The role of asymmetric interactions on the effect of habitat destruction in mutualistic networks

Plant-pollinator mutualistic networks are asymmetric in their interactions: specialist plants are pollinated by generalist animals, while generalist plants are pollinated by a broad involving specialists and generalists. It has been suggested that this asymmetric ---or disassortative--- assemblage could play an important role in determining the equal susceptibility of specialist and generalist plants under habitat destruction. At the core of the argument lies the observation that specialist plants, otherwise candidates to extinction, could cope with the disruption thanks to their interaction with generalist pollinators. We present a theoretical framework that supports this thesis. We analyze a dynamical model of a system of mutualistic plants and pollinators, subject to the destruction of their habitat. We analyze and compare two families of interaction topologies, ranging from highly assortative to highly disassortative ones, as well as real pollination networks. We found that several features observed in natural systems are predicted by the mathematical model. First, there is a tendency to increase the asymmetry of the network as a result of the extinctions. Second, an entropy measure of the differential susceptibility to extinction of specialist and generalist species show that they tend to balance when the network is disassortative. Finally, the disappearance of links in the network, as a result of extinctions, shows that specialist plants preserve more connections than the corresponding plants in an assortative system, enabling them to resist the disruption.Comment: 14 pages, 7 figure

Impact of proton pump inhibitor treatment on gastrointestinal bleeding associated with non-steroidal anti-inflammatory drug use among post-myocardial infarction patients taking antithrombotics: nationwide study

Study question What is the effect of proton pump inhibitors (PPIs) on the risk of gastrointestinal bleeding in post-myocardial infarction patients taking antithrombotics and treated with non-steroidal anti-inflammatory drugs (NSAIDs)? Methods This was a nationwide cohort study based on linked administrative registry data from all hospitals in Denmark between 1997 and 2011. The study included patients aged 30 years and over admitted with a first myocardial infarction who survived at least 30 days after discharge. The association between PPIs and risk of gastrointestinal bleeding according to NSAID plus antithrombotic therapy was estimated using adjusted time dependent Cox regression models. Study answer and limitations The use of PPIs was independently associated with decreased risk of gastrointestinal bleeding in post-myocardial infarction patients taking antithrombotics and treated with NSAIDs. Of 82 955 post-myocardial infarction patients (mean age 67.4 years, 64% (n=53 070) men), all of whom were taking single or dual antithrombotic therapy, 42.5% (n=35 233) filled at least one prescription for NSAIDs and 45.5% (n=37 771) received PPIs. Over a mean follow-up of 5.1 years, 3229 gastrointestinal bleeds occurred. The crude incidence rates of bleeding (events/100 person years) on NSAID plus antithrombotic therapy were 1.8 for patients taking PPIs and 2.1 for those not taking PPIs. The adjusted risk of bleeding was lower with PPI use (hazard ratio 0.72, 95% confidence interval 0.54 to 0.95) regardless of antithrombotic treatment regimen, type of NSAID, and type of PPI used. The main limitation of the study is its observational non-randomised design. The results suggest that PPI treatment probably has a beneficial effect regardless of underlying gastrointestinal risk and that when NSAIDs cannot be avoided in post-myocardial infarction patients, physicians might prescribe a PPI as well. The study does not clarify whether PPIs might be safely omitted in specific subgroups of patients with a low risk of gastrointestinal bleeding. What this study adds In post-myocardial infarction patients, bleeding complications have been associated with both antithrombotic and NSAID treatment. Concurrent use of PPIs was independently associated with a decreased risk of gastrointestinal bleeding in post-myocardial infarction patients taking antithrombotics and NSAID, regardless of antithrombotic treatment regimen, type of NSAID, and type of PPI used. Funding, competing interests, data sharing AMSO has received a grant from the Danish Council of Independent Research (grant 12-132760). GHG is supported by an unrestricted research scholarship from the Novo Nordisk Foundation

Damage in step-overs may enable large cascading earthquakes

Seismic hazard analysis relies on the ability to predict whether an earthquake will terminate at a fault tip or propagate onto adjacent faults, cascading into a larger, more devastating event. While ruptures are expected to arrest at fault discontinuities larger than 4–5 km, scientists are often puzzled by much larger rupture jumps. Here we show that material properties between faults significantly affect the ability to arrest propagating ruptures. Earthquake simulations accounting for fault step-over zones weakened by accumulated damage provide new insights into rupture propagation. Revealing that lowered rigidity and material interfaces promote rupture propagation, our models show for the first time that step-overs as wide as 10 km may not constitute effective earthquake barriers. Our results call for re-evaluation of seismic hazard analyses that predict rupture length and earthquake magnitude based on historic records and fault segmentation models

