67 research outputs found
On a subordination result for analytic functions defined by convolution
In this paper we discuss some subordination results for a subclass of functions analytic in the unit disk U
Subordination Properties for Analytic Functions Defined By Convolution
In this paper, we derive several interesting subordination results for certain class of analytic functions defined by the Salagean Operator which was introduced and studied by Oyekan et. Al.[1]
Economic Impact Assessment for Technology: The Case of Improved Soybean Varieties in Southwest Nigeria
The Study on economic impact assessment for the production of improved soybean varieties in Nigeria was carried out in Nigeria using the agronomic data on yield of the nationally coordinated soybean research from two major zones namely the southwest and the middle belt.The study assesses the economic returns due to improved soybean varieties. Primary data were collected with the use of structured and validated questionnaires. A sample of 288 respondents was drawn from four states namely Oyo, Ogun, Kwara and Niger State at 72 respondents per state.Secondary data were collected from Agricultural Development Programme (ADP), International Institute for Tropical Agriculture (IITA), Institute of Agricultural Research and Training, (IAR & T), National Cereals Research Institute (NCRI), Central Bank of Nigeria CBN and Federal Office of Statistics (FOS).An internal rate of return (IRR) of 38 percent was estimated from the stream of netted real social gains at 1985 constant.The return to investment in soybean production technology is attractive and justifies the investments made on the technologies. The policy implication is that there is underinvestment in soybean production research
Circular Production and Maintenance of Automotive Parts:An Internet of Things (IoT) Data Framework and Practice Review
The adoption of the Circular Economy paradigm by industry leads to increased responsibility of manufacturing to ensure a holistic awareness of the environmental impact of its operations. In mitigating negative effects in the environment, current maintenance practice must be considered for its potential contribution to a more sustainable lifecycle for the manufacturing operation, its products and related services. Focusing on the matching of digital technologies to maintenance practice in the automotive sector, this paper outlines a framework for organisations pursuing the integration of environmentally aware solutions in their production systems. This research sets out an agenda and framework for digital maintenance practice within the Circular Economy and the utilisation of Industry 4.0 technologies for this purpose
Relationship between PPARα activation and NO on proximal tubular Na(+ )transport in the rat
BACKGROUND: Nitric oxide (NO) regulates renal proximal tubular (PT) Na(+ )handling through modulation of Na(+)-K(+ )ATPase. Peroxisome Proliferator Activated Receptorα (PPARα), a nuclear transcription factor, is expressed in PTs and has been reported to influence NO generation/activity in renal tissues. This study tested the hypothesis that PPARα interacts with NO and thereby affects renal tubular Na(+ )transport. Urinary excretion of nitrite (UNO(X)V) and Na(+ )(U(Na)V) and PT Na(+ )transport (Na(+)-K(+ )ATPase activity) were determined in rats treated with clofibrate (250 mg/kg i.p) or WY14643 (45 mg/kg; i.p.), a PPARα ligand, 2% NaCl (orally), clofibrate/NaCl, L-NAME, an inhibitor of NO production (100 mg/kg; orally), L-NAME/Clofibrate. RESULTS: Clofibrate or WY14643 increased PPARα expression by 106 ± 7% (p < 0.05) and 113 ± 8% (p < 0.05), respectively. Similarly, clofibrate and WY14643 increased expression of MCAD, a downstream target protein of PPARα by 123 ± 8% (p < 0.05) and 143 ± 8% (p < 0.05), respectively. L-NAME attenuated clofibrate-induced increase in PPARα expression by 27 ± 2% (p < 0.05) but did not affect MCAD expression. UNO(X)V excretion increased 3–4 fold in rats treated with clofibrate, WY14643 or NaCl from 44 ± 7 to 170 ± 15, 144 ± 18 or 132 ± 11 nmol/24 hr, respectively (p < 0.05). Similarly, clofibrate, WY14643 or NaCl elicited a 2–5 fold increase in U(Na)V. L-NAME significantly reduced basal UNO(X)V and U(Na)V and abolished the clofibrate-induced increase. Clofibrate, WY14643, NaCl or clofibrate + NaCl treatment reduced Na(+)-K(+)-ATPase activity in the PT by 89 ± 23, 62 ± 10, 43 ± 9 and 82 ± 15% (p < 0.05), respectively. On the contrary, L-NAME or ODQ, inhibitor of sGC, abolished the inhibition of Na(+)-K(+)-ATPase activity by clofibrate (p < 0.05). Clofibrate either alone or with NaCl elicited ~2-fold increase in the expression of the α1 subunit of Na(+)-K(+ )ATPase in the PT while L-NAME abolished clofibrate-induced increase in Na(+)-K(+ )ATPase expression. CONCLUSION: These data suggest that PPARα activation, through increased NO generation promotes renal excretion of Na(+ )through reduced Na(+)-K(+ )ATPase activity in the PT probably via post translational modification of Na(+)-K(+)-ATPase
XAI Sustainable Human in the Loop Maintenance
