Rotational properties of the Haumea family members and candidates: Short-term variability

Haumea is one of the most interesting and intriguing transneptunian objects (TNOs). It is a large, bright, fast rotator, and its spectrum indicates nearly pure water ice on the surface. It has at least two satellites and a dynamically related family of more than ten TNOs with very similar proper orbital parameters and similar surface properties. The Haumean family is the only one currently known in the transneptunian belt. Various models have been proposed but the formation of the family remains poorly understood. In this work, we have investigated the rotational properties of the family members and unconfirmed family candidates with short-term variability studies, and report the most complete review to date. We present results based on five years of observations and report the short-term variability of five family members, and seven candidates. The mean rotational periods, from Maxwellian fits to the frequency distributions, are 6.27+/-1.19 h for the confirmed family members, 6.44+/-1.16 h for the candidates, and 7.65+/-0.54 h for other TNOs (without relation to the family). According to our study, there is a suggestion that Haumea family members rotate faster than other TNOs, however, the sample of family member is still too limited for a secure conclusion. We also highlight the fast rotation of 2002 GH32. This object has a 0.36+/-0.02 mag amplitude lightcurve and a rotational period of about 3.98 h. Assuming 2002 GH32 is a triaxial object in hydrostatic equilibrium, we derive a lower limit to the density of 2.56 g cm^-3. This density is similar to Haumea's and much more dense than other small TNO densities.Comment: Accepted for publication, A

Thanatometabolomics: introducing NMR-based metabolomics to identify metabolic biomarkers of the time of death.

Death is the permanent cessation of the critical functions of the organism as a whole. However, the shutdown of a complex biological organism does not abruptly terminate at time of death. New high-throughput technologies allow the systematic investigation of the biochemical modulations occurring after death. Recent genomics studies have demonstrated that genes remain active after death, triggering upregulation of some genes and initiating feedback loops. These genes were mostly involved in pathways related to immunity, inflammation and cancer. These genetic modulations suggest many biochemical events persist after death, which can be captured using a metabolomics approach. This proof of concept work aimed to determine whether NMR spectroscopy could identify metabolomics changes occurring after death, and characterise the nature of these metabolomics modulations. High-resolution H-NMR spectroscopy was applied to six biological matrices: heart, kidney, liver, spleen, skin and white adipose tissue of ten adult mice at three different type points. Forty-three metabolites were associated with post mortem metabolomics modulations. Kidney, heart and spleen showed the highest metabolic perturbations. Conversely, skin and white adipose tissue were the least altered matrices. Early metabolic modulations were associated with energy metabolism and DNA synthesis, by contrast, late metabolomics modulations were associated with microbial metabolism. NMR has proven potential to determine the time of death based on post-mortem metabolomics modulations. This could be useful in the context of transplants, forensic studies and as internal quality control in metabolomics studies. Further investigations are required to validate these findings in humans in order to determine which compounds robustly reflect post-mortem metabolic fluctuations to accurately determine the time of death

NMR metabolomics identifies over 60 biomarkers associated with Type II Diabetes impairment in db/db mice

The rapid expansion of Type 2 Diabetes (T2D), that currently affects 90% of people suffering from diabetes, urges us to develop a better understanding of the metabolic processes involved in the disease process in order to develop better therapies. The most commonly used model for T2D research is the db/db (BKS.Cg-Dock7  +/+ Lepr /J) mouse model. Yet, a systematic H NMR based metabolomics characterisation of most tissues in this animal model has not been published. Here, we provide a systematic organ-specific metabolomics analysis of this widely employed model using NMR spectroscopy. The aim of this study was to characterise the metabolic modulations associated with T2D in db/db mice in 18 relevant biological matrices. High-resolution H-NMR and 2D-NMR spectroscopy were applied to 18 biological matrices of 12 db/db mice (WT control n = 6, db/db = 6) aged 22 weeks, when diabetes is fully established. 61 metabolites associated with T2D were identified. Kidney, spleen, eye and plasma were the biological matrices carrying the largest metabolomics modulations observed in established T2D, based on the total number of metabolites that showed a statistical difference between the diabetic and control group in each tissue (16 in each case) and the strength of the O-PLS DA model for each tissue. Glucose and glutamate were the most commonly associated metabolites found significantly increased in nine biological matrices. Investigated sections where no increase of glucose was associated with T2D include all intestinal segments (i.e. duodenum, jejunum, ileum and colon). Microbial co-metabolites such as acetate and butyrate, used as carbon sources by the host, were identified in excess in the colonic tissues of diabetic individuals. The metabolic biomarkers identified using H NMR-based metabolomics will represent a useful resource to explore metabolic pathways involved in T2D in the db/db mouse model

