Evolution of the screening program for congenital hypothyroidism and phenylketonuria in Sergipe State from 1995 to 2003

Avaliamos o tempo gasto nas diferentes etapas do Programa de Triagem para o Hipotireoidismo Congênito (HC) e Fenilcetonúria (PKU), sua cobertura e a freqüência em Sergipe, de 1998 a 2003, e comparamos com 1995. A idade da criança na coleta foi 12 ± 11 dias (Média ± Desvio Padrão) em 2003, inferior aos 30 ± 19 dias no 2o semestre de 1995. No 2o semestre/2003, o resultado foi analisado pelo médico com 28 ± 15 dias para o HC e 25 ± 15 dias para o PKU, menor que o tempo utilizado pelo médico no 2o semestre de 1995, 80 ± 40 dias. O tempo, no 2o semestre de 2003, entre o recebimento da amostra da coleta no laboratório e a realização do ensaio foi de 6 ± 4 dias para o TSH e de 3 ± 2 dias para a fenilalanina. A cobertura, em 2003, para o Interior foi de 67% e 85% para a Capital contra 5% e 42% no 2o semestre de 1995, respectivamente. A incidência de 1998 a 2003, no Serviço Público de Saúde de Sergipe para o HC, foi de 1/4850 e para o PKU, de 1/23036. De 1998 a 2003, a terapia foi iniciada com 49 ± 17 e 51 ± 12 dias para o HC e PKU, respectivamente. A redução do tempo nas etapas do programa e o aumento da cobertura indicam uma evolução favorável do referido programa._________________________________________________________________________________________ ABSTRACT: An evaluation was made of the timing delays in the various phases of the Screening Program for Congenital Hypothyroidism (HC) and Phenylketonuria (PKU), the coverage and incidence in the State of Sergipe from 1998 to 2003. The results were compared to the data from 1995. The age of the children in the sampling was 12 ± 11 days (mean ± standard deviation) lower than the 30 ± 19 days in the second semester of 1995. In the second half of 2003, the results were analyzed by the physician after 28 ± 15 days for HC and 25 ± 15 days for PKU, lower than 80 ± 40 days for the second semester of 1995. The period between the receipt of the samples at the laboratory and the assay in the second half of 2003 was 6 ± 4 days for TSH and 3 ± 2 days for phenylalanine. The coverage in 2003 for the interior of the State and the Capital was 67% and 85%, compared with 5% and 42% in the second semester of 1995, respectively. The incidence from 1998 to 2003 in the Public Health Service of Sergipe for HC was 1/4928 and 1/23406 for PKU. From 1998 to 2003 the therapy was initiated after 49 ± 17 days and 51 ± 12 days for HC and PKU, respectively. The reduction in the program timing delays and the increase in the coverage indicate development in the referred program

ESTRATÉGIAS DE MARKETING APLICADAS Á FARMÁCIA UNIVERSITÁRIA IRMÃ DULCE DO CENTRO UNIVERSITÁRIO CATÓLICA DE QUIXADÁ

O marketing é considerado uma das áreas extremamente abrangentes e seu significado pode gerar muitas dúvidas, porém, atua como ferramenta fundamental e indispensável para o sucesso dos negócios e o bom relacionamento entre empresa e consumidor. “Farmácia Comunitária” trata-se de estabelecimentos farmacêuticos não hospitalares e não ambulatoriais que recebem à comunidade. No ramo da saúde em específico das ciências farmacêuticas, envolve variáveis de peso como a comunicação adequada. Diante disso este estudo tem como objetivo desenvolver estratégias de marketing e aplica-las a favor de uma Farmácia Universitária de uma Instituição de Ensino Superior (IES) do município de Quixadá-CE. O presente trabalho caracteriza-se como uma pesquisa aplicada de caráter transversal e abordagem descritiva. Sendo assim, se fará uso da técnica de coleta de dados através de um questionário semiestruturado com os acadêmicos a fim de obter informações sobre seu grau de conhecimento sobre os serviços de farmácia da instituição. A amostragem será composta pelo primeiro e último semestre dos cursos da saúde, no período de 2018 a 2019. Os resultados obtidos do questionário será ferramenta para corroborar com a justificativa do estudo

