A response to the problems of teaching a highly technical subject to students without A-level Maths or Science

Brunel University offers a BSc in Industrial Design with a high technology content. Crucially we teach the Mechanics, Electrics and Materials in the same language as would be used to teach engineers. Ideally this course has recruited students who had A-level Maths as well as a good portfolio of Art and Design work, together with additional Science or D&T A-levels. It will be no secret that students of this background are an endangered species. In order not to abandon the technological approach, the following long term strategy has been devised: 1. An accelerated introduction to selected elements of the Maths Curriculum by carefully chosen tutors with a small targeted group of students; 2. The use of the Computer Aided Learning in Mathematics project to back up these lectures. 3. The development of Mechanics and Electrics CAL materials based on a unique combination of the constructivist approach to science pioneered by Driver and Osborne presented in a HyperCard environment

Wnt-11 expression promotes invasiveness and correlates with survival in human pancreatic ductal adeno carcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer, proving difficult to manage clinically. Wnt-11, a developmentally regulated gene producing a secreted protein, has been associated with various carcinomas but has not previously been studied in PDAC. The present study aimed to elucidate these aspects first in vitro and then in a clinical setting in vivo. Molecular analyses of Wnt-11 expression as well as other biomarkers involved qRT-PCR, RNA-seq and siRNA. Proliferation was measured by MTT; invasiveness was quantified by Boyden chamber (Matrigel) assay. Wnt-11 mRNA was present in three different human PDAC cell lines. Wnt-11 loss affected epithelial-mesenchymal transition and expression of neuronal and stemness biomarkers associated with metastasis. Indeed, silencing Wnt-11 in Panc-1 cells significantly inhibited their Matrigel invasiveness without affecting their proliferative activity. Consistently with the in vitro data, human biopsies of PDAC showed significantly higher Wnt-11 mRNA levels compared with matched adjacent tissues. Expression was significantly upregulated during PDAC progression (TNM stage I to II) and maintained (TNM stages III and IV). Wnt-11 is expressed in PDAC in vitro and in vivo and plays a significant role in the pathophysiology of the disease; this evidence leads to the conclusion that Wnt-11 could serve as a novel, functional biomarker PDA

Optimal generalization of power filters for gravitational wave bursts, from single to multiple detectors

Searches for gravitational wave signals which do not have a precise model describing the shape of their waveforms are often performed using power detectors based on a quadratic form of the data. A new, optimal method of generalizing these power detectors so that they operate coherently over a network of interferometers is presented. Such a mode of operation is useful in obtaining better detection efficiencies, and better estimates of the position of the source of the gravitational wave signal. Numerical simulations based on a realistic, computationally efficient hierarchical implementation of the method are used to characterize its efficiency, for detection and for position estimation. The method is shown to be more efficient at detecting signals than an incoherent approach based on coincidences between lists of events. It is also shown to be capable of locating the position of the source.Comment: 16 pages, 5 figure

Time-frequency detection algorithm for gravitational wave bursts

An efficient algorithm is presented for the identification of short bursts of gravitational radiation in the data from broad-band interferometric detectors. The algorithm consists of three steps: pixels of the time-frequency representation of the data that have power above a fixed threshold are first identified. Clusters of such pixels that conform to a set of rules on their size and their proximity to other clusters are formed, and a final threshold is applied on the power integrated over all pixels in such clusters. Formal arguments are given to support the conjecture that this algorithm is very efficient for a wide class of signals. A precise model for the false alarm rate of this algorithm is presented, and it is shown using a number of representative numerical simulations to be accurate at the 1% level for most values of the parameters, with maximal error around 10%.Comment: 26 pages, 15 figures, to appear in PR

Optimal detection of burst events in gravitational wave interferometric observatories

