Are the Narrow Line Regions in Active Galaxies Dusty and Radiation Pressure Dominated?

The remarkable similarity between emission spectra of narrow line regions (NLR) in Seyfert Galaxies has long presented a mystery. In photoionization models, this similarity implies that the ionization parameter is nearly always the same, about U ~ 0.01. Here we present dusty, radiation-pressure dominated photoionization models that can provide natural physical insight into this problem. In these models, dust and the radiation pressure acting on it provide the controlling factor in moderating the density, excitation and surface brightness of photoionized NLR structures. Additionally, photoelectric heating by the dust is important in determining the temperature structure of the models. These models can also explain the coexistence of the low-, intermediate- and coronal ionization zones within a single self-consistent physical structure. The radiation pressure acting on dust may also be capable of driving the fast (~3000 km/s) outflows such as are seen in the HST observations of NGC 1068.Comment: 23 pages, 8 figures, Accepted by Ap

Dusty, Radiation Pressure Dominated Photoionization. I. Model Description, Structure And Grids

We present the implementation of dusty, radiation pressure dominated photoionization models applicable to the Narrow Line Regions (NLRs) of Active Galactic Nuclei, using the \mapiii code. We give a grid of the predicted intensities of the most commonly used diagnostic spectral lines in the UV, optical and IR, covering a wide range of density, metallicity, the power-law index characterizing the photoionizing source and photoionization parameter, for use in the diagnosis of NLRs. We examine the temperature, density and ionization structure of these models, investigating the effect of variation of these parameters in order to gain a better understanding of NLR clouds themselves.Comment: Accepted by ApJS, full pdf including figures can be found at http://www.mso.anu.edu.au/~bgroves/Papers/ApJS1.pd

From transplant to novel cellular therapies in multiple myeloma: EMN guidelines and future perspectives.

Survival of myeloma patients has greatly improved with the use of autologous stem cell transplantation and novel agents, such as proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies. Compared to bortezomib- and lenalidomide-based regimens alone, the addition of high-dose melphalan followed by autologous transplantation significantly improves progression-free survival; although an overall survival benefit was not observed in all trials. Moreover, follow-up of recent trials is still too short to show any difference in survival. In the light of these findings, novel agent-based induction followed by autologous transplantation is considered the standard upfront treatment for eligible patients (level of evidence: 1A). Post-transplant consolidation and maintenance treatment can further improve patient outcome (1A). The availability of several novel agents has led to the development of multiple combination regimens as salvage treatment options. In this context, the role of salvage autologous transplantation and allotransplant have not been extensively evaluated. In case of prolonged remission after upfront autologous transplantation, another autologous transplantation at relapse can be considered (2B). Patients who experience early relapse and/or have high-risk features have a poor prognosis and may be considered as candidates for clinical trials that - in young and fit patients - may also include an allograft in combination with novel agents (2B). Ongoing studies are evaluating the role of novel cellular therapies, such as inclusion of antibody-based triplets and quadruplets and Chimeric Antigen Receptor-T cells: despite preliminary encouraging results, longer follow-up and larger patient numbers are needed before their clinical use can be widely recommended

Confluence for classical logic through the distinction between values and computations

International audienceWe apply an idea originated in the theory of programming languages - monadic meta-language with a distinction between values and computations - in the design of a calculus of cut-elimination for classical logic. The cut-elimination calculus we obtain comprehends the call-by-name and call-by-value fragments of Curien-Herbelin's lambda-bar-mu-mu-tilde-calculus without losing confluence, and is based on a distinction of "modes" in the proof expressions and "mode" annotations in types. Modes resemble colors and polarities, but are quite different: we give meaning to them in terms of a monadic meta-language where the distinction between values and computations is fully explored. This meta-language is a refinement of the classical monadic language previously introduced by the authors, and is also developed in the paper

Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study.

AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study, we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging. METHODS AND RESULTS: A total of 449 (mean age: 45.8 +/- 13.7 years) healthy volunteers (198 men and 251 women) were enrolled at the collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was obtained from all subjects following predefined protocols. The majority of the Doppler diastolic parameters (e', E/e') as well as right ventricle systolic s' wave velocity were similar in men and women. Left ventricle s' wave velocity was higher in men than in women. E wave and e' were higher in younger subjects and decreased progressively in the older ones. E/e' ratio increased with ageing. Septal e' /=60 year group. However, the cut-off value of average E/e' or lateral E/e' remained <15 or 13, respectively, in the majority of patients. CONCLUSION: The NORRE study provides the reference values for the most useful Doppler parameters in the evaluation of heart physiology. These data highlight the need of using age-specific reference values especially for the diagnosis of LV systolic and diastolic dysfunction and for the estimation of LV filling pressures