MEDIATING EFFECT OF TEACHER ATTITUDE ON THE RELATIONSHIP BETWEEN LEARNING ENVIRONMENT AND PERCEIVED WELLBEING OF PUBLIC SCHOOL TEACHERS

The aim of this study was to determine the mediating effect of teacher attitude towards a physical education learning environment and the perceived well-being of public school teachers. Utilizing quantitative, non-experimental design via correlational technique, data were obtained from 340 respondents of the study who are teachers in Physical Education in public schools (elementary and secondary) in Matanao, Bansalan and Magsaysay (MABAMA), Davao del Sur. The researcher utilized the total population technique and survey mode of data collection. The researcher also utilized the statistical tools mean, Pearson r, and for the mediation approach Medgraph using Sobel z-test. From the results of the study, it was found out that there is a high level of mean scores for all variables of learning environment, teacher attitude, and perceived well-being of public school teachers. Also, results revealed that there are significant relationships between learning environment and perceived well-being, between learning environment and teacher attitude, and between teacher attitude and perceived well-being of public school teachers. Further, it was revealed that there was a partial mediation on the effect of teacher attitude on the relationship between learning environment and perceived well-being of public school teachers. This implies that the learning environment conveys a good teacher attitude.  Article visualizations

ICT INDICATORS AND MUSIC PERFORMANCE OF MAPEH STUDENTS: THE MEDIATING ROLE OF TEACHING COMPETENCY

This study aimed to determine the mediating effect of teaching competency on the relationship between ICT Indicators and the music performance of MAPEH students. The researcher utilizes a quantitative, non-experimental design via a correlational technique. The researcher obtained data from 300 Grade 11 and 12 students of the three national high schools under the division of Davao del Sur in Region XI. The researcher utilized a stratified random sampling technique and an online survey mode of data collection. The researcher also utilized the statistical tools: mean, Pearson r, regression and med graph using the Sobel z- test. The study results found that there is a very high mean score of teaching competency, high levels of ICT indicators and music performance of MAPEH students. Furthermore, there are significant relationships between ICT indicators and music performance, ICT indicators and teaching competency and teaching competency and music performance of MAPEH students. Further, the result revealed that there was complete mediation on the effect of teaching competency on the relationship between ICT Indicators and the music performance of MAPEH students.  Article visualizations

Reacción de los mercados accionarios latinoamericanos a los anuncios macroeconómicos

Se presenta evidencia empírica sobre el efecto de los anuncios macroeconómicos de la inflación y el PIB en rendimientos y volatilidad diarios de los mercados accionarios de seis países latinoamericanos, empleando modelos de series de tiempo univariadas. Los efectos hallados de los anuncios sobre los rendimientos sólo son significativos y en la dirección esperada en inflación para Colombia y Perú, y en PIB, para Chile. Sin embargo, también se encuentran efectos en días anteriores y posteriores a los anuncios, contradiciendo la hipótesis de eficiencia de mercado. Además, los días de anuncios de la inflación están asociados a mayor volatilidad, pero los del PIB a menor.This paper shows empirical evidence of the effect of macroeconomic announcements (inflation and GDP) on returns, volatility and trading activity for the stock markets of Argentina, Brazil, Chile, Colombia, Mexico and Peru, using daily univariate time series models. Significant contemporaneous effects were found only for Colombia and Peru during inflation announcements and for Chile during GDP announcements. On the other hand, lagged and lead effects from announcements were found in most of the cases, contradicting market efficiency. Besides, inflation announcements are associated to higher volatility whereas those of GDP are to lower volatility for most of the countries

Presence and Distribution of Leptodactylus Guianensis Heyer and de Sa, 2011 in Colombia: Comparisons with Other Species in the L. Latrans Group.

Leptodactylus guianensis is reported for the first time for Colombia along with a distributional map of the species. The species is the fifth species of the L. latransspecies group documented in the country. Males possess a single, conical and slightly chisel-shaped thumb spine; only three species in the group have a single thumb spine. In collections, specimens of L. guianensis are misidentified as L. macrosternum, L. latrans or L. bolivianus. We provide morphological, colouration and habitat descriptions for where the species occurs in Colombia

SNP Assay Development for Linkage Map Construction, Anchoring Whole-Genome Sequence, and Other Genetic and Genomic Applications in Common Bean.

