Optimization of permeable membrane microchannel heat sinks for additive manufacturing

The design freedom brought by additive manufacturing (AM) can be leveraged in the design of microchannel heat sinks to improve their cooling performance. The permeable membrane microchannel (PMM) heat sink geometry was inspired by the ability of powder bed AM processes to fabricate partially porous metal parts having small internal flow features on the order of the powder size. The design routes coolant through a parallel array of thin permeable membranes arranged in a single-layer-manifold configuration. The permeable membranes provide effective heat exchange surfaces and the manifold configuration yields a low flow resistance across the PMM heat sink, all incorporated in a single layer by the use of AM. Past work has introduced the PMM heat sink concept, but the optimal geometric feature sizes were not explored or identified. The n current study is first to explore design optimization of the PMM heat sink to identify target feature sizes for AM fabrication, assessment of the conditions under which the PMM geometry outperforms other standard microchannel heat sink designs, and inspection of the ability of metal 3D printing process to produce the optimal features. To this end, a reduced-order PMM heat sink model is developed, a gradient-based-multi-objective optimization is performed to identify the optimal feature sizes for different coolants (water and 48/52 water/ethylene glycol mixture) at different flow rates (100 – 500 mL/min), footprint areas (49 – 900 mm2), and channel heights (0.5 – 2.5 mm). The optimization results are benchmarked against an optimized straight microchannel (SMC) heat sink design. Optimized PMM designs offer up to 68% lower thermal resistance at a set pressure drop compared to optimized SMC designs. A pair of SMC and PMM heat sinks optimized for the same operating conditions are 3D printed using direct-metal-laser-sintering (DMLS) of AlSi10Mg. X-ray microtomography is used to characterize the geometry of the 3D-printed parts. The model identifies that optimal membrane gap sizes on the order of ~10s μm are required for the PMM to realize performance advantages compared to SMC heat sinks under the same operating conditions. The performance is predicted to be highly sensitive to this pore size, and even though DMLS is shown to produce parts with gaps as small as 26.7 microns, morphological deviations between the design and as-printed part are shown to lead to noticeable performance differences. Albeit excellent performance potential reinforced by this work, these findings call for further AM process development to ensure reliable, as-predicted PMM heat sinks to realize this potential

Topology Optimization of Microchannel Heat Sinks using a Homogenization Approach

Topology optimization for heat sink devices typically relies on penalization methods to ensure the fi- nal designs are composed of strictly solid or open regions. In this work, we formulate a homogenization approach wherein the partial densities are physically represented as porous microstructures. This formu- lation allows design of thermal management components that have sub-grid features and leverages ad- ditive manufacturing techniques that can produce such partially porous regions within the build volume. Topology optimization of a liquid-cooled microchannel heat sink is presented for a hotspot over a uniform background heat input. The partial densities are represented as arrays of pin fins with varying gap sizes to achieve sub-grid-resolution features. To this end, the pin fins are modeled as a porous medium with volume-averaged effective properties. Height-averaged two-dimensional flow and non-equilibrium ther- mal models for porous media are developed for transport in the pin fin array. Through multi-objective optimization, the hydraulic and the thermal performance of the topologically optimized designs is inves- tigated. The pin fin thickness is chosen based on the minimum reliable printing feature size of state-of- the-art direct metal laser sintering machines, and the gap sizes between the pin fins are optimized. The resulting topologies have porous-membrane-like designs where the liquid is transported through a fractal network of open, low-hydraulic-resistance manifold pathways and then forced across tightly spaced ar- rays of pin fins for effective heat transfer. The effects of the grid resolution and the initial design guess on the resulting topologies and performances are reported. The topologically optimized designs are revealed to offer significant performance improvements relative to the benchmark, a straight microchannel heat sink with features optimized under the same multi-objective cost function. The work demonstrates that representing partial densities as porous microstructures results in nearly resolution-independent perfor- mance at sufficiently-small grid sizes through the use of sub-grid features

Perceptual 3D rendering based on principles of analytical cubism

Cataloged from PDF version of article.Cubism, pioneered by Pablo Picasso and Georges Braque, was a breakthrough in art, influencing artists to abandon existing traditions. In this paper, we present a novel approach for cubist rendering of 3D synthetic environments. Rather than merely imitating cubist paintings, we apply the main principles of analytical cubism to 3D graphics rendering. In this respect, we develop a new cubist camera providing an extended view, and a perceptually based spatial imprecision technique that keeps the important regions of the scene within a certain area of the output. Additionally, several methods to provide a painterly style are applied. We demonstrate the effectiveness of our extending view method by comparing the visible face counts in the images rendered by the cubist camera model and the traditional perspective camera. Besides, we give an overall discussion of final results and apply user tests in which users compare our results very well with analytical cubist paintings but not synthetic cubist paintings. (c) 2012 Elsevier Ltd. All rights reserved

Prognostic factors affecting survival after surgical resection of gastrointestinal stromal tumours: a two-unit experience over 10 years