We consider the problem of detecting a burst signal of unknown shape. We introduce a statistic which generalizes the excess power statistic proposed by Flanagan and Hughes and extended by Anderson et al. The statistic we propose is shown to be optimal for arbitrary noise spectral characteristic, under the two hypotheses that the noise is Gaussian, and that the prior for the signal is uniform. The statistic derivation is based on the assumption that a signal affects only affects N samples in the data stream, but that no other information is a priori available, and that the value of the signal at each sample can be arbitrary. We show that the proposed statistic can be implemented combining standard time-series analysis tools which can be efficiently implemented, and the resulting computational cost is still compatible with an on-line analysis of interferometric data. We generalize this version of an excess power statistic to the multiple detector case, also including the effect of correlated noise. We give full details about the implementation of the algorithm, both for the single and the multiple detector case, and we discuss exact and approximate forms, depending on the specific characteristics of the noise and on the assumed length of the burst event. As a example, we show what would be the sensitivity of the network of interferometers to a delta-function burst.Comment: 21 pages, 5 figures in 3 groups. Submitted for publication to Phys.Rev.D. A Mathematica notebook is available at http://www.ligo.caltech.edu/~avicere/nda/burst/Burst.nb which allows to reproduce the numerical results of the pape

Measurements of Scintillation Efficiency and Pulse-Shape for Low Energy Recoils in Liquid Xenon

Results of observations of low energy nuclear and electron recoil events in liquid xenon scintillator detectors are given. The relative scintillation efficiency for nuclear recoils is 0.22 +/- 0.01 in the recoil energy range 40 keV - 70 keV. Under the assumption of a single dominant decay component to the scintillation pulse-shape the log-normal mean parameter T0 of the maximum likelihood estimator of the decay time constant for 6 keV < Eee < 30 keV nuclear recoil events is equal to 21.0 ns +/- 0.5 ns. It is observed that for electron recoils T0 rises slowly with energy, having a value ~ 30 ns at Eee ~ 15 keV. Electron and nuclear recoil pulse-shapes are found to be well fitted by single exponential functions although some evidence is found for a double exponential form for the nuclear recoil pulse-shape.Comment: 11 pages, including 5 encapsulated postscript figure

A Review of the fossil record of turtles of the clade Baenidae

The fossil record of the turtle clade Baenidae ranges from the Early Cretaceous (Aptian—Albian) to the Eocene. The group is present throughout North America during the Early Cretaceous, but is restricted to the western portions of the continents in the Late Cretaceous and Paleogene. No credible remains of the clade have been reported outside of North America to date. Baenids were warmadapted freshwater aquatic turtles that supported high levels of diversity at times through niche partitioning, particularly by adapting to a broad range of dietary preferences ranging from omnivorous to molluscivorous. Current phylogenies place Baenidae near the split of crown-group Testudines. Within Baenidae three more inclusive, named clades are recognized: Baenodda, Palatobaeninae and Eubaeninae. A taxonomic review of the group concludes that of 49 named taxa, 30 are nomina valida, 12 are nomina invalida and 7 are nomina dubia

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

AbstractCleidocranial dysplasia (CCD) is an autosomal-dominant condition characterized by hypoplasia/aplasia of clavicles, patent fontanelles, supernumerary teeth, short stature, and other changes in skeletal patterning and growth. In some families, the phenotype segregates with deletions resulting in heterozygous loss of CBFA1, a member of the runt family of transcription factors. In other families, insertion, deletion, and missense mutations lead to translational stop codons in the DNA binding domain or in the C-terminal transactivating region. In-frame expansion of a polyalanine stretch segregates in an affected family with brachydactyly and minor clinical findings of CCD. We conclude that CBFA1 mutations cause CCD and that heterozygous loss of function is sufficient to produce the disorder

Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV

We report the results of a study of color coherence effects in ppbar collisions based on data collected by the D0 detector during the 1994-1995 run of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8 TeV. Initial-to-final state color interference effects are studied by examining particle distribution patterns in events with a W boson and at least one jet. The data are compared to Monte Carlo simulations with different color coherence implementations and to an analytic modified-leading-logarithm perturbative calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters

Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial change