Genes of tumor necrosis factors and their receptors and the primary open angle glaucoma in the population of Central Russia

To examine the association of genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663) A/G TNFR2 with the development of primary open angle glaucoma (POAG) among people in Central Russi

Genes of tumor necrosis factors and their receptors and the primary open angle glaucoma in the population of Central Russia

To examine the association of genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663) A/G TNFR2 with the development of primary open angle glaucoma (POAG) among people in Central Russi

Precise U-pb age constrains on the ediacaran biota in podolia, east european platform, Ukraine

International audiencethe Neoproterozoic era was characterized by rapidly changing paleogeography, global climate changes and especially by the rise and fall of the ediacaran macro-biota. the correlation between disparate ediacaran fossil-bearing localities and the tentative reconstruction of their paleoenvironmental and paleogeographic contexts are usually complicated by the lack of precise and accurate age data. For this reason, Neoproterozoic sedimentary sections associating ediacaran biota fossils and fresh volcanic material are especially valuable for radioisotopic dating. our research in the podolya Basin, southwestern Ukraine, revealed the presence of four Neoproterozoic volcanic ash deposits (potassium-bentonite layers) within ediacaran fossil-bearing siliciclastic rocks of the Mohyliv-podilskyi Group. We used zircon U-pb LA-ICpMs and CA-ID-tIMs methods to date two of those layers. the results indicate that a diverse assemblage of body and trace Ediacaran fossils occurred as early as 556.78 ± 0.18 million years (Ma) ago. By combining morphological evidence and new age determinations, we suggest a closer paleobiogeographical relationship between the Ukrainian ediacaran assemblage and the Avalon paleocontinent than previously estimated. The Neoproterozoic Era corresponds to a period of global changes related to the breakup of the supercontinent Rodinia and to protracted global glacial events 1. In terms of biological evolution, it is associated with deep innovations likely related to the so-called 'second great oxygenation event' (NOE) 2 , and is marked by the rise and fall of the Ediacaran biota 3-8. As revealed by over thirty sites inventoried worldwide 6,9-14 , the soft body imprints of the Ediacaran macro-organisms have been preserved in various marine environments and related deposits, such as carbonate rocks 15-17 , turbidites and volcanoclastic successions 18,19 , as well as siliciclastic deposits 20-22. Several species forming the Ediacaran biota-e.g., Charnia (575-545 Ma), Dickinsonia (560-541 Ma), Onegia (558-543 Ma), Rangea (558-545 Ma), Palaeopascichnus and Tribrachidium (558-541 Ma)-are long-lived taxa without substantial morphological change 10 , and their presence/absence thus does not represent a useful indicator for reliable biostratigraphical assessment. Additionally, the common lack of datable ash beds interlayered with the sedimentary sequences is the major obstacle for geochronological correlations between different Ediacaran fossil bearing sections 6,8,13. In most contexts, the only way Ediacaran biostratigraphy could be appropriately placed into reliable chronological order is by high-precision radioisotopic dating of zircons from the products of large explosive volcanic eruptions such as ash, tuff or ignimbrite interlayered within Ediacaran fossil bearing strata 19,23-25. In some Proterozoic terrains, ash deposits are altered and transformed into bentonite, whose chemical composition and mineralogy depend on the alteration processes and diagenetic history 26. In southwestern Ukraine, the siliciclastic deposits of the Mohyliv-Podilskyi Group outcropping in the Podolya Basin have revealed an abundant Ediacaran macrofauna 22 , but the preservation conditions of the fossil assemblages do not systematically grant secure biostratigraphic correlations at macro-regional scale across different sedimentary basins. For now, only one bentonite bed has been described in the Yarishyvska Formation 27. However, the only available date for this context of 553 Ma 28 is from the tuffaceous level without related information on its stratigraphical position as well as petrological description. Therefore, with the aim of constraining th

