Imágenes para la memoria. Fotografías de las muestras de duelo por el 11-M

Actas del Primer Congreso Internacional sobre Imagen, Cultura y Tecnología celebrado del 3 al 5 de septiembre de 2008 en la Universidad Carlos III de Madri

Una lectura antropológica de la fotografía familiar

Actas de las Cuartas Jornadas Imagen, Cultura y Tecnología celebradas el 4, 5 y 6 de julio de 2005 en la Universidad Carlos III de MadridPublicad

The Prison of Carabanchel (Madrid, Spain). A Life Story

In this chapter we examine the biography of the prison of Carabnachel: including not just its birth, life and death, but also its afterlife. The prison of Carabanchel has been one of the most monumental and recognizable symbols of repression in Spain from its construction in 1940 until its destruction in 2008. Even today, it looms large in the imagination of many Spaniards as the quintessential space of punishment in the recent history of the country, although its meanings and functions have changed over time. The short but complex history (and post-history) of Carabanchel makes the prison a multifaceted and often contradictory site. It has been a place of political repression and resistance, a place of memory and oblivion, and of abjection and heroism.Peer reviewe

XXVI International Conference of the Spanish Society for Comparative Psychology

Braga (Portugal), 10 - 12 de septiembre de 201

Fernando Hernández Holgado y Tomás Montero Aparicio (eds.) Morir en Madrid (1939-1944). Las ejecuciones masivas del franquismo en la capital Madrid: Antonio Machado Libros, 2020, 400 páginas.

Peer reviewe

La antropología pedagógica en España durante el primer tercio del siglo XX

From the standpoint of a concept of anthropoiogy as a «moral and political» science, the author reviews the relationships between, and common interests shared by, anthropoiogy and pedagogy. She also discusses a number of specific achievements in Spain before the civil war in the fields of biological anthropoiogy, folklore and education, especially those accomplished at the Escuela de Estudios Superiores del Magisterio in Madrid.Partiendo de un concepto de la antropología como ciencia "moral y política", se repasan las relaciones y comunes intereses de la antropología y la pedagogía y se exponen algunas realizaciones concretas llevadas a cabo en España en el periodo anterior a la guerra civil, en relación con la antropología biológica, el folklore y la educación; especialmente las organizadas en la Escuela de Estudios Superiores del Magisterio de Madrid

Inhibitors and effectors of the glycosidases as therapeutic tools

Motivation: The lysosomal storage disorders (LSDs) conforms a group of over fifty monogenetic diseases characterized by the dysfunction of a lysosomal enzyme, frequently a glycosidase, and the subsequent accumulation of the corresponding substrate, which gives rise to several pathological manifestations. Individually they are rare diseases, but taken together they affect at 1 in 7,000 newborns. For some of these conditions enzyme replacement and/or substrate reduction therapeutic strategies (ERT and SRT, respectively) are available. Yet, most LSDs course with neurological deterioration and are refractory to ERT and SRT, remaining orphan diseases, sice the respective active principles are unable to cros the blood brain barrier (BBB). Ironically, in most of the LSD patients the causative mutation leads to the expression of a mutated ezyme that retains catalytic activity, but it is unable to properly fold at the endoplasmic reticulum (ER) and undertake the secretory pathway to the lysosome. Small molecules capable of promoting the correct folding and restore traficking, termed pharmacological chaperones (PCs), represents therefore a promising therapeutic option that is, in principle, better suited than ERT and SRT to target the neuronopathic forms. Methods: We have conducted research aiming at developing active site-directed pharmacologial chaperones for several LSDs based on glycomimetics (sugar lookaalikes). The molecular design implies a nitrogen-in-the-ring cycle bearing a hydroxylation profile that matches that of the monosaccharide cleave off by the target enzyme (Sánchez-Fernández et al. 2016). Such compounds can sit at the active site of the glycosidase, behaving as competitive inhibitors, subsequently inducing proper folding and trafficking. The chaperones are further elaborated to make them dissociate from the chaperone:enzyme complex at the lysosome, allowing substrate processing (Mena-Barragán et al. 2015).Results: PCs acting as glycosidase effectors in Gaucher, Fabry and GM1 gangliosidosis LSDs have been prepared based on the above concept.Conclusions: The ability of the PCs to cross the (BBB) and revert the accumulus of the substrate in the brain tissue (Takai et al. 2013) supports the promise of pharmacological chaperone therapy for a range of LSDs with neurological implications

Pimentel, Juan. Fantasmas de la ciencia española. Madrid, Marcial Pons Historia, 2020, 413 pp. [ISBN: 978-84-17945-01-5]

Reseña del libro Fantasmas de la ciencia española, de Juan Pimentel, publicado en 2020.Con este título paradójico, que aparentemente reúne en el mismo enunciado dos conceptos pertenecientes a campos contradictorios -la creencia y la razón; lo sobrenatural y lo natural; lo imaginado y lo ocurrido; lo falso e improbable y lo veraz y demostrable-, se abre en realidad un libro de historia. Una historia que se ocupa además de una actividad precisa y particular, como es el conocimiento y la actividad científica