Portable instrument for in-vivo infrared oxymetry using spread-spectrum modulation

Near Infrared Spectroscopy (NIRS) can be employed to monitor noninvasively and continuously local changes in hemodynamics and oxygenation of human tissues. A portable NIRS research-grade acquisition system, dedicated to measurements during muscular exercise, is presented. The instrument is able to control up to eight LED sources and two detectors. A digital correlation technique, implemented on a single-chip RISC microcontroller, performs source-to-detector multiplexing. Such algorithm is highly optimized for computational efficiency and ambient noise rejection. Software-configurable input stages allow for flexibility in instrument setup. As a result of the specific correlation technique employed, the instrument is compact, lightweight and efficient. Clinical tests on oxygen consumption show excellent performance

Portable instrument for in-vivo infrared oxymetry using spread-spectrum modulation

Near Infrared Spectroscopy (NIRS) can be employed to monitor noninvasively and continuously local changes in hemodynamics and oxygenation of human tissues. A portable NIRS research-grade acquisition system, dedicated to measurements during muscular exercise, is presented. The instrument is able to control up to eight LED sources and two detectors. A digital correlation technique, implemented on a single-chip RISC microcontroller, performs source-to-detector multiplexing. Such algorithm is highly optimized for computational efficiency and ambient noise rejection. Software-configurable input stages allow for flexibility in instrument setup. As a result of the specific correlation technique employed, the instrument is compact, lightweight and efficient. Clinical tests on oxygen consumption show excellent performance

Blue urea : fertilizer with reduced environmental impact

Synthetic nitrogen fertilizers such as urea are a necessity for food production, making them invaluable toward achieving global food security. Conventional manufacture of urea is conducted in centralized production plants at an enormous scale, with the subsequent prilled urea product distributed to the point-of-use. Despite consuming carbon dioxide in the synthesis, the overall process is carbon positive due to the use of fossil feedstocks, resulting in significant net emissions. Blue Urea could be produced using attenuated reaction conditions and hydrogen derived from renewable-powered electrolysis to produce a reduced-carbon alternative. This paper demonstrates the intensified production of urea and ammonium nitrate fertilizers from sustainable feedstocks, namely water, nitrogen, and carbon dioxide. Critically, the process can be scaled-down such that equipment can be housed in a standardized ISO container deployed at the point-of-use, delocalizing production and eliminating costs, and emissions associated with transportation. The urea and ammonium nitrate were synthesized in a semi-continuous process under considerably milder conditions to produce aqueous fertilizers suitable for direct soil application, eliminating the financial and energetic costs associated with drying and prilling. The composition of the fertilizers from this process were found to be free from contaminants, making them ideal for application. In growth studies, the synthesized urea and ammonium nitrate were applied under controlled conditions and found to perform comparably to a commercial fertilizer (Nitram). Crucially, both the synthesized fertilizers enhanced biomass growth, nitrogen uptake and leaf chlorophylls (even in depleted soils), strongly suggesting they would be effective toward improving crop yields and agricultural output. The Blue Urea concept is proposed for installation in ISO containers and deployment on farms, offering a turnkey solution for point-of-need production of nitrogen fertilizers

Fe@CNT-monoliths for the conversion of carbon dioxide to hydrocarbons:Structural characterisation and Fischer-Tropsch reactivity investigations

High carbon dioxide conversion to hydrocarbons using iron nanoparticle (Fe@CNT) catalysts supported on cordierite monoliths.</p

‘Ethnic group’, the state and the politics of representation

The assertion, even if only by implication, that ‘ethnic group’ categories represent ‘real’ tangible entities, indeed identities, is commonplace not only in the realms of political and policy discourse but also amongst contemporary social scientists. This paper, following Brubaker (2002), questions this position in a number of key respects: of these three issues will dominate the discussion that follows. First, there is an interrogation of the proposition that those to whom the categories/labels refer constitute sociologically meaningful ‘groups’ as distinct from (mere) human collectivities. Secondly, there is the question of how these categories emerge, i.e. exactly what series of events, negotiations and contestations lie behind their construction and social acceptance. Thirdly, and as a corollary to the latter point, we explore the process of reification that leads to these categories being seen to represent ‘real things in the world’ (ibid.)

