1,034 research outputs found
PMH37 COST-EFFECTIVENESS OF PREGABALIN VERSUS USUAL CARE IN DULOXETINE-REFRACTORY OUT-PATIENTS WITH GENERALIZED ANXIETY DISORDER: AN ECONOMIC EVALUATION UNDER MEDICAL USUAL PRACTICE IN MENTAL HEALTH CENTERS
Elementos móviles: ¿Ventaja evolutiva o parasitismo molecular?
Las secuencias de ADN repetidas–dispersas constituyen una elevada proporción del genoma de organismos eucariotasy procariotas. La primera descripción de movilidad de estas secuencias fue realizada por Barbara McClintock enlos años 50, la cual, estudiando la herencia del color y distribución de la pigmentación del maíz, demostró laexistencia de elementos genéticos con capacidad de transponerse. En el presente trabajo se realiza una revisiónde las características moleculares, filogenéticas y funcionales de los elementos móviles, centrada especialmente enlos elementos LINE. El análisis de la presencia de elementos móviles en los organismos hospedadores, muestra queestos evolucionan coincidentemente con el hospedador para evitar o mitigar el efecto deletéreo de su inserción eincluso para proporcionarle beneficio. Actualmente, se está empezando a considerar que estos elementos jueganun importante papel en la evolución de los organismos, probablemente como resultado del desarrollo de unarelación simbiótica con su hospedador
Comorbilidad y esquizofrenia .
Hemos estudiado 19 variables de la información contenida en 199 dosieres de pacientes diagnosticados de esquizofrenia e ingresados en nuestro hospital en dos trienios diferentes: 1977 a 1979 y 1990 a 1992. También, con el fin de estudiar la frecuentación de los Servicios de Salud Mental (SSM) de toxicómanos, hemos realizado una encuesta entre 90 pacientes que son tratados en los Centros de Atención al Drogodependiente (CAD). Ha habido una sustitución casi total del alcohol por las drogas ilegales y los consumidores de sustancias presentan más síntomas tanto positivos como negativos que el resto de los pacientes no consumidores
Comorbilidad y esquizofrenia .
Hemos estudiado 19 variables de la información contenida en 199 dosieres de pacientes diagnosticados de esquizofrenia e ingresados en nuestro hospital en dos trienios diferentes: 1977 a 1979 y 1990 a 1992. También, con el fin de estudiar la frecuentación de los Servicios de Salud Mental (SSM) de toxicómanos, hemos realizado una encuesta entre 90 pacientes que son tratados en los Centros de Atención al Drogodependiente (CAD). Ha habido una sustitución casi total del alcohol por las drogas ilegales y los consumidores de sustancias presentan más síntomas tanto positivos como negativos que el resto de los pacientes no consumidores
Long acting risperidone in Australian patients with chronic schizophrenia: 24-month data from the e-STAR database
<p>Abstract</p> <p>Background</p> <p>This observational study was designed to collect treatment outcomes data in patients using the electronic Schizophrenia Treatment Adherence Registry (e-STAR).</p> <p>Methods</p> <p>Patients with schizophrenia or schizoaffective disorder in Australia who were prescribed risperidone long-acting injection (RLAI) between 2003 and 2007 were assessed 12-months retrospectively, at baseline and 24-months prospectively at 3-monthly intervals. The intent-to-treat population, defined as all patients who received at least one dose of RLAI at baseline, was used for the efficacy and safety analyses.</p> <p>Results</p> <p>At total of 784 patients (74% with schizophrenia, 69.8% male) with a mean age of 37.1 ± 12.5 years and 10.6 ± 9.5 years since diagnosis were included in this Australian cohort. A significant improvement in mean Clinical Global Impression - severity score was observed at 24-months (4.52 ± 1.04 at baseline, 3.56 ± 1.10 at 24-months). Most of this improvement was seen by 3-months and was also reflected in mean Global Assessment of Functioning score, which improved significantly at 24-months (42.9 ± 14.5 at baseline, 59 ± 15.4 at 24-months). For patients still receiving RLAI at 24-months there was an increase from a mean baseline RLAI dose of 26.4 ± 5 mg to 43.4 ± 15.7 mg. Sixty-six percent of patients discontinued RLAI before the 24-month period--this decreased to 46% once patients lost to follow-up were excluded.</p> <p>Conclusion</p> <p>Over the 24-month period, initiation of RLAI was associated with improved patient functioning and illness severity in patients with schizophrenia or schizoaffective disorder. Improved outcomes were observed early and sustained throughout the study.</p> <p>Trial Registration</p> <p>Clinical Trials Registration Number, <a href="http://www.clinicaltrials.gov/ct2/show/NCT00283517">NCT00283517</a>.</p
Recommended from our members
Serological profile of first SARS-CoV-2 reinfection cases detected within the SIREN study.