A new history-Independent modeling approach for feature-Based design

10.1007/s00170-011-3559-0International Journal of Advanced Manufacturing Technology599-12841-858IJAT

Cenozoic granitoids in the Dinarides of southern Serbia: age of intrusion, isotope geochemistry, exhumation history and significance for the geodynamic evolution of the Balkan Peninsula

Two age groups were determined for the Cenozoic granitoids in the Dinarides of southern Serbia by high-precision single grain U–Pb dating of thermally annealed and chemically abraded zircons: (1) Oligocene ages (Kopaonik, Drenje, Z ˇ eljin) ranging from 31.7 to 30.6 Ma (2) Miocene ages (Golija and Polumir) at 20.58–20.17 and 18.06–17.74 Ma, respectively. Apatite fission-track central ages, modelling combined with zircon central ages and additionally, local structural observations constrain the subsequent exhumation history of the magmatic rocks. They indicate rapid cooling from above 300°C to ca. 80°C between 16 and 10 Ma for both age groups,  induced by extensional exhumation of the plutons located in the footwall of core complexes. Hence, Miocene magmatism and core-complex formation not only affected the Pannonian basin but also a part of the mountainous areas of the internal Dinarides. Based on an extensive set of existing age data combined with our own analyses, we propose a geodynamical model for the Balkan Peninsula: The Late Eocene to Oligocene magmatism, which affects the Adria derived lower plate units of the internal Dinarides, was caused by delamination of the Adriatic mantle from the overlying crust, associated with post-collisional convergence that propagated outward into the external Dinarides.  Miocene magmatism, on the other hand, is associated with core-complex formation along the southern margin of the Pannonian basin, probably associated with the W-directed subduction of the European lithosphere beneath the Carpathians and interfering with ongoing Dinaridic–Hellenic back-arc extension

Peri-Gondwanan Ordovician crustal fragments in the high-grade basement of the Eastern Rhodope Massif, Bulgaria: evidence from U-Pb LA-ICP-MS zircon geochronology and geochemistry

Field, geochemical, and geochronologic data of high-grade basement metamafic and evolved rocks are used to identify the nature and timing of pre-Alpine crustal growth of the Rhodope Massif. These rocks occur intrusive into clastic-carbonate metasedimentary succession. Petrography and mineral chemistry show compositions consistent with Alpine amphibolite-facies metamorphism that obliterated the original igneous textures of the protoliths. Bulk-rock geochemistry identifies low-Ti tholeiitic to calc-alkaline gabbroic-basaltic and plagiogranite precursors, with MORB-IAT supra-subduction zone signature and trace elements comparable to modern back-arc basalts. The U-Pb zircon dating revealed a mean age of 455 Ma for the magmatic crystallization of the protoliths that contain inherited Cambrian (528–534 Ma) zircons. Carboniferous, Jurassic, and Eocene metamorphic events overprinted the Ordovician protoliths. The radiometric results of the metamorphic rocks demonstrate that Ordovician oceanic crust was involved in the build-up of the Rhodope high-grade basement. Dating of Eocene-Oligocene volcanic rocks overlying or cross-cutting the metamorphic rocks supplied Neoproterozoic, Ordovician and Permo-Carboniferous xenocrystic zircons that were sampled en route to the surface from the basement. The volcanic rocks thus confirm sub-regionally present Neoproterozoic and Paleozoic igneous and metamorphic basement. We interpret the origin of the Middle-Late Ordovician oceanic magmatism in a back-arc rift-spreading center propagating along peri-Gondwanan Cadomian basement terrane related to the Rheic Ocean widening. The results highlight the presence of elements of Cadomian northern Gondwana margin in the high-grade basement and record of Rheic Ocean evolution. The eastern Rhodope Massif high-grade basement compared to adjacent terranes with Neoproterozoic and Cambro-Ordovician evolution shares analogous tectono-magmatic record providing a linkage among basement terranes incorporated in the Alpine belt of the north Aegean region