A characterization of 3-graded Lie algebras generated by a pair

AbstractWe prove that any 3-graded Lie algebra generated by an element of degree −1 and another of degree 1 over a field K of characteristic zero is isomorphic to a 3-graded Lie subalgebra of sl2(K[t]/(p(t)·K[t])) endowed with its usual 3-gradation, for some p(t)∈K[t]. We also give a thorough description of the ideals in the free case

Embryonic development of selectively vulnerable neurons in Parkinson's disease

A specific set of brainstem nuclei are susceptible to degeneration in Parkinson’s disease. We hypothesise that neuronal vulnerability reflects shared phenotypic characteristics that confer selective vulnerability to degeneration. Neuronal phenotypic specification is mainly the cumulative result of a transcriptional regulatory program that is active during the development. By manual curation of the developmental biology literature, we comprehensively reconstructed an anatomically resolved cellular developmental lineage for the adult neurons in five brainstem regions that are selectively vulnerable to degeneration in prodromal or early Parkinson’s disease. We synthesised the literature on transcription factors that are required to be active, or required to be inactive, in the development of each of these five brainstem regions, and at least two differentially vulnerable nuclei within each region. Certain transcription factors, e.g., Ascl1 and Lmx1b, seem to be required for specification of many brainstem regions that are susceptible to degeneration in early Parkinson’s disease. Some transcription factors can even distinguish between differentially vulnerable nuclei within the same brain region, e.g., Pitx3 is required for specification of the substantia nigra pars compacta, but not the ventral tegmental area. We do not suggest that Parkinson’s disease is a developmental disorder. In contrast, we consider identification of shared developmental trajectories as part of a broader effort to identify the molecular mechanisms that underlie the phenotypic features that are shared by selectively vulnerable neurons. Systematic in vivo assessment of fate determining transcription factors should be completed for all neuronal populations vulnerable to degeneration in early Parkinson’s disease

FINITE SIZE SCALING FOR FIRST ORDER TRANSITIONS: POTTS MODEL

The finite-size scaling algorithm based on bulk and surface renormalization of de Oliveira (1992) is tested on q-state Potts models in dimensions D = 2 and 3. Our Monte Carlo data clearly distinguish between first- and second-order phase transitions. Continuous-q analytic calculations performed for small lattices show a clear tendency of the magnetic exponent Y = D - beta/nu to reach a plateau for increasing values of q, which is consistent with the first-order transition value Y = D. Monte Carlo data confirm this trend.Comment: 5 pages, plain tex, 5 EPS figures, in file POTTS.UU (uufiles

Corpus luteum blood flow evaluation on Day 21 to improve the management of embryo recipient herds

AbstractThe aim of the present study was to use blood flow evaluation of the CL at 14 days after embryo transfer to detect nonpregnant animals and optimize the management of bovine recipients. The estrous cycle was synchronized in 165 recipients, and the day of expected ovulation was considered to be Day 0. Embryo transfer was performed 7 days later, on Day 7. On Day 21, pregnancy was diagnosed on the basis of blood flow evaluation of the CL (DG21—predictive diagnostic). To validate this methodology, visual scores for blood flow were compared to objective data extracted from CL ultrasound images recorded in the Doppler mode. The size was also evaluated using recorded images of the CL in the B mode. Blood samples were also collected for further analysis of the progesterone (P4) concentration. The diagnosis of pregnancy was confirmed at 35 days after estrus (DG35—definitive diagnostic). The DG21 showed that 55.2% (90 of 163) of the animals were presumptively pregnant, and this value was higher (P < 0.04) than that obtained at DG35 (43.6%, 71 of 163). The predictive diagnostic achieved moderate specificity (79.3%) for the detection of pregnancy, but most importantly, high sensitivity (100%) for the detection of nonpregnant recipients. The overall accuracy of the diagnosis was 88.3%. The P4 concentrations were different (P < 0.02) and correlated with each visual score assigned for the CL size. Visual scores for CL blood flow were also efficient (P < 0.0001) to distinguish animals with different levels of P4; however, P4 concentrations were higher for scores 1 and 2 (high and regular blood flow, respectively) than those for score 3 (low blood flow). This technique showed high sensitivity and facilitated the early detection of nonpregnant animals. The DG21 would allow about 79.3% of nonpregnant animals to be resynchronized 9 to 14 days earlier, when compared to conventional management based on pregnancy diagnosis at Days 30 to 35

Preparation And Characterization Of Maleic Anhydride Grafted Poly (hydroxybutirate-co-hydroxyvalerate)-phbv-g-ma

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)A compatibilizer agent was successfully produced by grafting maleic anhydride (MA) to poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) chains on a reactive processing by mechanical mixing, using a mixture of PHBV, MA and dicumyl peroxide (DCP) as initiator. The resulting PHBV grafted MA (PHBV-g-MA) was characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC), and its properties were compared to neat PHBV. FTIR showed an absorption band at 699 cm-1 for PHBV-g-MA, related to CH group of grafted anhydride ring. The initial thermal degradation temperature of the compatibilizer agent was reduced when compared to neat PHBV. DSC analysis showed that after grafting MA onto PHBV the crystallization temperature was about 20°C higher than neat PHBV, and the degree of crystallinity was increased. GPC analysis showed that MA when grafted onto PHBV led to a reduction of molecular weight and polydispersity.191229235CAPES, Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFAPESP, São Paulo Research FoundationCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

Fatigue Behavior of Metallic Components Obtained by Topology Optimization for Additive Manufacturing

The main goal of the present research is to propose an integrated methodology to address the fatigue performance of topology optimized components, produced by additive manufacturing. The main steps of the component design will be presented, specially the methods and parameters applied to the topology optimization and the post-smoothing process. The SIMP method was applied in order to obtain a lighter component and a suitable stiffness for the desired application. In addition, since residual stresses are intrinsic to every metallic additive manufacturing process, the influence of those stresses will be also analyzed. The Laser Powder Bed Fusion was numerically simulated aiming at evaluating the residual stresses the workpiece during the manufacturing process and to investigate how they could influence the fatigue behavior of the optimized component. The effect of the built orientation of the workpiece on the residual stresses at some selected potential critical points are evaluated. The final design solution presented a stiffness/volume ratio nearly 6 times higher when compared to the initial geometry. By choosing the built orientation, it is possible impact favorably in the fatigue life of the component

Effects of air temperature on physiology and productive performance of pigs during growing and finishing phases

Thirty-six castrated male pigs were used to determine the influence of thermal environment and reduction of consumption on performance and carcass composition. Animals were housed in two climate chambers. In one, animals were in thermal comfort (TN) (22 °C), and in the other, pigs were under heat stress (HS) (34 °C). Animals were distributed in a randomized block design, making three treatments (TN, HS and animals in thermal comfort with food consumption paired with that observed in HS (PFTN)), with six replicates and two animals per experimental unit. Data were obtained on performance and carcass composition. The weight gains of HS and PFTN animals were reduced by 40.5% and 34.7%, respectively, reflecting a reduction of 13.2% in the final weight of PFTN animals. Triiodothyronine concentration was not affected by heat, but there was an increase in lymphocyte numbers in PFTN animals. The HS and PFTN animals showed lower hot carcass weight. However, there were no effects on hot carcass yield and relative weights of heart, lung and spleen. Heat stress compromised performance. The negative effects of high temperature on pigs include reduction in feed intake and changes in physiology.Keywords: Environment, heat stress, pair feed, pig growth, pig productio