ITIL V4 para la gestión de incidencias en el área recursos humanos de una unidad de gestión educativa, Lima 2023

El objetivo del estudio fue determinar el impacto de ITIL V4 en la gestión de incidencias del área de recursos humanos de una unidad de gestión educativa en Lima. La metodología aplicada comprendió un enfoque cuantitativo con un diseño preexperimental de tipo aplicado sobre una muestra de 156 registros. Los resultados evidenciaron que ITIL V4 incrementó el porcentaje de incidencias resueltas al 100% de 27.6% a 43%, redujo el tiempo de solución a menos de 5 días en el 78.2% de casos versus un 51.9% inicialmente y mejoró la efectividad de registros a una clasificación sesgada de 92.3% luego de implementarlo. El análisis estadístico mediante la prueba U de Mann-Whitney en las 3 dimensiones evaluadas demostró que ITIL V4 tiene un alto impacto positivo en la gestión de incidencias. En conclusión, la implementación de ITIL V4 resultó muy beneficiosa para mejorar la cantidad, tiempo y efectividad en la gestión de incidencias del área de recursos humanos de la unidad de gestión educativa estudiada

Aspergillus Pneumonia in pos-COVID-19 patient

Introduction: The new SARS-CoV-2 coronavirus disease (COVID-19) spread rapidly throughout the world, which created a great challenge. The appearance of coinfections is among the most serious complications that these patients can develop. Pulmonary aspergillosis has been identified as a complication of COVID-19 pneumonia among ventilated patients in intensive care. Objective: To present an unusual clinical case of pulmonary aspergillosis. Clinical case: It is presented the case of a patient with a recent history of COVID-19, with an enteral clinical picture of diarrhea and vomiting plus respiratory failure, in which the evolution of colon cancer and ventilator-associated pneumonia caused by Aspergillus niger are concomitant. Conclusions: Pulmonary aspergillosis associated with COVID-19 is a complication that should be considered and sought in patients with a recent history of this disease

DESARROLLO DE UNA ESTRATEGIA DE MODULACION BASADO EN CONTROL PREDICTIVO APLICADO EN SISTEMAS CONECTADOS A LA RED ELÉCTRICA (DEVELOPMENT OF A MODULATION STRATEGY BASED ON PREDICTIVE CONTROL APPLIED TO GRID-CONNECTED SYSTEM)

Resumen Se presenta una estrategia de modulación basada en técnicas de control predictivo, la cual es implementada en un inversor monofásico sin transformador en modo común conectado a la red eléctrica; dicha estrategia, se conforma de un algoritmo que actúa de acuerdo con la toma de decisiones basadas en la comparación de las señales de referencia y la respuesta completa del sistema. Se pretende obtener una intensidad de corriente de salida que se encuentre con el mismo ángulo de fase con la tensión de la red ante cambios de carga resistiva y de valores de referencia. Por otra parte, se desea que esta modulación sea igualmente efectiva ante cargas reactivas no lineales. Palabras Clave: Carga resistiva, Control predictivo, Inversor monofásico sin transformador, Respuesta completa. Abstract A modulation strategy based in predictive control techniques is presented, which is implemented in a Transformerless Common-Mode Current-Source Inverter Grid-Connected. The strategy is conformed by an algorithm that responds according to the decision making between reference signals and the complete response of the system. This work seeks to obtain an output signal of current in the same phase than the voltage grid which responds on resistive loads and reference values changes. Finally, it is desired to obtain same performance. Even with non-lineal reactive loads. Keywords: Complete response, Predictive control, resistive load, Transformerless Single Phase Inverter

Películas proteicas de soja nanoreforzadas con celulosa microfibrilada extraída de fibras de formio

En este trabajo se estudió la obtención de celulosa microfibrilada (MFC) mediante tratamiento mecánico a partir de fibras de formio, lográndose obtener nanofibras de celulosa (d≈50-60 nm y L≈485 μm). Estas nanofibras se utilizaron como nano-refuerzos en la formulación de películas en base a proteína de soja (SPI) obtenidas por casting. Fue posible obtener películas homogéneas hasta con un 12 % de MFC (respecto de la cantidad de SPI). El agregado de las fibras provocó un aumento progresivo en la tensión a la rotura y módulo de Young en detrimento de la elongación a la rotura, y una disminución significativa en la permeabilidad al vapor de agua y en el contenido de agua pero un aumento en la solubilidad solo para las mayores concentraciones de MFC. El efecto refuerzo que la celulosa microfibrilada estaría ejerciendo sobre las películas proteicas, daría indicio de una buena compatibilidad entre esta matriz y las nanofibras.Facultad de Ciencias ExactasCentro de Investigación y Desarrollo en Criotecnología de Alimento