4,030 research outputs found
Measuring the technical efficiency of cooperative societies in Kuwait
© 2018 John Wiley & Sons, Ltd. This study employs bootstrap data envelopment analysis to measure the technical efficiencies of 48 Kuwaiti retail cooperative societies (coops) during the years 2012–2015. Average profit efficiency falls substantially from 84% to 70% after applying a bootstrap correction. The bias is larger for coops originally identified as being on the efficient frontier. The average coop is too small, but both profitability and efficiency are negatively related to the number of direct branches (mini-marts). Also, coops can increase profitability through greater equity capitalization, whereas better control of labor costs leads to higher profit efficiency
Hysteresis and Noise in Stripe and Clump Forming Systems
We use simulations to examine hysteresis and noise in a model system that
produces heterogeneous orderings including stripe and clump phases. In the
presence of a disordered substrate, these heterogeneous phases exhibit
1/f noise and hysteresis in transport. The noise fluctuations are
maximal in the heterogeneous phases, while in the uniform phases the hysteresis
vanishes and both and the noise power decrease. We compare our results
to recent experiments exhibiting noise and hysteresis in high-temperature
superconductors where charge heterogeneities may occur.Comment: 4 pages, 5 postscript figure
Current neurologic treatment and emerging therapies in CDKL5 deficiency disorder
BACKGROUND: CDKL5 deficiency disorder (CDD) is associated with refractory infantile onset epilepsy, global developmental delay, and variable features that include sleep, behavioral disturbances, and movement disorders. Current treatment is primarily symptom-based and informed by experience in caring for this population.
METHODS: We describe medication and non-medication approaches to treatment of epilepsy and additional key neurologic symptoms (sleep disturbances, behavioral issues, movement disorders, and swallowing dysfunction) in a cohort of 177 individuals meeting criteria for CDD, 154 evaluated at 4 CDKL5 Centers of Excellence in the USA and 40 identified through the NIH Natural History Study of Rett and Related Disorders.
RESULTS: The four most frequently prescribed anti-seizure medications were broad spectrum, prescribed in over 50% of individuals. While the goal was not to ascertain efficacy, we obtained data from 86 individuals regarding response to treatment, with 2-week response achieved in 14-48% and sustained 3-month response in 5-36%, of those with known response. Additional treatments for seizures included cannabis derivatives, tried in over one-third of individuals, and clinical trial medications. In combination with pharmacological treatment, 50% of individuals were treated with ketogenic diet for attempted seizure control. Surgical approaches included vagus nerve stimulators, functional hemispherectomy, and corpus callosotomy, but numbers were too limited to assess response. Nearly one-third of individuals received pharmacologic treatment for sleep disturbances, 13% for behavioral dysregulation and movement disorders, and 43% had gastrostomy tubes.
CONCLUSIONS: Treatment for neurologic features of CDD is currently symptom-based and empiric rather than CDD-specific, though clinical trials for CDD are emerging. Epilepsy in this population is highly refractory, and no specific anti-seizure medication was associated with improved seizure control. Ketogenic diet is commonly used in patients with CDD. While behavioral interventions are commonly instituted, information on the use of medications for sleep, behavioral management, and movement disorders is sparse and would benefit from further characterization and optimization of treatment approaches. The heterogeneity in treatment approaches highlights the need for systematic review and guidelines for CDD. Additional disease-specific and disease-modifying treatments are in development
Engine Driven Pumps - Vibration Problem Resolution Using Specialized Testing Techniques
Case StudyOutline: Problem description and approach overview. Specialized testing to characterize the problem. Conclusions and recommendations based on the
test results. Implementing the solution. Lessons learned
Dipolar versus multipolar dynamos: the influence of the background density stratification
Context: dynamo action in giant planets and rapidly rotating stars leads to a
broad variety of magnetic field geometries including small scale multipolar and
large scale dipole-dominated topologies. Previous dynamo models suggest that
solutions become multipolar once inertia becomes influential. Being tailored
for terrestrial planets, most of these models neglected the background density
stratification. Aims: we investigate the influence of the density
stratification on convection-driven dynamo models. Methods: three-dimensional
nonlinear simulations of rapidly rotating spherical shells are employed using
the anelastic approximation to incorporate density stratification. A systematic
parametric study for various density stratifications and Rayleigh numbers
allows to explore the dependence of the magnetic field topology on these
parameters. Results: anelastic dynamo models tend to produce a broad range of
magnetic field geometries that fall on two distinct branches with either strong
dipole-dominated or weak multipolar fields. As long as inertia is weak, both
branches can coexist but the dipolar branch vanishes once inertia becomes
influential. The dipolar branch also vanishes for stronger density
stratifications. The reason is the concentration of the convective columns in a
narrow region close to the outer boundary equator, a configuration that favors
non-axisymmetric solutions. In multipolar solutions, zonal flows can become
significant and participate in the toroidal field generation. Parker dynamo
waves may then play an important role close to onset of dynamo action leading
to a cyclic magnetic field behavior. Conclusion: Our simulations also suggest
that the fact that late M dwarfs have dipolar or multipolar magnetic fields can
be explained in two ways. They may differ either by the relative influence of
inertia or fall into the regime where both types of solutions coexist.Comment: 13 pages, 13 figures, 2 tables, accepted for publication in A&
Amicable pairs and aliquot cycles for elliptic curves
An amicable pair for an elliptic curve E/Q is a pair of primes (p,q) of good
reduction for E satisfying #E(F_p) = q and #E(F_q) = p. In this paper we study
elliptic amicable pairs and analogously defined longer elliptic aliquot cycles.
