Potenciación de las competencias en inglés técnico en los estudios de ingeniería industrial

Desde hace dos años se está incrementando la introducción de nuevos objetivos en forma de competencias de inglés técnico en los descriptores de algunas asignaturas de Proyectos, tanto en los estudios de primer como segundo ciclo en la titulación de Ingeniería Industrial que se imparte en la ETSEIAT (Escuela Técnica Superior de Ingenierías Industrial y Aeronáutica de Terrassa), adscrita a la Universidad Politécnica de Cataluña. En esta comunicación se describe el proceso seguido en estos años así como los resultados obtenidos y las nuevas propuestas a plantear en el futuro.Postprint (published version

ROLE OF TANKYRASE 1/2 IN THE HYPOXIC RESPONSE

Tankyrase 1 (TNKS1) and Tankyrase 2 (TNKS2) are two proteins that form a distinct subgroup inside the PARP family. Both TNKS share 82% of its sequence and have been linked to different cellular functions such as mitotic progression, glucose metabolism, stress granule formation and Wnt signaling. Furthermore, altered levels of TNKS1 and/or TNKS2 expression have been reported in several types of cancer such as colon, lung or brain. Both tankyrases synthesize linear chains of poly(ADP-ribose) (PAR) to produce posttranslational modifications of their target proteins and also itself through automodification. PARylation by TNKS appears to be tightly linked to ubiquitination by ubiquitin E3 ligases like RNF146. Deficient angiogenesis leads to tumor hypoxia resulting in increased aggressiveness and therapeutic resistance. The adaptation to this situation is carried out by the heterodimeric transcription factors hypoxia-inducible factor (HIF). In particular, the oxygen-dependent protein HIF-1/HIF-2 and the constitutively expressed protein HIF-1 are responsible for the induction of genes that allow the adaptation and survival of cells to hypoxia

Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification

Here we present the synthesis and post-polymerisation modification of poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: poly(acryloyl hydrazide) was prepared from commercially available starting materials in a three step synthesis on a large scale, in good yields and high purity. Our synthetic approach included the synthesis of a Boc-protected acryloyl hydrazide, the preparation of polymers via RAFT polymerisation and the deprotection of the corresponding Boc-protected poly(acryloyl hydrazide). Post-polymerisation modification of poly(acryloyl hydrazide) was then demonstrated using a range of conditions for both hydrophilic and hydrophobic aldehydes. These experiments demonstrate the potential of poly(acryloyl hydrazide) as a scaffold in the synthesis of functional polymers, in particular those applications where in situ screening of the activity of the functionalised polymers may be required (e.g. biological applications)This work was supported by the Royal Society, U.K (IE130688) and the Wellcome Trust (177ISSFPP). F. F.-T. thanks the Birmingham Science City and the European Regional Development Fund, the Royal Society (RG140273), and the University of Birmingham (John Evans Fellowship). J. M. thanks funding from MINECO (CTQ2014-59646-R, RYC-2013-1378) the Xunta de Galicia (ED431G/09 and 2016-AD031) and the ERC (Stg-DYNAP-677786)S

Degradable high Tg sugar-derived polycarbonates from isosorbide and dihydroxyacetone

Polycarbonates from isosorbide and dihydroxyacetone (DHA) have been synthesised using organocatalytic step-growth polymerization of their corresponding diols and bis-carbonylimidazolide monomers. By the choice of the feed ratio and monomer activation, either isosorbide or ketal protected DHA, random and alternating poly(Iso-co-DHA) carbonates have been formed. Thermal properties by DSC and TGA were herein strongly correlated to the monomer composition. Dilution studies using 1H-NMR spectroscopy of a model compound DHA-diethyl carbonate in CD3CN and D2O highlighted the influence of alfa-substituents on the keto/hydrate equilibrium of DHA. Further kinetics studies in the pH* range of 4.7 to 9.6 serve to show the hydrolytic pH-profile of DHA-carbonates. The hydrolytic degradation of deprotected polymer pellets shows an increased degradation with increasing DHA content. Pellets with a random or alternating configuration show different characteristics in terms of mass loss and molecular weight loss profile over time

Convertidor Cc-Cc Reductor Síncrono con Red de Cancelación de Rizado para un Amplificador de Envolvente de Alto Ancho de Banda y Alto Rendimiento

En este artículo se presenta un convertidor CC-CC de una etapa para un amplificador de envolvente de alto rendimiento y alto ancho de banda. Se ha aplicado la técnica de cancelación de rizado a un convertidor reductor síncrono para cancelar el rizado de corriente de salida y así poder disminuir la frecuencia de conmutación sin una reducción en el ancho de banda de gran señal. Se ha modelado el convertidor reductor con red de cancelación de rizado y se detalla el nuevo diseño del mismo, presentándose las ventajas del diseño propuesto así como la validación experimental. La función de transferencia del filtro de salida del convertidor reductor con red de cancelación de rizado se ha modelado y comparado con medidas experimentales, mostrando una buena correspondencia. Se ha validado experimentalmente el diseño propuesto para una frecuencia de conmutación de 4MHz para tensión de salida continua y con una referencia inusoidal. Asimismo, se incluye una validación experimental adicional, donde se compara el rendimiento de esta solución con el del diseño equivalente (mismo ancho de banda y rizado de tensión de salida) del convertidor reductor síncrono convencional

Analysis and Design Considerations for the Right Half -Plane Zero Cancellation on a Boost Derived dc/dc Converter

