2,7-Bis(pyridin-3-ylethynyl)fluoren-9-one

2,7-bis(pyridin-3-ylethynyl)fluoren-9-one [(3-PyE)2FO] was synthesized in one step by the Sonogashira coupling reaction between 3-ethynylpyridine and 2,7-dibromofluoren-9-one. The title compound was fully characterized, and its crystal structure was determined through single-crystal XRD analysis

The multiple sclerosis risk sharing scheme monitoring study - early results and lessons for the future

Background: Risk sharing schemes represent an innovative and important approach to the problems of rationing and achieving cost-effectiveness in high cost or controversial health interventions. This study aimed to assess the feasibility of risk sharing schemes, looking at long term clinical outcomes, to determine the price at which high cost treatments would be acceptable to the NHS. Methods: This case study of the first NHS risk sharing scheme, a long term prospective cohort study of beta interferon and glatiramer acetate in multiple sclerosis ( MS) patients in 71 specialist MS centres in UK NHS hospitals, recruited adults with relapsing forms of MS, meeting Association of British Neurologists (ABN) criteria for disease modifying therapy. Outcome measures were: success of recruitment and follow up over the first three years, analysis of baseline and initial follow up data and the prospect of estimating the long term cost-effectiveness of these treatments. Results: Centres consented 5560 patients. Of the 4240 patients who had been in the study for a least one year, annual review data were available for 3730 (88.0%). Of the patients who had been in the study for at least two years and three years, subsequent annual review data were available for 2055 (78.5%) and 265 (71.8%) patients respectively. Baseline characteristics and a small but statistically significant progression of disease were similar to those reported in previous pivotal studies. Conclusion: Successful recruitment, follow up and early data analysis suggest that risk sharing schemes should be able to deliver their objectives. However, important issues of analysis, and political and commercial conflicts of interest still need to be addressed

Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Clutia lanceolata Forssk. (C. lanceolata) is a medicinal plant native to sub-Saharan Africa and the Arabian Peninsula. Phytochemical investigation of the aerial parts of C. lanceolata yielded twenty-one coumarins including methylthio and methylsulfinyl-coumarins. Thirteen of these compounds are reported here for the first time, named as cluteolin A to M. The remaining eight compounds are known but have not been associated previously with C. lanceolata. The structures of the undescribed compounds were elucidated from their 2D NMR and MS spectra. Single crystal X-ray analyses confirmed the structures of eleven compounds. As, in Saudi Arabian tradition, C. lanceolata has been reported to have anti-diabetic and anti-fungal properties, the coumarins were examined for their biological activity. Seven compounds strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets, with two compounds showing more than two-fold enhancement of insulin secretion, compared with the standard drug glimepiride

Slight ligand modifications within multitopic linear hydroxamates promotes connectivity differences in Cu(II) 1-D coordination polymers

© 2021 The Authors. Published by Royal Society of Chemistry. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1039/D1CE00807BThe novel multitopic ligands N-hydroxy-4-((2-hydroxy-3-methoxybenzyl)amino)benzamide (L3H3) and N-hydroxy-4-((2- hydroxybenzyl)amino)benzamide (L4H3) have been synthesised through the Schiff base coupling and subsequent reduction of 4-aminophenylhydroxamic acid and either o-vanillin (to give L3H3) or 2-hydroxybenzaldehyde (to give L4H3). These linear multitopic ligands bind Cu(II) centres at both the hydroxamate and phenol ends to form the 1-D coordination polymers [Cu(II)(L3H2)2]n (1) and {[Cu(II)(L4H2)2].2MeOH}n (2). Slight differences in the structures of L3H3 and L4H3 lead to significant extended connectivity changes upon Cu(II) metalation that are exampled by a 27% decrease in intra-chain Cu(II)…Cu(II) distance upon moving from 1 to 2. The significant conformation and metal binding differences shown by L3H2 and L4H2 in 1 and 2 respectively have been rationalised using density functional theory (DFT) calculations. Hirschfeld surface analysis has been employed to assess and visualise the intra- and intermolecular interactions in both complexes.Published onlin

Spatial organization and time dependence of Jupiter's tropospheric temperatures, 1980-1993

The spatial organization and time dependence of Jupiter's temperature near 250-millibar pressure were measured through a jovian year by imaging thermal emission at 18 micrometers. The temperature field is influenced by seasonal radiative forcing, and its banded organization is closely correlated with the visible cloud field. Evidence was found for a quasi-periodic oscillation of temperatures in the Equatorial Zone, a correlation between tropospheric and stratospheric waves in the North Equatorial Belt, and slowly moving thermal features in the North and South Equatorial Belts. There appears to be no common relation between temporal changes of temperature and changes in the visual albedo of the various axisymmetric bands

Spatial Variations in the Altitude of the CH4 Homopause at Jupiter's Mid-to-high Latitudes, as Constrained from IRTF-TEXES Spectra

Peer reviewedPublisher PD

Emerging Capabilities for Detection and Characterization of Near-Earth Objects (NEOs)

Here we describe the status for the detection and characterization of Near- Earth Objects (NEO) with current and future observatories. A summary of the capabilities, limitations, and obtainable NEO parameters is provided. <p/

Emerging Capabilities for Detection and Characterization of Near-Earth Objects (NEOs)

Here we describe the status for the detection and characterization of Near- Earth Objects (NEO) with current and future observatories. A summary of the capabilities, limitations, and obtainable NEO parameters is provided. <p/