Analysis of notch effect on the fracture behaviour of granite and limestone: An approach from the Theory of Critical Distances

This paper presents the analysis of the notch effect on granite and limestone fracture specimens. The research is based on the results obtained in an experimental programme composed of 84 fracture specimens, combining the two materials and 7 different notch radii varying from 0.15 mm up to 10 mm. The notch effect is analysed through the evolution of the apparent fracture toughness and the application of the Theory of the Critical Distances. The results reveal a significant notch effect in the limestone, whereas the notch effect in the granite is negligible for the range of notch radii analysed. Both observations are justified by the corresponding critical distance of the material

Linkage of murine (T,G)-A- -L-specific idiotypic determinants to the heavy chain constant region allotypic markers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46735/1/251_2005_Article_BF01567784.pd

Cellular and humoral sensitivity to gluten fractions in patients with treated nontropical sprue

The presence of circulating antibodies and lymphocyte response to gliadin and fraction III were measured in three groups of 12 patients each. Group I consisted of patients with nontropical sprue maintained on a gluten-free diet; Group II contained patients with other gastrointestinal diseases manifesting malabsorption and Group III was composed of normal controls. Rabbits immunized to both antigens provided positive controls for each method of antibody determination. Results agree with those previously reported in that negligible antibody titers were present to either antigen in normals, patients with other forms of malabsorption or patients with nontropical sprue maintained, for some time, on a gluten-free diet. Lymphocyte stimulation failed to occur with either gluten fraction although the hyporesponsiveness to phytohemagglutinin, previously reported by others, was not observed. Further studies are needed in patients with nontropical sprue following controlled antigenic challenge. Antibody levels in jejunal fluid should also be studied. Until such studies are carried out, evaluation of immunologic factors in the pathogenesis of nontropical sprue will be incomplete.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44378/1/10620_2005_Article_BF02232292.pd

Genetic control of quantitative variation in carbonic anhydrase isozymes of mammals. I. The concentration within single erythrocytes of the mouse

The levels of the carbonic anhydrase isozymes (CA and CA II) in single erythrocytes of DBA/2J mice were assayed by measuring the specific immunofluorescence of CA I and CA II with a microspectrofluorometric technique. Measurements of 100 randomly selected cells showed a range (in relative fluorescence units) of 21–52 (mean 31.3±7.5) for CA I and 30–80 (mean 45.6±10.7) for CA II. The CA II/CA I ratio of the means obtained by the single-cell fluorescence assay was similar to the ratios obtained for the two isozymes from hemolysates of DBA/2J mice using an immunodiffusion assay. The influence of cell age on the variation in carbonic anhydrase levels was determined by separating red cells into several fractions by a gravity sedimentation procedure. The younger cells showed higher levels of CA I and CA II than the older cells; however, the extensive overlap in the variability between the cells from the different fractions indicated that although cell age was contributing to the overall heterogeneity, its influence was not pronounced.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44126/1/10528_2004_Article_BF00483984.pd