5,650 research outputs found
QuaSI: Quantile Sparse Image Prior for Spatio-Temporal Denoising of Retinal OCT Data
Optical coherence tomography (OCT) enables high-resolution and non-invasive
3D imaging of the human retina but is inherently impaired by speckle noise.
This paper introduces a spatio-temporal denoising algorithm for OCT data on a
B-scan level using a novel quantile sparse image (QuaSI) prior. To remove
speckle noise while preserving image structures of diagnostic relevance, we
implement our QuaSI prior via median filter regularization coupled with a Huber
data fidelity model in a variational approach. For efficient energy
minimization, we develop an alternating direction method of multipliers (ADMM)
scheme using a linearization of median filtering. Our spatio-temporal method
can handle both, denoising of single B-scans and temporally consecutive
B-scans, to gain volumetric OCT data with enhanced signal-to-noise ratio. Our
algorithm based on 4 B-scans only achieved comparable performance to averaging
13 B-scans and outperformed other current denoising methods.Comment: submitted to MICCAI'1
Fulde-Ferrell-Larkin-Ovchinnikov State in Heavy Fermion Superconductors
The Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) state is a novel superconducting
state in a strong magnetic field characterized by the formation of Cooper pairs
with nonzero total momentum (k \uparrow, -k+q \downarrow), instead of the
ordinary BCS pairs (k \uparrow, -k \downarrow). A fascinating aspect of the
FFLO state is that it exhibits inhomogeneous superconducting phases with a
spatially oscillating order parameter and spin polarization. The FFLO state has
been of interest in various research fields, not only in superconductors in
solid state physics, but also in neutral Fermion superfluid of ultracold atomic
gases and in color superconductivity in high energy physics. In spite of
extensive studies of various superconductors, there has been no undisputed
experimental verification of the FFLO state, mainly because of the very
stringent conditions required of the superconducting materials. Among several
classes of materials, certain heavy fermion and organic superconductors are
believed to provide conditions that are favorable to the formation of the FFLO
state. This review presents recent experimental and theoretical developments of
the FFLO state mainly in heavy fermion superconductors. In particular we
address the recently discovered quasi-two-dimensional superconductor CeCoIn_5,
which is a strong candidate for the formation of the FFLO state.Comment: 17 pages, 12 figures with jpsf2.cls, to be published in J. Phys. Soc.
Jpn. (Special Topics - Frontiers of Novel Superconductivity in Heavy Fermion
Compounds
Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces Remission of Diabetes in db/db Mice
OBJECTIVE—Imatinib has been reported to induce regression of type 2 diabetes in chronic leukemia patients. However, the mechanism of diabetes amelioration by imatinib is unknown, and it is uncertain whether imatinib has effects on type 2 diabetes itself without other confounding diseases like leukemia. We studied the effect of imatinib on diabetes in db/db mice and investigated possible mechanism's underlying improved glycemic control by imatinib
“Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress
A novel mechanism explains how exercise exerts its beneficial effects on energy balance through an effect at the level of the hypothalamus
Influences of Excluded Volume of Molecules on Signaling Processes on Biomembrane
We investigate the influences of the excluded volume of molecules on
biochemical reaction processes on 2-dimensional surfaces using a model of
signal transduction processes on biomembranes. We perform simulations of the
2-dimensional cell-based model, which describes the reactions and diffusion of
the receptors, signaling proteins, target proteins, and crowders on the cell
membrane. The signaling proteins are activated by receptors, and these
activated signaling proteins activate target proteins that bind autonomously
from the cytoplasm to the membrane, and unbind from the membrane if activated.
If the target proteins bind frequently, the volume fraction of molecules on the
membrane becomes so large that the excluded volume of the molecules for the
reaction and diffusion dynamics cannot be negligible. We find that such
excluded volume effects of the molecules induce non-trivial variations of the
signal flow, defined as the activation frequency of target proteins, as
follows. With an increase in the binding rate of target proteins, the signal
flow varies by i) monotonically increasing; ii) increasing then decreasing in a
bell-shaped curve; or iii) increasing, decreasing, then increasing in an
S-shaped curve. We further demonstrate that the excluded volume of molecules
influences the hierarchical molecular distributions throughout the reaction
processes. In particular, when the system exhibits a large signal flow, the
signaling proteins tend to surround the receptors to form receptor-signaling
protein clusters, and the target proteins tend to become distributed around
such clusters. To explain these phenomena, we analyze the stochastic model of
the local motions of molecules around the receptor.Comment: 31 pages, 10 figure
Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice
OBJECTIVE Obesity is associated with increased activation of the c-Jun NH2-terminal kinase (JNK) in several metabolic organs, including adipose tissue, liver, and skeletal muscle. In this study, we aimed to define the role of JNK activation in adipose tissue in the development of obesity-related insulin resistance.
RESEARCH DESIGN AND METHODS Transgenic mice with adipose tissue–specific overexpression of dominant-negative JNK (ap2-dn-JNK) under the transcriptional control of the aP2 gene promoter were generated and subjected to metabolic characterization together with the wild-type littermates.
RESULTS On a high-fat diet (HFD), the ap2-dn-JNK mice displayed a marked suppression of both JNK1 and JNK2 activation in their adipose tissue, accompanied by a marked reduction in weight gain, fat mass, and size of the adipocytes. The transgenic mice were resistant to the deleterious impact of an HFD on systemic insulin sensitivity, glucose tolerance, and hepatic steatosis. Reduced hepatic gluconeogenesis was evident in in vivo and ex vivo studies and showed greater insulin-induced glucose uptake in skeletal muscles. These changes were accompanied by reduced macrophage infiltration in adipose tissue, decreased production of proinflammatory adipokines, and increased expression of adiponectin. Indirect calorimetry analysis showed that the transgenic mice had significant increases in oxygen consumption and reductions in respiration exchange rates compared with their wild-type littermates.
CONCLUSIONS Selective suppression of JNK activation in adipose tissue alone is sufficient to counteract HFD-induced obesity and its associated metabolic dysregulations, in part through an increase in energy expenditure and a decrease in systemic inflammation
Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex
It is unknown whether adipokines derived from adipose tissues modulate endoplasmic reticulum (ER) stress induced in obesity. Here, we show that visceral adipose tissue-derived serine protease inhibitor (vaspin) binds to cell-surface 78-kDa glucose-regulated protein (GRP78), which is recruited from ER to plasma membrane under ER stress. Vaspin transgenic mice were protected from diet-induced obesity, glucose intolerance, and hepatic steatosis, while vaspin-deficient mice developed glucose intolerance associated with upregulation of ER stress markers. With tandem affinity tag purification using HepG2 cells, we identified GRP78 as an interacting molecule. The complex formation of vaspin, GRP78, and murine tumor cell DnaJ-like protein 1 (MTJ-1) (DnaJ homolog, subfamily C, member 1) on plasma membrane was confirmed by cell-surface labeling with biotin and immunoprecipitation in liver tissues and H-4-II-E-C3 cells. The addition of recombinant human vaspin in the cultured H-4-II-E-C3 cells also increased the phosphorylation of Akt and AMP-activated protein kinase (AMPK) in a dose-dependent manner, and anti-GRP78 antibodies completely abrogated the vaspin-induced upregulation of pAkt and pAMPK Vaspin is a novel ligand for cell-surface GRP78/MTJ-1 complex, and its subsequent signals exert beneficial effects on ER stress-induced metabolic dysfunctions. Diabetes 61:2823-2832, 201
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