Application of Artificial Neural Network to Search for Gravitational-Wave Signals Associated with Short Gamma-Ray Bursts

We apply a machine learning algorithm, the artificial neural network, to the search for gravitational-wave signals associated with short gamma-ray bursts. The multi-dimensional samples consisting of data corresponding to the statistical and physical quantities from the coherent search pipeline are fed into the artificial neural network to distinguish simulated gravitational-wave signals from background noise artifacts. Our result shows that the data classification efficiency at a fixed false alarm probability is improved by the artificial neural network in comparison to the conventional detection statistic. Therefore, this algorithm increases the distance at which a gravitational-wave signal could be observed in coincidence with a gamma-ray burst. In order to demonstrate the performance, we also evaluate a few seconds of gravitational-wave data segment using the trained networks and obtain the false alarm probability. We suggest that the artificial neural network can be a complementary method to the conventional detection statistic for identifying gravitational-wave signals related to the short gamma-ray bursts.Comment: 30 pages, 10 figure

Voltage-independent SK-channel dysfunction causes neuronal hyperexcitability in the hippocampus of Fmr1 knock-out mice

Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (

Investigating the local atmospheric response to a realistic shift in the Oyashio Sea surface Temperature Front

Author Posting. © American Meteorological Society, 2015. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 28 (2015): 1126–1147, doi:10.1175/JCLI-D-14-00285.1.The local atmospheric response to a realistic shift of the Oyashio Extension SST front in the western North Pacific is analyzed using a high-resolution (HR; 0.25°) version of the global Community Atmosphere Model, version 5 (CAM5). A northward shift in the SST front causes an atmospheric response consisting of a weak surface wind anomaly but a strong vertical circulation extending throughout the troposphere. In the lower troposphere, most of the SST anomaly–induced diabatic heating is balanced by poleward transient eddy heat and moisture fluxes. Collectively, this response differs from the circulation suggested by linear dynamics, where extratropical SST forcing produces shallow anomalous heating balanced by strong equatorward cold air advection driven by an anomalous, stationary surface low to the east. This latter response, however, is obtained by repeating the same experiment except using a relatively low-resolution (LR; 1°) version of CAM5. Comparison to observations suggests that the HR response is closer to nature than the LR response. Strikingly, HR and LR experiments have almost identical vertical profiles of . However, diagnosis of the diabatic quasigeostrophic vertical pressure velocity (ω) budget reveals that HR has a substantially stronger response, which together with upper-level mean differential thermal advection balances stronger vertical motion. The results herein suggest that changes in transient eddy heat and moisture fluxes are critical to the overall local atmospheric response to Oyashio Front anomalies, which may consequently yield a stronger downstream response. These changes may require the high resolution to be fully reproduced, warranting further experiments of this type with other high-resolution atmosphere-only and fully coupled GCMs.We gratefully acknowledge funding provided by NSF to DS and MN (AGS CLD 1035325) and Y-OK and CF (AGS CLD 1035423) and by DOE to Y-OK (DE-SC0007052).2015-08-0

Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs

Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroidal anti-inflammatory drugs (NSAIDs) have opened a new era for its prevention. This review focuses on the role of NSAIDs in pancreatitis, the pharmacokinetics of these agents, and summarizes the results of clinical trials with rectal NSAIDs alone and combination regimens in the prevention of post-ERCP pancreatitis

Pointing all around you : selection performance of mouse and ray-cast pointing in full-coverage displays

Funding: SurfNet (NSERC, Canada), EPSRC (Small Equipment Grant).As display environments become larger and more diverse - now often encompassing multiple walls and room surfaces - it is becoming more common that users must find and manipulate digital artifacts not directly in front of them. There is little understanding, however, about what techniques and devices are best for carrying out basic operations above, behind, or to the side of the user. We conducted an empirical study comparing two main techniques that are suitable for full-coverage display environments: mouse-based pointing, and ray-cast `laser' pointing. Participants completed search and pointing tasks on the walls and ceiling, and we measured completion time, path lengths and perceived effort. Our study showed a strong interaction between performance and target location: when the target position was not known a priori the mouse was fastest for targets on the front wall, but ray-casting was faster for targets behind the user. Our findings provide new empirical evidence that can help designers choose pointing techniques for full-coverage spaces.Postprin

Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning

Background In this study, we investigated the clinical characteristics of acute kidney injury (AKI) in patients with glyphosate surfactant herbicide (GSH) poisoning. Methods This study was performed between 2008 and 2021 and included 184 patients categorized into the AKI (n = 82) and non-AKI (n = 102) groups. The incidence, clinical characteristics, and severity of AKI were compared between the groups based on the Risk of renal dysfunction, Injury to the kidney, Failure or Loss of kidney function, and End-stage kidney disease (RIFLE) classification. Results The incidence of AKI was 44.5%, of which 25.0%, 6.5%, and 13.0% of patients were classified into the Risk, Injury, and Failure categories, respectively. Patients in the AKI group were older (63.3 ± 16.2 years vs. 57.4 ± 17.5 years, p = 0.02) than those in the non-AKI group. The length of hospitalization was longer (10.7 ± 12.1 days vs. 6.5 ± 8.1 days, p = 0.004) and hypotensive episodes occurred more frequently in the AKI group (45.1% vs. 8.8%, p < 0.001). Electrocardiographic (ECG) abnormalities on admission were more frequently observed in the AKI group than in the non-AKI group (80.5% vs. 47.1%, p < 0.001). Patients in the AKI group had poorer renal function (estimated glomerular filtration rate at the time of admission, 62.2 ± 22.9 mL/min/1.73 m2 vs. 88.9 ± 26.1 mL/min/1.73 m2, p < 0.001) on admission. The mortality rate was higher in the AKI group than in the non-AKI group (18.3% vs. 1.0%, p < 0.001). Multiple logistic regression analysis showed that hypotension and ECG abnormalities upon admission were significant predictors of AKI in patients with GSH poisoning. Conclusion The presence of hypotension on admission may be a useful predictor of AKI in patients with GSH intoxication