This is the final version. Available on open access from Elsevier via the DOI in this recordThe field of Explainable Artificial Intelligence (XAI) is a relatively new approach to AI, with the aim to provide black box algorithms with human intelligible narrative functionality. It is most often in end-of-life considerations of the asset lifecycle that sustainability issues are encountered. Modern maintenance practice requires a holistic understanding of lifecycle and options for sustainable asset treatments. human in the loop solutions offer a way to leverage both machine and human skill sets to provide the next level of automaton solutions for industrial maintenance activities. This paper presents a framework for human in the loop Intelligent and Sustainable Maintenance. In bridging the gap between machines and humans XAI leverages the best of both worlds to provide a new level of agility to cyber assisted maintenance activities and full lifecycle consideration of assets; a notion that is necessary throughout the organization in the achievement of sustainability goals set by governments around the world in the achievement of a net zero carbon emission economy
Circular production and maintenance of automotive parts: an Internet of Things (IoT) data framework and practice review
The adoption of the Circular Economy paradigm by industry leads to increased responsibility of manufacturing to ensure a holistic awareness of the environmental impact of its operations. In mitigating negative effects in the environment, current maintenance practice must be considered for its potential contribution to a more sustainable lifecycle for the manufacturing operation, its products and related services. Focusing on the matching of digital technologies to maintenance practice in the automotive sector, this paper outlines a framework for organisations pursuing the integration of environmentally aware solutions in their production systems. This research sets out an agenda and framework for digital maintenance practice within the Circular Economy and the utilisation of Industry 4.0 technologies for this purpose
A digital maintenance practice framework for circular production of automotive parts
The adoption of the Circular Economy paradigm by industry leads to increased responsibility of manufacturing to ensure a holistic awareness of the environmental impact of its operations. In mitigating negative effects in the environment, current maintenance practice must be considered, not just for the reduction of its own direct impact but also for its potential contribution to a more sustainable lifecycle for the manufacturing operation, its products and related services. Focusing on the matching of digital technologies to maintenance practice in the automotive sector, this paper outlines a framework for organisations pursuing the integration of environmentally aware solutions in their production systems. This research acts as a primer for digital maintenance practice within the Circular Economy and the utilisation of Industry 4.0 technologies for this purpose
Factors associated with spontaneous stone passage in a contemporary cohort of patients presenting with acute ureteric colic. Results from the MIMIC Study (A Multi-centre cohort study evaluating the role of Inflammatory Markers in patients presenting with acute ureteric Colic)
Objectives
There is conflicting data on the role of white blood cell count (WBC) and other inflammatory markers in spontaneous stone passage in patients with acute ureteric colic. The aim of the study was to assess the relationship of WBC and other routinely collected inflammatory and clinical markers including stone size, stone position and Medically Expulsive Therapy use (MET) with spontaneous stone passage (SSP) in a large contemporary cohort of patients with acute ureteric colic.
Subjects and Methods
Multi‐centre retrospective cohort study coordinated by the British Urology Researchers in Surgical Training (BURST) Research Collaborative at 71 secondary care hospitals across 4 countries (United Kingdom, Republic of Ireland, Australia and New Zealand). 4170 patients presented with acute ureteric colic and a computer tomography confirmed single ureteric stone. Our primary outcome measure was SSP as defined by the absence of need for intervention to assist stone passage. Multivariable mixed effects logistic regression was used to explore the relationship between key patient factors and SSP.
Results
2518 patients were discharged with conservative management and had further follow up with a SSP rate of 74% (n = 1874/2518). Sepsis after discharge with conservative management was reported in 0.6% (n = 16/2518). On multivariable analysis neither WBC, Neutrophils or CRP were seen to predict SSP, with an adjusted OR of 0.97 [95% CI 0.91 to 1.04, p = 0.38], 1.06 [95% CI 0.99 to 1.13, p = 0.1] and 1.00 [95% CI 0.99 to 1.00, p = 0.17], respectively. Medical expulsive therapy (MET) also did not predict SSP [adjusted OR 1.11 [95% CI 0.76 to 1.61]). However, stone size and stone position were significant predictors. SSP for stones 7mm. For stones in the upper ureter the SSP rate was 52% [95% CI 48 to 56], middle ureter was 70% [95% CI 64 to 76], and lower ureter was 83% [95% CI 81 to 85].
Conclusion
In contrast to the previously published literature, we found that in patients with acute ureteric colic who are discharged with initial conservative management, neither WBC, Neutrophil count or CRP help determine the likelihood of spontaneous stone passage. We also found no overall benefit from the use of MET. Stone size and position are important predictors and our findings represent the most comprehensive stone passage rates for each mm increase in stone size from a large contemporary cohort adjusting for key potential confounders. We anticipate that these data will aid clinicians managing patients with acute ureteric colic and help guide management decisions and the need for intervention
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