Efficiency of management of sustainable development – challenges, problems, barriers

This paper discusses such issues as the importance of efficiency management of sustainable development. In the authors’ opinion, this matter is currently topical subject due to, among others, on the still high costs of irrational management in the field. Dynamically changing environment forces to search for new solutions for efficiency management of sustainable development, and unfortunately, in many countries it is still a significant problem. For some countries, the efficiency management of sustainable development is difficult. It should be noted that the problem with the inaction of relevant activities of the countries in the field of development of efficiency management of sustainability development will grow, because globalization makes it necessary to generate new solutions emerging to date problems. Facing each country there are so many challenges in the field. However, some countries are aware of the seriousness of the problem and therefore take a number of measures in this regard, often regardless of the amount of costs. This has an impact on their competitiveness. Apparent is also increasing incorporation of new original solutions in the field of sustainable development management

A convenient route to optically pure α-alkyl-β-(sec-amino)alanines

The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protein amino acids

Code of ethics as a tool for resolving conflict in the organization

This article addresses the issues as selection tools to resolve conflicts in organizations because of the importance and topicality of this issue. One such tool among these is the effective functioning of the organization code of ethics. This document, the more detailed, the more effective. Nowadays, more and more organizations have their own codes of ethics. Therefore, it would be wrong underestimation of the code of ethics as a tool that could be used to resolve conflicts in organizations

Code of ethics as a tool for resolving conflict in the organization

This article addresses the issues as selection tools to resolve conflicts in organizations because of the importance and topicality of this issue. One such tool among these is the effective functioning of the organization code of ethics. This document, the more detailed, the more effective. Nowadays, more and more organizations have their own codes of ethics. Therefore, it would be wrong underestimation of the code of ethics as a tool that could be used to resolve conflicts in organizations

Dynamic Spatial Coding within the Dorsal Frontoparietal Network during a Visual Search Task

To what extent are the left and right visual hemifields spatially coded in the dorsal frontoparietal attention network? In many experiments with neglect patients, the left hemisphere shows a contralateral hemifield preference, whereas the right hemisphere represents both hemifields. This pattern of spatial coding is often used to explain the right-hemispheric dominance of lesions causing hemispatial neglect. However, pathophysiological mechanisms of hemispatial neglect are controversial because recent experiments on healthy subjects produced conflicting results regarding the spatial coding of visual hemifields. We used an fMRI paradigm that allowed us to distinguish two attentional subprocesses during a visual search task. Either within the left or right hemifield subjects first attended to stationary locations (spatial orienting) and then shifted their attentional focus to search for a target line. Dynamic changes in spatial coding of the left and right hemifields were observed within subregions of the dorsal front-parietal network: During stationary spatial orienting, we found the well-known spatial pattern described above, with a bilateral hemifield representation in the right hemisphere and a contralateral preference in the left hemisphere. However, during search, the right hemisphere had a contralateral preference and the left hemisphere equally represented both hemifields. This finding leads to novel perspectives regarding models of visuospatial attention and hemispatial neglect

Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Identification of Yeasts Is Contingent on Robust Reference Spectra

BACKGROUND: Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for yeast identification is limited by the requirement for protein extraction and for robust reference spectra across yeast species in databases. We evaluated its ability to identify a range of yeasts in comparison with phenotypic methods. METHODS: MALDI-TOF MS was performed on 30 reference and 167 clinical isolates followed by prospective examination of 67 clinical strains in parallel with biochemical testing (total n = 264). Discordant/unreliable identifications were resolved by sequencing of the internal transcribed spacer region of the rRNA gene cluster. PRINCIPAL FINDINGS: Twenty (67%; 16 species), and 24 (80%) of 30 reference strains were identified to species, (spectral score ≥2.0) and genus (score ≥1.70)-level, respectively. Of clinical isolates, 140/167 (84%) strains were correctly identified with scores of ≥2.0 and 160/167 (96%) with scores of ≥1.70; amongst Candida spp. (n = 148), correct species assignment at scores of ≥2.0, and ≥1.70 was obtained for 86% and 96% isolates, respectively (vs. 76.4% by biochemical methods). Prospectively, species-level identification was achieved for 79% of isolates, whilst 91% and 94% of strains yielded scores of ≥1.90 and ≥1.70, respectively (100% isolates identified by biochemical methods). All test scores of 1.70-1.90 provided correct species assignment despite being identified to "genus-level". MALDI-TOF MS identified uncommon Candida spp., differentiated Candida parapsilosis from C. orthopsilosis and C. metapsilosis and distinguished between C. glabrata, C. nivariensis and C. bracarensis. Yeasts with scores of <1.70 were rare species such as C. nivariensis (3/10 strains) and C. bracarensis (n = 1) but included 4/12 Cryptococcus neoformans. There were no misidentifications. Four novel species-specific spectra were obtained. Protein extraction was essential for reliable results. CONCLUSIONS: MALDI-TOF MS enabled rapid, reliable identification of clinically-important yeasts. The addition of spectra to databases and reduction in identification scores required for species-level identification may improve its utility

Association of stroke lesion shape with newly detected atrial fibrillation - Results from the MonDAFIS study

Paroxysmal Atrial fibrillation (AF) is often clinically silent and may be missed by the usual diagnostic workup after ischemic stroke. We aimed to determine whether shape characteristics of ischemic stroke lesions can be used to predict AF in stroke patients without known AF at baseline. Lesion shape quantification on brain MRI was performed in selected patients from the intervention arm of the Impact of standardized MONitoring for Detection of Atrial Fibrillation in Ischemic Stroke (MonDAFIS) study, which included patients with ischemic stroke or TIA without prior AF. Multiple morphologic parameters were calculated based on lesion segmentation in acute brain MRI data. Multivariate logistic models were used to test the association of lesion morphology, clinical parameters, and AF. A stepwise elimination regression was conducted to identify the most important variables. A total of 755 patients were included. Patients with AF detected within 2 years after stroke (n = 86) had a larger overall oriented bounding box (OBB) volume (p = 0.003) and a higher number of brain lesion components (p = 0.008) than patients without AF. In the multivariate model, OBB volume (OR 1.72, 95%CI 1.29–2.35, p < 0.001), age (OR 2.13, 95%CI 1.52–3.06, p < 0.001), and female sex (OR 2.45, 95%CI 1.41–4.31, p = 0.002) were independently associated with detected AF. Ischemic lesions in patients with detected AF after stroke presented with a more dispersed infarct pattern and a higher number of lesion components. Together with clinical characteristics, these lesion shape characteristics may help in guiding prolonged cardiac monitoring after stroke

Efficiency of management of sustainable development – challenges, problems, barriers

This paper discusses such issues as the importance of efficiency management of sustainable development. In the authors’ opinion, this matter is currently topical subject due to, among others, on the still high costs of irrational management in the field. Dynamically changing environment forces to search for new solutions for efficiency management of sustainable development, and unfortunately, in many countries it is still a significant problem. For some countries, the efficiency management of sustainable development is difficult. It should be noted that the problem with the inaction of relevant activities of the countries in the field of development of efficiency management of sustainability development will grow, because globalization makes it necessary to generate new solutions emerging to date problems. Facing each country there are so many challenges in the field. However, some countries are aware of the seriousness of the problem and therefore take a number of measures in this regard, often regardless of the amount of costs. This has an impact on their competitiveness. Apparent is also increasing incorporation of new original solutions in the field of sustainable development management