Theoretical study of angle-resolved two-photon photoemission in two-dimensional insulating cuprates

We propose angle-resolved two-photon photoemission spectroscopy (AR-2PPES) as a technique to detect the location of the bottom of the upper Hubbard band (UHB) in two-dimensional insulating cuprates. The AR-2PPES spectra are numerically calculated for small Hubbard clusters. When the pump photon excites an electron from the lower Hubbard band, the bottom of the UHB is less clear, but when an electron in the nonbonding oxygen band is excited, the bottom of the UHB can be identified clearly, accompanied with additional spectra originated from the spin-wave excitation at half filling.Comment: 5 pages, 4 figure

Investigation of the thermal expansion and heat capacity of the CaCu3Ti4O12 ceramics

The thermal expansion of the CaCu3Ti4O12 ceramics has been measured over a wide temperature range 120–1200 K. The high quality of the samples under study has been confirmed by good agreement of the results of measurements of the heat capacity in the range 2–300 K and in the vicinity of the phase transition of magnetic nature at 25 K with the data for the single crystal. No anomalies in the thermal expansion that can be associated with the phase transition at 726–732 K assumed by other investigators have been found. The influence exerted on the thermal expansion by the heat treatment of the sample in a helium atmosphere and in air has been investigated

Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.

Well-differentiated papillary mesothelioma is an uncommon mesothelial neoplasm that most frequently arises in the peritoneal cavity of women of reproductive age. Whereas malignant mesothelioma is an aggressive tumor associated with poor outcome, well-differentiated papillary mesothelioma typically exhibits indolent behavior. However, histologically differentiating between these two entities can be challenging, necessitating the development of distinguishing biomarkers. While the genetic alterations that drive malignant mesothelioma have recently been determined, the molecular pathogenesis of well-differentiated papillary mesothelioma is unknown. Here we performed genomic profiling on a cohort of ten well-differentiated papillary mesothelioma of the peritoneum. We identified that all tumors harbored somatic missense mutations in either the TRAF7 or CDC42 genes, and lacked alterations involving BAP1, NF2, CDKN2A, DDX3X, SETD2, and ALK that are frequent in malignant mesothelioma. We recently identified that another mesothelial neoplasm, adenomatoid tumor of the genital tract, is genetically defined by somatic missense mutations in the TRAF7 gene, indicating a shared molecular pathogenesis between well-differentiated papillary mesothelioma and adenomatoid tumors. To the best of our knowledge, well-differentiated papillary mesothelioma is the first human tumor type found to harbor recurrent mutations in the CDC42 gene, which encodes a Rho family GTPase. Immunohistochemistry demonstrated intact BAP1 expression in all cases of well-differentiated papillary mesothelioma, indicating that this is a reliable marker for distinguishing well-differentiated papillary mesothelioma from malignant mesotheliomas that frequently display loss of expression. Additionally, all well-differentiated papillary mesothelioma demonstrated robust expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation, similar to that observed in adenomatoid tumors. In contrast, we have previously shown that L1CAM staining is not observed in normal mesothelial cells and malignant mesotheliomas of the peritoneum. Together, these studies demonstrate that well-differentiated papillary mesothelioma is genetically defined by mutually exclusive mutations in TRAF7 and CDC42 that molecularly distinguish this entity from malignant mesothelioma

Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.

Malignant mesothelioma is a rare cancer that arises from the mesothelial cells that line the pleural cavity and less commonly from the peritoneal lining of the abdomen and pelvis. Most pleural mesotheliomas arise in patients with a history of asbestos exposure, whereas the association of peritoneal mesotheliomas with exposure to asbestos and other potential carcinogens is less clear, suggesting that the genetic alterations that drive malignant peritoneal mesothelioma may be unique from those in pleural mesothelioma. Treatment options for all malignant mesotheliomas are currently limited, with no known targeted therapies available. To better understand the molecular pathogenesis of malignant peritoneal mesothelioma, we sequenced 510 cancer-related genes in 13 patients with malignant mesothelioma arising in the peritoneal cavity. The most frequent genetic alteration was biallelic inactivation of the BAP1 gene, which occurred in 9/13 cases, with an additional two cases demonstrating monoallelic loss of BAP1. All 11 of these cases demonstrated loss of BAP1 nuclear staining by immunohistochemistry, whereas two tumors without BAP1 alteration and all 42 cases of histologic mimics in peritoneum (8 multilocular peritoneal inclusion cyst, 6 well-differentiated papillary mesothelioma of the peritoneum, 16 adenomatoid tumor, and 12 low-grade serous carcinoma of the ovary) demonstrated intact BAP1 nuclear staining. Additional recurrently mutated genes in this cohort of malignant peritoneal mesotheliomas included NF2 (3/13), SETD2 (2/13), and DDX3X (2/13). While these genes are known to be recurrently mutated in pleural mesotheliomas, the frequencies are distinct in peritoneal mesotheliomas, with nearly 85% of peritoneal tumors harboring BAP1 alterations versus only 20-30% of pleural tumors. Together, these findings demonstrate the importance of epigenetic modifiers including BAP1, SETD2, and DDX3X in mesothelial tumorigenesis and suggest opportunities for targeted therapies

