Targeting Cutaneous Cannabinoid Signaling in Inflammation: a "High"-way to Heal?

K

„Aszpirinnel fogok áldozni” : Jancsó Miklós: Bayer-aszpirin, 1982 = „I will take Communion with Aspirin”. Miklós Jancsó: Bayer Aspirin, 1982)

Katalin Ladik’s self-focused, neo-avant-garde multimedia art and activity as a performance artist gives her a unique place among Hungarian actors and actresses in Vojvodina. Ottó Tolnai dedicated his monodrama Bayer Aspirin to her. The poetic text resisted the requirements of the psychological realist paradigm in almost every aspect, its dramaturgy and the weaving of its motivic web were guided by free associations, metaphors, metonymies, and poetic visions, rather than by its reduced plot. The text was staged by Miklós Jancsó at the Theatre of Novi Sad. Ladik described the performance as a “ritual happening” because its form was both “ritually bound and loosely performance-like.” As a performer, she often changed her stage gestures and vocalizations according to her emotional state of the moment. This monodrama was an important phase in her career, as her identity as a performer, actress, and poet interacted with each other

Subchondral bone remodeling patterns in larger animal models of meniscal injuries inducing knee osteoarthritis - a systematic review

Purpose Elucidating subchondral bone remodeling in preclinical models of traumatic meniscus injury may address clinically relevant questions about determinants of knee osteoarthritis (OA). Methods Studies on subchondral bone remodeling in larger animal models applying meniscal injuries as standardizing entity were systematically analyzed. Of the identifed 5367 papers reporting total or partial meniscectomy, meniscal transection or destabilization, 0.4% (in guinea pigs, rabbits, dogs, minipigs, sheep) remained eligible. Results Only early or mid-term time points were available. Larger joint sizes allow reporting higher topographical details. The most frequently reported parameters were BV/TV (61%), BMD (41%), osteophytes (41%) and subchondral bone plate thickness (39%). Subchondral bone plate microstructure is not comprehensively, subarticular spongiosa microstructure is well characterized. The subarticular spongiosa is altered shortly before the subchondral bone plate. These early changes involve degradation of subarticular trabecular elements, reduction of their number, loss of bone volume and reduced mineralization. Soon thereafter, the previously normal subchondral bone plate becomes thicker. Its porosity frst increases, then decreases. Conclusion The specifc human topographical pattern of a thinner subchondral bone plate in the region below both menisci is present solely in the larger species (partly in rabbits), but absent in rodents, an important fact to consider when designing animal studies examining subchondral consequences of meniscus damage. Large animal models are capable of providing high topographical detail, suggesting that they may represent suitable study systems refecting the clinical complexities. For advanced OA, signifcant gaps of knowledge exist. Future investigations assessing the subchondral bone in a standardized fashion are warranted