BACKGROUND: Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal (GI) tract which has only been recently described based on their specific immunohistochemistry and the presence of particular KIT-related mutations which potentially make them targets for tyrosine kinase inhibition. METHODS: Sixty-one patients (29 M; 32 F, median age 60 years; range: 23–86 years) between June 1994 and March 2005, were analyzed from two allied institutions. Patient, tumour, and treatment variables were analyzed to identify factors affecting survival. RESULTS: Of the 61 patients, 55 (90%) underwent complete surgical resection of macroscopic disease. The 5-year overall survival (OS) rate in the 61 patients was 88% and the 5-year disease-free survival (DFS) in the 55 cases completely resected was 75%. Univariate analysis revealed that R0 resection was strongly associated with a better OSrate (p < 0.0001). Likewise, univariate analysis also showed high mitotic count of > 10 mitoses/per 50 HPF was a significant variable in worse prognosis for OS (≤ 10 mitoses/per 50 HPF 95% 5-year OS vs. > 10 mitoses/per 50 HPF 74% 5-year OS, respectively; p = 0.013). On subsequent multivariate analysis, only high mitotic count remained as a significant negative prognostic variable for OS (p = 0.029). Among patients resected for cure, there were 8 recurrences during follow-up. The mean time to recurrence was 21 ± 10 months (range: 4–36 months). Univariate analysis revealed that mitotic count of > 10 mitoses per 50 high power fields, intratumoural necrosis, and pathological tumour size (> 10 cm in maximal diameter) significantly correlated with DFS (p = 0.006, 0.002 and 0.02, respectively), with tumour necrosis and high mitotic count remaining as independent predictive variables affecting prognosis on subsequent multivariate analysis. CONCLUSION: Most GISTs are resectable with survival principally dependent upon mitotic count and completeness of resection. Future metabolic and genetic analyses will define the role of and resistance to induction or postoperative adjuvant targeted kinase inhibition therapy

A New Interface for Conceptual Design Based on Object Reconstruction from a Single Freehand Sketch

are troublesome for curvature-based classification, and (b) it has a short execution time that is not dependent on the length of the stroke or the number of sample points acquired (assuming coordinates have been summed while drawing the stroke). The procedure can therefore be used to provide continuous feedback of the interpreted entity during drawing, in real time. However, in spite of this ability, it is evident that geometrical-based classification is inherently limited and a more general, context-sensitive approach must be pursued. A new endpoint clustering scheme has also been presented based on adaptive tolerances at different parts of the sketch. The proposed formulation provides a framework for implementing various criteria for determining local thresholds, such as detail sensitive criteria, dynamic criteria, or other application specific criteria. Again, clustering can be improved using a contextsensitive approach. Acknowledgments This research has been supported in part by the Fund for 4 Pavlidis, T., and Van Wyk, C. J., 1985, &quot;An Automatic Beautifler for Drawings and Illustrations,&quot; SIGGRAPH 85, Vol. 19, No. 3, pp. 225-234. 5 Bengi, F., and Ozguc, B., 1990, &quot;Architectural Sketch Recognition,&quot; Architectural Science Review, Vol. 33, pp. 3-16. 6 Eggli, L., BrUderlin, B. P., and Elber, G. Introduction Improperly designed engineering products may fail in fatigue causing losses in revenue and personal injury or death. Currently, these failures are avoided by either using expensive design techniques involving extensive modeling and testing or by over designing the part. The expense of testing and modification of the initial design is reduced if the design criterion gives a good initial approximation. Several design approaches have been developed to address the problem of fatigue damage of ductile metals loaded with positive mean and alternating stresses. The Bagci, Gerber, Nichihara, modified Goodman, Quadratic, and Soderberg lines are a few of the techniques that have been proposed to address the problem. This paper presents the modified Findley line for designing parts which experience positive mean stress fatigue loading. The modified Findley line is based on the assumption that the critical shear decreases with an increase in the normal stress acting on the same plane, and is simple and less conservative than the modified Goodman line. The Modified Findley Line Flavenot and Skalli (1984) stated &quot;the mechanism corresponding to the initiation of fatigue cracks is most often the shearing of crystallographic planes. It appears logical then to have a criterion relating the normal stress to alternating shear stress which might be local shear stress in most favorable oriented plane.&quot; This assumption was used before by Stanfield (1935), who suggested that both the shear and normal stresses on the fatigue plane should be considered in a fatigue failure criterion and proposed the relation (1) where TN and ON are the shear and normal stresses components on the critical plane; /and k are materials constants. Stulen and Cummings (1954), and Findley et al. (195 6) used similar forms as fatigue criteria to address the problem of absolutely reversing fatigue. Findley (1959) used the linear relationship between shear stress and normal stress on a critical plane to include the effect of mean stress on the fatigue of metals under combined loading. Journal of Mechanical Design MARCH 1997, Vol. 119/135 Copyright © 1997 by ASME where a^^&quot; and &lt;7&quot; are the maximum and alternating fatigue stresses; / and k are experimental constants. Since these constants may vary with the design parameters, including materials, the actual design must be tested to determine the values of / and k. To experimentally find the values of these constants, the life of the part is determined, and at this point the values of / and k are of only academic interest. Thus, if the fatigue criterion presented in Eq. It should be noted that the negative root of Eq. Upon the application of condition (b), Eq. (4) becomes /=A:5&quot;,. Equations Substituting Eqs. 5&quot; -[-S&quot; + 4SI + 4(5&quot;, -5&quot;)(S&quot;, -a&quot;) ], (10) 2(5&quot;,-5&quot;) which is called the modified Findley line. Comparison With Actual Experimental Data The modified Findley, Gerber, and modified Goodman lines were compared with the experimentally developed fatigue data found in the literature. Typical data showing the fatigue points of both ferrous and non-ferrous ductile materials are shown in As shown in these figures and comparison done by Wang (1995), the modified Findley line falls between the modified Goodman line and Gerber parabola, which is supported by Conclusion The modified Findley line is based on the assumption that the critical shear decreases with an increase in the normal stress acting on the same plane, then by using ultimate strength and endurance limit as parameters to obtain a good initial approximation. Limited fatigue data is available in the open literature, and more comparison should be made before the modified Findley line is universally adopted. However, form the references found, it appears that the modified Findley line is a strong candidate for .fatigue criterion for parts made of non-ferrous ductile materials, and is conservative for ferrous parts. For a design engineer, the modified Findley line is simple and easy to use, and represents a very promising approach for leading to reasonable starting designs involving positive mean stress fatigue. Reference