Rest-UV Absorption Lines as Metallicity Estimator: the Metal Content of Star-Forming Galaxies at z~5

We measure a relation between the depth of four prominent rest-UV absorption complexes and metallicity for local galaxies and verify it up to z~3. We then apply this relation to a sample of 224 galaxies at 3.5 = 4.8) in COSMOS, for which unique UV spectra from DEIMOS and accurate stellar masses from SPLASH are available. The average galaxy population at z~5 and log(M/Msun) > 9 is characterized by 0.3-0.4 dex (in units of 12+log(O/H)) lower metallicities than at z~2, but comparable to z~3.5. We find galaxies with weak/no Ly-alpha emission to have metallicities comparable to z~2 galaxies and therefore may represent an evolved sub-population of z~5 galaxies. We find a correlation between metallicity and dust in good agreement with local galaxies and an inverse trend between metallicity and star-formation rate (SFR) consistent with observations at z~2. The relation between stellar mass and metallicity (MZ relation) is similar to z~3.5, however, there are indications of it being slightly shallower, in particular for the young, Ly-alpha emitting galaxies. We show that, within a "bathtub" approach, a shallower MZ relation is expected in the case of a fast (exponential) build-up of stellar mass with an e-folding time of 100-200 Myr. Due to this fast evolution, the process of dust production and metal enrichment as a function of mass could be more stochastic in the first billion years of galaxy formation compared to later times.Comment: 20 pages, 13 figures, 4 tables; Submitted to Ap

Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation.

Adenomatoid tumors are the most common neoplasm of the epididymis, and histologically similar adenomatoid tumors also commonly arise in the uterus and fallopian tube. To investigate the molecular pathogenesis of these tumors, we performed genomic profiling on a cohort of 31 adenomatoid tumors of the male and female genital tracts. We identified that all tumors harbored somatic missense mutations in the TRAF7 gene, which encodes an E3 ubiquitin ligase belonging to the family of tumor necrosis factor receptor-associated factors (TRAFs). These mutations all clustered into one of five recurrent hotspots within the WD40 repeat domains at the C-terminus of the protein. Functional studies in vitro revealed that expression of mutant but not wild-type TRAF7 led to increased phosphorylation of nuclear factor-kappa B (NF-kB) and increased expression of L1 cell adhesion molecule (L1CAM), a marker of NF-kB pathway activation. Immunohistochemistry demonstrated robust L1CAM expression in adenomatoid tumors that was absent in normal mesothelial cells, malignant peritoneal mesotheliomas and multilocular peritoneal inclusion cysts. Together, these studies demonstrate that adenomatoid tumors of the male and female genital tract are genetically defined by TRAF7 mutation that drives aberrant NF-kB pathway activation

A wide area survey for high-redshift massive galaxies. I. Number counts and clustering of BzKs and EROs

We have combined deep BRIz' imaging over 2x940 arcmin^2 fields obtained with the Suprime-Cam on the Subaru telescope with JKs imaging with the SOFI camera at the New Technology Telescope to search for high-redshift massive galaxies. K-band selected galaxies have been identified over an area of ~920 arcmin^2 to K_Vega=19.2, of which 320 arcmin^2 are complete to K_Vega=20. The BzK selection technique was used to obtain complete samples of ~500 candidate massive star-forming galaxies (sBzKs) and ~160 candidate massive, passively-evolving galaxies (pBzKs), both at 1.4 5 criterion we also identified ~850 extremely red objects (EROs). The surface density of sBzKs and pBzKs is found to 1.20+/-0.05 arcmin^{-2} and 0.38+/-0.03 arcmin^{-2}, respectively. Both sBzKs and pBzKs are strongly clustered, at a level at least comparable to that of EROs, with pBzKs appearing more clustered than sBzKs. We estimate the reddening, star formation rates (SFRs) and stellar masses (M_*) of the sBzKs, confirming that to K_Vega~20 median values are M_*~10^{11}M_sun, SFR 190M_sun yr^{-1}, and E(B-V)~0.44. The most massive sBzKs are also the most actively star-forming, an effect which can be seen as a manifestation of downsizing at early epochs. The space density of massive pBzKs at z~1.4-2 is 20%+/-7% that of similarly massive early-type galaxies at z~0, and similar to that of sBzKs of the same mass. We argue that star formation quenching in these sBzKs will result in nearly doubling the space density of massive early-type galaxies, thus matching their local density.Comment: 19 pages, 13 figures, accepted by ApJ. While checking the proofs we became aware of a material mistake of non-trivial scientific relevance. In the original it was reported that the comoving volume density of passive BzK-selected galaxies with =1.7 and more massive than 10^{11}M_sun was 45%+/-15% of the local number density of similarly massive early-type galaxies. This fraction actually turns out to be 20%+/-7%. Section 6.4, point 5 in section 7, and the abstract have been modified accordingl

Passive galaxies as tracers of cluster environments at z~2

Even 10 billion years ago, the cores of the first galaxy clusters are often found to host a characteristic population of massive galaxies with already suppressed star formation. Here we search for distant cluster candidates at z~2 using massive passive galaxies as tracers. With a sample of ~40 spectroscopically confirmed passive galaxies at 1.3<z<2.1, we tune photometric redshifts of several thousands passive sources in the full 2 sq.deg. COSMOS field. This allows us to map their density in redshift slices, probing the large scale structure in the COSMOS field as traced by passive sources. We report here on the three strongest passive galaxy overdensities that we identify in the redshift range 1.5<z<2.5. While the actual nature of these concentrations is still to be confirmed, we discuss their identification procedure, and the arguments supporting them as candidate galaxy clusters (likely mid-10^13 M_sun range). Although this search approach is likely biased towards more evolved structures, it has the potential to select still rare, cluster-like environments close to their epoch of first appearance, enabling new investigations of the evolution of galaxies in the context of structure growth.Comment: 5 pages, 5 figures; A&A Letters, in pres

HST grism spectroscopy of z ∼3 massive quiescent galaxies: Approaching the metamorphosis

Tracing the emergence of the massive quiescent galaxy (QG) population requires the build-up of reliable quenched samples by distinguishing these systems from red, dusty star-forming sources. We present Hubble Space Telescope WFC3/G141 grism spectra of ten quiescent galaxy candidates selected at 2.5 &lt; z &lt; 3.5 in the COSMOS field. Spectroscopic confirmation for the whole sample is obtained within one to three orbits through the detection of strong spectral breaks and Balmer absorption lines. When their spectra are combined with optical to near-infrared photometry, star-forming solutions are formally rejected for the entire sample. Broad spectral indices are consistent with the presence of young A-type stars, which indicates that the last major episode of star formation has taken place no earlier than ∼300-800 Myr prior to observation. This confirms clues from their post-starburst UVJ colors. Marginalising over three different slopes of the dust attenuation curve, we obtain young mass-weighted ages and an average peak star formation rate (SFR) of ∼103 M yr-1 at zformation ∼ 3.5. Although mid- and far-IR data are too shallow to determine the obscured SFR on a galaxy-by-galaxy basis, the mean stacked emission from 3 GHz data constrains the level of residual-obscured SFR to be globally below 50 M yr-1, three times below the scatter of the coeval main sequence. Alternatively, the very same radio detection suggests a widespread radio-mode feedback by active galactic nuclei (AGN) four times stronger than in z ∼ 1.8 massive QGs. This is accompanied by a 30% fraction of X-ray luminous AGN with a black hole accretion rate per unit SFR enhanced by a factor of ∼30 with respect to similarly massive QGs at lower redshift. The average compact, high Sérsic index morphologies of the galaxies in this sample, coupled with their young mass-weighted ages, suggest that the mechanisms responsible for the development of a spheroidal component might be concomitant with (or preceding) those causing their quenching

Interlayer Registry Determines the Sliding Potential of Layered Metal Dichalcogenides: The case of 2H-MoS2

We provide a simple and intuitive explanation for the interlayer sliding energy landscape of metal dichalcogenides. Based on the recently introduced registry index (RI) concept, we define a purely geometrical parameter which quantifies the degree of interlayer commensurability in the layered phase of molybdenum disulphide (2HMoS2). A direct relation between the sliding energy landscape and the corresponding interlayer registry surface of 2H-MoS2 is discovered thus marking the registry index as a computationally efficient means for studying the tribology of complex nanoscale material interfaces in the wearless friction regime.Comment: 13 pages, 7 figure