Anonymization of Sensitive Quasi-Identifiers for l-diversity and t-closeness

A number of studies on privacy-preserving data mining have been proposed. Most of them assume that they can separate quasi-identifiers (QIDs) from sensitive attributes. For instance, they assume that address, job, and age are QIDs but are not sensitive attributes and that a disease name is a sensitive attribute but is not a QID. However, all of these attributes can have features that are both sensitive attributes and QIDs in practice. In this paper, we refer to these attributes as sensitive QIDs and we propose novel privacy models, namely, (l1, ..., lq)-diversity and (t1, ..., tq)-closeness, and a method that can treat sensitive QIDs. Our method is composed of two algorithms: an anonymization algorithm and a reconstruction algorithm. The anonymization algorithm, which is conducted by data holders, is simple but effective, whereas the reconstruction algorithm, which is conducted by data analyzers, can be conducted according to each data analyzer’s objective. Our proposed method was experimentally evaluated using real data sets

Hepatocellular Carcinoma 11 and a Half Years after the Resolution of Chronic Hepatitis C Virus Infection Successfully Treated with Interferon

A 41-year-old Japanese man had received successful interferon (IFN) therapy against chronic hepatitis C in 1994. Since then, serum hepatitis C virus (HCV) RNA had been negative, and aminotransferase levels had been continuously normal. He had abstained from alcohol. However, his serum aminotransferase levels showed slight elevation as his body weight increased gradually. He was diagnosed as having fatty liver and diabetes mellitus. In January 2006, 11 and a half years after the resolution of HCV infection, he was found to have a hepatic nodule 4.0 cm in diameter at liver S4/8 region by plain abdominal CT at an annual follow-up examination. He was diagnosed as having hepatocellular carcinoma (HCC) by angiography. The tumor was curatively resected and its histological diagnosis was moderately differentiated HCC. Noncancerous lesion of the liver revealed fibrosis of stage F2 and mild inflammation of grade A1 with mild steatosis. This case suggests that all patients with chronic HCV infection should be followed as long as possible for the potential development of HCC even after clearance of the virus

National survey of catheter ablation for atrial fibrillation: The Japanese catheter ablation registry of atrial fibrillation (J-CARAF)

AbstractTo assess the current status of atrial fibrillation (AF) ablation in Japan, the Japanese Heart Rhythm Society (JHRS) instituted a national registry, the Japanese Catheter Ablation Registry of AF (J-CARAF).MethodsUsing an online questionnaire, the JHRS invited electrophysiology centers in Japan to voluntarily and retrospectively register data regarding the AF ablation procedures performed in September, 2011.ResultsA total of 128 centers submitted data regarding AF ablation procedures in 932 patients (age 62.1±10.4 years; male 76.8%; paroxysmal AF 65.7%, CHADS2 score 1.0±1.0). The majority received oral anticoagulant therapy during and following the procedure (68.9% and 97.5%, respectively). Pulmonary vein isolation (PVI) was performed in 97.5% of the patients; ipsilateral encircling PVI was the preferred technique (79.7%). Three-dimensional (3D) mapping systems and irrigated-tip catheters were used in 94.8% and 87.7% of the procedures, respectively. Ablation methods other than PVI were performed in 78.8% of all the patients and 73.5% of the patients with paroxysmal AF. Acute complications were reported in 6.2% of the patients, but no early deaths were recorded.ConclusionsIpsilateral encircling PVI, using 3D mapping and irrigated-tip catheters, is the standard AF ablation method in Japan. However, adjunctive ablations were performed frequently, even in patients with paroxysmal AF

A NEW OPERATIVE TECHNIQUE FOR ESOPHAGEAL RECONSTRUCTION USING A LONG GASTRIC TUBE OF 3 CM DIAMETER

The anthors have successfully prepared a 3 cm diameter gastric tube with a more favorable blood supply than the conventional one by performing interrupted suture each of the mucosal layers and seromuscular layers of the stomach separately with pyloromyotomy as a drainage procedure. This gastric tube caused no clavicular pressure on the anastomotic portion through a retrosternal route, so that we could perform end-to-end anastomosis between the cervical esophagus and the gastric tube in a region higher than the clavicle. We report in this paper the clinical findings of our procedure : it was effective in preventing postoperative complications such as suture insufficiency and passage disturbance other than postoperative complaints due to dumping and reflux esophagitis, etc

Prognostic significance of nonsustained ventricular tachycardia in patients receiving cardiac resynchronization therapy for primary prevention: Analysis of the Japan cardiac device treatment registry database

