CARACTERIZAÇÃO EPIDEMIOLÓGICA E HISTOPATOLÓGICA DAS NEOPLASIAS MAMÁRIAS DE FELINOS EM FORTALEZA E REGIÃO METROPOLITANA

Mammary neoplasms are one of the three most neoplasms common types in female domestic cats, with an occurrence of 20 cases and a frequency of 33.90% in animals aged 10 to 12 years. Factors such as the use of hormones, pseudocyesis, obesity, and a diet rich in lipids in the young phase may be a part of the etiology of this pathologyin cats. There is a high rate of malignancy in most feline mammary tumors, most being carcinomas corresponding to 42.86% of the cases. The most common benign neoplasms are adenomas. The prognosis is reserved for most cats, and death is usually caused by clinical effects secondary to the progression of the local disease (disease located in the mammarychain) or due to metastatic spread to vital organs. Thus, the diagnosis is of extreme importance for a good prognosis. The present work aimed at the epidemiological and histopathological characterization of mammary neoplasms in felines in the city of Fortaleza and its metropolitan region, analyzing data from 59 histopathological exams of mammary tissue samples of this species.As neoplasias mamárias são um dos três tipos neoplásicos mais frequentes nas fêmeas de gatos domésticos, sendo observada a ocorrência de 20 casos e frequência de 33,90% em animais com idade de 10 a 12 anos. Fatores como a utilização de hormônios, pseudociese, obesidade e alimentação rica em lipídeos na fase jovem podem estar envolvidos na etiologia desta patologia mamária em gatas. Existe um alto índice de malignidade na maioria dos tumores mamários felinos, sendo a maior parte carcinomas com 42,86% dos casos verificados. As neoplasias benignas mais comuns são os adenomas. O prognóstico é reservado para a maioria das gatas, sendo a morte geralmente causada por efeitos clínicos secundários à progressão da doença local (doença localizada na cadeia mamária) ou devido à disseminação metastática para órgãos vitais. Desta forma, o diagnóstico é de extrema importância para um bom prognóstico. O presente trabalho teve como objetivo a caracterização epidemiológica e histopatológica das neoplasias mamárias em felinos no município de Fortaleza e região metropolitana, fazendo uma análise de dados de 59 exames histopatológicos de amostras de tecido mamário desta espécie

AMPUTAÇÃO DE TIBIOTARSO DEVIDO Á FRATURA EXPOSTA EM PERIQUITO-RICO

The increase of urbanization in Brazil near native forest areas has led to great risk factors for most birds, especially when it comes to building the nest. Most birds that live in big cities use different materials such as wires, plastic pieces, but mostly construction materials that are available near their nesting areas, which may lead to offspring damage and eventually death threatening situations. The present work reports an amputation and a fracture of the posterior limb, in a specimen of free-living plain parakeet, attended by a veterinary clinic specialized in wild animals. The bird was found on the ground with wires wrapped around its left posterior limb, that caused compression and led to an amputation.The increase of urbanization in Brazil near native forest areas has led to great risk factors for most birds, especially when it comes to building the nest. Most birds that live in big cities use different materials such as wires, plastic pieces, but mostly construction materials that are available near their nesting areas, which may lead to offspring damage and eventually death threatening situations. The present work reports an amputation and a fracture of the posterior limb, in a specimen of free-living plain parakeet, attended by a veterinary clinic specialized in wild animals. The bird was found on the ground with wires wrapped around its left posterior member, that caused compression and led to an amputation

Immunity to Lutzomyia intermedia Saliva Modulates the Inflammatory Environment Induced by Leishmania braziliensis

Transmission of Leishmania parasites occurs during blood feeding, when infected female sand flies inject humans with parasites and saliva. Chemokines and cytokines are secreted proteins that regulate the initial immune responses and have the potential of attracting and activating cells. Herein, we studied the expression of such molecules and the cellular recruitment induced by salivary proteins of the Lutzomyia intermedia sand fly. Of note, Lutzomyia intermedia is the main vector of Leishmania braziliensis, a parasite species that causes cutaneous leishmaniasis, a disease associated with the development of destructive skin lesions that can be fatal if left untreated. We observed that L. intermedia salivary proteins induce a potent cellular recruitment and modify the expression profile of chemokines and cytokines in mice. More importantly, in mice previously immunized with L. intermedia saliva, the alteration in the initial inflammatory response was even more pronounced, in terms of the number of cells recruited and in terms of gene expression pattern. These findings indicate that an existing immunity to L. intermedia sand fly induces an important modulation in the initial immune response that may, in turn, promote parasite multiplication, leading to the development of cutaneous leishmaniasis

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

Regulatory T Cells Phenotype in Different Clinical Forms of Chagas' Disease

CD25High CD4+ regulatory T cells (Treg cells) have been described as key players in immune regulation, preventing infection-induced immune pathology and limiting collateral tissue damage caused by vigorous anti-parasite immune response. In this review, we summarize data obtained by the investigation of Treg cells in different clinical forms of Chagas' disease. Ex vivo immunophenotyping of whole blood, as well as after stimulation with Trypanosoma cruzi antigens, demonstrated that individuals in the indeterminate (IND) clinical form of the disease have a higher frequency of Treg cells, suggesting that an expansion of those cells could be beneficial, possibly by limiting strong cytotoxic activity and tissue damage. Additional analysis demonstrated an activated status of Treg cells based on low expression of CD62L and high expression of CD40L, CD69, and CD54 by cells from all chagasic patients after T. cruzi antigenic stimulation. Moreover, there was an increase in the frequency of the population of Foxp3+ CD25HighCD4+ cells that was also IL-10+ in the IND group, whereas in the cardiac (CARD) group, there was an increase in the percentage of Foxp3+ CD25High CD4+ cells that expressed CTLA-4. These data suggest that IL-10 produced by Treg cells is effective in controlling disease development in IND patients. However, in CARD patients, the same regulatory mechanism, mediated by IL-10 and CTLA-4 expression is unlikely to be sufficient to control the progression of the disease. These data suggest that Treg cells may play an important role in controlling the immune response in Chagas' disease and the balance between regulatory and effector T cells may be important for the progression and development of the disease. Additional detailed analysis of the mechanisms on how these cells are activated and exert their function will certainly give insights for the rational design of procedure to achieve the appropriate balance between protection and pathology during parasite infections

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost