1,439 research outputs found
WHAT GOES BETWEEN TEACHING AND LEARNING
O presente artigo tem como propósito um convite para pensar o que se passa entre ensinar e aprender em Deleuze e Guattari. Para tanto, parte da ideia de que não se trata de explicar Deleuze, e nem de tomá-lo como critério, mas de ver o transdiferencialismo deleuzo-guattariano como a mais forte inspiração contemporânea a respeito da problemática das conexões verbais em filosofia. Isso é claro para nós, pois não há linhas de fuga sem fugir pelos verbos.The purpose of this article is an invitation to think about what happens between teaching and learning in Deleuze and Guattari. Therefore, it starts from the idea that it is not about explaining Deleuze, nor taking him as a criterion, but seeing deleuzo-guattarian transdifferentialism as the strongest contemporary inspiration regarding the problematic of verbal connections in philosophy. This is clear to us, as there are no lines of flight without escaping through the verbs
On the Unruh effect in de Sitter space
We give an interpretation of the temperature in de Sitter universe in terms
of a dynamical Unruh effect associated with the Hubble sphere. As with the
quantum noise perceived by a uniformly accelerated observer in static
space-times, observers endowed with a proper motion can in principle detect the
effect. In particular, we study a "Kodama observer" as a two-field Unruh
detector for which we show the effect is approximately thermal. We also
estimate the back-reaction of the emitted radiation and find trajectories
associated with the Kodama vector fields are stable.Comment: 8 pages; corrected typos; sections structure revise
Cellular retinol-binding protein-1 expression in endometrial stromal cells: physiopathological and diagnostic implications
Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiated state of the endometrium through retinol bioavailability regulation. The aim was to analyse CRBP-1 expression in endometrial stromal cells at eutopic and ectopic sites in different physiopathological conditions
On the possibility of magnetic Weyl fermions in non-symmorphic compound PtFeSb
Weyl fermions are expected to exhibit exotic physical properties such as the
chiral anomaly, large negative magnetoresistance or Fermi arcs. Recently a new
platform to realize these fermions has been introduced based on the appearance
of a three-fold band crossing at high symmetry points of certain space groups.
These band crossings are composed of two linearly dispersed bands that are
topologically protected by a Chern number, and a at band with no topological
charge. In this paper we present a new way of inducing two kinds of Weyl
fermions, based on two- and three-fold band crossings, in the non-symmorphic
magnetic material PtFeSb. By means of density functional theory calculations
and group theory analysis we show that magnetic order can split a six-fold
degeneracy enforced by non-symmoprhic symmetry to create three-fold or two-fold
degenerate Weyl nodes. We also report on the synthesis of a related phase
potentially containing two-fold degenerate magnetic Weyl points and extend our
group theory analysis to that phase. This is the first study showing that
magnetic ordering has the potential to generate new threefold degenerate Weyl
nodes, advancing the understanding of magnetic interactions in topological
materials.Comment: 8 pages, 5 figure
Brain natriuretic peptide: Much more than a biomarker.
Brain natriuretic peptide (BNP) modulates several biological processes by activating the natriuretic peptide receptor A (NPR-A). Atria and ventricles secrete BNP. BNP increases natriuresis, diuresis and vasodilatation, thus resulting in a decreased cardiac workload. BNP and NT-proBNP, which is the biologically inactive N-terminal portion of its pro-hormone, are fast and sensitive biomarkers for diagnosing heart failure. The plasma concentrations of both BNP and NT-proBNP also correlate with left ventricular function in patients with acute exacerbation of COPD, even without history of heart failure. Several studies have been conducted in vitro and in vivo, both in animals and in humans, in order to assess the potential role of the NPR-A activation as a novel therapeutic approach for treating obstructive pulmonary disorders. Unfortunately, these studies have yielded conflicting results. Nevertheless, further recent specific studies, performed in ex vivo models of asthma and COPD, have confirmed the bronchorelaxant effect of BNP and its protective role against bronchial hyperresponsiveness in human airways. These studies have also clarified the intimate mechanism of action of BNP, represented by an autocrine loop elicited by the activation of NPR-A, localized on bronchial epithelium, and the relaxant response of the surrounding ASM, which does not expresses NPR-A. This review explores the teleological activities and paradoxical effects of BNP with regard to chronic obstructive respiratory disorders, and provides an excursus on the main scientific findings that explain why BNP should be considered much more than a biomarker
Extracellular matrix features discriminate aggressive HER2-positive breast cancer patients who benefit from trastuzumab treatment
We previously identified an extracellular matrix (ECM) gene expression pattern in breast cancer (BC), called ECM3, characterized by a high expression of genes encoding structural ECM proteins. Since ECM is reportedly implicated in response to therapy of BCs, the aim of this work is to investigate the prognostic and predictive value of ECM3 molecular classification in HER2-positive BCs. ECM3 resulted in a robust cluster that identified a subset of 25-37% of HER2-positive tumors with molecular aggressive features. ECM3 was significantly associated with worse prognosis in two datasets of HER2-positive BCs untreated with adjuvant therapy. Analyses carried out on two of our cohorts of patients treated or not with adjuvant trastuzumab showed association of ECM3 with worse prognosis only in patients not treated with trastuzumab. Moreover, investigating a dataset that includes gene profile data of tumors treated with neoadjuvant trastuzumab plus chemotherapy or chemotherapy alone, ECM3 was associated with increased pathological complete response if treated with trastuzumab. In the in vivo experiments, increased diffusion and trastuzumab activity were found in tumors derived from injection of HER2-positive cells with Matrigel that creates an ECM-rich tumor environment. Taken together, these results indicate that HER2-positive BCs classified as ECM3 have an aggressive phenotype but they are sensitive to trastuzumab treatment
Causal RLGC( Æ‘ ) Models for Transmission Lines from Measured S-Parameters
Frequency-dependent causal RLGC(f) models are proposed for single-ended and coupled transmission lines. Dielectric loss, dielectric dispersion, and skin-effect loss are taken into account. The dielectric substrate is described by the two-term Debye frequency dependence, and the transmission line conductors are of finite conductivity. In this paper, three frequency-dependent RLGC models are studied. One is the known frequency-dependent analytical RLGC model ( RLGC-I), the second is the RLGC(f) model (RLGC-II) proposed in this paper, and the third (RLGC-III) is same as the RLGC -II, but with causality enforced by the Hilbert transform in frequency domain. The causalities of the three RLGC models are corroborated in the time domain by examining the propagation of a well-defined pulse through three different transmission lines: a single-ended stripline, a single-ended microstrip line, and an edge-coupled differential stripline pair. A clear time-domain start point is shown on each received pulse for the RLGC-II model and the RLGC-III model, where their corresponding start points overlap. This indicates that the proposed RLGC(f) model (RLGC-II) is causal. Good agreement of simulated and measured S-parameters has also been achieved in the frequency domain for the three transmission lines by using the proposed frequency-dependent RLGC (f) model
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