The Self Model and the Conception of Biological Identity in Immunology

The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for sixty years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity

Points in Mental Space: an Interdisciplinary Study of Imagery in Movement Creation

As part of a programme of research that is developing tools to enhance choreographic practice, an interdisciplinary team of cognitive scientists, neuroscientists and dance professionals collaborated on two studies examining the mental representations used to support movement creation. We studied choreographer Wayne McGregor’s approach to movement creation through tasking, in which he asks dancers to create movement in response to task instructions that require a great deal of mental imagery and decision making. In our first experiment, we used experience sampling methods (self-report scales and reports about the current focus of thought) with the full company of Wayne McGregor | Random Dance to describe what the dancers report thinking about while creating movement, and to establish how their experiences change as a function of different task conditions. In particular, we contrasted a conventional ‘active’ condition (where dancers are free to move around) with a ‘static’ condition (where they have to create movement mentally, without moving), because all neuroimaging studies of dance require participants to lie motionless within a scanner. We adapted the static mode from Experiment 1 for the neuroimaging session in Experiment 2. Here we recorded the brain activity of an experienced dancer from Wayne McGregor | Random Dance while she mentally undertook movement creation tasks similar to those used in our experience sampling experiment. Both studies involved imagery tasks of a primarily spatial-praxic nature (involving an imagined object or volume that could be approached and manipulated) and imagery that focused on content invoking emotional narratives. In the first study, the dancers’ awareness was focused more than they had anticipated upon conceptual rather than physical or bodily aspects. The very act of reflecting on, and categorising, their experiences provided the dancers with insights about their mental habits during innovative movement creation. Such insights provide conditions under which habits can be recognised and then altered to adopt alternative points in mental space from which to create movement material. Providing the dancers and McGregor with a means to communicate more productively about the properties of the task-based instructions has been acknowledged by the company to be of clear benefit and a useful addition to their working process. In the second study we assessed the feasibility of using fMRI to study the neural underpinnings of choreographing movement tasks. The experiment enabled us to compare brain activity in imagery and movement creation. The data raise some key questions Points in Mental Space 3 concerning the mental context in which such thinking occurs and, given the clear limitations of the current fMRI and experience sampling work, how future research might usefully be directed. Taken together, these two exploratory studies indicate that the experiential and neural attributes of imagery during movement creation are open to systematic investigation: innovative movement creation can start from alternative points in mental, as well as physical, space. This enables us to look forward to establishing with greater precision how tasks that challenge dancers in different ways may affect mental and neural processes and how variation in imagery use across dancers might contribute to the variety of movement creation that they produce. Notably, the act of reflecting on the experience of movement creation also offers some practical leverage to help dancers develop a wider range of strategies for innovation. These findings are being used to contribute to further work informing the development of personal, notebook-like, Choreographic Thinking Tools

The fitness landscape of the African salmonella typhimurium ST313 strain D23580 reveals unique properties of the pBT1 plasmid

We have used a transposon insertion sequencing (TIS) approach to establish the fitness landscape of the African Salmonella enterica serovar Typhimurium ST313 strain D23580, to complement our previous comparative genomic and functional transcriptomic studies. We used a genome-wide transposon library with insertions every 10 nucleotides to identify genes required for survival and growth in vitro and during infection of murine macrophages. The analysis revealed genomic regions important for fitness under two in vitro growth conditions. Overall, 724 coding genes were required for optimal growth in LB medium, and 851 coding genes were required for growth in SPI-2-inducing minimal medium. These findings were consistent with the essentiality analyses of other S. Typhimurium ST19 and S. Typhi strains. The global mutagenesis approach also identified 60 sRNAs and 413 intergenic regions required for growth in at least one in vitro growth condition. By infecting murine macrophages with the transposon library, we identified 68 genes that were required for intra-macrophage replication but did not impact fitness in vitro. None of these genes were unique to S. Typhimurium D23580, consistent with a high conservation of gene function between S. Typhimurium ST313 and ST19 and suggesting that novel virulence factors are not involved in the interaction of strain D23580 with murine macrophages. We discovered that transposon insertions rarely occurred in many pBT1 plasmid-encoded genes (36), compared with genes carried by the pSLT-BT virulence plasmid and other bacterial plasmids. The key essential protein encoded by pBT1 is a cysteinyl-tRNA synthetase, and our enzymological analysis revealed that the plasmid-encoded CysRSpBT1 had a lower ability to charge tRNA than the chromosomally-encoded CysRSchr enzyme. The presence of aminoacyl-tRNA synthetases in plasmids from a range of Gram-negative and Gram-positive bacteria suggests that plasmid-encoded essential genes are more common than had been appreciated

Backward pion-nucleon scattering

A global analysis of the world data on differential cross sections and polarization asymmetries of backward pion-nucleon scattering for invariant collision energies above 3 GeV is performed in a Regge model. Including the $N_\alpha$, $N_\gamma$, $\Delta_\delta$ and $\Delta_\beta$ trajectories, we reproduce both angular distributions and polarization data for small values of the Mandelstam variable $u$, in contrast to previous analyses. The model amplitude is used to obtain evidence for baryon resonances with mass below 3 GeV. Our analysis suggests a $G_{39}$ resonance with a mass of 2.83 GeV as member of the $\Delta_{\beta}$ trajectory from the corresponding Chew-Frautschi plot.Comment: 12 pages, 16 figure