We show that there exist elliptic curves with arbitrarily long aliqout cycles,
but that CM elliptic curves (with j not 0) have no aliqout cycles of length
greater than two. We give conjectural formulas for the frequency of amicable
pairs. For CM curves, the derivation of precise conjectural formulas involves a
detailed analysis of the values of the Grossencharacter evaluated at a prime
ideal P in End(E) having the property that #E(F_P) is prime. This is especially
intricate for the family of curves with j = 0.Comment: 53 page
Engine Driven Pumps - Vibration Problem Resolution Using Specialized Testing Techniques
Case StudyOutline: Problem description and approach overview. Specialized testing to characterize the problem. Conclusions and recommendations based on the
test results. Implementing the solution. Lessons learned
Sibling relationships and family functioning in siblings of early adolescents, adolescents and young adults with autism spectrum disorder
The purpose of the study was to investigate how family functioning (defined as the ability that family members hold to manage stressful events, and intimate and social relationships), the degree to which family members feel happy and fulfilled with each other (called family satisfaction), and the demographical characteristics of siblings (age and gender) impacted on sibling relationships. The Circumplex Model of Marital and Family Systems and Behavioral Systems constituted the theoretical frameworks that guided our study. Eighty-six typically developing adolescents and young adults having a sister or a brother with autism spectrum disorder were enrolled. Results indicated that the youngest age group (early adolescents) reported to engage more frequently in negative behaviors with their siblings with ASD than the two older age groups (middle adolescents and young adults). No significant differences were found among the three age groups regarding behaviors derived from attachment, caregiving and affiliative systems. Family satisfaction and age significantly predicted behaviors during sibling interactions. Suggestions on prevention and intervention programs were discussed in order to prevent parentification among typically developing
siblings and decrease episodes of quarrels and overt conflicts between brothers and sisters with and without AS
Chemical data assimilation estimates of continental U.S. ozone and nitrogen budgets during the Intercontinental Chemical Transport Experiment-North America
Global ozone analyses, based on assimilation of stratospheric profile and ozone column measurements, and NOy predictions from the Real-time Air Quality Modeling System (RAQMS) are used to estimate the ozone and NOy budget over the continental United States during the July-August 2004 Intercontinental Chemical Transport Experiment-North America (INTEX-A). Comparison with aircraft, satellite, surface, and ozonesonde measurements collected during INTEX-A show that RAQMS captures the main features of the global and continental U.S. distribution of tropospheric ozone, carbon monoxide, and NOy with reasonable fidelity. Assimilation of stratospheric profile and column ozone measurements is shown to have a positive impact on the RAQMS upper tropospheric/lower stratosphere ozone analyses, particularly during the period when SAGE III limb scattering measurements were available. Eulerian ozone and NOy budgets during INTEX-A show that the majority of the continental U.S. export occurs in the upper troposphere/lower stratosphere poleward of the tropopause break, a consequence of convergence of tropospheric and stratospheric air in this region. Continental U.S. photochemically produced ozone was found to be a minor component of the total ozone export, which was dominated by stratospheric ozone during INTEX-A. The unusually low photochemical ozone export is attributed to anomalously cold surface temperatures during the latter half of the INTEX-A mission, which resulted in net ozone loss during the first 2 weeks of August. Eulerian NOy budgets are shown to be very consistent with previously published estimates. The NOy export efficiency was estimated to be 24%, with NOx + PAN accounting for 54% of the total NOy export during INTEX-A. Copyright 2007 by the American Geophysical Union
All-Inorganic Spin-Cast Nanoparticle Solar Cells with Non-Selective Electrodes
Spin-cast all-inorganic nanoparticle solutions have been used to make a
CdTe/CdSe solar cell with an efficiency of up to 2.8% without alumina or
calcium buffer layers. The type of junction and non-selective nature of the
contacts made to these devices is explored
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