OBJECTIVES: To describe the serological profile of first two SARS-CoV-2 confirmed reinfections in the national healthcare worker cohort study SARS-CoV-2 Immunity and Reinfection Evaluation (SIREN) and potentially identify correlates of protection against reinfection. METHODS: In addition to routine testing within the SIREN study, viral culture, sequencing and phylogenetic analysis were performed. Total antibody testing (Anti-SARS-CoV-2 nucleocapsid and Anti-SARS-CoV-2 spike) were complemented by receptor binding domain indirect ELISA and neutralising antibody assays. RESULTS: The first two SARS-CoV-2 confirmed reinfections had mild symptomatic illness episodes from which infectious virus was recovered at the time of reinfection. The recovered viruses and their sequences were closely related to viruses circulating locally during the time of reinfection and serology was consistent with reinfection. Prior to reinfection, both cases had ELISA and immunoblot detectable anti-N antibodies, but lacked live virus neutralising antibody. Within days following reinfection, neutralising antibodies became detectable and anti-N and anti-S binding antibodies were boosted. CONCLUSIONS: We hypothesise that titres of neutralising antibody can be used as a correlate of protection against reinfection. Further analysis using a case-control design is essential in order to confirm this hypothesis
Efficacy of different strategies to treat anemia in children: a randomized clinical trial
<p>Abstract</p> <p>Background</p> <p>Anemia continues to be a major public health problem among children in many regions of the world, and it is still not clear which strategy to treat it is most effective.</p> <p>Objective</p> <p>To evaluate the efficacy and children's acceptance of several recognized strategies to treat anemia.</p> <p>Methods</p> <p>Non-breastfed children (n = 577), 6 to 43 mo of age, were screened for the trial; 267 were anemic (hemoglobin < 11.7 g/dL), and 266 of those were randomized into 1 of 5 treatments to received daily either: an iron supplement (IS), an iron+folic acid supplement (IFS), a multiple micronutrient supplement (MMS), a micronutrient-fortified complementary food as porridge powder (FCF), or zinc+iron+ascorbic acid fortified water (FW). The iron content of each daily dose was 20, 12.5, 10, 10 and 6.7 mg respectively. Hemoglobin (Hb), ferritin, total iron, weight and height were measured at baseline and after 4 months of treatment. Morbidity, treatment acceptability and adherence were recorded during the intervention.</p> <p>Results</p> <p>All treatments significantly increased Hb and total iron concentration; ferritin did not change significantly. Groups MMS, IS and IFS increased Hb (g/dL) [1.50 (95%CI: 1.17, 1.83), 1.48 [(1.18, 1.78) and 1.57 (1.26, 1.88), respectively] and total iron ((μg/dL) [0.15 (0.01, 0.29), 0.19 (0.06, 0.31) and 0.12(-0.01, 0.25), respectively] significantly more than FCF [0.92 (0.64, 1.20)] but not to FW group [0.14 (0.04, 0.24)]. The prevalence of anemia was reduced to a greater extent in the MMS and IFS groups (72% and 69%, respectively) than in the FCF group (45%) (p < 0.05). There were no significant differences in anthropometry or in the number of episodes of diarrhea and respiratory infections among treatment groups. The supplements MMS and IS were less acceptable to children, than IFS, FCF and FW.</p> <p>Conclusion</p> <p>The three supplements IS, ISF and MMS increased Hb more than the FCF; the supplements that contained micronutrients (IFS and MMS) were more effective for reducing the prevalence of anemia. In general, fortified foods were better accepted by the study participants than supplements.</p> <p>ClinicalTrial.gov Identifier</p> <p>NCT00822380</p
ASASSN-15lh: The Most Luminous Supernova Ever Discovered
We report the discovery and early evolution of ASASSN-15lh, the most luminous supernova ever found. At redshift z=0.2326, ASASSN-15lh reached an absolute magnitude of M_{u,AB} ~ -23.5 and bolometric luminosity L_bol ~ 2.2x10^45 ergs/s, which is >~ 2 times more luminous than any previously known supernova. Its spectra match the hydrogen-poor sub-class of super-luminous supernovae (SLSNe-I), whose energy sources and progenitors are poorly understood. In contrast to known SLSNe-I, most of which reside in star-forming, dwarf galaxies, its host appears to be a luminous galaxy (M_V ~ -22; M_K ~ -25.1) with little star formation. In the two months since its first detection, ASASSN-15lh has radiated ~7.5x10^51 ergs, challenging the popular magnetar model for the engine of SLSNe-I
Micromechanical study of the load transfer in a polycaprolactone-collagen hybrid scaffold when subjected to unconfined and confined compression
Scaffolds are used in diverse tissue engineering applications as hosts for cell proliferation and extracellular matrix formation. One of the most used tissue engineering materials is collagen, which is well known to be a natural biomaterial, also frequently used as cell substrate, given its natural abundance and intrinsic biocompatibility. This study aims to evaluate how the macroscopic biomechanical stimuli applied on a construct made of polycaprolactone scaffold embedded in a collagen substrate translate into microscopic stimuli at the cell level. Eight poro-hyperelastic finite element models of 3D printed hybrid scaffolds from the same batch were created, along with an equivalent model of the idealized geometry of that scaffold. When applying an 8% confined compression at the macroscopic level, local fluid flow of up to 20 [Formula: see text]m/s and octahedral strain levels mostly under 20% were calculated in the collagen substrate. Conversely unconfined compression induced fluid flow of up to 10 [Formula: see text]m/s and octahedral strain from 10 to 35%. No relevant differences were found amongst the scaffold-specific models. Following the mechanoregulation theory based on Prendergast et al. (J Biomech 30:539-548, 1997. https://doi.org/10.1016/S0021-9290(96)00140-6 ), those results suggest that mainly cartilage or fibrous tissue formation would be expected to occur under unconfined or confined compression, respectively. This in silico study helps to quantify the microscopic stimuli that are present within the collagen substrate and that will affect cell response under in vitro bioreactor mechanical stimulation or even after implantation
- …