BackgroundWhether nonsustained ventricular tachycardia (NSVT) is a marker of increased risk of sustained ventricular tachyarrhythmias (VTAs) remains to be established in patients receiving cardiac resynchronization therapy with a defibrillator (CRT‐D) for primary prevention.MethodsAmong the follow‐up data of the Japan cardiac device treatment registry (JCDTR) with an implantation date between January 2011 and August 2015, information regarding a history of NSVT before the CRT‐D implantation for primary prevention had been registered in 269 patients. Outcomes were compared between two groups with and without NSVT: NSVT group (n = 179) and No NSVT group (n = 90).ResultsThere was no significant difference with regard to age, gender, and NYHA class between the two groups. Left ventricular ejection fraction (LVEF) was 25.6% in the NSVT group and 28.0% in the No NSVT group (P = .046). The rate of appropriate therapy at 24 months was 26.0% and 18.4% in the NSVT and No NSVT groups (P = .22), respectively. Survival free from heart failure death was reduced in the NSVT group, as compared with the No NSVT group, with the rate of 90.2% vs 97.2% at 24 months (P = .030). A multivariate analysis identified a history of NSVT, anemia, and no use of angiotensin‐converting enzyme inhibitor (ACEI) or angiotensin‐receptor blocker (ARB) as predictors of heart failure death.ConclusionsNSVT appears to be a surrogate marker of severe heart failure rather than a substrate for subsequent sustained VTAs in patients with CRT‐D for primary prevention

Increasing early insulin secretion compensate adequately for hepatic insulin resistance in CCl4-induced cirrhosis rats

A number of recent publications have reported an increased frequency prevalence of glucose intolerance with hyperinsulinemia in liver cirrhosis. The aim of this work was to detect, in CCl4-induced liver cirrhosis rat, the presence and starting point of muscle and liver insulin resistance. Eighteen rats received intraperitoneal injection of 2 ml of soybean oil containing of CCl4 twice a week for 20 weeks. We executed standard oral glucose tolerance and clamp study to evaluate systemic insulin resistance. Hepatic glucose uptake was much lower in CCl4 group than that in control group, but peripheral glucose uptake was not decreased in this study. In contrast, early-phase insulin secretion was enhanced in CCl4 rat using oral glucose load during clamp methods. These data suggested that increased early insulin secretion compensate adequately for hepatic insulin resistance in rats. However there was a report that peripheral glucose uptake was decreased in the case of human liver cirrhosis, which was formed in the course of time. In a chronic condition, this may be associated with reduced insulin content and developed systemic insulin resistance in liver cirrhosis. Then a long term observation study will be required to examine the presence of muscle insulin resistance in liver cirrhosis

Very Early Diuretic Response After Admission for Acute Heart Failure

BACKGROUND: In hospitalized heart failure patients, a poor diuretic response (DR) during the first days of hospital admission is associated with worse outcomes. However, it remains unknown whether diuretic response in the first hours has similar prognostic value. Moreover, data on the sequential change in DR during hospital admission are lacking. METHODS AND RESULTS: DR (urine output per 40 mg furosemide-equivalent diuretics dose) was measured from 0 to 6 hours (DR6), 6 to 48 hours (DR6-48), and 0 to 48 hours (DR48) of the patient's arrival to the emergency department (ED) in 1551 patients with AHF (mean age 78 years old; 56% were male; and 48% were de-novo patients with heart failure). Patients with a poor DR within the first 6 hours were older age, had worse renal function and were already on diuretic treatment before admission. DR6 was only weakly correlated with DR6-48 (Spearman's rho=0.273; p<0.001). DR6, DR6-48 and DR48 were all significantly associated with 60-day mortality independent of other prognostic factors. DR6 and DR48 showed comparable prognostic ability. However, the model combining DR6 with DR6-48 significantly exceeded both DR6 (NRI: 0.249, p=0.032) and DR48 (NRI: 0.287, p=0.025) with regard to 60-day mortality prediction. CONCLUSION: Both DR measured within the first 6 hours of ED arrival and DR measured during the first 48 hours in patients with AHF have similar prognostic value, although they were moderately correlated. Changes in DR over time provide additional prognostic information

Giant Molecular Clouds in the Spiral Arm of IC 342

We present results of 12CO (1--0) and 13CO (1--0) observations of the northeastern spiral arm segment of IC 342 with a ~50pc resolution carried out with the Nobeyama Millimeter Array. Zero-spacing components were recovered by combining with the existing data taken with the Nobeyama 45m telescope. The objective of this study is to investigate the variation of cloud properties across the spiral arm with a resolution comparable to the size of giant molecular clouds (GMCs). The observations cover a 1 kpc times 1.5 kpc region located ~2 kpc away from the galactic center, where a giant molecular association is located at trailing side and associated star forming regions at leading side. The spiral arm segment was resolved into a number of clouds whose size, temperature and surface mass density are comparable to typical GMCs in the Galaxy. Twenty-six clouds were identified from the combined data cube and the identified clouds followed the line width-size relation of the Galactic GMCs. The identified GMCs were divided into two categories according to whether they are associated with star formation activity or not. Comparison between both categories indicated that the active GMCs are more massive, have smaller line width, and are closer to virial equilibrium compared to the quiescent GMCs. These variations of the GMC properties suggest that dissipation of excess kinetic energy of GMC is a required condition for the onset of massive star formation.Comment: 17 pages, 13 figures, accepted for publication in Ap