Synthesis of the distribution of subsidence of the lower Ganges-Brahmaputra Delta, Bangladesh

Deltas, the low-lying land at river mouths, are sensitive to the delicate balance between sea level rise, land subsidence and sedimentation. Bangladesh and the Ganges-Brahmaputra Delta (GBD) have been highlighted as a region at risk from sea-level rise, but reliable estimates of land subsidence have been limited. While early studies suggested high rates of relative sea-level rise, recent papers estimate more modest rates. Our objective is to better quantify the magnitude, spatial variability, and depth variation of sediment compaction and land subsidence in the lower GBD to better evaluate the processes controlling them and the pattern of relative sea level rise in this vulnerable region. We combine subsidence and compaction estimates from hand-drilled tube wells and historic sites (1–5 mm/y), GNSS and river gauges (4–8 mm/y) and RSET-MH and borehole vertical strainmeters (9–10 mm/y) in SW Bangladesh. The differences between the different types of measurements reflect the different timescales, spatial distribution and depth sensitivity of the different observations. Rates are lower for times >300y providing data on the timescale of compaction. We also observe differences related to the degree to which different devices measure shallow and deep subsidence. Higher values reflect a greater component of subsidence from young shallow deposits from soil compaction and organic matter degradation. Thus, we observe different rates for different environments and physical settings. These differences indicate that in planning adaptation for rising sea level, hard construction with a solid foundation may experience different subsidence rates than open fields or reclaimed land with recent natural or anthropogenic sedimentation. Significance statement: Land subsidence increases the impact of sea level rise. We combine six different types of measurements that examine land subsidence in coastal Bangladesh. The results show that causes of subsidence, including compaction of the sediments varies both spatially and with depth, and that compaction and organic matter degradation from young shallow deposits is a significant contribution to subsidence. This suggests that hard construction with a solid foundation, such as buildings and embankments, may experience a lower subsidence rates than open fields or reclaimed land with recent natural or anthropogenic sedimentation

Long-term and short-term processes affecting inelastic deformation above subduction zone interfaces

Numerous observations suggest that the elastic description of the subduction earthquake cycles is incomplete. Micro-seismicity is recorded in active margins that are believed to be locked, while peculiar extensional earthquakes occur in convergent plate boundaries following tsunami earthquakes. The morphology of active margins, which evolves on time scales of 100s of kyr, shows similarities to ongoing deformation documented over 10–100 yrs and the coastal domains of Cascadia, Chile, and other subduction zones record long-term uplift. Lastly, the very threshold where faults break and earthquake nucleate has been vigorously debated for years. In this thesis, I combine various geophysical tools to study short- and long-term processes and learn how their interplay can shape the deformation field imparted by earthquake cycles, mainly in the upper plate of subduction zones. In the first chapter, I analyze surface heat flow measurements taken in the proximity of the southern Dead Sea fault to demonstrate its friction is 0.27±0.17. In the second chapter, I compute an updated horizontal and vertical GNSS velocity field for Bangladesh, Myanmar, and adjacent regions. I show that the Kabaw fault, which lies east of the primary thrust system, is accommodating shortening that was initially attributed to the main thrust and demonstrate that the Indo-Burma subduction is locked, converging, and capable of hosting great megathrust events. In the third chapter, I use thermomechanical models to show that reducing the dip angle of a subducting slab, on a timescale of millions of years, can result in extensional fault failure above a megathrust earthquake on timescales of seconds to months. In the fourth chapter, I demonstrate how the buildup of interseismic elastic stresses brings sections of the forearc into compressional failure, which yields irreversible uplift of the coastal domain per evidence from Chile. Finally, I argue that combining short- and long-term processes into subduction zone models can better mitigate tsunami and earthquake hazards. I show how long-term reduction of slab dip angle could culminate in devastating tsunamis. I argue that the collection of long-term uplift records of upper plates or volcanic arc migration can constrain slab dip changes and so may identify areas with increased tsunami potential. In addition, upper plate irreversible deformation should be introduced to earthquake rupture models as these may hold significant implications for understanding and mitigating earthquake hazards

Regional Heat Flow Analysis Reveals Frictionally Weak Dead Sea Fault

Abstract The strength of faults was vigorously debated for years, but lately a growing number of studies suggest that faults are weaker than originally suggested. Nonetheless, only a handful of natural faults have been studied in detail, and only one, the San Andreas, is a strike‐slip fault. Here, we reanalyze 268 surface heat flow measurements taken in the proximity of the southern Dead Sea Transform fault to evaluate its friction. To account for large terrain relief, and the presence of salt diapirs, we apply 3‐D terrain and salt diapir corrections. Based on these corrected heat flow values we estimate that the long‐term frictional resistance of the Dead Sea fault is 0.28 ± 0.17. This low value is similar to friction estimates from the San Andreas fault and several subduction zones

Megathrust locking encoded in subduction landscapes

International audienceLocked areas of subduction megathrusts are increasingly found to coincide with landscape features sculpted over hundreds of thousand years, yet the mechanisms that underlie such correlations remain elusive. We show that interseismic locking gradients induce increments of irreversible strain across the overriding plate manifested predominantly as distributed seismicity. Summing these increments over hundreds of earthquake cycles produces a spatially variable field of uplift representing the unbalance of co-, post-, and interseismic strain. This long-term uplift explains first-order geomorphological features of subduction zones such as the position of the continental erosive shelf break, the distribution of marine terraces and peninsulas, and the profile of forearc rivers. Inelastic yielding of the forearc thus encodes short-term locking patterns in subduction landscapes, hinting that megathrust locking is stable over multiple earthquake cycles and highlighting the role geomorphology can play in constraining Earth’s greatest source of seismic hazard

Anti-Cancer Effects of Cyclic Peptide ALOS4 in a Human Melanoma Mouse Model

We examined the effects of ALOS4, a cyclic peptide discovered previously by phage library selection against integrin αvβ3, on a human melanoma (A375) xenograft model to determine its abilities as a potential anti-cancer agent. We found that ALOS4 promoted healthy weight gain in A375-engrafted nude mice and reduced melanoma tumor mass and volume. Despite these positive changes, examination of the tumor tissue did not indicate any significant effects on proliferation, mitotic index, tissue vascularization, or reduction of αSMA or Ki-67 tumor markers. Modulation in overall expression of critical downstream αvβ3 integrin factors, such as FAK and Src, as well as reductions in gene expression of c-Fos and c-Jun transcription factors, indirectly confirmed our suspicions that ALOS4 is likely acting through an integrin-mediated pathway. Further, we found no overt formulation issues with ALOS4 regarding interaction with standard inert laboratory materials (polypropylene, borosilicate glass) or with pH and temperature stability under prolonged storage. Collectively, ALOS4 appears to be safe, chemically stable, and produces anti-cancer effects in a human xenograft model of melanoma. We believe these results suggest a role for ALOS4 in an integrin-mediated pathway in exerting its anti-cancer effects possibly through immune response modulation