IS Programs Responding to Industry Demands for Data Scientists: A Comparison Between 2011-2016

The term data scientist has only been in common use since 2008, but in 2016 it is considered one of the top careers in the United States. The purpose of this paper is to explore the growth of data science content areas such as analytics, business intelligence, and big data in AACSB Information Systems (IS) programs between 2011 and 2016. A secondary purpose is to analyze the effect of IS programs’ adherence to IS 2010 Model Curriculum Guidelines for undergraduate MIS programs, as well as the impact of IS programs offering an advanced database course in 2011 on data science course offerings in 2016. A majority (60%) of AACSB IS programs added data science-related courses between 2011 and 2016. Results indicate dramatic increases in courses offered in big data analytics (583%), visualization (300%), business data analysis (260%), and business intelligence (236%). ANOVA results also find a significant effect of departments offering advanced database courses in 2011 on new analytics course offerings in 2016. A Chi-Square analysis did not find an effect of IS 2010 Model Curriculum adherence on analytics course offerings in 2016. Implications of our findings for an MIS department’s ability to respond to changing needs of the marketplace and its students are discussed

Inferring individual fate from aquatic acoustic telemetry data

Acoustic telemetry has become a popular means of obtaining individual behavioural data from a wide array of species in marine and freshwater systems. Fate information is crucial to understand important aspects of population dynamics such as mortality, predation or dispersal rates. Here we present a method to infer individual fate from acoustic telemetry arrays of receivers with overlapping detection ranges. Our method depends exclusively on information on animal movements and the characteristics and configuration of the telemetry equipment. By answering a limited number of simple questions, our method identifies six different fates: tagging mortality, natural mortality, fishing mortality, predation, dispersal and survival. Applying the method to a cod telemetry dataset, we were able to determine the fate of 97% of the individuals. We validate the results using several external sources of information, such as recaptures from fishers and control fish with known fate. The method is readily applicable to a wide array of species with minimal adjustments, expanding the range of hypotheses that can be tested using telemetry data.publishedVersio

Statistical mechanics of transcription-factor binding site discovery using Hidden Markov Models

Hidden Markov Models (HMMs) are a commonly used tool for inference of transcription factor (TF) binding sites from DNA sequence data. We exploit the mathematical equivalence between HMMs for TF binding and the "inverse" statistical mechanics of hard rods in a one-dimensional disordered potential to investigate learning in HMMs. We derive analytic expressions for the Fisher information, a commonly employed measure of confidence in learned parameters, in the biologically relevant limit where the density of binding sites is low. We then use techniques from statistical mechanics to derive a scaling principle relating the specificity (binding energy) of a TF to the minimum amount of training data necessary to learn it.Comment: 25 pages, 2 figures, 1 table V2 - typos fixed and new references adde

Parental psychological control dimensions: Connections with Russian preschoolers\u27 physical and relational aggression

Parental psychological control generally consists of overinvolved/protective and critical/rejecting elements, both being linked to children\u27s psychosocial maladjustment. The critical/rejecting element is multidimensional in nature, and few studies have explored this conceptual fullness. It is possible that some dimensions, if they can be statistically differentiated, are uniquely tied to various child behaviors. This may help resolve some of the inconsistency apparent across studies, such as studies of relational aggression. Accordingly, we examined the association between parental psychological control and childhood physical and relational aggression using a dimensional approach. Participants were 204 Russian preschoolers and their parents. The results revealed that dimensions of psychosocial control (i.e., shaming/disappointment, constraining verbal expressions, invalidating feelings, love withdrawal, and guilt induction) could be statistically differentiated, even though most dimensions tended to be significantly correlated. Furthermore, all dimensions, except for invalidating feelings, were significantly associated with childhood aggression, but predominantly in same-gender parent-child dyads. © 2012 Elsevier Inc.

The Spectroscopic Orbit of the Planetary Companion Transiting HD209458

We report a spectroscopic orbit with period P = 3.52433 +/- 0.00027 days for the planetary companion that transits the solar-type star HD209458. For the metallicity, mass, and radius of the star we derive [Fe/H] = 0.00 +/- 0.02, M = 1.1 +/- 0.1 solar masses, and R = 1.3 +/- 0.1 solar radii. This is based on a new analysis of the iron lines in our HIRES template spectrum, and also on the absolute magnitude and color of the star, and uses isochrones from four different sets of stellar evolution models. Using these values for the stellar parameters we reanalyze the transit data and derive an orbital inclination of i = 85.2 +/- 1.4 degrees. For the planet we derive a mass of Mp = 0.69 +/- 0.05 Jupiter masses, a radius of Rp = 1.54 +/- 0.18 Jupiter radii, and a density of 0.23 +/- 0.08 grams per cubic cm.Comment: 11 pages, 1 figure, 2 tables, LaTex, aastex, accepted for publication by ApJ Letter

Quantitative Analysis of Survivin Protein Expression and Its Therapeutic Depletion by an Antisense Oligonucleotide in Human Lung Tumors

RNA-directed antisense and interference therapeutics are a promising treatment option for cancer. The demonstration of depletion of target proteins within human tumors in vivo using validated methodology will be a key to the application of this technology. Here, we present a flow cytometric-based approach to quantitatively determine protein levels in solid tumor material derived by fiber optic brushing (FOB) of non-small cell lung cancer (NSCLC) patients. Focusing upon the survivin protein, and its depletion by an antisense oligonucleotide (ASO) (LY2181308), we show that we can robustly identify a subpopulation of survivin positive tumor cells in FOB samples, and, moreover, detect survivin depletion in tumor samples from a patient treated with LY2181308. Survivin depletion appears to be a result of treatment with this ASO, because a tumor treated with conventional cytotoxic chemotherapy did not exhibit a decreased percentage of survivin positive cells. Our approach is likely to be broadly applicable to, and useful for, the quantification of protein levels in tumor samples obtained as part of clinical trials and studies, facilitating the proof-of-principle testing of novel targeted therapies

An Improved Methodology for Multidimensional High- Throughput Preformulation Characterization of Protein Conformational Stability

The Empirical Phase Diagram (EPD) technique is a vector-based multidimensional analysis method for summarizing large data sets from a variety of biophysical techniques. It can be used to provide comprehensive preformulation characterization of a macromolecule’s higher-order structural integrity and conformational stability. In its most common mode, it represents a type of stimulus-response diagram using environmental variables such as temperature, pH, and ionic strength as the stimulus, with alterations in macromolecular structure being the response. Until now EPD analysis has not been available in a high throughput mode because of the large number of experimental techniques and environmental stressor/stabilizer variables typically employed. A new instrument has been developed that combines circular dichroism, UV-absorbance, fluorescence spectroscopy and light scattering in a single unit with a 6-position temperature controlled cuvette turret. Using this multifunctional instrument and a new software system we have generated EPDs for four model proteins. Results confirm the reproducibility of the apparent phase boundaries and protein behavior within the boundaries. This new approach permits two EPDs to be generated per day using only 0.5 mg of protein per EPD. Thus, the new methodology generates reproducible EPDs in high-throughput mode, and represents the next step in making such determinations more routine