study was conducted on 54 ADPKD patients recruited from the Nephrology outpatient clinic between June and July 2014. TKV was determined by magnetic-resonance imaging and general characteristics, biochemical and urinary parameters were determined. The nutrient intakes of patients were calculated using the three-day dietary records obtained on three consecutive days. Results: The total kidney-volume median was found to be 1407 mL. Patients’ total dietary energy and protein intakes were 25.8±9.4 kcal/kg, 0.9±0.3 g/kg, respectively. The percentage of carbohydrates, protein, and fat in energy was 49±7%, 14±3%, 37±7%, respectively. The mean intakes of thiamin, riboflavin, B6, calcium, magnesium, and zinc were sufficient, the mean dietary potassium intake was insufficient; and sodium intake was excessive in both sexes. In females, there was a negative but weak correlation between dietary vitamin C intake and TKV. In males, a negative but weak correlation was found between TKV and dietary intake of fiber, water, vitamin B6, vitamin K, magnesium, and iron. Conclusions: Dietary micronutrient intake may affect TKV according to sex. © 2022, Galenos Publishing House. All rights reserved

Clinical assessment of epidural analgesia induced by xylazine-lidocaine combination accompanied by xylazine sedation in calves

<p/> <p>The aim of the present study was to investigate whether epidural administration of a xylazine-lidocaine combination accompanied by xylazine sedation would provide satisfactory analgesia for some surgical procedures on 10 calves admitted to the Department of Veterinary Surgery, University of Kafkas with perineal urolithiasis (n:2), rectovaginal fistula (n:1), atresia ani (n:2), omphalophlebitis (n:2), omphaloarteritis (n:1) and umbilical hernia (n:2).</p> <p>Following intramuscular injection of xylazine at a dose of 0.05 mg/kg for sedation, xylazine-lidocaine combination (0.2 mg/kg lidocaine + 0.02 mg/kg xylazine + 5 ml 0.9% NaCl) was administrated into the lumbosacral (L₆-S₁), sacrococcygeal (S₅-Co₁) or intercoccygeal (Co₁-Co₂) space. Heart rate, respiratory rate and rectal temperature were recorded prior to and during analgesia at 5, 10, 15, 30 and 60 minutes. Furthermore, depth and duration of analgesia were evaluated during surgical intervention.</p> <p>The study revealed that the combination of epidural xylazine-lidocaine with xylazine sedation was highly satisfactory for surgery of the lower urinary tract and the perineal region, but it was less so for surgery of the umbilical area.</p

Design and implementation of a fast and scalable NTT-based polynomial multiplier architecture

In this paper, we present an optimized FPGA implementation of a novel, fast and highly parallelized NTT-based polynomial multiplier architecture, which proves to be effective as an accelerator for lattice-based homomorphic cryptographic schemes. As I/O operations are as time-consuming as NTT operations during homomorphic computations in a host processor/accelerator setting, instead of achieving the fastest NTT implementation possible on the target FPGA, we focus on a balanced time performance between the NTT and I/O operations. Even with this goal, we achieved the fastest NTT implementation in literature, to the best of our knowledge. For proof of concept, we utilize our architecture in a framework for Fan-Vercauteren (FV) homomorphic encryption scheme, utilizing a hardware/software co-design approach, in which polynomial multiplication operations are offloaded to the accelerator via PCIe bus while the rest of operations in the FV scheme are executed in software running on an off-the-shelf desktop computer. Specifically, our framework is optimized to accelerate Simple Encrypted Arithmetic Library (SEAL), developed by the Cryptography Research Group at Microsoft Research, for the FV encryption scheme, where large degree polynomial multiplications are utilized extensively. The hardware part of the proposed framework targets Xilinx Virtex-7 FPGA device and the proposed framework achieves almost 11x latency speedup for the offloaded operations compared to their pure software implementations

Accelerating LTV based homomorphic encryption in reconfigurable hardware

After being introduced in 2009, the first fully homomorphic encryption (FHE) scheme has created significant excitement in academia and industry. Despite rapid advances in the last 6 years, FHE schemes are still not ready for deployment due to an efficiency bottleneck. Here we introduce a custom hardware accelerator optimized for a class of reconfigurable logic to bring LTV based somewhat homomorphic encryption (SWHE) schemes one step closer to deployment in real-life applications. The accelerator we present is connected via a fast PCIe interface to a CPU platform to provide homomorphic evaluation services to any application that needs to support blinded computations. Specifically we introduce a number theoretical transform based multiplier architecture capable of efficiently handling very large polynomials. When synthesized for the Xilinx Virtex 7 family the presented architecture can compute the product of large polynomials in under 6.25 msec making it the fastest multiplier design of its kind currently available in the literature and is more than 102 times faster than a software implementation. Using this multiplier we can compute a relinearization operation in 526 msec. When used as an accelerator, for instance, to evaluate the AES block cipher, we estimate a per block homomorphic evaluation performance of 442 msec yielding performance gains of 28.5 and 17 times over similar CPU and GPU implementations, respectively

Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot

Wstęp: Celem badania była ocena wpływu leczenia tlenem w komorze hiperbarycznej (HBOT, hyperbaric oxygen therapy) na kontrolę glikemii, czynniki ryzyka miażdżycy, wskaźniki zapalenia oraz inne kliniczne i laboratoryjne parametry u chorych z owrzodzeniem w przebiegu zespołu stopy cukrzycowej poddanych systemowej HBOT. Materiał i metody: Do badania włączono 28 chorych z owrzodzeniem stopy 2-4 stopnia według skali Wagnera. Wszyscy chorzy odbyli 30 sesji terapii 100-procentowym tlenem przy ciśnieniu 2,4 ATA przez około 105 minut, 5 razy w tygodniu. Zmierzono następujące parametry: glikemię na czczo, odsetek HbA1c, wskaźnik insulinooporności HOMA-IR, stężenie wysokoczułego białka C-reaktywnego (hs-CRP, high sensitivity C-reactive protein), stężenie kwasu moczowego, średnią objętość płytek krwi, a ponadto zbadano morfologię krwi i profil lipidowy. Wyniki: Po zakończeniu terapii stwierdzono istotną poprawę średnich wartości wszystkich badanych parametrów. Wnioski: Wykazano, że HBOT wpływa korzystnie na czynniki ryzyka miażdżycy i kontrolę glikemii u chorych na cukrzycę. Potrzebne są dalsze, prowadzone na szeroką skalę badania z randomizacją, aby ocenić ogólnoustrojowe efekty HBOT. (Endokrynol Pol 2010; 61 (3): 275-279)Introduction: The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on glycaemic control, atherosclerosis, inflammatory markers, and other clinical and laboratory parameters in patients undergoing systemic HBOT for diabetic foot ulcerations. Material and methods: Twenty-eight patients with Wagner grade 2-4 diabetic foot ulcerations were included. All patients were given 100% oxygen at 2.4 absolute atmosphere (ATA) for about 105 minutes, five times a week for a total of 30 sessions. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), homeostasis model measurement-insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP), uric acid, mean platelet volume (MPV), complete blood count, and lipid profile were tested. Results: Upon completion of treatment, a statistically significant improvement was observed in the mean values of all assessed parameters. Conclusions: HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control in diabetic patients. Further large-scale randomized studies are needed to study the systemic effects of HBOT. (Pol J Endocrinol 2010; 61 (3): 275-279

The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 controls of East Asian and European ancestries. We discover two previously unreported loci, NFKB1 (rs230540, OR = 1.25, P = 3.4 × 10-12) and IRF4 (rs9405192, OR = 1.29, P = 1.4 × 10-14), fine-map the PLA2R1 locus (rs17831251, OR = 2.25, P = 4.7 × 10-103) and report ancestry-specific effects of three classical HLA alleles: DRB1*1501 in East Asians (OR = 3.81, P = 2.0 × 10-49), DQA1*0501 in Europeans (OR = 2.88, P = 5.7 × 10-93), and DRB1*0301 in both ethnicities (OR = 3.50, P = 9.2 × 10-23 and OR = 3.39, P = 5.2 × 10-82, respectively). GWAS loci explain 32% of disease risk in East Asians and 25% in Europeans, and correctly re-classify 20-37% of the cases in validation cohorts that are antibody-negative by the serum anti-PLA2R ELISA diagnostic test. Our findings highlight an unusual genetic architecture of MN, with four loci and their interactions accounting for nearly one-third of the disease risk

Whole-exome resequencing distinguishes cystic kidney diseases from phenocopies in renal ciliopathies

Rare single-gene disorders cause chronic disease. However, half of the 6,000 recessive single gene causes of disease are still unknown. Because recessive disease genes can illuminate, at least in part, disease pathomechanism, their identification offers direct opportunities for improved clinical management and potentially treatment. Rare diseases comprise the majority of chronic kidney disease (CKD) in children but are notoriously difficult to diagnose. Whole exome resequencing facilitates identification of recessive disease genes. However, its utility is impeded by the large number of genetic variants detected. We here overcome this limitation by combining homozygosity mapping with whole exome resequencing in 10 sib pairs with a nephronophthisis-related ciliopathy, which represents the most frequent genetic cause of CKD in the first three decades of life. In 7 of 10 sib-ships with a histologic or ultrasonographic diagnosis of nephronophthisis-related ciliopathy we detect the causative gene. In six sib-ships we identify mutations of known nephronophthisis-related ciliopathy genes, while in two additional sib-ships we found mutations in the known CKD-causing genes SLC4A1 and AGXT as phenocopies of nephronophthisis-related ciliopathy. Thus whole exome resequencing establishes an efficient, non-invasive approach towards early detection and causation-based diagnosis of rare kidney diseases. This approach can be extended to other rare recessive disorders, thereby providing accurate diagnosis and facilitating the study of disease mechanisms

Renal involvement in leprosy: evaluation of patients in Turkey

Introduction: Renal involvement in leprosy has previously been described in the literature and can include amyloidosis, glomerulonephritis, nephrosclerosis, tubulointerstitial nephritis, and granulomas. Aim: To evaluate renal involvement in Turkish patients with leprosy. Material and methods : In total, 32 patients with lepromatous leprosy but without any co-morbidities and 35 healthy control subjects were evaluated for renal involvement at the Elazig Training and Research Hospital in Turkey. The laboratory tests and radiological results concerning renal function were taken from both the patients’ medical records and from current examinations. Results: The levels of creatinine, urea, and leukocyturia in the lepromatous leprosy patients were significantly higher than in the controls (p < 0.001, p < 0.001; p = 0.001, p < 0.01; p = 0.036, p 0.05). On ultrasonographic examination, the prevalence of renal cortical cysts and renal cortical echogenicity in the leprosy patients was significantly higher than in the controls (p = 0.020, p 0.05). Conclusions : Evaluating the renal function in all leprosy patients is important to detect abnormalities and to prevent renal failure, which remains a potential cause of death in this disease