Construction of an Ophthalmological Calendar for the Therapeutic Follow-Up of Glaucoma in the Elderly

Abstract: Health teams in primary care play a key role in the eye health of users as they understand that early identification of any visual change can result in satisfactory outcomes and better prognoses, preventing damage that is often irreversible to health. Building an ophthalmological calendar for the therapeutic follow-up of glaucoma in the elderly, this is a methodological study, as the process of constructing the calendar’s content followed the Raymundo theoretical framework. The calendar was built in the following steps: bibliographic survey, content development, transformation of the language of scientific information into easy-to-understand expressions, creation and production of illustrations of the first draft, evaluation of the first draft made by the examining board, diagramming and presentation of the product. The construction of the calendar covers a specific theme for the elderly with glaucoma, which emphasizes the need to invest more in the inclusion of new technologies that will provide greater effectiveness and adherence of the user and the health team for the management of comprehensive care. The implementation of the produced calendar will allow for a better understanding and bond between the team professionals and the user and, consequently, a better monitoring of the therapeutic process of the patient involved.info:eu-repo/semantics/publishedVersio

Valorization of sugarcane by-products through synthesis of biogenic amorphous silica microspheres for sustainable cosmetics

Ashes from sugarcane by-product incineration were used to synthesize silica powders through alkaline hot extraction, followed by ethanol/acid precipitation or the sol–gel method. Both production methods allowed amorphous spherical silica microparticles with sizes ranging from 1–15 μm and 97% purity to be obtained. Water absorption ranged from 135–155 mL/100 g and 150–250 mL/100 g for precipitated silica and silica gel, respectively, while oil absorption ranged from 305 to 390 and from 250 to 350 mL/100 g. The precipitation with ethanol allowed the recovery of 178 g silica/kg ash, with a lab process cost of EUR 28.95/kg, while the sol-gel process showed a yield of 198 g silica/kg ash with a cost of EUR 10.89/kg. The experimental data suggest that ash from sugarcane by-products is a promising source to be converted into a competitive value-added product, minimizing the environmental impact of disposal problems.info:eu-repo/semantics/publishedVersio

CD44v6 high membranous expression is a predictive marker of therapy response in gastric cancer patients

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).In gastric cancer (GC), biomarkers that define prognosis and predict treatment response remain scarce. We hypothesized that the extent of CD44v6 membranous tumor expression could predict prognosis and therapy response in GC patients. Two GC surgical cohorts, from Portugal and South Korea (n = 964), were characterized for the extension of CD44v6 membranous immuno-expression, clinicopathological features, patient survival, and therapy response. The value of CD44v6 expression in predicting response to treatment and its impact on prognosis was determined. High CD44v6 expression was associated with invasive features (perineural invasion and depth of invasion) in both cohorts and with worse survival in the Portuguese GC cohort (HR 1.461; 95% confidence interval 1.002-2.131). Patients with high CD44v6 tumor expression benefited from conventional chemotherapy in addition to surgery (p < 0.05), particularly those with heterogeneous CD44v6-positive and -negative populations (CD44v6_3+) (p < 0.007 and p < 0.009). Our study is the first to identify CD44v6 high membranous expression as a potential predictive marker of response to conventional treatment, but it does not clarify CD44v6 prognostic value in GC. Importantly, our data support selection of GC patients with high CD44v6-expressing tumors for conventional chemotherapy in addition to surgery. These findings will allow better stratification of GC patients for treatment, potentially improving their overall survival.This work was funded by FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020–Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT–Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). This work was also financed by the projects NORTE-01-0145-FEDER-000003 and NORTE-01-0145-FEDER-000029, supported by the Norte Portugal Regional Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); project POCI-01-0145-FEDER-016390 and SAICTPAC/0022/2015, funded by ERDF, POCI, and FCT; project PTDC/CTM-NAN/120958/2010, from FCT; and by project PTDC/BTM-TEC/30164/2017 funded by ERDF funds through the COMPETE 2020–POCI, Portugal 2020, and by FCT. Salary support to G.M.A. by PTDC/BTM-TEC/30164/2017 project; C.P. was supported by the grant SFRH/BD/113031/2015 from FCT.info:eu-repo/semantics/publishedVersio