A boost derived topology, the two inductor boost with switch near ground presents some advantages over the conventional boost topology like continuous output current and MOSFET near ground [1]. The main advantage of this new topology is that the right half-plane (RHP) zero (inherent to the boost topology) can be cancelled by means of a new energy transference principle. This work presents a dynamic study of the topology and it shows that the RHP zero cancellation is not achieved for all design cases. The aim of this work is to develop a model for this topology in order to analyze the design requirements to obtain the RHP zero cancellation. A design condition has been derived from the dynamic analysis for achieving minimum phase characteristics on the new boost topology. The model and conclusions have been validated by means of an actual prototype. Considerations about the influence of the theoretical condition on the design and the field of application of this topology are shown in this paper

Ripple cancellation technique applied to a synchronous buck converter to achieve very high bandwidth and very high efficiency envelope amplifier

This work presents a single stage converter for a high bandwidth and a high efficiency envelope amplifier. The current ripple cancellation technique is applied to a synchronous buck converter to cancel the output current ripple and to decrease the switching frequency without a reduction in the large signal bandwidth. The converter is modeled and the new design with ripple cancellation circuit is detailed. The advantages of the proposed design are presented and validated experimentally. The transfer function of the output filter of the buck converter with ripple cancellation circuit has been modeled and compared to measurements, showing a good correspondence. Experimental validation is provided at 4MHz of switching frequency for DC and variable output voltage for a sinusoidal and a 64QAM signal. Additional experimental validation of the efficiency improvement is provided, compared to the equivalent design (same bandwidth and output voltage ripple) of the conventional buck converter

Analysis of local extinction of a n-heptane spray flame using large-eddy simulation with tabulated chemistry

This work is focused on the study of flame stabilization and local extinction of a spray flame in an atmospheric non-swirled test rig referred to as the CORIA Rouen Spray Burner. This burner shows a double reaction front structure, with an outer laminar diffusion flame and an inner wrinkled partially-premixed flame undertaking local extinction. This unsteady phenomenon is investigated here using large-eddy simulations with a tabulated chemistry method based on steady and unsteady diffusion flamelets with heat loss. A validation of the numerical simulations is conducted first for the carrier and dispersed phase and good agreement with the experimental data is found for mean and fluctuating quantities. The present results were able to predict relevant parameters of the flame like the lift-off length and flame shape. Numerical results evidence some intermittency on the OH concentration with the presence of high values of formaldehyde indicating the existence of localized extinction in the leading edge of the flame. A detailed analysis showed the impact of droplets on the reacting layer and the existence of rich pockets quenching the flame front. Further downstream, it was shown that when the scalar dissipation rate reaches high values near the reaction zone, the flame front becomes thinner and wrinkled until it eventually quenches. The numerical results evidence that the applied tabulated chemistry method is capable of capturing the local extinction and re-ignition events occurring in the inner layer.This work was partially funded by the Spanish Ministerio de Econom´ıa y Competitividad within the frame of the CHEST (TRA2017-89139-C2-1-R) project. BSC also acknowledges the funding from the CoEC project through the European Union’s Horizon 2020 research and innovation programme under grant agreement No 952181. Authors acknowledge the computer resources at Marenostrum and the technical support provided by Barcelona Supercomputing Center (BSC) (IM-2019-3-0025, IM-2020-1-0017, IM-2020-2-0026). Authors also thank the access to the CRSB database kindly provided by Prof. B. Renou.Peer ReviewedPostprint (author's final draft

High Efficiency Power Amplifier Based on Envelope Elimination and Restoration Technique

Due to complex envelope and phase modulation employed in modern transmitters it is necessary to use power amplifiers that have high linearity. Linear power amplifiers (classes A, B and AB) are commonly used, but they suffer from low efficiency especially if the transmitted signal has high peak to average power ratio (PAPR). Kahn's technique based on envelope elimination and restoration (EER) is based on idea that high efficiency power supply (envelope amplifier) could be used to modulate the envelope of high efficient non linear power amplifiers (classes D or E). This paper presents solutions for power amplifier that performs envelope modulation and class E amplifier that is used as a non linear amplifier. The envelope amplifier is implemented as a multilevel converter in series with linear regulator and can provide up to 100 W of instantaneous power and reproduce 2 MHz sine wave. The implemented Class E amplifier can operate at 120 MHz with efficiency near to 85%. The envelope amplifier and class E amplifier have been integrated and efficiency and linearity of the implemented transmitter has been measured and presente

Multilevel Power Supply for High Efficiency RF Amplifiers

In radio systems linear power amplifiers (class A, B or AB) are usually used as a solution for the power amplifier stage. These amplifiers have high linearity, but suffer from low efficiency when the transmitted signal has low peak-to-average power ratio. The Kahn envelope elimination and restoration (EER) technique is used to enhance efficiency of RF transmitters, by combining highly efficient, nonlinear RF amplifier (class D or E) with a highly efficient envelope amplifier in order to obtain linear and highly efficient RF amplifier. This paper presents a solution for the envelope amplifier based on a combination of multilevel converter and linear regulator. The proposed solution can reproduce any signal with maximal spectral component of 2 MHz and give instantaneous maximal power of 50 W. The efficiency measurements show that when the signals with low average value are transmitted, it has up to 15% higher efficiency than linear regulator that is used as a conventional solution. Additionally, the algorithm for selection of voltage levels for the multilevel converter is explained, as well