A total of 992,682 single-nucleotide polymorphisms (SNPs) was identified as ideal for Illumina Infinium II BeadChip design after sequencing a diverse set of 17 common bean (Phaseolus vulgaris L) varieties with the aid of next-generation sequencing technology. From these, two BeadChips each with >5000 SNPs were designed. The BARCBean6K_1 BeadChip was selected for the purpose of optimizing polymorphism among market classes and, when possible, SNPs were targeted to sequence scaffolds in the Phaseolus vulgaris 14× genome assembly with sequence lengths >10 kb. The BARCBean6K_2 BeadChip was designed with the objective of anchoring additional scaffolds and to facilitate orientation of large scaffolds. Analysis of 267 F2 plants from a cross of varieties Stampede × Red Hawk with the two BeadChips resulted in linkage maps with a total of 7040 markers including 7015 SNPs. With the linkage map, a total of 432.3 Mb of sequence from 2766 scaffolds was anchored to create the Phaseolus vulgaris v1.0 assembly, which accounted for approximately 89% of the 487 Mb of available sequence scaffolds of the Phaseolus vulgaris v0.9 assembly. A core set of 6000 SNPs (BARCBean6K_3 BeadChip) with high genotyping quality and polymorphism was selected based on the genotyping of 365 dry bean and 134 snap bean accessions with the BARCBean6K_1 and BARCBean6K_2 BeadChips. The BARCBean6K_3 BeadChip is a useful tool for genetics and genomics research and it is widely used by breeders and geneticists in the United States and abroad

Review of Contemporary Self-Assembled Systems for the Controlled Delivery of Therapeutics in Medicine.

The novel and unique design of self-assembled micro and nanostructures can be tailored and controlled through the deep understanding of the self-assembly behavior of amphiphilic molecules. The most commonly known amphiphilic molecules are surfactants, phospholipids, and block copolymers. These molecules present a dual attraction in aqueous solutions that lead to the formation of structures like micelles, hydrogels, and liposomes. These structures can respond to external stimuli and can be further modified making them ideal for specific, targeted medical needs and localized drug delivery treatments. Biodegradability, biocompatibility, drug protection, drug bioavailability, and improved patient compliance are among the most important benefits of these self-assembled structures for drug delivery purposes. Furthermore, there are numerous FDA-approved biomaterials with self-assembling properties that can help shorten the approval pathway of efficient platforms, allowing them to reach the therapeutic market faster. This review focuses on providing a thorough description of the current use of self-assembled micelles, hydrogels, and vesicles (polymersomes/liposomes) for the extended and controlled release of therapeutics, with relevant medical applications. FDA-approved polymers, as well as clinically and commercially available nanoplatforms, are described throughout the paper

Damaging variants in FOXI3 cause microtia and craniofacial microsomia

Q1Q1Pacientes con Microtia y Microsomía craneofacialPurpose: Craniofacial microsomia (CFM) represents a spectrum of craniofacial malformations, ranging from isolated microtia with or without aural atresia to underdevelopment of the mandible, maxilla, orbit, facial soft tissue, and/or facial nerve. The genetic causes of CFM remain largely unknown. Methods: We performed genome sequencing and linkage analysis in patients and families with microtia and CFM of unknown genetic etiology. The functional consequences of damaging missense variants were evaluated through expression of wild-type and mutant proteins in vitro. Results: We studied a 5-generation kindred with microtia, identifying a missense variant in FOXI3 (p.Arg236Trp) as the cause of disease (logarithm of the odds = 3.33). We subsequently identified 6 individuals from 3 additional kindreds with microtia-CFM spectrum phenotypes harboring damaging variants in FOXI3, a regulator of ectodermal and neural crest development. Missense variants in the nuclear localization sequence were identified in cases with isolated microtia with aural atresia and found to affect subcellular localization of FOXI3. Loss of function variants were found in patients with microtia and mandibular hypoplasia (CFM), suggesting dosage sensitivity of FOXI3. Conclusion: Damaging variants in FOXI3 are the second most frequent genetic cause of CFM, causing 1% of all cases, including 13% of familial cases in our cohort.https://orcid.org/0000-0003-3822-7780https://orcid.org/0000-0002-0729-6866Revista Internacional - IndexadaA1N