Metabolomics to unveil and understand phenotypic diversity between pathogen populations

Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance. Improving our understanding of the mechanisms used by the parasite to adapt to drugs and achieve resistance is crucial for developing future treatment strategies. Unfortunately, the biological mechanism whereby Leishmania acquires drug resistance is poorly understood. Recent years have brought new technologies with the potential to increase greatly our understanding of drug resistance mechanisms. The latest mass spectrometry techniques allow the metabolome of parasites to be studied rapidly and in great detail. We have applied this approach to determine the metabolome of drug-sensitive and drug-resistant parasites isolated from patients with leishmaniasis. The data show that there are wholesale differences between the isolates and that the membrane composition has been drastically modified in drug-resistant parasites compared with drug-sensitive parasites. Our findings demonstrate that untargeted metabolomics has great potential to identify major metabolic differences between closely related parasite strains and thus should find many applications in distinguishing parasite phenotypes of clinical relevance

The local stellar population of nova regions in the Large Magellanic Cloud

This study aims at identifying and understanding the parent population of novae in the Large Magellanic Cloud (LMC) by studying the local, projected, stellar population. The star formation history of the local environment around novae is studied based on photometric data of stars and star clusters in the nova neighbourhood, available in the OGLE II survey and star cluster catalogues. The ages of stellar population within a few arcmin around novae regions are estimated using isochrone fits to the V vs (V-I) colour-magnitude diagrams. The fraction of stars in various evolutionary states are compared using luminosity functions of the main-sequence stars and the red giant stars. The age, density and luminosity function of the stellar population are estimated around 15 novae. The upper limit of the age of the intermediate stellar population is found to be 4 Gyr in all the regions, excepting the region around the slow nova LMC 1948. Star formation in these regions is found to have started between 4 - 2.0 Gyr, with a majority of the regions starting the star formation at 3.2 Gyr. This star formation event lasted until 1.6 - 0.8 Gyr The star formation history of the underlying population of both the fast and moderately fast novae indicate their parent population to be similar and likely to be in the age range 3.2 - 1.0 Gyr. This is in good agreement with the theoretical age estimates for Galactic cataclysmic variables. The region around the slow nova shows a stellar population in the age range 1 - 10 Gyr, with a good fraction belonging to an older population, consistent with the idea that the progenitors of slow novae belong to older population.Comment: to appear in A&A (final version - error analysis included, typos corrected, figures 17 and 18 changed

Openness to World Music Predicts Adaptation to a New Culture among Student Sojourners

Student sojourners temporarily live in a foreign country to pursue higher education. Research has shown that student sojourners’ openness to new experience and cultural values predict their adaptation to the host culture. However, it is unclear whether music – a major medium of cultural communication – also plays a role in adaptation to a host culture. This study examined whether student sojourners’ world music open-earedness (a willingness to explore, listen to, tolerate, and learn about music from diverse cultures) and functions of music in intercultural settings (the psychosocial reasons people engage with music) predict psychological and sociocultural adaptation. Seventy-six student sojourners in Australia reported their musical inclinations and adaptation to Australian society. World music open-earedness was significantly correlated with psychological and sociocultural adaptation. However, multiple regression modelling revealed that after statistically controlling for personal characteristics (e.g., age, musical training), personality traits (e.g., openness), and acculturation strategies, psychological adaptation was predicted by the music functions ‘arousal and activation’ and ‘self-reflection’, whereas sociocultural adaptation was predicted by world music open-earedness and the music function ‘arousal and activation’. Mechanisms that account for these associations and implications for identifying at-risk international students are discussed

Using Social Media for Actionable Disease Surveillance and Outbreak Management: A Systematic Literature Review

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The effects of weather and climate change on dengue

There is much uncertainty about the future impact of climate change on vector-borne diseases. Such uncertainty reflects the difficulties in modelling the complex interactions between disease, climatic and socioeconomic determinants. We used a comprehensive panel dataset from Mexico covering 23 years of province-specific dengue reports across nine climatic regions to estimate the impact of weather on dengue, accounting for the effects of non-climatic factors